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Volumn 98, Issue 1, 2013, Pages 27-34

Chronic hepatitis B: What should be the goal for new therapies?

Author keywords

Chronic hepatitis B; Direct acting antivirals; Hepatitis B virus

Indexed keywords

LAMIVUDINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PEGINTERFERON ALPHA; VIRUS DNA;

EID: 84874638128     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2013.01.006     Document Type: Note
Times cited : (111)

References (74)
  • 1
    • 58149296156 scopus 로고    scopus 로고
    • Clinical practice guidelines: management of chronic hepatitis B
    • EASL
    • EASL Clinical practice guidelines: management of chronic hepatitis B. J. Hepatol. 2009, 50:227-242.
    • (2009) J. Hepatol. , vol.50 , pp. 227-242
  • 2
    • 33748328352 scopus 로고    scopus 로고
    • Causes of death after diagnosis of hepatitis B or hepatitis C infection: a large community-based linkage study
    • Amin J., Law M.G., Bartlett M., Kaldor J.M., Dore G.J. Causes of death after diagnosis of hepatitis B or hepatitis C infection: a large community-based linkage study. Lancet 2006, 368:938-945.
    • (2006) Lancet , vol.368 , pp. 938-945
    • Amin, J.1    Law, M.G.2    Bartlett, M.3    Kaldor, J.M.4    Dore, G.J.5
  • 3
    • 0023933449 scopus 로고
    • Hepatitis B virus. The major etiology of hepatocellular carcinoma
    • Beasley R.P. Hepatitis B virus. The major etiology of hepatocellular carcinoma. Cancer 1988, 61:1942-1956.
    • (1988) Cancer , vol.61 , pp. 1942-1956
    • Beasley, R.P.1
  • 4
    • 84856514985 scopus 로고    scopus 로고
    • IFN-alpha inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome
    • Belloni L., Allweiss L., Guerrieri F., Pediconi N., Volz T., Pollicino T., Petersen J., Raimondo G., Dandri M., Levrero M. IFN-alpha inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome. J. Clin. Invest. 2012, 122:529-537.
    • (2012) J. Clin. Invest. , vol.122 , pp. 529-537
    • Belloni, L.1    Allweiss, L.2    Guerrieri, F.3    Pediconi, N.4    Volz, T.5    Pollicino, T.6    Petersen, J.7    Raimondo, G.8    Dandri, M.9    Levrero, M.10
  • 5
    • 35548983363 scopus 로고    scopus 로고
    • Molecular virology of hepatitis B virus for clinicians
    • vii
    • Block T.M., Guo H., Guo J.T. Molecular virology of hepatitis B virus for clinicians. Clin. Liver Dis. 2007, 11:685-706. vii.
    • (2007) Clin. Liver Dis. , vol.11 , pp. 685-706
    • Block, T.M.1    Guo, H.2    Guo, J.T.3
  • 9
    • 33746675024 scopus 로고    scopus 로고
    • Past HBV viral load as predictor of mortality and morbidity from HCC and chronic liver disease in a prospective study
    • Chen G., Lin W., Shen F., Iloeje U.H., London W.T., Evans A.A. Past HBV viral load as predictor of mortality and morbidity from HCC and chronic liver disease in a prospective study. Am. J. Gastroenterol. 2006, 101:1797-1803.
    • (2006) Am. J. Gastroenterol. , vol.101 , pp. 1797-1803
    • Chen, G.1    Lin, W.2    Shen, F.3    Iloeje, U.H.4    London, W.T.5    Evans, A.A.6
  • 10
    • 84857194778 scopus 로고    scopus 로고
    • Decreasing levels of HBsAg predict HBsAg seroclearance in patients with inactive chronic hepatitis B virus infection
    • Chen Y.C., Jeng W.J., Chu C.M., Liaw Y.F. Decreasing levels of HBsAg predict HBsAg seroclearance in patients with inactive chronic hepatitis B virus infection. Clin. Gastroenterol. Hepatol. 2012, 10:297-302.
    • (2012) Clin. Gastroenterol. Hepatol. , vol.10 , pp. 297-302
    • Chen, Y.C.1    Jeng, W.J.2    Chu, C.M.3    Liaw, Y.F.4
  • 11
    • 0032869876 scopus 로고    scopus 로고
    • Pretherapy alanine transaminase level as a determinant for hepatitis B e antigen seroconversion during lamivudine therapy in patients with chronic hepatitis B. Asian hepatitis lamivudine trial group.
