메뉴 건너뛰기




Volumn 36, Issue 3, 2016, Pages 437-448

α-Synuclein in Extracellular Vesicles: Functional Implications and Diagnostic Opportunities

Author keywords

Exosomes; Extracellular vesicles; Synuclein

Indexed keywords

ALPHA SYNUCLEIN; BIOLOGICAL MARKER;

EID: 84961231281     PISSN: 02724340     EISSN: 15736830     Source Type: Journal    
DOI: 10.1007/s10571-015-0317-0     Document Type: Review
Times cited : (51)

References (71)
  • 1
    • 70349991886 scopus 로고    scopus 로고
    • LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model
    • COI: 1:CAS:528:DC%2BD1MXht1CrtrvN, PID: 19640926
    • Alegre-Abarrategui J, Christian H, Lufino MM, Mutihac R, Venda LL, Ansorge O, Wade-Martins R (2009) LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model. Hum Mol Genet 18(21):4022–4034. doi:10.1093/hmg/ddp346
    • (2009) Hum Mol Genet , vol.18 , Issue.21 , pp. 4022-4034
    • Alegre-Abarrategui, J.1    Christian, H.2    Lufino, M.M.3    Mutihac, R.4    Venda, L.L.5    Ansorge, O.6    Wade-Martins, R.7
  • 2
    • 79954631518 scopus 로고    scopus 로고
    • Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission
    • COI: 1:CAS:528:DC%2BC3MXkvVGlur0%3D, PID: 21303699
    • Alvarez-Erviti L, Seow Y, Schapira AH, Gardiner C, Sargent IL, Wood MJ, Cooper JM (2011) Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission. Neurobiol Dis 42(3):360–367. doi:10.1016/j.nbd.2011.01.029
    • (2011) Neurobiol Dis , vol.42 , Issue.3 , pp. 360-367
    • Alvarez-Erviti, L.1    Seow, Y.2    Schapira, A.H.3    Gardiner, C.4    Sargent, I.L.5    Wood, M.J.6    Cooper, J.M.7
  • 4
    • 32544442518 scopus 로고    scopus 로고
    • Gastric alpha-synuclein immunoreactive inclusions in Meissner’s and Auerbach’s plexuses in cases staged for Parkinson’s disease-related brain pathology
    • COI: 1:CAS:528:DC%2BD28XhsF2gurc%3D, PID: 16330147
    • Braak H, de Vos RA, Bohl J, Del Tredici K (2006) Gastric alpha-synuclein immunoreactive inclusions in Meissner’s and Auerbach’s plexuses in cases staged for Parkinson’s disease-related brain pathology. Neurosci Lett 396(1):67–72. doi:10.1016/j.neulet.2005.11.012
    • (2006) Neurosci Lett , vol.396 , Issue.1 , pp. 67-72
    • Braak, H.1    de Vos, R.A.2    Bohl, J.3    Del Tredici, K.4
  • 6
    • 78049383132 scopus 로고    scopus 로고
    • Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo
    • COI: 1:CAS:528:DC%2BC3cXhtlKhur%2FO, PID: 20887775
    • Chinta SJ, Mallajosyula JK, Rane A, Andersen JK (2010) Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo. Neurosci Lett 486(3):235–239. doi:10.1016/j.neulet.2010.09.061
    • (2010) Neurosci Lett , vol.486 , Issue.3 , pp. 235-239
    • Chinta, S.J.1    Mallajosyula, J.K.2    Rane, A.3    Andersen, J.K.4
  • 7
    • 84929506373 scopus 로고    scopus 로고
    • Ectosomes and exosomes: shedding the confusion between extracellular vesicles
    • COI: 1:CAS:528:DC%2BC2MXitFCqs7c%3D, PID: 25683921
    • Cocucci E, Meldolesi J (2015) Ectosomes and exosomes: shedding the confusion between extracellular vesicles. Trends Cell Biol 25(6):364–372. doi:10.1016/j.tcb.2015.01.004
    • (2015) Trends Cell Biol , vol.25 , Issue.6 , pp. 364-372
    • Cocucci, E.1    Meldolesi, J.2
  • 8
    • 0034681163 scopus 로고    scopus 로고
    • Acceleration of oligomerization, not fibrillization, is a shared property of both a-synuclein mutations limked to early-onset Parkinson’s disease: implications for pathogenesis and therapy
