NovJ/NovK catalyze benzylic oxidation of a β-hydroxyl tyrosyl-S-pantetheinyl enzyme during aminocoumarin ring formation in novobiocin biosynthesis

Biochemistry

Volumn 44, Issue 38, 2005, Pages 12819-12826

  Pacholec, M ^a   Hillson, N J ^a,b   Walsh, C T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANTIBIOTICS; BACTERIA; BIOSYNTHESIS; CATALYST ACTIVITY; DNA; ESTERS;

BENZYLIC CARBON; BENZYLIC OXIDATION; DNA GYRASES; PHOSPHOPANTETHEINYL THIOESTER; TYROSINE;

ENZYMES;

AMINO ACID; AMINOCOUMARIN; BENZILIC ACID DERIVATIVE; BETA HYDROXYLTYROSYL S PANTETHEINYL ENZYME; CLOROBIOCIN; COUMAMYCIN; COUMARIN DERIVATIVE; DNA TOPOISOMERASE (ATP HYDROLYSING); HEMOPROTEIN; NATURAL PRODUCT; NOVOBIOCIN; PEPTIDE SYNTHASE; PROTEIN NOVI; PROTEIN NOVJ; PROTEIN NOVK; THIOESTER; TYROSINE; UNCLASSIFIED DRUG;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; CYCLIZATION; ENZYME DEGRADATION; ESCHERICHIA COLI; GENE MUTATION; HYDROXYLATION; MASS SPECTROMETRY; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PRODUCT RECOVERY; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN TARGETING; STREPTOMYCES; STREPTOMYCES SPHAEROIDES;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CATALYSIS; CHROMATOGRAPHY, GEL; COUMARINS; MUTATION; NADP; NOVOBIOCIN; OXIDATION-REDUCTION; OXIDOREDUCTASES; PANTETHEINE; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STREPTOMYCES; TYROSINE; ULTRACENTRIFUGATION;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; STREPTOMYCES CAERULEUS;

EID: 25444475215     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi051297m     Document Type: Article

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