    • Chien R.N., Liaw Y.F., Atkins M. Pretherapy alanine transaminase level as a determinant for hepatitis B e antigen seroconversion during lamivudine therapy in patients with chronic hepatitis B. Asian hepatitis lamivudine trial group. Hepatology 1999, 30:770-774.
    • (1999) Hepatology , vol.30 , pp. 770-774
    • Chien, R.N.1    Liaw, Y.F.2    Atkins, M.3
  • 12
    • 34247603423 scopus 로고    scopus 로고
    • The role of cells refractory to productive infection in acute hepatitis B viral dynamics
    • Ciupe S.M., Ribeiro R.M., Nelson P.W., Dusheiko G., Perelson A.S. The role of cells refractory to productive infection in acute hepatitis B viral dynamics. Proc. Nat. Acad. Sci. 2007, 104:5050-5055.
    • (2007) Proc. Nat. Acad. Sci. , vol.104 , pp. 5050-5055
    • Ciupe, S.M.1    Ribeiro, R.M.2    Nelson, P.W.3    Dusheiko, G.4    Perelson, A.S.5
  • 14
    • 79956049416 scopus 로고    scopus 로고
    • The emerging race to cure HIV infections
    • Cohen J. The emerging race to cure HIV infections. Science 2011, 332(784-785):787-789.
    • (2011) Science , vol.332 , Issue.784-785 , pp. 787-789
    • Cohen, J.1
  • 15
    • 54849146600 scopus 로고    scopus 로고
    • Hepatitis B virus infection
    • Dienstag J.L. Hepatitis B virus infection. N. Engl. J. Med. 2008, 359:1486-1500.
    • (2008) N. Engl. J. Med. , vol.359 , pp. 1486-1500
    • Dienstag, J.L.1
  • 17
    • 0034722741 scopus 로고    scopus 로고
    • Risk factors for the rising rates of primary liver cancer in the United States
    • El-Serag H.B., Mason A.C. Risk factors for the rising rates of primary liver cancer in the United States. Arch. Intern. Med. 2000, 160:3227-3230.
    • (2000) Arch. Intern. Med. , vol.160 , pp. 3227-3230
    • El-Serag, H.B.1    Mason, A.C.2
  • 18
    • 84875640776 scopus 로고    scopus 로고
    • Chronic HBV infection outside treatment guidelines: Is treatment needed?
    • [Epub ahead of print]
    • Evans, A.E., London, W.T., Gish, R.G., Cohen, C. and Block, T.M., 2012. Chronic HBV infection outside treatment guidelines: Is treatment needed? Antivir Ther. http://dx.doi.org/10.3851/IMP2325. [Epub ahead of print].
    • (2012) Antivir Ther
    • Evans, A.E.1    London, W.T.2    Gish, R.G.3    Cohen, C.4    Block, T.M.5
  • 19
    • 84867307862 scopus 로고    scopus 로고
    • Recent successes and noteworthy future prospects in the treatment of chronic hepatitis C
    • Fox A.N., Jacobson I.M. Recent successes and noteworthy future prospects in the treatment of chronic hepatitis C. Clin. Infect. Dis. 2012, 55(Suppl. 1):S16-S24.
    • (2012) Clin. Infect. Dis. , vol.55 , Issue.SUPPL. 1
    • Fox, A.N.1    Jacobson, I.M.2
  • 20
    • 1542316127 scopus 로고    scopus 로고
    • Hepatitis B infection: natural history and clinical consequences
    • Ganem D., Prince A.M. Hepatitis B infection: natural history and clinical consequences. N. Engl. J. Med. 2004, 350:1118-1129.
    • (2004) N. Engl. J. Med. , vol.350 , pp. 1118-1129
    • Ganem, D.1    Prince, A.M.2
  • 21
    • 77951781372 scopus 로고    scopus 로고
    • A multidisciplinary approach to the management of hepatocellular carcinoma
    • Gish R.G., Marrero J.A., Benson A.B. A multidisciplinary approach to the management of hepatocellular carcinoma. Gastroenterol. Hepatol. (NY) 2010, 6:1-16.
    • (2010) Gastroenterol. Hepatol. (NY) , vol.6 , pp. 1-16
    • Gish, R.G.1    Marrero, J.A.2    Benson, A.B.3
  • 22
    • 33645729182 scopus 로고    scopus 로고
    • Immunobiology and pathogenesis of viral hepatitis
    • Guidotti L.G., Chisari F.V. Immunobiology and pathogenesis of viral hepatitis. Annu. Rev. Pathol. 2006, 1:23-61.