    • COI: 1:CAS:528:DC%2BD3cXot1ajtw%3D%3D, PID: 10639120
    • Conway K, Lee S-J, Rochet J-C, Ding T, Williamson RE, Lansbury P (2000) Acceleration of oligomerization, not fibrillization, is a shared property of both a-synuclein mutations limked to early-onset Parkinson’s disease: implications for pathogenesis and therapy. Proc Natl Acad Sci USA 97:571–576
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 571-576
    • Conway, K.1    Lee, S.-J.2    Rochet, J.-C.3    Ding, T.4    Williamson, R.E.5    Lansbury, P.6
  • 9
    • 34548172773 scopus 로고    scopus 로고
    • Different species of alpha-synuclein oligomers induce calcium influx and seeding
    • COI: 1:CAS:528:DC%2BD2sXhtVSnsLfM, PID: 17715357
    • Danzer KM, Haasen D, Karow AR, Moussaud S, Habeck M, Giese A, Kretzschmar H, Hengerer B, Kostka M (2007) Different species of alpha-synuclein oligomers induce calcium influx and seeding. J Neurosci 27(34):9220–9232. doi:10.1523/JNEUROSCI.2617-07.2007
    • (2007) J Neurosci , vol.27 , Issue.34 , pp. 9220-9232
    • Danzer, K.M.1    Haasen, D.2    Karow, A.R.3    Moussaud, S.4    Habeck, M.5    Giese, A.6    Kretzschmar, H.7    Hengerer, B.8    Kostka, M.9
  • 11
    • 69149089854 scopus 로고    scopus 로고
    • Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein
    • COI: 1:CAS:528:DC%2BD1MXhtVKru7%2FM, PID: 19651612
    • Desplats P, Lee HJ, Bae EJ, Patrick C, Rockenstein E, Crews L, Spencer B, Masliah E, Lee SJ (2009) Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci USA 106(31):13010–13015. doi:10.1073/pnas.0903691106
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.31 , pp. 13010-13015
    • Desplats, P.1    Lee, H.J.2    Bae, E.J.3    Patrick, C.4    Rockenstein, E.5    Crews, L.6    Spencer, B.7    Masliah, E.8    Lee, S.J.9
  • 13
    • 85028134157 scopus 로고    scopus 로고
    • Clinical use of novel urine and blood based prostate cancer biomarkers: a review
    • COI: 1:CAS:528:DC%2BC3sXhslOrtrfK, PID: 24177197
    • Dijkstra S, Mulders PF, Schalken JA (2014) Clinical use of novel urine and blood based prostate cancer biomarkers: a review. Clin Biochem 47(10–11):889–896. doi:10.1016/j.clinbiochem.2013.10.023
    • (2014) Clin Biochem , vol.47 , Issue.10-11 , pp. 889-896
    • Dijkstra, S.1    Mulders, P.F.2    Schalken, J.A.3
  • 14
    • 77952648551 scopus 로고    scopus 로고
    • Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival
    • COI: 1:CAS:528:DC%2BC3cXovVWnurk%3D, PID: 20484626
    • Emmanouilidou E, Melachroinou K, Roumeliotis T, Garbis SD, Ntzouni M, Margaritis LH, Stefanis L, Vekrellis K (2010) Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival. J Neurosci 30(20):6838–6851. doi:10.1523/JNEUROSCI.5699-09.2010
    • (2010) J Neurosci , vol.30 , Issue.20 , pp. 6838-6851
    • Emmanouilidou, E.1    Melachroinou, K.2    Roumeliotis, T.3    Garbis, S.D.4    Ntzouni, M.5    Margaritis, L.H.6    Stefanis, L.7    Vekrellis, K.8
  • 19
    • 84921915868 scopus 로고    scopus 로고
    • Acceleration of alpha-synuclein aggregation by exosomes
    • COI: 1:CAS:528:DC%2BC2MXhvVersLw%3D, PID: 25425650
    • Grey M, Dunning CJ, Gaspar R, Grey C, Brundin P, Sparr E, Linse S (2015) Acceleration of alpha-synuclein aggregation by exosomes. J Biol Chem 290(5):2969–2982. doi:10.1074/jbc.M114.585703
    • (2015) J Biol Chem , vol.290 , Issue.5 , pp. 2969-2982
    • Grey, M.1    Dunning, C.J.2    Gaspar, R.3    Grey, C.4    Brundin, P.5    Sparr, E.6    Linse, S.7
  • 20
