Transcriptional regulation of the novobiocin biosynthetic gene cluster

Microbiology

Volumn 155, Issue 12, 2009, Pages 4025-4035

  Dangel, Volker ^a   Härle, Johannes ^a,d   Goerke, Christiane ^b   Wolz, Christiane ^b   Gust, Bertolt ^a   Pernodet, Jean Luc ^c   Heide, Lutz ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^c UNIVERSITÉ PARIS SACLAY   (France)

^d UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DNA TOPOISOMERASE (ATP HYDROLYSING) B; GENE PRODUCT; NEPHROBLASTOMA OVEREXPRESSED PROTEIN; NOVOBIOCIN; PROTEIN NOVE; PROTEIN NOVG; PROTEIN NOVW; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; BINDING SITE; GENE CASSETTE; GENE CLUSTER; GENE FUNCTION; GENE INSERTION; GENE LOCATION; GENE MUTATION; GENE SEQUENCE; NONHUMAN; NUCLEOTIDE SEQUENCE; OPERON; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REGULATOR GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STREPTOMYCES; TRANSCRIPTION REGULATION;

BACTERIAL PROTEINS; BASE SEQUENCE; BINDING SITES; DNA GYRASE; DNA, BACTERIAL; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; GENETIC VECTORS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; NOVOBIOCIN; PLASMIDS; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, BACTERIAL; RNA, MESSENGER; STREPTOMYCES; TRANSCRIPTION, GENETIC;

STREPTOMYCES;

EID: 71449085267     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.032649-0     Document Type: Article

References (31)

