메뉴 건너뛰기




Volumn 46, Issue 3, 2016, Pages 191-203

Current status of immunotherapy

Author keywords

Clinical trials; Immunology; Immunotherapy

Indexed keywords

CHEMOKINE RECEPTOR CCR4; DACARBAZINE; DACLIZUMAB; DENDRITIC CELL VACCINE; DOCETAXEL; IPILIMUMAB; MOGAMULIZUMAB; NIVOLUMAB; PEMBROLIZUMAB; ANTINEOPLASTIC AGENT; IMMUNOSUPPRESSIVE AGENT; LYMPHOCYTE ANTIGEN RECEPTOR; MONOCLONAL ANTIBODY;

EID: 84960332327     PISSN: 03682811     EISSN: 14653621     Source Type: Journal    
DOI: 10.1093/jjco/hyv201     Document Type: Review
Times cited : (53)

References (133)
  • 1
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012;22:252-64.
    • (2012) Nat Rev Cancer , vol.22 , pp. 252-264
    • Pardoll, D.M.1
  • 2
    • 0023514599 scopus 로고
    • Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system
    • Aruffo A, Seed B. Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system. Proc Natl Acad Sci USA 1987;84:8573-7.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 8573-8577
    • Aruffo, A.1    Seed, B.2
  • 3
    • 0033590502 scopus 로고    scopus 로고
    • ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
    • Hutloff A, Dittrich AM, Beier KC, et al. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature 1999;397:263-6.
    • (1999) Nature , vol.397 , pp. 263-266
    • Hutloff, A.1    Dittrich, A.M.2    Beier, K.C.3
  • 4
    • 0344247505 scopus 로고
    • cDNA sequences of two inducible T-cell genes
    • Kwon BS, Weissman SM. cDNA sequences of two inducible T-cell genes. Proc Natl Acad Sci USA 1989;86:1963-7.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 1963-1967
    • Kwon, B.S.1    Weissman, S.M.2
  • 5
    • 0028297408 scopus 로고
    • The human OX40 homolog: cDNA structure, expression and chromosomal assignment of the ACT35 antigen
    • Latza U, Dürkop H, Schnittger S, et al. The human OX40 homolog: cDNA structure, expression and chromosomal assignment of the ACT35 antigen. Eur J Immunol 1994;24:677-83.
    • (1994) Eur J Immunol , vol.24 , pp. 677-683
    • Latza, U.1    Dürkop, H.2    Schnittger, S.3
  • 6
    • 0026075319 scopus 로고
    • The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family
    • Camerini D, Walz G, Loenen WA, Borst J, Seed B. The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family. J Immunol 1991;147:3165-9.
    • (1991) J Immunol , vol.147 , pp. 3165-3169
    • Camerini, D.1    Walz, G.2    Loenen, W.A.3    Borst, J.4    Seed, B.5
  • 7
    • 0024205313 scopus 로고
    • Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains
    • Dariavach P, Mattéi MG, Golstein P, Lefranc MP. Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains. Eur J Immunol 1988;18:1901-5.
    • (1988) Eur J Immunol , vol.18 , pp. 1901-1905
    • Dariavach, P.1    Mattéi, M.G.2    Golstein, P.3    Lefranc, M.P.4
  • 8
    • 0026700235 scopus 로고
    • Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
    • Ishida Y, Agata Y, Shibahara K, Honjo T. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J 1992;11:3887-95.
    • (1992) EMBO J , vol.11 , pp. 3887-3895
    • Ishida, Y.1    Agata, Y.2    Shibahara, K.3    Honjo, T.4
  • 9
    • 0037203867 scopus 로고    scopus 로고
    • Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease
    • Monney L, Sabatos CA, Gaglia JL, et al. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 2002;415:536-41.
    • (2002) Nature , vol.415 , pp. 536-541
    • Monney, L.1    Sabatos, C.A.2    Gaglia, J.L.3
  • 10
    • 0025338920 scopus 로고
    • LAG-3, a novel lymphocyte activation gene closely related to CD4
    • Triebel F, Jitsukawa S, Baixeras E, et al. LAG-3, a novel lymphocyte activation gene closely related to CD4. J Exp Med 1990;171:1393-405.
