-
1
-
-
1542316127
-
Hepatitis B virus infection-natural history and clinical consequences
-
Ganem D, Prince AM. Hepatitis B virus infection-natural history and clinical consequences. N Engl J Med 2004; 350: 1118-29.
-
(2004)
N Engl J Med
, vol.350
, pp. 1118-1129
-
-
Ganem, D.1
Prince, A.M.2
-
2
-
-
80053088189
-
Hepatocellular carcinoma
-
El-Serag HB. Hepatocellular carcinoma. N Engl J Med 2011; 365: 1118-27.
-
(2011)
N Engl J Med
, vol.365
, pp. 1118-1127
-
-
El-Serag, H.B.1
-
3
-
-
29944436855
-
Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level
-
Chen CJ, Yang HI, Su J, et al. Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA 2006; 295: 65-73.
-
(2006)
JAMA
, vol.295
, pp. 65-73
-
-
Chen, C.J.1
Yang, H.I.2
Su, J.3
-
4
-
-
84879607066
-
Long-term entecavir treatment reduces hepatocellular carcinoma incidence in patients with hepatitis B virus infection
-
Hosaka T, Suzuki F, Kobayashi M, et al. Long-term entecavir treatment reduces hepatocellular carcinoma incidence in patients with hepatitis B virus infection. Hepatology 2013; 58: 98-107.
-
(2013)
Hepatology
, vol.58
, pp. 98-107
-
-
Hosaka, T.1
Suzuki, F.2
Kobayashi, M.3
-
5
-
-
84879241608
-
Meta-analysis: the impact of oral anti-viral agents on the incidence of hepatocellular carcinoma in chronic hepatitis B
-
Singal AK, Salameh H, Kuo YF, Fontana RJ. Meta-analysis: the impact of oral anti-viral agents on the incidence of hepatocellular carcinoma in chronic hepatitis B. Aliment Pharmacol Ther 2013; 38: 98-106.
-
(2013)
Aliment Pharmacol Ther
, vol.38
, pp. 98-106
-
-
Singal, A.K.1
Salameh, H.2
Kuo, Y.F.3
Fontana, R.J.4
-
6
-
-
80055012486
-
Review article: current antiviral therapy of chronic hepatitis B
-
Ayoub WS, Keeffe EB. Review article: current antiviral therapy of chronic hepatitis B. Aliment Pharmacol Ther 2011; 34: 1145-58.
-
(2011)
Aliment Pharmacol Ther
, vol.34
, pp. 1145-1158
-
-
Ayoub, W.S.1
Keeffe, E.B.2
-
7
-
-
84872047678
-
Treatment of HBeAg positive chronic hepatitis B: interferon or nucleoside analogues
-
Dusheiko G. Treatment of HBeAg positive chronic hepatitis B: interferon or nucleoside analogues. Liver Int 2013; 33: 137-50.
-
(2013)
Liver Int
, vol.33
, pp. 137-150
-
-
Dusheiko, G.1
-
9
-
-
0027378724
-
Effect of alpha-interferon treatment in patients with hepatitis B e antigen-positive chronic hepatitis BA meta-analysis
-
Wong DKH, Cheung AM, O'Rourke K, et al. Effect of alpha-interferon treatment in patients with hepatitis B e antigen-positive chronic hepatitis BA meta-analysis. Ann Intern Med 1993; 119: 312-23.
-
(1993)
Ann Intern Med
, vol.119
, pp. 312-323
-
-
Wong, D.K.H.1
Cheung, A.M.2
O'Rourke, K.3
-
10
-
-
21244447705
-
Peginterferon Alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B
-
Lau GKK, Piratvisuth T, Luo KX, et al. Peginterferon Alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B. N Engl J Med 2005; 352: 2682-95.
-
(2005)
N Engl J Med
, vol.352
, pp. 2682-2695
-
-
Lau, G.K.K.1
Piratvisuth, T.2
Luo, K.X.3
-
11
-
-
66449121130
-
Sustained response of hepatitis B e antigen-negative patients 3 years after treatment with peginterferon Alfa-2a
-
2169-79e4
-
Marcellin P, Bonino F, Lau GKK, et al. Sustained response of hepatitis B e antigen-negative patients 3 years after treatment with peginterferon Alfa-2a. Gastroenterology 2009; 136: 2169-79.e4.
-
(2009)
Gastroenterology
, vol.136
-
-
Marcellin, P.1
Bonino, F.2
Lau, G.K.K.3
-
12
-
-
19944428132
-
Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial
-
Janssen HLA, van Zonneveld M, Senturk H, et al. Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial. The Lancet 2005; 365: 123-9.
