'Omics analysis of low dose acetaminophen intake demonstrates novel response pathways in humans

Toxicology and Applied Pharmacology

Volumn 259, Issue 3, 2012, Pages 320-328

  Jetten, Marlon J A ^a   Gaj, Stan ^a   Ruiz Aracama, Ainhoa ^b   de Kok, Theo M ^a   van Delft, Joost H M ^a   Lommen, Arjen ^b   van Someren, Eugene P ^c   Jennen, Danyel G J ^a   Claessen, Sandra M ^a   Peijnenburg, Ad A C M ^b   Stierum, Rob H ^c   Kleinjans, Jos C S ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c TNO   (Netherlands)

Author keywords

Acetaminophen; Human; Metabolomics; MicroRNA; Toxicogenomics; Transcriptomics

Indexed keywords

DRUG METABOLITE; MESSENGER RNA; MICRORNA; PARACETAMOL;

ADULT; AEROBIC METABOLISM; APOPTOSIS; ARTICLE; BLOOD SAMPLING; CELL SURVIVAL; CHOLESTEROL TRANSPORT; CLINICAL ARTICLE; CLINICAL CHEMISTRY; DNA DAMAGE; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG METABOLISM; DRUG OVERDOSE; DRUG SCREENING; DRUG USE; FEMALE; GENE EXPRESSION; GENOMICS; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; IMMUNOMODULATION; LIPID METABOLISM; LIVER TOXICITY; LOW DRUG DOSE; MALE; METABOLOMICS; NORMAL HUMAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PHARMACOGENOMICS; POLARIZATION; PROTEIN EXPRESSION; RNA ANALYSIS; TABLET; TRANSCRIPTOMICS; URINALYSIS;

ACETAMINOPHEN; ADULT; ANALGESICS, NON-NARCOTIC; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENOME, HUMAN; HUMANS; MALE; MICRORNAS; MIDDLE AGED; OXIDATION-REDUCTION; OXIDATIVE STRESS; RNA, MESSENGER; TRANSCRIPTOME;

EID: 84858081410     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.01.009     Document Type: Article

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