Effects of cadmium on estrogen receptor mediated signaling and estrogen induced DNA synthesis in T47D human breast cancer cells

Toxicology Letters

Volumn 184, Issue 2, 2009, Pages 134-138

  Zang, Yu ^a   Odwin DaCosta, Shelly ^a   Yager, James D ^a  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Cadmium; DNA synthesis; Estrogen receptor signaling; T47D cells

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; CADMIUM; CADMIUM DERIVATIVE; DNA; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; FULVESTRANT; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROGESTERONE RECEPTOR; PROTEIN PS2;

ARTICLE; BREAST CANCER; CANCER CELL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA SYNTHESIS; ENZYME PHOSPHORYLATION; GENOMICS; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

BREAST NEOPLASMS; CADMIUM CHLORIDE; CARCINOGENS, ENVIRONMENTAL; CELL LINE, TUMOR; DNA, NEOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ESTRADIOL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HUMANS; PHOSPHORYLATION; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; SIGNAL TRANSDUCTION;

EID: 58149280227     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2008.10.032     Document Type: Article

References (33)

1. Acconcia F., and Kumar R. Signaling regulation of genomic and nongenomic functions of estrogen receptors. Cancer Lett. 238 (2006) 1-14
2. Atanaskova N., Keshamouni V.G., Krueger J.S., Schwartz J.A., Miller F., and Reddy K.B. MAP kinase/estrogen receptor cross-talk enhances estrogen-mediated signaling and tumor growth but does not confer tamoxifen resistance. Oncogene 21 (2002) 4000-4008
3. Brama M., Gnessi L., Basciani S., Cerulli N., Politi L., Spera G., Mariani S., Cherubini S., d'Abusco A.S., Scandurra R., and Migliaccio S. Cadmium induces mitogenic signaling in breast cancer cell by an ERalpha-dependent mechanism. Mol. Cell Endocrinol. 264 (2007) 102-108
4. Choe S.-Y., Kim S.-J., Kim H.-G., Lee J.H., Choi Y., Lee H., and Kim Y. Evaluation of estrogenicity of major heavy metals. Sci. Total Environ. 312 (2003) 15-21
5. Darbre P.D. Metalloestrogens: an emerging class of inorganic xenoestrogens with potential to add to the oestrogenic burden of the human breast. J. Appl. Toxicol. 26 (2006) 191-197
6. Garcia-Morales P., Saceda M., Kenney N., Kim N., Salomon D.S., Gottardis M.M., Solomon H.B., Sholler P.F., Jordan V.C., and Martin M.B. Effect of cadmium on estrogen receptor levels and estrogen-induced responses in human breast cancer cells. J. Biol. Chem. 269 (1994) 16896-16901
7. Geffroy N., Guedin A., Dacquet C., and Lefebvre P. Cell cycle regulation of breast cancer cells through estrogen-induced activities of ERK and Akt protein kinases. Mol. Cell. Endocrinol. 237 (2005) 11-23
8. Guevel R.L., Petit F.G., Goff P.L., Metivier R., Valotaire Y., and Pakdel F. Inhibition of rainbow trout (Oncorhynchus mykiss) estrogen receptor activity by cadmium. Biol. Reprod. 63 (2000) 259-266
9. Huss J.M., and Kelly D.P. Nuclear receptor signaling and cardiac energetics. Circ. Res. 95 (2004) 568-578
10. International Agency for Research on Cancer, 1993. Beryllium, Cadmium, Mercury and Exposures in the Glass Manufacturing Industry, vol. 58.
11. Johnson M.D., Kenney N., Stoica A., Hilakivi-Clarke L., Singh B., Chepko G., Clarke R., Sholler P.F., Lirio A.A., Foss C., Reiter R., Trock B., Paik S., and Martin M.B. Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland. Nat. Med. 9 (2003) 1081-1084
12. Kortenkamp A. Breast cancer, oestrogens and environmental pollutants: a re-evaluation from a mixture perspective. Int. J. Androl. 29 (2006) 193-198
13. Levin E.R., and Pietras R.J. Estrogen receptors outside the nucleus in breast cancer. Breast Cancer Res. Treat. (2007)