-
(2005)
The Lancet
, vol.365
, pp. 123-129
-
-
Janssen, H.L.A.1
van Zonneveld, M.2
Senturk, H.3
-
13
-
-
84935878242
-
Sequential Combination Therapy with Pegylated Interferon Leads to Loss of Hepatitis B Surface Antigen and Hepatitis B e Antigen (HBeAg) Seroconversion in HBeAg-Positive Chronic Hepatitis B Patients Receiving Long-Term Entecavir Treatment
-
Li G-J, Yu Y-Q, Chen S-L, et al. Sequential Combination Therapy with Pegylated Interferon Leads to Loss of Hepatitis B Surface Antigen and Hepatitis B e Antigen (HBeAg) Seroconversion in HBeAg-Positive Chronic Hepatitis B Patients Receiving Long-Term Entecavir Treatment. Antimicrob Agents Chemother 2015; 59: 4121-8.
-
(2015)
Antimicrob Agents Chemother
, vol.59
, pp. 4121-4128
-
-
Li, G.-J.1
Yu, Y.-Q.2
Chen, S.-L.3
-
14
-
-
84940195264
-
Chronic hepatitis B: Virology, natural history, current management and a glimpse at future opportunities
-
Gish RG, Given BD, Lai C-L, et al. Chronic hepatitis B: Virology, natural history, current management and a glimpse at future opportunities. Antiviral Res 2015; 121: 47-58.
-
(2015)
Antiviral Res
, vol.121
, pp. 47-58
-
-
Gish, R.G.1
Given, B.D.2
Lai, C.-L.3
-
15
-
-
84874638128
-
Chronic hepatitis B: what should be the goal for new therapies?
-
Block TM, Gish R, Guo H, et al. Chronic hepatitis B: what should be the goal for new therapies? Antiviral Res 2013; 98: 27-34.
-
(2013)
Antiviral Res
, vol.98
, pp. 27-34
-
-
Block, T.M.1
Gish, R.2
Guo, H.3
-
16
-
-
78650477355
-
Three-year efficacy and safety of tenofovir disoproxil fumarate treatment for chronic hepatitis B
-
Heathcote EJ, Marcellin P, Buti M, et al. Three-year efficacy and safety of tenofovir disoproxil fumarate treatment for chronic hepatitis B. Gastroenterology 2011; 140: 132-43.
-
(2011)
Gastroenterology
, vol.140
, pp. 132-143
-
-
Heathcote, E.J.1
Marcellin, P.2
Buti, M.3
-
17
-
-
57349095400
-
Tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B
-
Marcellin P, Heathcote EJ, Buti M, et al. Tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B. N Engl J Med 2008; 359: 2442-55.
-
(2008)
N Engl J Med
, vol.359
, pp. 2442-2455
-
-
Marcellin, P.1
Heathcote, E.J.2
Buti, M.3
-
18
-
-
33748929265
-
Peginterferon alpha-2b plus adefovir induce strong cccDNA decline and HBsAg reduction in patients with chronic hepatitis B
-
Wursthorn K, Lutgehetmann M, Dandri M, et al. Peginterferon alpha-2b plus adefovir induce strong cccDNA decline and HBsAg reduction in patients with chronic hepatitis B. Hepatology 2006; 44: 675-84.
-
(2006)
Hepatology
, vol.44
, pp. 675-684
-
-
Wursthorn, K.1
Lutgehetmann, M.2
Dandri, M.3
-
19
-
-
0033617583
-
Viral clearance without destruction of infected cells during acute HBV Infection
-
Guidotti LG, Rochford R, Chung J, et al. Viral clearance without destruction of infected cells during acute HBV Infection. Science 1999; 284: 825-9.
-
(1999)
Science
, vol.284
, pp. 825-829
-
-
Guidotti, L.G.1
Rochford, R.2
Chung, J.3
-
20
-
-
84935475377
-
Chronic hepatitis B: a wave of new therapies on the horizon
-
Block TM, Rawat S, Brosgart CL. Chronic hepatitis B: a wave of new therapies on the horizon. Antiviral Res 2015; 121: 69-81.
-
(2015)
Antiviral Res
, vol.121
, pp. 69-81
-
-
Block, T.M.1
Rawat, S.2
Brosgart, C.L.3
-
21
-
-
84955183087
-
Present and future therapies of hepatitis B: from discovery to cure
-
Liang TJ, Block TM, McMahon BJ, et al. Present and future therapies of hepatitis B: from discovery to cure. Hepatology 2015; 62: 1893-908.
-
(2015)
Hepatology
, vol.62
, pp. 1893-1908
-
-
Liang, T.J.1
Block, T.M.2
McMahon, B.J.3
-
22
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
-
Fire A, Xu S, Montgomery MK, et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998; 391: 806-11.