    • (2006) Annu. Rev. Pathol. , vol.1 , pp. 23-61
    • Guidotti, L.G.1    Chisari, F.V.2
  • 23
    • 0033617583 scopus 로고    scopus 로고
    • Viral clearance without destruction of infected cells during acute HBV infection
    • Guidotti L.G., Rochford R., Chung J., Shapiro M., Purcell R., Chisari F.V. Viral clearance without destruction of infected cells during acute HBV infection. Science 1999, 284:825-829.
    • (1999) Science , vol.284 , pp. 825-829
    • Guidotti, L.G.1    Rochford, R.2    Chung, J.3    Shapiro, M.4    Purcell, R.5    Chisari, F.V.6
  • 24
    • 58149517671 scopus 로고    scopus 로고
    • Activation of pattern recognition receptor-mediated innate immunity inhibits the replication of hepatitis B virus in human hepatocyte-derived cells
    • Guo H., Jiang D., Ma D., Chang J., Dougherty A.M., Cuconati A., Block T.M., Guo J.T. Activation of pattern recognition receptor-mediated innate immunity inhibits the replication of hepatitis B virus in human hepatocyte-derived cells. J. Virol. 2009, 83:847-858.
    • (2009) J. Virol. , vol.83 , pp. 847-858
    • Guo, H.1    Jiang, D.2    Ma, D.3    Chang, J.4    Dougherty, A.M.5    Cuconati, A.6    Block, T.M.7    Guo, J.T.8
  • 26
    • 66149190943 scopus 로고    scopus 로고
    • Reactivation of hepatitis B
    • Hoofnagle J.H. Reactivation of hepatitis B. Hepatology 2009, 49:S156-S165.
    • (2009) Hepatology , vol.49
    • Hoofnagle, J.H.1
  • 27
    • 78349252277 scopus 로고    scopus 로고
    • Increased PD-1 and decreased CD28 expression in chronic hepatitis B patients with advanced hepatocellular carcinoma
    • Hsu P.N., Yang T.C., Kao J.T., Cheng K.S., Lee Y.J., Wang Y.M., Hsieh C.T., Lin C.W., Wu Y.Y. Increased PD-1 and decreased CD28 expression in chronic hepatitis B patients with advanced hepatocellular carcinoma. Liver Int. 2010, 30:1379-1386.
    • (2010) Liver Int. , vol.30 , pp. 1379-1386
    • Hsu, P.N.1    Yang, T.C.2    Kao, J.T.3    Cheng, K.S.4    Lee, Y.J.5    Wang, Y.M.6    Hsieh, C.T.7    Lin, C.W.8    Wu, Y.Y.9
  • 28
    • 84862896269 scopus 로고    scopus 로고
    • 100 Therapeutic efficacy of the TLR7 agonist GS-9620 for HBV chronic infection in chimpanzees
    • Lanford R.E., Guerra B., Chavez D.C., Hodara V.L., Zheng X., Wolfgang G., Tumas D. 100 Therapeutic efficacy of the TLR7 agonist GS-9620 for HBV chronic infection in chimpanzees. J. Hepatol. 2011, 54(Suppl. 1):S45.
    • (2011) J. Hepatol. , vol.54 , Issue.SUPPL. 1
    • Lanford, R.E.1    Guerra, B.2    Chavez, D.C.3    Hodara, V.L.4    Zheng, X.5    Wolfgang, G.6    Tumas, D.7
  • 29
    • 1642410856 scopus 로고    scopus 로고
    • Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures
    • Lavanchy D. Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J. Viral Hepat. 2004, 11:97-107.
    • (2004) J. Viral Hepat. , vol.11 , pp. 97-107
    • Lavanchy, D.1
  • 30
    • 84859067322 scopus 로고    scopus 로고
    • New therapies for chronic hepatitis C infection: a systematic review of evidence from clinical trials
    • Lee L.Y., Tong C.Y., Wong T., Wilkinson M. New therapies for chronic hepatitis C infection: a systematic review of evidence from clinical trials. Int. J. Clin. Pract. 2012, 66:342-355.