    • 84879602725 scopus 로고    scopus 로고
    • LRRK2 interactions with alpha-synuclein in Parkinson’s disease brains and in cell models
    • COI: 1:CAS:528:DC%2BC3sXltFCitbc%3D
    • Guerreiro PS, Huang Y, Gysbers A, Cheng D, Gai WP, Outeiro TF, Halliday GM (2013) LRRK2 interactions with alpha-synuclein in Parkinson’s disease brains and in cell models. J Mol Med (Berl) 91(4):513–522. doi:10.1007/s00109-012-0984-y
    • (2013) J Mol Med (Berl) , vol.91 , Issue.4 , pp. 513-522
    • Guerreiro, P.S.1    Huang, Y.2    Gysbers, A.3    Cheng, D.4    Gai, W.P.5    Outeiro, T.F.6    Halliday, G.M.7
  • 21
    • 84947745257 scopus 로고    scopus 로고
    • Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease
    • Gui YX, Liu H, Zhang LS, Lv W, Hu XY (2015) Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease. Oncotarget. doi:10.18632/oncotarget.6158
    • (2015) Oncotarget
    • Gui, Y.X.1    Liu, H.2    Zhang, L.S.3    Lv, W.4    Hu, X.Y.5
  • 23
    • 0034827449 scopus 로고    scopus 로고
    • Cortical Lewy body pathology in the diagnosis of dementia
    • COI: 1:CAS:528:DC%2BD3MXmsFWgs7w%3D, PID: 11603811
    • Harding AJ, Halliday GM (2001) Cortical Lewy body pathology in the diagnosis of dementia. Acta Neuropathol 102(4):355–363
    • (2001) Acta Neuropathol , vol.102 , Issue.4 , pp. 355-363
    • Harding, A.J.1    Halliday, G.M.2
  • 24
    • 84912535407 scopus 로고    scopus 로고
    • Increased DJ-1 in urine exosome of Korean males with Parkinson’s disease
    • PID: 25478574
    • Ho DH, Yi S, Seo H, Son I, Seol W (2014) Increased DJ-1 in urine exosome of Korean males with Parkinson’s disease. BioMed Res Int 2014:704678. doi:10.1155/2014/704678
    • (2014) BioMed Res Int , vol.2014 , pp. 704678
    • Ho, D.H.1    Yi, S.2    Seo, H.3    Son, I.4    Seol, W.5
  • 27
    • 52049098478 scopus 로고    scopus 로고
    • Structural characteristics of alpha-synuclein oligomers stabilized by the flavonoid baicalein
    • COI: 1:CAS:528:DC%2BD1cXhtFeksbfP, PID: 18775438
    • Hong DP, Fink AL, Uversky VN (2008) Structural characteristics of alpha-synuclein oligomers stabilized by the flavonoid baicalein. J Mol Biol 383(1):214–223. doi:10.1016/j.jmb.2008.08.039
    • (2008) J Mol Biol , vol.383 , Issue.1 , pp. 214-223
    • Hong, D.P.1    Fink, A.L.2    Uversky, V.N.3
  • 29
    • 84874894136 scopus 로고    scopus 로고
    • alpha-Synuclein as CSF and Blood Biomarker of Dementia with Lewy Bodies
    • Kasuga K, Nishizawa M, Ikeuchi T (2012) alpha-Synuclein as CSF and Blood Biomarker of Dementia with Lewy Bodies. Int J Alzheimer’s Dis 2012:437025. doi:10.1155/2012/437025
    • (2012) Int J Alzheimer’s Dis , vol.2012 , pp. 437025
    • Kasuga, K.1    Nishizawa, M.2    Ikeuchi, T.3
  • 31
    • 43249114934 scopus 로고    scopus 로고
    • Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson’s disease
    • COI: 1:CAS:528:DC%2BD1cXlsFCmsrg%3D, PID: 18391962
    • Kordower JH, Chu Y, Hauser RA, Freeman TB, Olanow CW (2008) Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson’s disease. Nat Med 14(5):504–506
    • (2008) Nat Med , vol.14 , Issue.5 , pp. 504-506
    • Kordower, J.H.1    Chu, Y.2    Hauser, R.A.3    Freeman, T.B.4    Olanow, C.W.5
  • 32
    • 84893437162 scopus 로고    scopus 로고
    • Dynamic biodistribution of extracellular vesicles in vivo using a multimodal imaging reporter
    • COI: 1:CAS:528:DC%2BC2cXhsl2qtA%3D%3D, PID: 24383518