-
(1998)
Nature
, vol.391
, pp. 806-811
-
-
Fire, A.1
Xu, S.2
Montgomery, M.K.3
-
23
-
-
0038023197
-
Inhibition of hepatitis B virus in mice by RNA interference
-
McCaffrey AP, Nakai H, Pandey K, et al. Inhibition of hepatitis B virus in mice by RNA interference. Nat Biotech 2003; 21: 639-44.
-
(2003)
Nat Biotech
, vol.21
, pp. 639-644
-
-
McCaffrey, A.P.1
Nakai, H.2
Pandey, K.3
-
24
-
-
0037382795
-
Inhibition of hepatitis B virus expression and replication by RNA interference
-
Shlomai A, Shaul Y. Inhibition of hepatitis B virus expression and replication by RNA interference. Hepatology 2003; 37: 764-70.
-
(2003)
Hepatology
, vol.37
, pp. 764-770
-
-
Shlomai, A.1
Shaul, Y.2
-
25
-
-
11144250767
-
RNA interference - small RNAs effectively fight viral hepatitis
-
Shlomai A, Shaul Y. RNA interference - small RNAs effectively fight viral hepatitis. Liver Int 2004; 24: 526-31.
-
(2004)
Liver Int
, vol.24
, pp. 526-531
-
-
Shlomai, A.1
Shaul, Y.2
-
26
-
-
84948448959
-
ARC-520 RNAi therapeutic reduces hepatitis B virus DNA, S antigen and e antigen in a chimpanzee with a very high viral titer
-
Lanford RE, Wooddell CI, Chavez D, et al. ARC-520 RNAi therapeutic reduces hepatitis B virus DNA, S antigen and e antigen in a chimpanzee with a very high viral titer. Hepatology 2013; 58: 707A-07A.
-
(2013)
Hepatology
, vol.58
, pp. 707A-707A
-
-
Lanford, R.E.1
Wooddell, C.I.2
Chavez, D.3
-
27
-
-
84936939671
-
Phase II, dose ranging study of ARC-520, a siRNA-based therapeutic, in patients with chronic hepatitis B virus infection
-
Yuen MF, Chan HLY, Given B, et al. Phase II, dose ranging study of ARC-520, a siRNA-based therapeutic, in patients with chronic hepatitis B virus infection. Hepatology 2014; 60: 1280A-80A.
-
(2014)
Hepatology
, vol.60
, pp. 1280A-1280A
-
-
Yuen, M.F.1
Chan, H.L.Y.2
Given, B.3
-
28
-
-
84955349803
-
Targeted In Vivo Delivery of siRNA and an Endosome-Releasing Agent to Hepatocytes
-
Sebestyén M, Wong S, Trubetskoy V, Lewis D, Wooddell C. Targeted In Vivo Delivery of siRNA and an Endosome-Releasing Agent to Hepatocytes. Methods Mol Biol. 2015; 1218:163-86.
-
(2015)
Methods Mol Biol
, vol.1218
, pp. 163-186
-
-
Sebestyén, M.1
Wong, S.2
Trubetskoy, V.3
Lewis, D.4
Wooddell, C.5
-
29
-
-
84936972283
-
Core protein: a pleiotropic keystone in the HBV lifecycle
-
Zlotnick A, Venkatakrishnan B, Tan Z, et al. Core protein: a pleiotropic keystone in the HBV lifecycle. Antiviral Res 2015; 121: 82-93.
-
(2015)
Antiviral Res
, vol.121
, pp. 82-93
-
-
Zlotnick, A.1
Venkatakrishnan, B.2
Tan, Z.3
-
30
-
-
0347928672
-
Inhibition of hepatitis B virus replication by drug-induced depletion of nucleocapsids
-
Deres K, Schröder CH, Paessens A, et al. Inhibition of hepatitis B virus replication by drug-induced depletion of nucleocapsids. Science 2003; 299: 893-6.
-
(2003)
Science
, vol.299
, pp. 893-896
-
-
Deres, K.1
Schröder, C.H.2
Paessens, A.3
-
31
-
-
20444421508
-
A heteroaryldihydropyrimidine activates and can misdirect hepatitis B virus capsid assembly
-
Stray SJ, Bourne CR, Punna S, et al. A heteroaryldihydropyrimidine activates and can misdirect hepatitis B virus capsid assembly. Proc Natl Acad Sci USA 2005; 102: 8138-43.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 8138-8143
-
-
Stray, S.J.1
Bourne, C.R.2
Punna, S.3
-
32
-
-
84940452094
-
High antiviral activity of the hbv core inhibitor NVR 3-778 in the humanized UPA/SCID mouse model
-
Klumpp K, Shimada T, Allweiss L, et al. High antiviral activity of the hbv core inhibitor NVR 3-778 in the humanized UPA/SCID mouse model. J Hepatol 2015; 62: S250-S50.
