Cadmium, lead, and mercury in relation to reproductive hormones and anovulation in premenopausal women

Environmental Health Perspectives

Volumn 119, Issue 8, 2011, Pages 1156-1161

  Pollack, Anna Z ^a,b   Schisterman, Enrique F ^a   Goldman, Lynn R ^b   Mumford, Sunni L ^a   Albert, Paul S ^a   Jones, Robert L ^c   Wactawski Wende, Jean ^d  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c NATIONAL CENTER FOR ENVIRONMENTAL HEALTH   (United States)

^d UNIVERSITY AT BUFFALO   (United States)

Author keywords

Anovulation; Cadmium; Lead; Menstrual cycle; Mercury; Reproductive hormones

Indexed keywords

CADMIUM; ESTRADIOL; FOLLITROPIN; LEAD; LUTEINIZING HORMONE; MERCURY; METAL; PROGESTERONE;

ADULT; ANOVULATION; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEMALE; FOLLOW UP; GEOMETRY; HORMONE BLOOD LEVEL; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MASS SPECTROMETRY; MENSTRUAL CYCLE; NONLINEAR SYSTEM; PREMENOPAUSE; PRIORITY JOURNAL; PROBABILITY;

ADOLESCENT; ADULT; ANOVULATION; CADMIUM; ESTRADIOL; FEMALE; FOLLICLE STIMULATING HORMONE; HUMANS; LEAD; LUTEINIZING HORMONE; MASS SPECTROMETRY; MENSTRUAL CYCLE; MERCURY; PREMENOPAUSE; PROGESTERONE; YOUNG ADULT;

EID: 79961090796     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1003284     Document Type: Article

References (53)

