Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen

Clinical Pharmacology and Therapeutics

Volumn 99, Issue 4, 2016, Pages 432-441

  Fannin, R D ^a   Gerrish, K ^a   Sieber, S O ^a   Bushel, P R ^a   Watkins, P B ^b   Paules, R S ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b Hamner University of North Carolina Institute for Drug Safety Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; GLUTATHIONE TRANSFERASE ALPHA; PARACETAMOL; TRANSCRIPTOME; ANALGESIC AGENT; GENETIC MARKER; MESSENGER RNA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANTIGEN PRESENTING CELL; ARTICLE; BLOOD SAMPLING; BONE MARROW CELL; CHEMOTAXIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; EOSINOPHIL; FEMALE; GENE EXPRESSION; GRANULOCYTE; HUMAN; HUMAN EXPERIMENT; HYPERTRANSAMINASEMIA; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; INNATE IMMUNITY; LYMPHOCYTE; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; MAST CELL; MONONUCLEAR CELL; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; RNA ISOLATION; T LYMPHOCYTE; TOXIC HEPATITIS; BLOOD; CHEMICAL AND DRUG INDUCED LIVER INJURY; DRUG ADMINISTRATION; DRUG EFFECTS; DRUG MONITORING; ENZYMOLOGY; GENE EXPRESSION PROFILING; GENETIC MARKER; GENETICS; IMMUNOLOGY; ORAL DRUG ADMINISTRATION; PREDICTIVE VALUE; PROCEDURES; TH2 CELL; TIME FACTOR; UPREGULATION;

ACETAMINOPHEN; ADMINISTRATION, ORAL; ALANINE TRANSAMINASE; ANALGESICS, NON-NARCOTIC; CHEMICAL AND DRUG INDUCED LIVER INJURY; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; DRUG MONITORING; GENE EXPRESSION PROFILING; GENETIC MARKERS; HUMANS; IMMUNITY, INNATE; PREDICTIVE VALUE OF TESTS; PRINCIPAL COMPONENT ANALYSIS; RNA, MESSENGER; TH2 CELLS; TIME FACTORS; TRANSCRIPTOME; UP-REGULATION;

EID: 84960404821     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1002/cpt.328     Document Type: Article

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