    • (1990) J Exp Med , vol.171 , pp. 1393-1405
    • Triebel, F.1    Jitsukawa, S.2    Baixeras, E.3
  • 11
    • 34247884612 scopus 로고    scopus 로고
    • The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection
    • Sharpe AH, Wherry EJ, Ahmed R, Freeman GJ. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nat Immunol 2007;8:239-45.
    • (2007) Nat Immunol , vol.8 , pp. 239-245
    • Sharpe, A.H.1    Wherry, E.J.2    Ahmed, R.3    Freeman, G.J.4
  • 13
    • 84925545111 scopus 로고    scopus 로고
    • Clinical blockade of PD1 and LAG3-potential mechanisms of action
    • Nguyen LT, Ohashi PS. Clinical blockade of PD1 and LAG3-potential mechanisms of action. Nat Rev Immunol 2015;15:45-56.
    • (2015) Nat Rev Immunol , vol.15 , pp. 45-56
    • Nguyen, L.T.1    Ohashi, P.S.2
  • 16
    • 0033427047 scopus 로고    scopus 로고
    • OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL responses after virus infection
    • Kopf M, Ruedl C, Schmitz N, et al. OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL responses after virus infection. Immunity 1999;11:699-708.
    • (1999) Immunity , vol.11 , pp. 699-708
    • Kopf, M.1    Ruedl, C.2    Schmitz, N.3
  • 17
    • 0036604470 scopus 로고    scopus 로고
    • Immune responses in 4-1BB (CD137)-deficient mice
    • Kwon BS, Hurtado JC, Lee ZH, et al. Immune responses in 4-1BB (CD137)-deficient mice. J Immunol 2002;168:5483-90.
    • (2002) J Immunol , vol.168 , pp. 5483-5490
    • Kwon, B.S.1    Hurtado, J.C.2    Lee, Z.H.3
  • 18
    • 74949120423 scopus 로고    scopus 로고
    • CD27 sustains survival of CTLs in virus-infected nonlymphoid tissue in mice by inducing autocrine IL-2 production
    • Peperzak V, Xiao Y, Veraar EA, Borst J. CD27 sustains survival of CTLs in virus-infected nonlymphoid tissue in mice by inducing autocrine IL-2 production. J Clin Invest 2010;120:168-78.
    • (2010) J Clin Invest , vol.120 , pp. 168-178
    • Peperzak, V.1    Xiao, Y.2    Veraar, E.A.3    Borst, J.4
  • 20
    • 0035804254 scopus 로고    scopus 로고
    • ICOS co-stimulatory receptor is essential for T-cell activation and function
    • Dong C, Juedes AE, Temann UA, et al. ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature 2001;409:97-101.
    • (2001) Nature , vol.409 , pp. 97-101
    • Dong, C.1    Juedes, A.E.2    Temann, U.A.3
  • 21
    • 79955491348 scopus 로고    scopus 로고
    • Lack of B and T lymphocyte attenuator exacerbates autoimmune disorders and induces Fasindependent liver injury in MRL-lpr/lpr mice
    • Oya Y, Watanabe N, Kobayashi Y, et al. Lack of B and T lymphocyte attenuator exacerbates autoimmune disorders and induces Fasindependent liver injury in MRL-lpr/lpr mice. Int Immunol 2011;23:335-44.
    • (2011) Int Immunol , vol.23 , pp. 335-344
    • Oya, Y.1    Watanabe, N.2    Kobayashi, Y.3
  • 22
    • 0033180181 scopus 로고    scopus 로고
    • Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
    • Nishimura H, Nose M, Hiai H, Minato N, Honjo T. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 1999;11:141-51.