-
(2015)
J Hepatol
, vol.62
, pp. S250-S250
-
-
Klumpp, K.1
Shimada, T.2
Allweiss, L.3
-
33
-
-
84966717430
-
Effect of the combination of the hbv core inhibitor NVR 3-778 with nucleoside analogs or other hbv core inhibitors on the inhibition of HBV DNA replication in HepG2.2.15 cells
-
Lam A, Espiritu C, Flores O, Hartman G, Klumpp K. Effect of the combination of the hbv core inhibitor NVR 3-778 with nucleoside analogs or other hbv core inhibitors on the inhibition of HBV DNA replication in HepG2.2.15 cells. J Hepatol 2015; 62: S559-S59.
-
(2015)
J Hepatol
, vol.62
, pp. S559-S559
-
-
Lam, A.1
Espiritu, C.2
Flores, O.3
Hartman, G.4
Klumpp, K.5
-
34
-
-
84949233995
-
Phase 1a safety and pharmacokinetics of NVR 3-778, a potential first-in-class HBV core inhibitor
-
Gane EJ, Schwabe C, Walker K, et al. Phase 1a safety and pharmacokinetics of NVR 3-778, a potential first-in-class HBV core inhibitor. Hepatology 2014; 60: 1279A-79A.
-
(2014)
Hepatology
, vol.60
, pp. 1279A-1279A
-
-
Gane, E.J.1
Schwabe, C.2
Walker, K.3
-
35
-
-
84949236288
-
High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein
-
Klumpp K, Lam AM, Lukacs C, et al. High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein. Proc Natl Acad Sci USA 2015; 112: 15196-201.
-
(2015)
Proc Natl Acad Sci USA
, vol.112
, pp. 15196-15201
-
-
Klumpp, K.1
Lam, A.M.2
Lukacs, C.3
-
36
-
-
84927950089
-
The hepatitis B virus ribonuclease H as a drug target
-
Tavis JE, Lomonosova E. The hepatitis B virus ribonuclease H as a drug target. Antiviral Res 2015; 118: 132-8.
-
(2015)
Antiviral Res
, vol.118
, pp. 132-138
-
-
Tavis, J.E.1
Lomonosova, E.2
-
37
-
-
84894237342
-
Hepatitis B and D viruses exploit sodium taurocholate co-transporting polypeptide for species-specific entry into hepatocytes
-
1070-83e6
-
Ni Y, Lempp FA, Mehrle S, et al. Hepatitis B and D viruses exploit sodium taurocholate co-transporting polypeptide for species-specific entry into hepatocytes. Gastroenterology 2014; 146: 1070-83.e6.
-
(2014)
Gastroenterology
, vol.146
-
-
Ni, Y.1
Lempp, F.A.2
Mehrle, S.3
-
38
-
-
84879327902
-
Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus
-
Yan H, Zhong G, Xu G, et al. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. eLife 2012; 1: e00049.
-
(2012)
eLife
, vol.1
, pp. e00049
-
-
Yan, H.1
Zhong, G.2
Xu, G.3
-
39
-
-
40449096921
-
Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein
-
Petersen J, Dandri M, Mier W, et al. Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein. Nat Biotech 2008; 26: 335-41.
-
(2008)
Nat Biotech
, vol.26
, pp. 335-341
-
-
Petersen, J.1
Dandri, M.2
Mier, W.3
-
40
-
-
84876295707
-
The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus
-
Volz T, Allweiss L, ḾBarek MB, et al. The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus. J Hepatol 2013; 58: 861-7.
-
(2013)
J Hepatol
, vol.58
, pp. 861-867
-
-
Volz, T.1
Allweiss, L.2
ḾBarek, M.B.3
-
41
-
-
84904671593
-
Inhibitors of hepatitis B virus attachment and entry
-
Lempp FA, Urban S. Inhibitors of hepatitis B virus attachment and entry. Intervirology 2014; 57: 151-7.
-
(2014)
Intervirology
, vol.57
, pp. 151-157
-
-
Lempp, F.A.1
Urban, S.2
-
43
-
-
84922832694
-
A proof-of-concept Phase 2a clinical trial with HBV/HDV entry inhibitor Myrcludex B
-
Bogomolov P, Voronkova N, Allweiss L, et al. A proof-of-concept Phase 2a clinical trial with HBV/HDV entry inhibitor Myrcludex B. Hepatology 2014; 60: 1279A-80A.