    • Lai CP, Mardini O, Ericsson M, Prabhakar S, Maguire CA, Chen JW, Tannous BA, Breakefield XO (2014) Dynamic biodistribution of extracellular vesicles in vivo using a multimodal imaging reporter. ACS Nano 8(1):483–494. doi:10.1021/nn404945r
    • (2014) ACS Nano , vol.8 , Issue.1 , pp. 483-494
    • Lai, C.P.1    Mardini, O.2    Ericsson, M.3    Prabhakar, S.4    Maguire, C.A.5    Chen, J.W.6    Tannous, B.A.7    Breakefield, X.O.8
  • 33
    • 84929353279 scopus 로고    scopus 로고
    • Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters
    • COI: 1:CAS:528:DC%2BC2MXhtF2ksb3N, PID: 25967391
    • Lai CP, Kim EY, Badr CE, Weissleder R, Mempel TR, Tannous BA, Breakefield XO (2015) Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters. Nat Commun 6:7029. doi:10.1038/ncomms8029
    • (2015) Nat Commun , vol.6 , pp. 7029
    • Lai, C.P.1    Kim, E.Y.2    Badr, C.E.3    Weissleder, R.4    Mempel, T.R.5    Tannous, B.A.6    Breakefield, X.O.7
  • 34
    • 44749083979 scopus 로고    scopus 로고
    • Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein
    • COI: 1:CAS:528:DC%2BD1cXnsF2mtrk%3D, PID: 18291704
    • Lee HJ, Suk JE, Bae EJ, Lee JH, Paik SR, Lee SJ (2008) Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein. Int J Biochem Cell Biol 40(9):1835–1849. doi:10.1016/j.biocel.2008.01.017
    • (2008) Int J Biochem Cell Biol , vol.40 , Issue.9 , pp. 1835-1849
    • Lee, H.J.1    Suk, J.E.2    Bae, E.J.3    Lee, J.H.4    Paik, S.R.5    Lee, S.J.6
  • 35
    • 77950571596 scopus 로고    scopus 로고
    • Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies
    • COI: 1:CAS:528:DC%2BC3cXjtFShtLk%3D, PID: 20071342
    • Lee HJ, Suk JE, Patrick C, Bae EJ, Cho JH, Rho S, Hwang D, Masliah E, Lee SJ (2010) Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies. J Biol Chem 285(12):9262–9272. doi:10.1074/jbc.M109.081125
    • (2010) J Biol Chem , vol.285 , Issue.12 , pp. 9262-9272
    • Lee, H.J.1    Suk, J.E.2    Patrick, C.3    Bae, E.J.4    Cho, J.H.5    Rho, S.6    Hwang, D.7    Masliah, E.8    Lee, S.J.9
  • 37
    • 84925884090 scopus 로고    scopus 로고
    • The role of the LRRK2 gene in Parkinsonism
    • COI: 1:CAS:528:DC%2BC2cXisV2ru7w%3D, PID: 25391693
    • Li JQ, Tan L, Yu JT (2014) The role of the LRRK2 gene in Parkinsonism. Mol Neurodegener 9:47. doi:10.1186/1750-1326-9-47
    • (2014) Mol Neurodegener , vol.9 , pp. 47
    • Li, J.Q.1    Tan, L.2    Yu, J.T.3
  • 39
    • 84869109864 scopus 로고    scopus 로고
    • Pathological alpha-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice
    • COI: 1:CAS:528:DC%2BC38Xhs1GntL7L
    • Luk KC, Kehm V, Carroll J, Zhang B, O’Brien P, Trojanowski JQ, Lee VM (2012a) Pathological alpha-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science (New York, NY) 338(6109):949–953. doi:10.1126/science.1227157
    • (2012) Science (New York, NY) , vol.338 , Issue.6109 , pp. 949-953
    • Luk, K.C.1    Kehm, V.2    Carroll, J.3    Zhang, B.4    O’Brien, P.5    Trojanowski, J.Q.6    Lee, V.M.7
  • 40
    • 84862609075 scopus 로고    scopus 로고
    • Intracerebral inoculation of pathological alpha-synuclein initiates a rapidly progressive neurodegenerative alpha-synucleinopathy in mice
    • COI: 1:CAS:528:DC%2BC38Xmsl2itb8%3D, PID: 22508839
    • Luk KC, Kehm VM, Zhang B, O’Brien P, Trojanowski JQ, Lee VM (2012b) Intracerebral inoculation of pathological alpha-synuclein initiates a rapidly progressive neurodegenerative alpha-synucleinopathy in mice. J Exp Med 209(5):975–986. doi:10.1084/jem.20112457