    • (2012) Int. J. Clin. Pract. , vol.66 , pp. 342-355
    • Lee, L.Y.1    Tong, C.Y.2    Wong, T.3    Wilkinson, M.4
  • 31
  • 32
    • 79960715806 scopus 로고    scopus 로고
    • Clinical utility of hepatitis B surface antigen quantitation in patients with chronic hepatitis B: a review
    • Liaw Y.F. Clinical utility of hepatitis B surface antigen quantitation in patients with chronic hepatitis B: a review. Hepatology 2011, 54:E1-E9.
    • (2011) Hepatology , vol.54
    • Liaw, Y.F.1
  • 35
    • 78650770247 scopus 로고    scopus 로고
    • The clinical implications of hepatitis B virus genotype: recent advances
    • Lin C.L., Kao J.H. The clinical implications of hepatitis B virus genotype: recent advances. J. Gastroenterol. Hepatol. 2011, 26(Suppl. 1):123-130.
    • (2011) J. Gastroenterol. Hepatol. , vol.26 , Issue.SUPPL. 1 , pp. 123-130
    • Lin, C.L.1    Kao, J.H.2
  • 36
    • 30344458192 scopus 로고    scopus 로고
    • Cellular and virological mechanisms of HBV drug resistance
    • Locarnini S., Mason W.S. Cellular and virological mechanisms of HBV drug resistance. J. Hepatol. 2006, 44:422-431.
    • (2006) J. Hepatol. , vol.44 , pp. 422-431
    • Locarnini, S.1    Mason, W.S.2
  • 37
    • 78851469544 scopus 로고    scopus 로고
    • Does antiviral therapy for hepatitis B and C prevent hepatocellular carcinoma?
    • Lok A.S. Does antiviral therapy for hepatitis B and C prevent hepatocellular carcinoma?. J. Gastroenterol. Hepatol. 2011, 26:221-227.
    • (2011) J. Gastroenterol. Hepatol. , vol.26 , pp. 221-227
    • Lok, A.S.1
  • 38
    • 70349240414 scopus 로고    scopus 로고
    • Chronic hepatitis B: update 2009
    • Lok A.S., McMahon B.J. Chronic hepatitis B: update 2009. Hepatology 2009, 50:661-662.
    • (2009) Hepatology , vol.50 , pp. 661-662
    • Lok, A.S.1    McMahon, B.J.2
  • 39
    • 84870804272 scopus 로고    scopus 로고
    • 737 A phase-I, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of single escalating oral doses of GD-9620 in healthy subjects
    • Lopatin U., Wolfgang G., Kimberlin R., Turnas D., Cornprost M., Chittick G., Frey C., Findlay J., Ohmstede C., Kearney B., Barnes C., McHutchinson J., Hirsch K. 737 A phase-I, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of single escalating oral doses of GD-9620 in healthy subjects. J. Hepatol. 2011, 54(Suppl. 1):S296.
    • (2011) J. Hepatol. , vol.54 , Issue.SUPPL. 1
    • Lopatin, U.1    Wolfgang, G.2    Kimberlin, R.3    Turnas, D.4    Cornprost, M.5    Chittick, G.6    Frey, C.7    Findlay, J.8    Ohmstede, C.9    Kearney, B.10    Barnes, C.11    McHutchinson, J.12    Hirsch, K.13
  • 40
    • 77956028579 scopus 로고    scopus 로고
    • Quantitative serum HBsAg and HBeAg are strong predictors of sustained HBeAg seroconversion to pegylated interferon alfa-2b in HBeAg-positive patients
    • Ma H., Yang R.F., Wei L. Quantitative serum HBsAg and HBeAg are strong predictors of sustained HBeAg seroconversion to pegylated interferon alfa-2b in HBeAg-positive patients. J. Gastroenterol. Hepatol. 2010, 25:1498-1506.
    • (2010) J. Gastroenterol. Hepatol. , vol.25 , pp. 1498-1506
    • Ma, H.1    Yang, R.F.2    Wei, L.3
  • 41
    • 12844283883 scopus 로고    scopus 로고
    • Clonal expansion of hepatocytes during chronic woodchuck hepatitis virus infection
    • Mason W.S., Jilbert A.R., Summers J. Clonal expansion of hepatocytes during chronic woodchuck hepatitis virus infection. Proc. Natl. Acad. Sci. USA 2005, 102:1139-1144.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 1139-1144
    • Mason, W.S.1    Jilbert, A.R.2    Summers, J.3
  • 42
    • 77954991668 scopus 로고    scopus 로고
    • Clonal expansion of normal-appearing human hepatocytes during chronic hepatitis B virus infection
    • Mason W.S., Liu C., Aldrich C.E., Litwin S., Yeh M.M. Clonal expansion of normal-appearing human hepatocytes during chronic hepatitis B virus infection. J. Virol. 2010, 84:8308-8315.
