Class i and IIa HDACs Mediate HIF-1α Stability Through PHD2-Dependent Mechanism, while HDAC6, a Class IIb Member, Promotes HIF-1α Transcriptional Activity in Nucleus Pulposus Cells of the Intervertebral Disc

Journal of Bone and Mineral Research

Volumn 31, Issue 6, 2016, Pages 1287-1299

  Schoepflin, Zachary R ^a   Shapiro, Irving M ^a   Risbud, Makarand V ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

HDAC6; HIF 1 ; HYPOXIA; INTERVERTEBRAL DISC; NUCLEUS PULPOSUS; TRANSCRIPTION FACTOR

Indexed keywords

HEAT SHOCK PROTEIN 90; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE INHIBITOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; TRICHOSTATIN A; HDAC6 PROTEIN, RAT; HIF1A PROTEIN, RAT; HISTONE ACETYLTRANSFERASE PCAF; P300-CBP-ASSOCIATED FACTOR; PHD2 PROTEIN, RAT;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL ISOLATION; DEACETYLATION; ENZYME INHIBITION; HYPOXIA; NONHUMAN; NUCLEUS PULPOSUS; PROTEIN DEGRADATION; PROTEIN STABILITY; RAT; TRANSACTIVATION; TRANSCRIPTION INITIATION; ANIMAL; CELL CULTURE; CYTOLOGY; GENETIC TRANSCRIPTION; GENETICS; INTERVERTEBRAL DISK; METABOLISM; PHYSIOLOGY;

ANIMALS; CELLS, CULTURED; HISTONE DEACETYLASE 6; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTERVERTEBRAL DISC; P300-CBP TRANSCRIPTION FACTORS; PROCOLLAGEN-PROLINE DIOXYGENASE; PROTEIN STABILITY; RATS; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 84960976844     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.2787     Document Type: Article

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