    • (2012) J Exp Med , vol.209 , Issue.5 , pp. 975-986
    • Luk, K.C.1    Kehm, V.M.2    Zhang, B.3    O’Brien, P.4    Trojanowski, J.Q.5    Lee, V.M.6
  • 44
    • 79151470406 scopus 로고    scopus 로고
    • The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of alpha-synuclein oligomers with distinct biochemical, morphological, and functional properties
    • PID: 21130160
    • Nasstrom T, Fagerqvist T, Barbu M, Karlsson M, Nikolajeff F, Kasrayan A, Ekberg M, Lannfelt L, Ingelsson M, Bergstrom J (2011) The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of alpha-synuclein oligomers with distinct biochemical, morphological, and functional properties. Free Radic Biol Med 50(3):428–437. doi:10.1016/j.freeradbiomed.2010.11.027
    • (2011) Free Radic Biol Med , vol.50 , Issue.3 , pp. 428-437
    • Nasstrom, T.1    Fagerqvist, T.2    Barbu, M.3    Karlsson, M.4    Nikolajeff, F.5    Kasrayan, A.6    Ekberg, M.7    Lannfelt, L.8    Ingelsson, M.9    Bergstrom, J.10
  • 45
    • 73549085595 scopus 로고    scopus 로고
    • Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis
    • COI: 1:CAS:528:DC%2BC3cXlt1KmsLw%3D, PID: 20152114
    • Nemani VM, Lu W, Berge V, Nakamura K, Onoa B, Lee MK, Chaudhry FA, Nicoll RA, Edwards RH (2010) Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis. Neuron 65(1):66–79. doi:10.1016/j.neuron.2009.12.023
    • (2010) Neuron , vol.65 , Issue.1 , pp. 66-79
    • Nemani, V.M.1    Lu, W.2    Berge, V.3    Nakamura, K.4    Onoa, B.5    Lee, M.K.6    Chaudhry, F.A.7    Nicoll, R.A.8    Edwards, R.H.9
  • 47
    • 84924410540 scopus 로고    scopus 로고
    • Extracellular alpha-synuclein alters synaptic transmission in brain neurons by perforating the neuronal plasma membrane
    • COI: 1:CAS:528:DC%2BC2MXkt1OjtLw%3D, PID: 25669123
    • Pacheco CR, Morales CN, Ramirez AE, Munoz FJ, Gallegos SS, Caviedes PA, Aguayo LG, Opazo CM (2015) Extracellular alpha-synuclein alters synaptic transmission in brain neurons by perforating the neuronal plasma membrane. J Neurochem 132(6):731–741. doi:10.1111/jnc.13060
    • (2015) J Neurochem , vol.132 , Issue.6 , pp. 731-741
    • Pacheco, C.R.1    Morales, C.N.2    Ramirez, A.E.3    Munoz, F.J.4    Gallegos, S.S.5    Caviedes, P.A.6    Aguayo, L.G.7    Opazo, C.M.8
  • 49
    • 84862916400 scopus 로고    scopus 로고
    • Elevated levels of alpha-synuclein oligomer in the cerebrospinal fluid of drug-naive patients with Parkinson’s disease
    • PID: 22259618
    • Park MJ, Cheon SM, Bae HR, Kim SH, Kim JW (2011) Elevated levels of alpha-synuclein oligomer in the cerebrospinal fluid of drug-naive patients with Parkinson’s disease. J Clin Neurol 7(4):215–222. doi:10.3988/jcn.2011.7.4.215
    • (2011) J Clin Neurol , vol.7 , Issue.4 , pp. 215-222
    • Park, M.J.1    Cheon, S.M.2    Bae, H.R.3    Kim, S.H.4    Kim, J.W.5
  • 50
  • 51
    • 67651008224 scopus 로고    scopus 로고
    • Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications
    • COI: 1:CAS:528:DC%2BD1MXptValsbY%3D, PID: 19576176
    • Qing H, Wong W, McGeer EG, McGeer PL (2009) Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications. Biochem Biophys Res Commun 387(1):149–152. doi:10.1016/j.bbrc.2009.06.142
    • (2009) Biochem Biophys Res Commun , vol.387 , Issue.1 , pp. 149-152
    • Qing, H.1    Wong, W.2    McGeer, E.G.3    McGeer, P.L.4
  • 57
    • 51449099473 scopus 로고    scopus 로고
    • Synuclein activates microglia in a model of Parkinson’s disease