    • (2010) J. Virol. , vol.84 , pp. 8308-8315
    • Mason, W.S.1    Liu, C.2    Aldrich, C.E.3    Litwin, S.4    Yeh, M.M.5
  • 44
    • 0036098137 scopus 로고    scopus 로고
    • Immunization with surface antigen vaccine alone and after treatment with 1-(2-fluoro-5-methyl-beta-l-arabinofuranosyl)-uracil (l-FMAU) breaks humoral and cell-mediated immune tolerance in chronic woodchuck hepatitis virus infection
    • Menne S., Roneker C.A., Korba B.E., Gerin J.L., Tennant B.C., Cote P.J. Immunization with surface antigen vaccine alone and after treatment with 1-(2-fluoro-5-methyl-beta-l-arabinofuranosyl)-uracil (l-FMAU) breaks humoral and cell-mediated immune tolerance in chronic woodchuck hepatitis virus infection. J. Virol. 2002, 76:5305-5314.
    • (2002) J. Virol. , vol.76 , pp. 5305-5314
    • Menne, S.1    Roneker, C.A.2    Korba, B.E.3    Gerin, J.L.4    Tennant, B.C.5    Cote, P.J.6
  • 45
    • 0036983178 scopus 로고    scopus 로고
    • Immunogenic effects of woodchuck hepatitis virus surface antigen vaccine in combination with antiviral therapy: breaking of humoral and cellular immune tolerance in chronic woodchuck hepatitis virus infection
    • Menne S., Roneker C.A., Tennant B.C., Korba B.E., Gerin J.L., Cote P.J. Immunogenic effects of woodchuck hepatitis virus surface antigen vaccine in combination with antiviral therapy: breaking of humoral and cellular immune tolerance in chronic woodchuck hepatitis virus infection. Intervirology 2002, 45:237-250.
    • (2002) Intervirology , vol.45 , pp. 237-250
    • Menne, S.1    Roneker, C.A.2    Tennant, B.C.3    Korba, B.E.4    Gerin, J.L.5    Cote, P.J.6
  • 46
    • 81355129949 scopus 로고    scopus 로고
    • 1114 Antiviral efficacy and induction of an antibody response against surface antigen with the TLR7 agonist GS-9620 in the woodchuck model of chronic HBV infection
    • Menne S., Tennant B.C., Liu K.H., Ascenzi M.A., Baldwin B.H., Bellezza C.A., Cote P.J., Zheng X., Wolfgang G., Turnas D. 1114 Antiviral efficacy and induction of an antibody response against surface antigen with the TLR7 agonist GS-9620 in the woodchuck model of chronic HBV infection. J. Hepatol. 2011, 54(Suppl. 1):S441.
    • (2011) J. Hepatol. , vol.54 , Issue.SUPPL. 1
    • Menne, S.1    Tennant, B.C.2    Liu, K.H.3    Ascenzi, M.A.4    Baldwin, B.H.5    Bellezza, C.A.6    Cote, P.J.7    Zheng, X.8    Wolfgang, G.9    Turnas, D.10
  • 47
    • 0034003174 scopus 로고    scopus 로고
    • Posttranscriptional inhibition of class I major histocompatibility complex presentation on hepatocytes and lymphoid cells in chronic woodchuck hepatitis virus infection
    • Michalak T.I., Hodgson P.D., Churchill N.D. Posttranscriptional inhibition of class I major histocompatibility complex presentation on hepatocytes and lymphoid cells in chronic woodchuck hepatitis virus infection. J. Virol. 2000, 74:4483-4494.
    • (2000) J. Virol. , vol.74 , pp. 4483-4494
    • Michalak, T.I.1    Hodgson, P.D.2    Churchill, N.D.3
  • 49
    • 84876072658 scopus 로고    scopus 로고
    • Preclinical development of the amphipathic DNA polymer rep 9AC for the treatment of HBV infection
    • Lahaina, Hawaii, R.F. Schinazi (Ed.) HepDart 2007 - Frontiers in Drug Development for Viral Hepatitis
    • Noordeen F., Vaillant A., Juteau J.M., Jilbert A.R. Preclinical development of the amphipathic DNA polymer rep 9AC for the treatment of HBV infection. Global Antivir. J. 2007, vol. 3:26-27. Lahaina, Hawaii. R.F. Schinazi (Ed.).