-
(2014)
Hepatology
, vol.60
, pp. 1279A-1280A
-
-
Bogomolov, P.1
Voronkova, N.2
Allweiss, L.3
-
45
-
-
84951107024
-
Early inhibition of hepatocyte innate responses by hepatitis B virus
-
Luangsay S, Gruffaz M, Isorce N, et al. Early inhibition of hepatocyte innate responses by hepatitis B virus. J Hepatol 2015; 63: 1314-22.
-
(2015)
J Hepatol
, vol.63
, pp. 1314-1322
-
-
Luangsay, S.1
Gruffaz, M.2
Isorce, N.3
-
47
-
-
84919698407
-
HBV and the immune response
-
Ferrari C. HBV and the immune response. Liver Int 2015; 35: 121-8.
-
(2015)
Liver Int
, vol.35
, pp. 121-128
-
-
Ferrari, C.1
-
48
-
-
84868702241
-
Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection
-
Bertoletti A, Ferrari C. Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection. Gut 2012; 61: 1754-64.
-
(2012)
Gut
, vol.61
, pp. 1754-1764
-
-
Bertoletti, A.1
Ferrari, C.2
-
49
-
-
84876122915
-
Pathogen recognition receptors: ligands and signaling pathways by toll-like receptors
-
Sasai M, Yamamoto M. Pathogen recognition receptors: ligands and signaling pathways by toll-like receptors. Int Rev Immunol 2013; 32: 116-33.
-
(2013)
Int Rev Immunol
, vol.32
, pp. 116-133
-
-
Sasai, M.1
Yamamoto, M.2
-
50
-
-
84929606985
-
Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B
-
Menne S, Tumas DB, Liu KH, et al. Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B. J Hepatol 2015; 62: 1237-45.
-
(2015)
J Hepatol
, vol.62
, pp. 1237-1245
-
-
Menne, S.1
Tumas, D.B.2
Liu, K.H.3
-
51
-
-
84935451137
-
The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection
-
Gane EJ, Lim Y-S, Gordon SC, et al. The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection. J Hepatol 2015; 63: 320-8.
-
(2015)
J Hepatol
, vol.63
, pp. 320-328
-
-
Gane, E.J.1
Lim, Y.-S.2
Gordon, S.C.3
-
52
-
-
84879408976
-
Structural mechanism of cytosolic DNA sensing by cGAS
-
Civril F, Deimling T, de Oliveira MCC, et al. Structural mechanism of cytosolic DNA sensing by cGAS. Nature 2013; 498: 332-7.
-
(2013)
Nature
, vol.498
, pp. 332-337
-
-
Civril, F.1
Deimling, T.2
de Oliveira, M.C.C.3
-
53
-
-
84921914245
-
Sting agonists induce an innate antiviral immune response against hepatitis B virus
-
Guo F, Han Y, Zhao X, et al. Sting agonists induce an innate antiviral immune response against hepatitis B virus. Antimicrob Agents Chemother 2015; 59: 1273-81.
-
(2015)
Antimicrob Agents Chemother
, vol.59
, pp. 1273-1281
-
-
Guo, F.1
Han, Y.2
Zhao, X.3
-
54
-
-
33645659565
-
5,6-Dimethylxanthenone-4-Acetic Acid in the Treatment of Refractory Tumors: a Phase I Safety Study of a Vascular Disrupting Agent
-
McKeage MJ, Fong P, Jeffery M, et al. 5, 6-Dimethylxanthenone-4-Acetic Acid in the Treatment of Refractory Tumors: a Phase I Safety Study of a Vascular Disrupting Agent. Clin Cancer Res 2006; 12: 1776-84.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 1776-1784
-
-
McKeage, M.J.1
Fong, P.2
Jeffery, M.3
-
55
-
-
57449103348
-
Randomised phase II study of ASA404 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer
-
McKeage MJ, Von Pawel J, Reck M, et al. Randomised phase II study of ASA404 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer. Br J Cancer 2008; 99: 2006-12.
-
(2008)
Br J Cancer
, vol.99
, pp. 2006-2012
-
-
McKeage, M.J.1
Von Pawel, J.2
Reck, M.3
-
56
-
-
0029147763
-
Persistent genital human papillomavirus infection as a risk factor for persistent cervical dysplasia
-
Ho GYF, Burk RD, Klein S, et al. Persistent genital human papillomavirus infection as a risk factor for persistent cervical dysplasia. J Natl Cancer Inst 1995; 87: 1365-71.