    • COI: 1:CAS:528:DC%2BD1cXhtFCksLzE, PID: 17537546
    • Su X, Maguire-Zeiss KA, Giuliano R, Prifti L, Venkatesh K, Federoff HJ (2008) Synuclein activates microglia in a model of Parkinson’s disease. Neurobiol Aging 29(11):1690–1701. doi:10.1016/j.neurobiolaging.2007.04.006
    • (2008) Neurobiol Aging , vol.29 , Issue.11 , pp. 1690-1701
    • Su, X.1    Maguire-Zeiss, K.A.2    Giuliano, R.3    Prifti, L.4    Venkatesh, K.5    Federoff, H.J.6
  • 59
    • 84862230811 scopus 로고    scopus 로고
    • gamma-Synuclein: seeding of alpha-synuclein aggregation and transmission between cells
    • COI: 1:CAS:528:DC%2BC38XnsVWitbw%3D, PID: 22620680
    • Surgucheva I, Sharov VS, Surguchov A (2012) gamma-Synuclein: seeding of alpha-synuclein aggregation and transmission between cells. Biochemistry 51(23):4743–4754. doi:10.1021/bi300478w
    • (2012) Biochemistry , vol.51 , Issue.23 , pp. 4743-4754
    • Surgucheva, I.1    Sharov, V.S.2    Surguchov, A.3
  • 60
    • 1042266326 scopus 로고    scopus 로고
    • Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective
    • COI: 1:CAS:528:DC%2BD2cXps12ksw%3D%3D, PID: 14627698
    • Tanaka M, Kim YM, Lee G, Junn E, Iwatsubo T, Mouradian MM (2004) Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective. J Biol Chem 279(6):4625–4631. doi:10.1074/jbc.M310994200
    • (2004) J Biol Chem , vol.279 , Issue.6 , pp. 4625-4631
    • Tanaka, M.1    Kim, Y.M.2    Lee, G.3    Junn, E.4    Iwatsubo, T.5    Mouradian, M.M.6
  • 61
  • 62
    • 84909952796 scopus 로고    scopus 로고
    • ATP13A2/PARK9 regulates secretion of exosomes and alpha-synuclein
    • PID: 25392495
    • Tsunemi T, Hamada K, Krainc D (2014) ATP13A2/PARK9 regulates secretion of exosomes and alpha-synuclein. J Neurosci 34(46):15281–15287. doi:10.1523/JNEUROSCI.1629-14.2014
    • (2014) J Neurosci , vol.34 , Issue.46 , pp. 15281-15287
    • Tsunemi, T.1    Hamada, K.2    Krainc, D.3
  • 64
    • 0035815664 scopus 로고    scopus 로고
    • Evidence for a partially folded intermediate in alpha-synuclein fibril formation
    • COI: 1:CAS:528:DC%2BD3MXjvFCqtLs%3D, PID: 11152691
    • Uversky VN, Li J, Fink AL (2001) Evidence for a partially folded intermediate in alpha-synuclein fibril formation. J Biol Chem 276(14):10737–10744. doi:10.1074/jbc.M010907200
    • (2001) J Biol Chem , vol.276 , Issue.14 , pp. 10737-10744
    • Uversky, V.N.1    Li, J.2    Fink, A.L.3
  • 65
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • COI: 1:CAS:528:DC%2BD2sXmtVSmtb8%3D, PID: 17486113
    • Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO (2007) Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 9(6):654–659. doi:10.1038/ncb1596
    • (2007) Nat Cell Biol , vol.9 , Issue.6 , pp. 654-659
    • Valadi, H.1    Ekstrom, K.2    Bossios, A.3    Sjostrand, M.4    Lee, J.J.5    Lotvall, J.O.6
  • 70
    • 20144389524 scopus 로고    scopus 로고
    • Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson’s disease
    • COI: 1:CAS:528:DC%2BD2MXjtFaqsrc%3D, PID: 15791003
    • Zhang W, Wang T, Pei Z, Miller DS, Wu X, Block ML, Wilson B, Zhou Y, Hong JS, Zhang J (2005) Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson’s disease. Faseb J 19(6):533–542. doi:10.1096/fj.04-2751com
    • (2005) Faseb J , vol.19 , Issue.6 , pp. 533-542
    • Zhang, W.1    Wang, T.2    Pei, Z.3    Miller, D.S.4    Wu, X.5    Block, M.L.6    Wilson, B.7    Zhou, Y.8    Hong, J.S.9    Zhang, J.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.