    • (2007) Global Antivir. J. , vol.3 , pp. 26-27
    • Noordeen, F.1    Vaillant, A.2    Juteau, J.M.3    Jilbert, A.R.4
  • 50
    • 77957939988 scopus 로고    scopus 로고
    • Glucosidase inhibition enhances presentation of de-N-glycosylated hepatitis B virus epitopes by major histocompatibility complex class I in vitro and in woodchucks
    • Norton P.A., Menne S., Sinnathamby G., Betesh L., Cote P.J., Philip R., Mehta A.S., Tennant B.C., Block T.M. Glucosidase inhibition enhances presentation of de-N-glycosylated hepatitis B virus epitopes by major histocompatibility complex class I in vitro and in woodchucks. Hepatology 2010, 52:1242-1250.
    • (2010) Hepatology , vol.52 , pp. 1242-1250
    • Norton, P.A.1    Menne, S.2    Sinnathamby, G.3    Betesh, L.4    Cote, P.J.5    Philip, R.6    Mehta, A.S.7    Tennant, B.C.8    Block, T.M.9
  • 52
    • 0029089777 scopus 로고
    • Detection of an RNase H activity associated with hepadnaviruses
    • Oberhaus S.M., Newbold J.E. Detection of an RNase H activity associated with hepadnaviruses. J. Virol. 1995, 69:5697-5704.
    • (1995) J. Virol. , vol.69 , pp. 5697-5704
    • Oberhaus, S.M.1    Newbold, J.E.2
  • 53
    • 70349255525 scopus 로고    scopus 로고
    • The mannose receptor acts as hepatitis B virus surface antigen receptor mediating interaction with intrahepatic dendritic cells
    • Op den Brouw M.L., Binda R.S., Geijtenbeek T.B., Janssen H.L., Woltman A.M. The mannose receptor acts as hepatitis B virus surface antigen receptor mediating interaction with intrahepatic dendritic cells. Virology 2009, 393:84-90.
    • (2009) Virology , vol.393 , pp. 84-90
    • Op den Brouw, M.L.1    Binda, R.S.2    Geijtenbeek, T.B.3    Janssen, H.L.4    Woltman, A.M.5
  • 54
    • 84857366393 scopus 로고    scopus 로고
    • Response to tenofovir monotherapy in chronic hepatitis B patients with prior suboptimal response to entecavir
    • Pan C.Q., Hu K.Q., Yu A.S., Chen W., Bunchorntavakul C., Reddy K.R. Response to tenofovir monotherapy in chronic hepatitis B patients with prior suboptimal response to entecavir. J. Viral Hepat. 2012, 19:213-219.
    • (2012) J. Viral Hepat. , vol.19 , pp. 213-219
    • Pan, C.Q.1    Hu, K.Q.2    Yu, A.S.3    Chen, W.4    Bunchorntavakul, C.5    Reddy, K.R.6
  • 55
    • 77955306935 scopus 로고    scopus 로고
    • Incidence of hepatocellular carcinoma in chronic hepatitis B patients receiving nucleos(t)ide therapy: a systematic review
    • Papatheodoridis G.V., Lampertico P., Manolakopoulos S., Lok A. Incidence of hepatocellular carcinoma in chronic hepatitis B patients receiving nucleos(t)ide therapy: a systematic review. J. Hepatol. 2010, 53:348-356.
    • (2010) J. Hepatol. , vol.53 , pp. 348-356
    • Papatheodoridis, G.V.1    Lampertico, P.2    Manolakopoulos, S.3    Lok, A.4
  • 57
    • 39349089594 scopus 로고    scopus 로고
    • Rapid virologic response: a new milestone in the management of chronic hepatitis C
    • Poordad F., Reddy K.R., Martin P. Rapid virologic response: a new milestone in the management of chronic hepatitis C. Clin. Infect. Dis. 2008, 46:78-84.
    • (2008) Clin. Infect. Dis. , vol.46 , pp. 78-84
    • Poordad, F.1    Reddy, K.R.2    Martin, P.3
  • 59
    • 84873299468 scopus 로고    scopus 로고
    • Sustained virologic response: Is this equivalent to cure of chronic hepatitis C?