    • (1999) Immunity , vol.11 , pp. 141-151
    • Nishimura, H.1    Nose, M.2    Hiai, H.3    Minato, N.4    Honjo, T.5
  • 23
    • 84928774156 scopus 로고    scopus 로고
    • The future of immune checkpoint therapy
    • Sharma P, Allison JP. The future of immune checkpoint therapy. Science 2015;348:56-61.
    • (2015) Science , vol.348 , pp. 56-61
    • Sharma, P.1    Allison, J.P.2
  • 24
    • 84884561907 scopus 로고    scopus 로고
    • Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy
    • Nirschl CJ, Drake CG. Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy. Clin Cancer Res 2013;19:4917-24.
    • (2013) Clin Cancer Res , vol.19 , pp. 4917-4924
    • Nirschl, C.J.1    Drake, C.G.2
  • 25
    • 84924274467 scopus 로고    scopus 로고
    • The path to reactivation of antitumor immunity and checkpoint immunotherapy
    • Kim HJ, Cantor H. The path to reactivation of antitumor immunity and checkpoint immunotherapy. Cancer Immunol Res 2014;2:926-36.
    • (2014) Cancer Immunol Res , vol.2 , pp. 926-936
    • Kim, H.J.1    Cantor, H.2
  • 27
    • 84859403357 scopus 로고    scopus 로고
    • Inhibitory receptors on lymphocytes: insights from infections
    • Odorizzi PM, Wherry EJ. Inhibitory receptors on lymphocytes: insights from infections. J Immunol 2012;188:2957-65.
    • (2012) J Immunol , vol.188 , pp. 2957-2965
    • Odorizzi, P.M.1    Wherry, E.J.2
  • 28
    • 0033859430 scopus 로고    scopus 로고
    • Loss of CD28 expression on CD8(+) T cells is induced by IL-2 receptor gamma chain signalling cytokines and type I IFN, and increases susceptibility to activation-induced apoptosis
    • Borthwick NJ, Lowdell M, Salmon M, Akbar AN. Loss of CD28 expression on CD8(+) T cells is induced by IL-2 receptor gamma chain signalling cytokines and type I IFN, and increases susceptibility to activation-induced apoptosis. Int Immunol 2000;12:1005-13.
    • (2000) Int Immunol , vol.12 , pp. 1005-1013
    • Borthwick, N.J.1    Lowdell, M.2    Salmon, M.3    Akbar, A.N.4
  • 30
    • 44449162734 scopus 로고    scopus 로고
    • Regulation of CD28 expression on CD8+ T cells by CTLA-4
    • Berg M, Zavazava N. Regulation of CD28 expression on CD8+ T cells by CTLA-4. J Leukoc Biol 2008;83:853-63.
    • (2008) J Leukoc Biol , vol.83 , pp. 853-863
    • Berg, M.1    Zavazava, N.2
  • 31
    • 33744940000 scopus 로고    scopus 로고
    • Modulation by IL-2 ofCD70 andCD27 expression on CD8+ T cells: importance for the therapeutic effectiveness of cell transfer immunotherapy
    • Huang J,Kerstann KW, Ahmadzadeh M, et al. Modulation by IL-2 ofCD70 andCD27 expression on CD8+ T cells: importance for the therapeutic effectiveness of cell transfer immunotherapy. J Immunol 2006;176:7726-35.
    • (2006) J Immunol , vol.176 , pp. 7726-7735
    • Huang, J.1    Kerstann, K.W.2    Ahmadzadeh, M.3
  • 32
    • 0036604898 scopus 로고    scopus 로고
    • The right place at the right time: novel B7 family members regulate effector T cell responses
    • Liang L, Sha WC. The right place at the right time: novel B7 family members regulate effector T cell responses. Curr Opin Immunol 2002;14:384-90.
    • (2002) Curr Opin Immunol , vol.14 , pp. 384-390
    • Liang, L.1    Sha, W.C.2
  • 33
    • 0036214017 scopus 로고    scopus 로고
    • The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses
    • Carreno BM, Collins M. The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses. Annu Rev Immunol 2002;20:29-53.
