Two transcription factors, CabA and CabR, are independently involved in multilevel regulation of the biosynthetic gene cluster encoding the novel aminocoumarin, cacibiocin

Applied Microbiology and Biotechnology

Volumn 100, Issue 7, 2016, Pages 3147-3164

  Wolański, Marcin ^a   Łebkowski, Tomasz ^a   Kois Ostrowska, Agnieszka ^a   Zettler, Judith ^c,d   Apel, Alexander K ^c,d   Jakimowicz, Dagmara ^a,b   Zakrzewska Czerwińska, Jolanta ^a,b  

^a UNIVERSITY OF WROC AW   (Poland)

^b INSTITUTE OF IMMUNOLOGY AND EXPERIMENTAL THERAPY   (Poland)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d German Centre for Infection Research (DZIF)   (Germany)

Author keywords

Antibiotics; Cacibiocin; Catenulispora acidiphila; Gene cluster; Genome mining; Streptomyces coelicolor; Transcription regulation

Indexed keywords

ANTIBIOTICS; BACTERIA; BIOCHEMISTRY; BIOSYNTHESIS; ENCODING (SYMBOLS); GENE ENCODING; GENE EXPRESSION; GENES; METABOLITES; TRANSCRIPTION;

CACIBIOCIN; CATENULISPORA ACIDIPHILA; GENE CLUSTERS; GENOME MINING; STREPTOMYCES COELICOLOR; TRANSCRIPTION REGULATIONS;

GENE EXPRESSION REGULATION;

AMINOCOUMARIN DERIVATIVE; ANTIBIOTIC AGENT; CACIBIOCIN; CACIBIOCIN A; REGULATOR PROTEIN; SPACER DNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CABA; TRANSCRIPTION FACTOR CABR; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; RECOMBINANT PROTEIN;

ANTIBIOTICS; ANTIMICROBIAL ACTIVITY; BACTERIUM; BIOTECHNOLOGY; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC ANALYSIS; GENOME; SECONDARY METABOLITE;

ACTINOBACTERIA; ARTICLE; BINDING AFFINITY; CATENULISPORA ACIDIPHILA; CONTROLLED STUDY; DNA BINDING; DNA FOOTPRINTING; DRUG SYNTHESIS; ESCHERICHIA COLI; GEL MOBILITY SHIFT ASSAY; GENE CLUSTER; GENE EXPRESSION REGULATION; HALOGENATION; HETEROLOGOUS EXPRESSION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; STREPTOMYCES COELICOLOR; SURFACE PLASMON RESONANCE; TRANSCRIPTION REGULATION; ACTINOMYCETALES; AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; BACTERIAL GENE; BACTERIAL GENOME; BIOSYNTHESIS; CHEMISTRY; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MOLECULAR CLONING; MULTIGENE FAMILY; NUCLEOTIDE SEQUENCE; OPERON; SEQUENCE ALIGNMENT;

ACTINOBACTERIA (CLASS); STREPTOMYCES COELICOLOR;

ACTINOMYCETALES; AMINO ACID SEQUENCE; AMINOCOUMARINS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BASE SEQUENCE; CLONING, MOLECULAR; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; GENE EXPRESSION; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; GENOME, BACTERIAL; MULTIGENE FAMILY; OPERON; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; STREPTOMYCES COELICOLOR; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 84960811836     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-015-7196-7     Document Type: Article

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