-
(1995)
J Natl Cancer Inst
, vol.87
, pp. 1365-1371
-
-
Ho, G.Y.F.1
Burk, R.D.2
Klein, S.3
-
57
-
-
0028270410
-
MHC class I and non-MHC-linked capacity for generating an anti-viral CTL response determines susceptibility to CTL exhaustion and establishment of virus persistence in mice
-
Moskophidis D, Lechner F, Hengartner H, Zinkernagel RM. MHC class I and non-MHC-linked capacity for generating an anti-viral CTL response determines susceptibility to CTL exhaustion and establishment of virus persistence in mice. J Immunol 1994; 152: 4976-83.
-
(1994)
J Immunol
, vol.152
, pp. 4976-4983
-
-
Moskophidis, D.1
Lechner, F.2
Hengartner, H.3
Zinkernagel, R.M.4
-
58
-
-
0032191962
-
Comparison of Activation versus Induction of Unresponsiveness of Virus-Specific CD4+ and CD8+ T Cells upon Acute versus Persistent Viral Infection
-
Oxenius A, Zinkernagel RM, Hengartner H. Comparison of Activation versus Induction of Unresponsiveness of Virus-Specific CD4+ and CD8+ T Cells upon Acute versus Persistent Viral Infection. Immunity 1998; 9: 449-57.
-
(1998)
Immunity
, vol.9
, pp. 449-457
-
-
Oxenius, A.1
Zinkernagel, R.M.2
Hengartner, H.3
-
59
-
-
84946018523
-
Current status of immunomodulatory therapy in chronic hepatitis B, fifty years after discovery of the virus: Search for the "magic bullet" to kill cccDNA
-
Zhang E, Kosinska A, Lu M, Yan H, Roggendorf M. Current status of immunomodulatory therapy in chronic hepatitis B, fifty years after discovery of the virus: Search for the "magic bullet" to kill cccDNA. Antiviral Res 2015; 123: 193-203.
-
(2015)
Antiviral Res
, vol.123
, pp. 193-203
-
-
Zhang, E.1
Kosinska, A.2
Lu, M.3
Yan, H.4
Roggendorf, M.5
-
60
-
-
36549028324
-
Therapeutic vaccination of chronic hepatitis B patients with virus suppression by antiviral therapy: a randomized, controlled study of co-administration of HBsAg/AS02 candidate vaccine and lamivudine
-
Vandepapelière P, Lau GKK, Leroux-Roels G, et al. Therapeutic vaccination of chronic hepatitis B patients with virus suppression by antiviral therapy: a randomized, controlled study of co-administration of HBsAg/AS02 candidate vaccine and lamivudine. Vaccine 2007; 25: 8585-97.
-
(2007)
Vaccine
, vol.25
, pp. 8585-8597
-
-
Vandepapelière, P.1
Lau, G.K.K.2
Leroux-Roels, G.3
-
61
-
-
84906090057
-
Safety, tolerability and immunogenicity of GS-4774, a hepatitis B virus-specific therapeutic vaccine, in healthy subjects: a randomized study
-
Gaggar A, Coeshott C, Apelian D, et al. Safety, tolerability and immunogenicity of GS-4774, a hepatitis B virus-specific therapeutic vaccine, in healthy subjects: a randomized study. Vaccine 2014; 32: 4925-31.
-
(2014)
Vaccine
, vol.32
, pp. 4925-4931
-
-
Gaggar, A.1
Coeshott, C.2
Apelian, D.3
-
62
-
-
84968934772
-
Safety and efficacy of GS-4774 in patients with chronic hepatitis B on oral antiviral therapy
-
Lok ASF, Pan CQ, Han S-H B, et al. Safety and efficacy of GS-4774 in patients with chronic hepatitis B on oral antiviral therapy. Hepatology 2015; 62: 1181A-95A.
-
(2015)
Hepatology
, vol.62
, pp. 1181A-1195A
-
-
Lok, A.S.F.1
Pan, C.Q.2
Han S-H, B.3
-
63
-
-
33646949662
-
Immunogenicity of a hepatitis B DNA vaccine administered to chronic HBV carriers
-
Mancini --BM, Fontaine H, Bréchot C, Pol S, Michel M-L. Immunogenicity of a hepatitis B DNA vaccine administered to chronic HBV carriers. Vaccine 2006; 24: 4482-9.
-
(2006)
Vaccine
, vol.24
, pp. 4482-4489
-
-
Mancini, B.M.1
Fontaine, H.2
Bréchot, C.3
Pol, S.4
Michel, M.-L.5
-
64
-
-
84919773476
-
Anti-HBV DNA vaccination does not prevent relapse after discontinuation of analogues in the treatment of chronic hepatitis B: a randomised trial-ANRS HB02 VAC-ADN
-
Fontaine H, Kahi S, Chazallon C, et al. Anti-HBV DNA vaccination does not prevent relapse after discontinuation of analogues in the treatment of chronic hepatitis B: a randomised trial-ANRS HB02 VAC-ADN. Gut 2015; 64: 139-47.