1. Abdulla U, Diver MJ, Hipkin LJ, Davis JC. 1983. Plasma progesterone levels as an index of ovulation. Br J Obstet Gynaecol 90:543-548.
2. Aberg B, Ekman L, Falk R, Greitz U, Persson G, Snihs JO. 1969. Metabolism of methyl mercury (203Hg) compounds in man. Arch Environ Health 19:478-484.
3. Akaike H. 1973. Information theory and an extension of the maximum likelihood principle. In: Second International Symposium on Information Theory, Tsahkadsor, Armenia, USSR, 2-8 September 1971 (Petrov BN, Csáki F, eds). Budapest, Hungary:Second International Symposium on Information Theory, 267-281.
4. Aksel S, Wiebe RH, Tyson JE, Jones GS. 1976. Hormonal findings associated with aluteal cycles. Obstet Gynecol 48:598-602.
5. Albert PS, Hunsberger S. 2005. On analyzing circadian rhythms data using nonlinear mixed models with harmonic terms. Biometrics 61:1115-1120.
6. ATSDR (Agency for Toxic Substances and Disease Registry). 1999a. Public Health Statement: Mercury. CAS ID 7439-97-6. Atlanta, GA:ATSDR.
7. ATSDR (Agency for Toxic Substances and Disease Registry). 1999b. Toxicological Profile for Cadmium. Atlanta, GA:Agency for Toxic Substances and Disease Registry, U.S. Department of Health and Human Services, Public Health Service.
8. Brinton LA, Schairer C, Hoover RN, Fraumeni JF. 1988. Menstrual factors and risk of breast cancer. Cancer Invest 6:245-254.
9. Chang SH, Cheng BH, Lee SL, Chuang HY, Yang CY, Sung FC, et al. 2006. Low blood lead concentration in association with infertility in women. Environ Res 101:380-386.
10. Choe SY, Kim SJ, Kim HG, Lee JH, Choi Y, Lee H, et al. 2003. Evaluation of estrogenicity of major heavy metals. Sci Total Environ 312:15-21.
11. Cole SR, Hernan MA. 2008. Constructing inverse probability weights for marginal structural models. Am J Epidemiol 168:656-664.
12. Craig CL, Marshall AL, Sjöström M, Bauman AE, Booth ML, Ainsworth BE, et al. 2003. International Physical Activity Questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 35:1381-1395.
13. Foster WG, McMahon A, Rice DC. 1996. Subclinical changes in luteal function in cynomolgus monkeys with moderate blood lead levels. J Appl Toxicol 16:159-163.
14. Gallagher CM, Moonga BS, Kovach JS. 2010. Cadmium, follicle-stimulating hormone, and effects on bone in women age 42-60 years, NHANES III. Environ Res 110:105-111.
15. Garcia-Morales P, Saceda M, Kenney N, Kim N, Salomon DS, Gottardis MM, et al. 1994. Effect of cadmium on estrogen receptor levels and estrogen-induced responses in human breast cancer cells. J Biol Chem 269:16896-16901.
16. Gaskins AJ, Mumford SL, Zhang C, Wactawski-Wende J, Hovey KM, Whitcomb BW, et al. 2009. Effect of daily fiber intake on reproductive function: the BioCycle Study. Am J Clin Nutr 90:1061-1069.
17. Gerhard I, Waibel S, Daniel V, Runnebaum B. 1998. Impact of heavy metals on hormonal and immunological factors in women with repeated miscarriages. Hum Reprod Update 4:301-309.
18. Gollenberg AL, Hediger ML, Lee PA, Himes JH, Buck Louis GM. 2010. Association between lead and cadmium and reproductive hormones in peripubertal U.S. girls. Environ Health Perspect 118:1782-1787.
19. Groten JP, van Bladeren PJ. 1994. Cadmium bioavailability and health risk in food. Trends Food Sci Technol 5:50-55.
20. Guével RL, Petit FG, Goff PL, Métivier R, Valotaire Y, Pakdel F. 2000. Inhibition of rainbow trout (Oncorhynchus mykiss) estrogen receptor activity by cadmium. Biol Reprod 63:259-266.
21. Howards PP, Schisterman EF, Wactawski-Wende J, Reschke JE, Frazer AA, Hovey KM. 2009. Timing clinic visits to phases of the menstrual cycle by using a fertility monitor: the BioCycle Study. Am J Epidemiol 169:105-112.
22. Hu H, Shih R, Rothenberg S, Schwartz BS. 2007. The epidemiology of lead toxicity in adults: measuring dose and consideration of other methodologic issues. Environ Health Perspect 115:455-462.
23. Jackson LW, Zullo MD, Goldberg JM. 2008. The association between heavy metals, endometriosis and uterine myomas among premenopausal women: National Health and Nutrition Examination Survey 1999-2002. Hum Reprod 23:679-687.
24. Järup L, Akesson A. 2009. Current status of cadmium as an environmental health problem. Toxicol Appl Pharmacol 238:201-208.
25. Kawai M, Swan KF, Green AE, Edwards DE, Anderson MB, Henson MC. 2002. Placental endocrine disruption induced by cadmium: effects on P450 cholesterol side-chain cleavage and 3beta-hydroxysteroid dehydrogenase enzymes in cultured human trophoblasts. Biol Reprod 67:178-183.
26. Kolesarova A, Roychoudhury S, Slivkova J, Sirotkin A, Capcarova M, Massanyi P. 2010. In vitro study on the effects of lead and mercury on porcine ovarian granulosa cells. J Environ Sci Health A Tox Hazard Subst Environ Eng 45:320-331.