    • (2002) Annu Rev Immunol , vol.20 , pp. 29-53
    • Carreno, B.M.1    Collins, M.2
  • 34
    • 0141609073 scopus 로고    scopus 로고
    • Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?
    • Croft M. Co-stimulatory members of the TNFR family: keys to effective T-cell immunity? Nat Rev Immunol 2003;3:609-20.
    • (2003) Nat Rev Immunol , vol.3 , pp. 609-620
    • Croft, M.1
  • 35
    • 0037810672 scopus 로고    scopus 로고
    • The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens
    • Lohr J, Knoechel B, Jiang S, Sharpe AH, Abbas AK. The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens. Nat Immunol 2003;4:664-9.
    • (2003) Nat Immunol , vol.4 , pp. 664-669
    • Lohr, J.1    Knoechel, B.2    Jiang, S.3    Sharpe, A.H.4    Abbas, A.K.5
  • 36
    • 84862739640 scopus 로고    scopus 로고
    • Immunotherapy of cancer with 4-1BB
    • Vinay DS, Kwon BS. Immunotherapy of cancer with 4-1BB. Mol Cancer Ther 2012;11:1062-70.
    • (2012) Mol Cancer Ther , vol.11 , pp. 1062-1070
    • Vinay, D.S.1    Kwon, B.S.2
  • 37
    • 0035399581 scopus 로고    scopus 로고
    • Enhancement of CD8+ T cell responses by ICOS/B7h costimulation
    • Wallin JJ, Liang L, Bakardjiev A, Sha WC. Enhancement of CD8+ T cell responses by ICOS/B7h costimulation. J Immunol 2001;167:132-9.
    • (2001) J Immunol , vol.167 , pp. 132-139
    • Wallin, J.J.1    Liang, L.2    Bakardjiev, A.3    Sha, W.C.4
  • 38
    • 0031694687 scopus 로고    scopus 로고
    • Strong expression of CD134 (OX40), a member of the TNF receptor family, in a T helper 2-type cytokine environment
    • Roos A, Schilder-Tol EJ, Weening JJ, Aten J. Strong expression of CD134 (OX40), a member of the TNF receptor family, in a T helper 2-type cytokine environment. J Leukoc Biol 1998;64:503-10.
    • (1998) J Leukoc Biol , vol.64 , pp. 503-510
    • Roos, A.1    Schilder-Tol, E.J.2    Weening, J.J.3    Aten, J.4
  • 39
    • 0029150110 scopus 로고
    • Immunologic selftolerance maintained by activated T cells expressing IL-2 receptor alphachains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic selftolerance maintained by activated T cells expressing IL-2 receptor alphachains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995;155:1151-64.
    • (1995) J Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 40
    • 0033571105 scopus 로고    scopus 로고
    • Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity
    • Shimizu J, Yamazaki S, Sakaguchi S. Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity. J Immunol 1999;163:5211-8.
    • (1999) J Immunol , vol.163 , pp. 5211-5218
    • Shimizu, J.1    Yamazaki, S.2    Sakaguchi, S.3
  • 41
    • 0035167967 scopus 로고    scopus 로고
    • The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
    • Bennett CL, Christie J, Ramsdell F, et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet 2001;27:20-1.
    • (2001) Nat Genet , vol.27 , pp. 20-21
    • Bennett, C.L.1    Christie, J.2    Ramsdell, F.3
  • 42
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003;299:1057-61.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 43
    • 84875498856 scopus 로고    scopus 로고
    • Development and maintenance of regulatory T cells
    • Ohkura N, Kitagawa Y, Sakaguchi S. Development and maintenance of regulatory T cells. Immunity 2013;38:414-23.
    • (2013) Immunity , vol.38 , pp. 414-423
    • Ohkura, N.1    Kitagawa, Y.2    Sakaguchi, S.3
  • 44
    • 84883681998 scopus 로고    scopus 로고
    • Natural and induced T regulatory cells in cancer
    • Adeegbe DO, Nishikawa H. Natural and induced T regulatory cells in cancer. Front Immunol 2013;4:190.