    • Seeff L.B. Sustained virologic response: Is this equivalent to cure of chronic hepatitis C?. Hepatology 2013, 57:438-440.
    • (2013) Hepatology , vol.57 , pp. 438-440
    • Seeff, L.B.1
  • 60
    • 53549107488 scopus 로고    scopus 로고
    • Meta-analysis: treatment of hepatitis B infection reduces risk of hepatocellular carcinoma
    • Sung J.J., Tsoi K.K., Wong V.W., Li K.C., Chan H.L. Meta-analysis: treatment of hepatitis B infection reduces risk of hepatocellular carcinoma. Aliment. Pharmacol. Ther. 2008, 28:1067-1077.
    • (2008) Aliment. Pharmacol. Ther. , vol.28 , pp. 1067-1077
    • Sung, J.J.1    Tsoi, K.K.2    Wong, V.W.3    Li, K.C.4    Chan, H.L.5
  • 63
    • 0037213545 scopus 로고    scopus 로고
    • CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection
    • Thimme R., Wieland S., Steiger C., Ghrayeb J., Reimann K.A., Purcell R.H., Chisari F.V. CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection. J. Virol. 2003, 77:68-76.
    • (2003) J. Virol. , vol.77 , pp. 68-76
    • Thimme, R.1    Wieland, S.2    Steiger, C.3    Ghrayeb, J.4    Reimann, K.A.5    Purcell, R.H.6    Chisari, F.V.7
  • 66
    • 0033029334 scopus 로고    scopus 로고
    • Biphasic clearance kinetics of hepatitis B virus from patients during adefovir dipivoxil therapy
    • Tsiang M., Rooney J.F., Toole J.J., Gibbs C.S. Biphasic clearance kinetics of hepatitis B virus from patients during adefovir dipivoxil therapy. Hepatology 1999, 29:1863-1869.
    • (1999) Hepatology , vol.29 , pp. 1863-1869
    • Tsiang, M.1    Rooney, J.F.2    Toole, J.J.3    Gibbs, C.S.4
  • 67
    • 84983720423 scopus 로고    scopus 로고
    • PD-1 blockage reverses immune dysfunction and hepatitis B viral persistence in a mouse animal model
    • Tzeng H.T., Tsai H.F., Liao H.J., Lin Y.J., Chen L., Chen P.J., Hsu P.N. PD-1 blockage reverses immune dysfunction and hepatitis B viral persistence in a mouse animal model. PLoS One 2012, 7:e39179.
    • (2012) PLoS One , vol.7
    • Tzeng, H.T.1    Tsai, H.F.2    Liao, H.J.3    Lin, Y.J.4    Chen, L.5    Chen, P.J.6    Hsu, P.N.7
  • 71
    • 77956592924 scopus 로고    scopus 로고
    • Kinetics of hepatitis B surface antigen decline during 3 years of telbivudine treatment in hepatitis B e antigen-positive patients
    • Wursthorn K., Jung M., Riva A., Goodman Z.D., Lopez P., Bao W., Manns M.P., Wedemeyer H., Naoumov N.V. Kinetics of hepatitis B surface antigen decline during 3 years of telbivudine treatment in hepatitis B e antigen-positive patients. Hepatology 2010, 52:1611-1620.
    • (2010) Hepatology , vol.52 , pp. 1611-1620
    • Wursthorn, K.1    Jung, M.2    Riva, A.3    Goodman, Z.D.4    Lopez, P.5    Bao, W.6    Manns, M.P.7    Wedemeyer, H.8    Naoumov, N.V.9
  • 73
    • 78650780786 scopus 로고    scopus 로고
    • Treatment of chronic hepatitis B: evolution over two decades
    • Yuen M.F., Lai C.L. Treatment of chronic hepatitis B: evolution over two decades. J. Gastroenterol. Hepatol. 2011, 26(Suppl. 1):138-143.
    • (2011) J. Gastroenterol. Hepatol. , vol.26 , Issue.SUPPL. 1 , pp. 138-143
    • Yuen, M.F.1    Lai, C.L.2
  • 74
    • 84857053151 scopus 로고    scopus 로고
    • Reasons to consider earlier treatment of chronic HBV infections
    • Zoulim F., Mason W.S. Reasons to consider earlier treatment of chronic HBV infections. Gut 2012, 61:333-336.
    • (2012) Gut , vol.61 , pp. 333-336
    • Zoulim, F.1    Mason, W.S.2


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