-
(2015)
Gut
, vol.64
, pp. 139-147
-
-
Fontaine, H.1
Kahi, S.2
Chazallon, C.3
-
65
-
-
84906044039
-
Coinhibitory receptors and CD8 T cell exhaustion in chronic infections
-
Kuchroo VK, Anderson AC, Petrovas C. Coinhibitory receptors and CD8 T cell exhaustion in chronic infections. Curr Opin HIV AIDS 2014; 9: 439-45.
-
(2014)
Curr Opin HIV AIDS
, vol.9
, pp. 439-445
-
-
Kuchroo, V.K.1
Anderson, A.C.2
Petrovas, C.3
-
66
-
-
33847406557
-
PD-1:PD-L1 interactions contribute to the functional suppression of virus-specific CD8+ T lymphocytes in the liver
-
Maier H, Isogawa M, Freeman GJ, Chisari FV. PD-1:PD-L1 interactions contribute to the functional suppression of virus-specific CD8+ T lymphocytes in the liver. J Immunol 2007; 178: 2714-20.
-
(2007)
J Immunol
, vol.178
, pp. 2714-2720
-
-
Maier, H.1
Isogawa, M.2
Freeman, G.J.3
Chisari, F.V.4
-
67
-
-
34247117935
-
Characterization of hepatitis B virus (HBV)-Specific T-Cell dysfunction in chronic HBV infection
-
Boni C, Fisicaro P, Valdatta C, et al. Characterization of hepatitis B virus (HBV)-Specific T-Cell dysfunction in chronic HBV infection. J Virol 2007; 81: 4215-25.
-
(2007)
J Virol
, vol.81
, pp. 4215-4225
-
-
Boni, C.1
Fisicaro, P.2
Valdatta, C.3
-
68
-
-
84876249437
-
Augmentation of Hepatitis B Virus-Specific Cellular Immunity with Programmed Death Receptor-1/Programmed Death Receptor-L1 Blockade in Hepatitis B Virus and HIV/Hepatitis B Virus Coinfected Patients Treated with Adefovir
-
Sherman AC, Trehanpati N, Daucher M, et al. Augmentation of Hepatitis B Virus-Specific Cellular Immunity with Programmed Death Receptor-1/Programmed Death Receptor-L1 Blockade in Hepatitis B Virus and HIV/Hepatitis B Virus Coinfected Patients Treated with Adefovir. AIDS Res Hum Retroviruses 2013; 29: 665-72.
-
(2013)
AIDS Res Hum Retroviruses
, vol.29
, pp. 665-672
-
-
Sherman, A.C.1
Trehanpati, N.2
Daucher, M.3
-
69
-
-
84893805242
-
Enhancing virus-specific immunity In vivo by combining therapeutic vaccination and PD-L1 blockade in chronic hepadnaviral infection
-
Liu J, Zhang E, Ma Z, et al. Enhancing virus-specific immunity In vivo by combining therapeutic vaccination and PD-L1 blockade in chronic hepadnaviral infection. PLoS Pathog 2014; 10: e1003856.
-
(2014)
PLoS Pathog
, vol.10
, pp. e1003856
-
-
Liu, J.1
Zhang, E.2
Ma, Z.3
-
70
-
-
84920764736
-
Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses
-
Koniger C, Wingert I, Marsmann M, et al. Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses. Proc Natl Acad Sci USA 2014; 111: E4244-53.
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, pp. E4244-E4253
-
-
Koniger, C.1
Wingert, I.2
Marsmann, M.3
-
71
-
-
84937889320
-
Does tyrosyl DNA phosphodiesterase-2 Play a Role in hepatitis B virus genome repair?
-
Cui X, McAllister R, Boregowda R, et al. Does tyrosyl DNA phosphodiesterase-2 Play a Role in hepatitis B virus genome repair? PLoS ONE 2015; 10: e0128401.
-
(2015)
PLoS ONE
, vol.10
, pp. e0128401
-
-
Cui, X.1
McAllister, R.2
Boregowda, R.3
-
72
-
-
84899134190
-
CRISPR-Cas systems: prokaryotes upgrade to adaptive immunity
-
Barrangou R, Marraffini LA. CRISPR-Cas systems: prokaryotes upgrade to adaptive immunity. Mol Cell 2014; 54: 234-44.