    • (2013) Front Immunol , vol.4 , pp. 190
    • Adeegbe, D.O.1    Nishikawa, H.2
  • 45
    • 84869148187 scopus 로고    scopus 로고
    • T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development
    • Ohkura N, Hamaguchi M, Morikawa H, et al. T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development. Immunity 2012;37:785-99.
    • (2012) Immunity , vol.37 , pp. 785-799
    • Ohkura, N.1    Hamaguchi, M.2    Morikawa, H.3
  • 46
    • 0036172220 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength
    • Egen JG, Allison JP. Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength. Immunity 2002;16:23-35.
    • (2002) Immunity , vol.16 , pp. 23-35
    • Egen, J.G.1    Allison, J.P.2
  • 47
    • 0028675006 scopus 로고
    • Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors
    • Linsley PS, Greene JL, Brady W, Bajorath J, Ledbetter JA, Peach R. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity 1994;1:793-801.
    • (1994) Immunity , vol.1 , pp. 793-801
    • Linsley, P.S.1    Greene, J.L.2    Brady, W.3    Bajorath, J.4    Ledbetter, J.A.5    Peach, R.6
  • 49
    • 0034077559 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells downregulate co-stimulatory molecules on antigen-presenting cells
    • Cederbom L, Hall H, Ivars F. CD4+CD25+ regulatory T cells downregulate co-stimulatory molecules on antigen-presenting cells. Eur J Immunol 2000;30:1538-43.
    • (2000) Eur J Immunol , vol.30 , pp. 1538-1543
    • Cederbom, L.1    Hall, H.2    Ivars, F.3
  • 50
    • 84919665688 scopus 로고    scopus 로고
    • Detection of self-reactive CD8+ T cells with an anergic phenotype in healthy individuals
    • Maeda Y, Nishikawa H, Sugiyama D, et al. Detection of self-reactive CD8+ T cells with an anergic phenotype in healthy individuals. Science 2014;346:1536-40.
    • (2014) Science , vol.346 , pp. 1536-1540
    • Maeda, Y.1    Nishikawa, H.2    Sugiyama, D.3
  • 51
    • 20844432429 scopus 로고    scopus 로고
    • Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level
    • Roncador G, Brown PJ, Maestre L, et al. Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level. Eur J Immunol 2005;35:1681-91.
    • (2005) Eur J Immunol , vol.35 , pp. 1681-1691
    • Roncador, G.1    Brown, P.J.2    Maestre, L.3
  • 52
    • 83555174415 scopus 로고    scopus 로고
    • Prognostic potential of FOXP3 expression in non-small cell lung cancer cells combined with tumor-infiltrating regulatory T cells
    • Tao H,Mimura Y, Aoe K, et al. Prognostic potential of FOXP3 expression in non-small cell lung cancer cells combined with tumor-infiltrating regulatory T cells. Lung Cancer 2012;75:95-101.
    • (2012) Lung Cancer , vol.75 , pp. 95-101
    • Tao, H.1    Mimura, Y.2    Aoe, K.3
  • 53
    • 64649088372 scopus 로고    scopus 로고
    • FOXP3 expression and overall survival in breast cancer
    • Merlo A, Casalini P, Carcangiu ML, et al. FOXP3 expression and overall survival in breast cancer. J Clin Oncol 2009;27:1746-52.
    • (2009) J Clin Oncol , vol.27 , pp. 1746-1752
    • Merlo, A.1    Casalini, P.2    Carcangiu, M.L.3
  • 54
    • 28544433483 scopus 로고    scopus 로고
    • The expression of the regulatory T cell-specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer
    • Wolf D, Wolf AM, Rumpold H, et al. The expression of the regulatory T cell-specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer. Clin Cancer Res 2005;11:8326-31.