27. Krieg J. 2007. The relationships between blood lead levels and serum follicle stimulating hormone and luteinizing hormone in the third National Health and Nutrition Examination Survey. Environ Res 104:374-382.
28. Laughlin NK, Bowman RE, Franks PA, Dierschke DJ. 1987. Altered menstrual cycles in rhesus-monkeys induced by lead. Fundam Appl Toxicol 9:722-729.
29. Lutoslawska G, Niedbalska M, Skierska E, Keska A, Szpocinska-Byszewska E, Zolnowska M. 2006. Plasma proinsulin, C-peptide and sex hormone concentrations in regularly menstruating premenopausal females with ovulatory and anovulatory menstrual cycles. J Sports Med Phys Fitness 46:138-142.
30. Malcolm CE, Cumming DC. 2003. Does anovulation exist in eumenorrheic women? Obstet Gynecol 102:317-318.
31. Mendola P, Messer LC, Rappazzo K. 2008. Science linking environmental contaminant exposures with fertility and reproductive health impacts in the adult female. Fertil Steril 89:e81-e94.
32. Mielke HW, Reagan PL. 1998. Soil is an important pathway of human lead exposure. Environ Health Perspect 106:217-229.
33. Mijal RS, Holzman CB. 2010. Blood cadmium levels in women of childbearing age vary by race/ethnicity. Environ Res 110:505-512.
34. Nagata C, Nagao Y, Shibuya C, Kashiki Y, Shimizu H. 2005. Urinary cadmium and serum levels of estrogens and androgens in postmenopausal Japanese women. Cancer Epidemiol Biomarkers Prev 14:705-708.
35. Pirkle JL, Brody DJ, Gunter EW, Kramer RA, Paschal DC, Flegal KM, et al. 1994. The decline in blood lead levels in the United States: the National Health and Nutrition Examination Surveys (NHANES). JAMA 272:284-291.
36. Rabinowitz MB. 1991. Toxicokinetics of bone lead. Environ Health Perspect 91:33-37.
37. Richardson DB, Ciampi A. 2003. Effects of exposure measurement error when an exposure variable is constrained by a lower limit. Am J Epidemiol 157:355-363.
38. Robins JM, Hernán MA, Brumback B. 2000. Marginal structural models and causal inference in epidemiology. Epidemiology 11:550-560.
39. Rossouw JE, Anderson GL, Prentice RL, Lacroix AZ, Kooperberg C, Stefanick ML, et al. 2002. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 288:321-333.
40. Santoro N, Brown JR, Adel T, Skurnick JH. 1996. Characterization of reproductive hormonal dynamics in the perimenopause. J Clin Endocrinol Metab 81:1495-1501.
41. Satarug S, Moore MR. 2004. Adverse health effects of chronic exposure to low-level cadmium in foodstuffs and cigarette smoke. Environ Health Perspect 112:1099-1103.
42. Schisterman EF, Vexler A, Whitcomb BW, Liu A. 2006. The limitations due to exposure detection limits for regression models. Am J Epidemiol 163:374-383.
43. Silva E, Lopez-Espinosa MJ, Molina-Molina JM, Fernández M, Olea N, Kortenkamp A. 2006. Lack of activity of cadmium in in vitro estrogenicity assays. Toxicol Appl Pharmacol 216:20-28.
44. Srivastava V, Dearth RK, Hiney JK, Ramirez LM, Bratton GR, Les Dees W. 2004. The effects of low-level Pb on steroidogenic acute regulatory protein (StAR) in the prepubertal rat ovary. Toxicol Sci 77:35-40.
45. Stasenko S, Bradford EM, Piasek M, Henson MC, Varnai VM, Jurasovic J, et al. 2010. Metals in human placenta: focus on the effects of cadmium on steroid hormones and leptin. J Appl Toxicol 30:242-253.
46. Stoica A, Katzenellenbogen BS, Martin MB. 2000. Activation of estrogen receptor-alpha by the heavy metal cadmium. Mol Endocrinol 14:545-553.
47. Tilghman SL, Nierth-Simpson EN, Wallace R, Burow ME, McLachlan JA. 2008. Environmental hormones: multiple pathways for response may lead to multiple disease outcomes. Steroids 75:520-523.
48. Vahter M, Berglund M, Akesson A, Lidén C. 2002. Metals and women's health. Environ Res 88:145-155.
49. Wactawski-Wende J, Schisterman EF, Hovey KM, Howards PP, Browne RW, Hediger M, et al. 2009. BioCycle Study: design of the longitudinal study of the oxidative stress and hormone variation during the menstrual cycle. Paediatr Perinat Epidemiol 23:171-184.
50. Yang DT, Owen WE, Ramsay CS, Xie H, Roberts WL. 2004. Performance characteristics of eight estradiol immunoassays. Am J Clin Pathol 122:332-337.
51. Zeger SL, Liang KY, Albert PS. 1988. Models for longitudinal data: a generalized estimating equation approach. Biometrics 44:1049-1060.
52. Zhang WC, Jia HM. 2007. Effect and mechanism of cadmium on the progesterone synthesis of ovaries. Toxicology 239:204-212.
53. Zhang XJ, Wang YD, Zhao YZ, Chen XY. 2008. Experimental study on the estrogen-like effect of mercuric chloride. Biometals 21:143-150.