-
(2014)
Mol Cell
, vol.54
, pp. 234-244
-
-
Barrangou, R.1
Marraffini, L.A.2
-
73
-
-
84920095727
-
Suppression of hepatitis B virus DNA accumulation in chronically infected cells using a bacterial CRISPR/Cas RNA-guided DNA endonuclease
-
Kennedy EM, Bassit LC, Mueller H, et al. Suppression of hepatitis B virus DNA accumulation in chronically infected cells using a bacterial CRISPR/Cas RNA-guided DNA endonuclease. Virology 2015; 476: 196-205.
-
(2015)
Virology
, vol.476
, pp. 196-205
-
-
Kennedy, E.M.1
Bassit, L.C.2
Mueller, H.3
-
74
-
-
84907379292
-
The CRISPR/Cas9 system facilitates clearance of the intrahepatic HBV templates in vivo
-
Lin S-R, Yang H-C, Kuo Y-T, et al. The CRISPR/Cas9 system facilitates clearance of the intrahepatic HBV templates in vivo. Mol Ther Nucleic Acids 2014; 3: e186.
-
(2014)
Mol Ther Nucleic Acids
, vol.3
, pp. e186
-
-
Lin, S.-R.1
Yang, H.-C.2
Kuo, Y.-T.3
-
75
-
-
84934877005
-
CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus
-
Ramanan V, Shlomai A, Cox DBT, et al. CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus. Sci Rep 2015; 5: 10833.
-
(2015)
Sci Rep
, vol.5
, pp. 10833
-
-
Ramanan, V.1
Shlomai, A.2
Cox, D.B.T.3
-
76
-
-
84927935415
-
Targeting Hepatitis B Virus With CRISPR/Cas9
-
Seeger C, Sohn JA. Targeting Hepatitis B Virus With CRISPR/Cas9. Mol Ther Nucleic Acids 2014; 3: e216.
-
(2014)
Mol Ther Nucleic Acids
, vol.3
, pp. e216
-
-
Seeger, C.1
Sohn, J.A.2
-
77
-
-
84929048246
-
Harnessing the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated Cas9 system to disrupt the hepatitis B virus
-
Zhen S, Hua L, Liu YH, et al. Harnessing the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated Cas9 system to disrupt the hepatitis B virus. Gene Ther 2015; 22: 404-12.
-
(2015)
Gene Ther
, vol.22
, pp. 404-412
-
-
Zhen, S.1
Hua, L.2
Liu, Y.H.3
-
78
-
-
84927514894
-
In vivo genome editing using Staphylococcus aureus Cas9
-
Ran FA, Cong L, Yan WX, et al. In vivo genome editing using Staphylococcus aureus Cas9. Nature 2015; 520: 186-91.
-
(2015)
Nature
, vol.520
, pp. 186-191
-
-
Ran, F.A.1
Cong, L.2
Yan, W.X.3
-
79
-
-
84864378861
-
Identification of Disubstituted Sulfonamide Compounds as Specific Inhibitors of Hepatitis B Virus Covalently Closed Circular DNA Formation
-
Cai D, Mills C, Yu W, et al. Identification of Disubstituted Sulfonamide Compounds as Specific Inhibitors of Hepatitis B Virus Covalently Closed Circular DNA Formation. Antimicrob Agents Chemother 2012; 56: 4277-88.
-
(2012)
Antimicrob Agents Chemother
, vol.56
, pp. 4277-4288
-
-
Cai, D.1
Mills, C.2
Yu, W.3
-
80
-
-
36049013787
-
Characterization of the Intracellular Deproteinized Relaxed Circular DNA of Hepatitis B Virus: an Intermediate of Covalently Closed Circular DNA Formation
-
Guo H, Jiang D, Zhou T, et al. Characterization of the Intracellular Deproteinized Relaxed Circular DNA of Hepatitis B Virus: an Intermediate of Covalently Closed Circular DNA Formation. J Virol 2007; 81: 12472-84.
-
(2007)
J Virol
, vol.81
, pp. 12472-12484
-
-
Guo, H.1
Jiang, D.2
Zhou, T.3
-
81
-
-
59849105037
-
Persistence of the hepatitis B virus covalently closed circular DNA in HepaRG human hepatocyte-like cells
-
Hantz O, Parent R, Durantel D, et al. Persistence of the hepatitis B virus covalently closed circular DNA in HepaRG human hepatocyte-like cells. J Gen Virol 2009; 90: 127-35.
-
(2009)
J Gen Virol
, vol.90
, pp. 127-135
-
-
Hantz, O.1
Parent, R.2
Durantel, D.3
-
82
-
-
84896029673
-
Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA
-
Lucifora J, Xia Y, Reisinger F, et al. Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA. Science 2014; 343: 1221-8.
-
(2014)
Science
, vol.343
, pp. 1221-1228
-
-
Lucifora, J.1
Xia, Y.2
Reisinger, F.3
|