14. Li X., Zhang S., and Safe S. Activation of kinase pathways in MCF-7 cells by 17beta-estradiol and structurally diverse estrogenic compounds. J. Steroid Biochem. Mol. Biol. 98 (2006) 122-132
15. Liu Z., Yu X., and Shaikh Z.A. Rapid activation of ERK1/2 and AKT in human breast cancer cells by cadmium. Toxicol. Appl. Pharmacol. 228 (2008) 286-294
16. Martin L.A., Farmer I., Johnston S.R., Ali S., and Dowsett M. Elevated ERK1/ERK2/estrogen receptor cross-talk enhances estrogen-mediated signaling during long-term estrogen deprivation. Endocr. Relat. Cancer 12 Suppl 1 (2005) S75-84
17. Martin P., Poggi M.C., Chambard J.C., Boulukos K.E., and Pognonec P. Low dose cadmium poisoning results in sustained ERK phosphorylation and caspase activation. Biochem. Biophys. Res. Commun. 350 (2006) 803-807
18. Meyer M.R., Haas E., and Barton M. Gender differences of cardiovascular disease: new perspectives for estrogen receptor signaling. Hypertension 47 (2006) 1019-1026
19. Nesatyy V.J., Ammann A.A., Rutishauser B.V., and Suter M.J. Effect of cadmium on the interaction of 17beta-estradiol with the rainbow trout estrogen receptor. Environ. Sci. Technol. 40 (2006) 1358-1363
20. NHANES, 2006. Laboratory Assessment: Lab 6-Blood Lead and Cadmium, Blood Total Mercury, and Blood Inorganic Mercury. National Health and Nutrition Examination Survey 2003-2004 Data Documentation.
21. Pillon A., Boussioux A.M., Escande A., Ait-Aissa S., Gomez E., Fenet H., Ruff M., Moras D., Vignon F., Duchesne M.J., Casellas C., Nicolas J.C., and Balaguer P. Binding of estrogenic compounds to recombinant estrogen receptor-alpha: application to environmental analysis. Environ. Health Perspect. 113 (2005) 278-284
22. Reddy K.B., Yee D., Hilsenbeck S.G., Coffey R.J., and Osborne C.K. Inhibition of estrogen-induced breast cancer cell proliferation by reduction in autocrine transforming growth factor alpha expression. Cell Growth Differ. 5 (1994) 1275-1282
23. Santen R.J., Song R.X., McPherson R., Kumar R., Adam L., Jeng M.H., and Yue W. The role of mitogen-activated protein (MAP) kinase in breast cancer. J. Steroid Biochem. Mol. Biol. 80 (2002) 239-256
24. Schafer T.E., Lapp C.A., Hanes C.M., Lewis J.B., Wataha J.C., and Schuster G.S. Estrogenicity of bisphenol A and bisphenol A dimethacrylate in vitro. J. Biomed. Mater. Res. 45 (1999) 192-197
25. Silva E., Lopez-Espinosa M.J., Molina-Molina J.M., Fernandez M., Olea N., and Kortenkamp A. Lack of activity of cadmium in in vitro estrogenicity assays. Toxicol. Appl. Pharmacol. 216 1 (2006) 20-28
26. Song R.X.D., McPherson R.A., Adam L., Bao Y., Shupnik M., Kumar R., and Santen R.J. Linkage of rapid estrogen action to MAPK activation by ER{alpha}-Shc association and Shc pathway activation, vol. 16 (2002) pp. 116-127
27. Stabile L.P., and Siegfried J.M. Estrogen receptor pathways in lung cancer. Curr. Oncol. Rep. 6 (2004) 259-267
28. Stoica A., Katzenellenbogen B.S., and Martin M.B. Activation of estrogen receptor-alpha by the heavy metal cadmium. Mol. Endocrinol. 14 (2000) 545-553
29. Stoica A., Pentecost E., and Martin M.B. Effects of arsenite on estrogen receptor-alpha expression and activity in MCF-7 breast cancer cells. Endocrinology 141 (2000) 3595-3602
30. Waalkes M.P. Cadmium carcinogenesis. Mutat. Res. 533 (2003) 107-120
31. Wilson V.S., Bobseine K., and Gray Jr. L.E. Development and characterization of a cell line that stably expresses an estrogen-responsive luciferase reporter for the detection of estrogen receptor agonist and antagonists. Toxicol. Sci. 81 (2004) 69-77
32. Yager J.D., and Davidson N.E. Estrogen carcinogenesis in breast cancer. N. Engl. J. Med. 354 (2006) 270-282
33. Zivadinovic D., and Watson C.S. Membrane estrogen receptor-alpha levels predict estrogen-induced ERK1/2 activation in MCF-7 cells. Breast Cancer Res. 7 (2005) R130-R144