1. Blondelet-Rouault, M. H., Weiser, J., Lebrihi, A., Branny, P. & Pernodet, J. L. (1997). Antibiotic resistance gene cassettes derived from the Ω interposon for use in E. coli and Streptomyces. Gene 190, 315-317.
2. Chandra, G. & Chater, K. F. (2008). Evolutionary flux of potentially bldA-dependent Streptomyces genes containing the rare leucine codon TTA. Antonie Van Leeuwenhoek 94, 111-126.
3. Dangel, V., Eustáquio, A. S., Gust, B. & Heide, L. (2008). novE and novG act as positive regulators of novobiocin biosynthesis. Arch Microbiol 190, 509-519.
4. Duetz, W. A., Rüedi, L., Hermann, R., O'Connor, K., Büchs, J. & Witholt, B. (2000). Methods for intense aeration, growth, storage, and replication of bacterial strains in microtiter plates. Appl Environ Microbiol 66, 2641-2646.
5. Eustáquio, A. S., Luft, T., Wang, Z. X., Gust, B., Chater, K. F., Li, S. M. & Heide, L. (2003). Novobiocin biosynthesis: inactivation of the putative regulatory gene novE and heterologous expression of genes involved in aminocoumarin ring formation. Arch Microbiol 180, 25-32.
6. Eustáquio, A. S., Gust, B., Galm, U., Li, S. M., Chater, K. F. & Heide, L. (2005a). Heterologous expression of novobiocin and clorobiocin biosynthetic gene clusters. Appl Environ Microbiol 71, 2452-2459.
7. Eustáquio, A. S., Li, S. M. & Heide, L. (2005b). NovG, a DNA-binding protein acting as a positive regulator of novobiocin biosynthesis. Microbiology 151, 1949-1961.
8. Fischbach, M. A. & Walsh, C. T. (2006). Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: logic, machinery, and mechanisms. Chem Rev 106, 3468-3496.
9. Gust, B., Challis, G. L., Fowler, K., Kieser, T. & Chater, K. F. (2003). PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin. Proc Natl Acad Sci U S A 100, 1541-1546.
10. Gust, B., Chandra, G., Jakimowicz, D., Yuqing, T., Bruton, C. J. & Chater, K. F. (2004). λ Red-mediated genetic manipulation of antibiotic-producing Streptomyces. Adv Appl Microbiol 54, 107-128.
11. Heide, L., Gust, B., Anderle, C. & Li, S. M. (2008). Combinatorial biosynthesis, metabolic engineering and mutasynthesis for the generation of new aminocoumarin antibiotics. Curr Top Med Chem 8, 667-679.
12. Kieser, T., Bibb, M. J., Buttner, M. J., Chater, K. F. & Hopwood, D. A. (2000). Practical Streptomyces Genetics. Norwich, UK: John Innes Foundation.
13. Kominek, L. A. (1972). Biosynthesis of novobiocin by Streptomyces niveus. Antimicrob Agents Chemother 1, 123-134.
14. Laing, E., Mersinias, V., Smith, C. P. & Hubbard, S. J. (2006). Analysis of gene expression in operons of Streptomyces coelicolor. Genome Biol 7, R46.
15. Li, S. M. & Heide, L. (2004). Functional analysis of biosynthetic genes of aminocoumarins and production of hybrid antibiotics. Curr Med Chem Anti-Infect Agents 3, 279-295.
16. Li, S. M. & Heide, L. (2005). New aminocoumarin antibiotics from genetically engineered Streptomyces strains. Curr Med Chem 12, 419-427.
17. Li, S. M. & Heide, L. (2006). The biosynthetic gene clusters of aminocoumarin antibiotics. Planta Med 72, 1093-1099.
18. MacNeil, D. J., Gewain, K. M., Ruby, C. L., Dezeny, G., Gibbons, P. H. & MacNeil, T. (1992). Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel integration vector. Gene 111, 61-68.
19. Maxwell, A. & Lawson, D. M. (2003). The ATP-binding site of type II topoisomerases as a target for antibacterial drugs. Curr Top Med Chem 3, 283-303.
20. Pojer, F., Kahlich, R., Kammerer, B., Li, S. M. & Heide, L. (2003a). CloR, a bifunctional non-heme iron oxygenase involved in clorobiocin biosynthesis. J Biol Chem 278, 30661-30668.
21. Pojer, F., Wemakor, E., Kammerer, B., Chen, H., Walsh, C. T., Li, S. M. & Heide, L. (2003b). CloQ, a prenyltransferase involved in clorobiocin biosynthesis. Proc Natl Acad Sci U S A 100, 2316-2321.
22. Prentki, P. & Krisch, H. M. (1984). In vitro insertional mutagenesis with a selectable DNA fragment. Gene 29, 303-313.
23. Raynal, A., Karray, F., Tuphile, K., Darbon-Rongere, E. & Pernodet, J. L. (2006). Excisable cassettes: new tools for functional analysis of Streptomyces genomes. Appl Environ Microbiol 72, 4839-4844.
24. Sambrook, J. & Russell, D. W. (2001). Molecular Cloning: a Laboratory Manual, 3rd edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
25. Shawky, R. M., Puk, O., Wietzorrek, A., Pelzer, S., Takano, E., Wohlleben, W. & Stegmann, E. (2007). The border sequence of the balhimycin biosynthesis gene cluster from Amycolatopsis balhimycina contains bbr, encoding a StrR-like pathway-specific regulator. J Mol Microbiol Biotechnol 13, 76-88.
26. Siebenberg, S., Bapat, P. M., Lantz, A. E., Gust, B. & Heide, L. (2009). Reducing the variability of antibiotic production in Streptomyces by cultivation in 24-square deepwell plates. J Biosci Bioeng (in press).
27. Thiara, A. S. & Cundliffe, E. (1989). Interplay of novobiocin-resistant and -sensitive DNA gyrase activities in self-protection of the novobiocin producer, Streptomyces sphaeroides. Gene 81, 65-72.
28. Tomono, A., Tsai, Y., Yamazaki, H., Ohnishi, Y. & Horinouchi, S. (2005). Transcriptional control by A-factor of strR, the pathway-specific transcriptional activator for streptomycin biosynthesis in Streptomyces griseus. J Bacteriol 187, 5595-5604.
29. Westpheling, J. & Brawner, M. (1989). Two transcribing activities are involved in expression of the Streptomyces galactose operon. J Bacteriol 171, 1355-1361.
30. Wilkinson, B. & Micklefield, J. (2007). Mining and engineering natural-product biosynthetic pathways. Nat Chem Biol 3, 379-386.
31. Zerikly, M. & Challis, G. L. (2009). Strategies for the discovery of new natural products by genome mining. ChemBioChem 10, 625-633.