    • (2005) Clin Cancer Res , vol.11 , pp. 8326-8331
    • Wolf, D.1    Wolf, A.M.2    Rumpold, H.3
  • 55
    • 61349195299 scopus 로고    scopus 로고
    • Increased intratumoral FOXP3-positive regulatory immune cells during interleukin-2 treatment in metastatic renal cell carcinoma
    • Jensen HK, Donskov F, Nordsmark M, Marcussen N, von der Maase H. Increased intratumoral FOXP3-positive regulatory immune cells during interleukin-2 treatment in metastatic renal cell carcinoma. Clin Cancer Res 2009;15:1052-8.
    • (2009) Clin Cancer Res , vol.15 , pp. 1052-1058
    • Jensen, H.K.1    Donskov, F.2    Nordsmark, M.3    Marcussen, N.4    von der Maase, H.5
  • 56
    • 84892420566 scopus 로고    scopus 로고
    • High expression of FOXP3 in primary melanoma is associated with tumour progression
    • Gerber AL, Münst A, Schlapbach C, et al. High expression of FOXP3 in primary melanoma is associated with tumour progression. Br J Dermatol 2014;170:103-9.
    • (2014) Br J Dermatol , vol.170 , pp. 103-109
    • Gerber, A.L.1    Münst, A.2    Schlapbach, C.3
  • 57
    • 52649169692 scopus 로고    scopus 로고
    • Incidence and prognostic impact of FoxP3+ regulatory T cells in human gliomas
    • Heimberger AB, Abou-Ghazal M, Reina-Ortiz C, et al. Incidence and prognostic impact of FoxP3+ regulatory T cells in human gliomas. Clin Cancer Res 2008;14:5166-72.
    • (2008) Clin Cancer Res , vol.14 , pp. 5166-5172
    • Heimberger, A.B.1    Abou-Ghazal, M.2    Reina-Ortiz, C.3
  • 58
    • 77950468866 scopus 로고    scopus 로고
    • Intratumoral CD8(+) T/FOXP3 (+) cell ratio is a predictive marker for survival in patients with colorectal cancer
    • Suzuki H, Chikazawa N, Tasaka T, et al. Intratumoral CD8(+) T/FOXP3 (+) cell ratio is a predictive marker for survival in patients with colorectal cancer. Cancer Immunol Immunother 2010;59:653-61.
    • (2010) Cancer Immunol Immunother , vol.59 , pp. 653-661
    • Suzuki, H.1    Chikazawa, N.2    Tasaka, T.3
  • 59
    • 29444442811 scopus 로고    scopus 로고
    • Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer
    • Sato E, Olson SH, Ahn J, et al. Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc Natl Acad Sci USA 2005;102:18538-43.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 18538-18543
    • Sato, E.1    Olson, S.H.2    Ahn, J.3
  • 60
    • 34247523605 scopus 로고    scopus 로고
    • Tumor-infiltrating Foxp3-CD4+CD25+ T cells predict poor survival in renal cell carcinoma
    • Siddiqui SA, Frigola X, Bonne-Annee S, et al. Tumor-infiltrating Foxp3-CD4+CD25+ T cells predict poor survival in renal cell carcinoma. Clin Cancer Res 2007;13:2075-81.
    • (2007) Clin Cancer Res , vol.13 , pp. 2075-2081
    • Siddiqui, S.A.1    Frigola, X.2    Bonne-Annee, S.3
  • 61
    • 58249089749 scopus 로고    scopus 로고
    • Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer
    • Salama P, Phillips M, Grieu F, et al. Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer. J Clin Oncol 2009;27:186-92.
    • (2009) J Clin Oncol , vol.27 , pp. 186-192
    • Salama, P.1    Phillips, M.2    Grieu, F.3
  • 62
    • 84896489624 scopus 로고    scopus 로고
    • High FoxP3 expression in tumour cells predicts better survival in gastric cancer and its role in tumour microenvironment
    • Ma GF, Miao Q, Liu YM, et al. High FoxP3 expression in tumour cells predicts better survival in gastric cancer and its role in tumour microenvironment. Br J Cancer 2014;110:1552-60.
    • (2014) Br J Cancer , vol.110 , pp. 1552-1560
    • Ma, G.F.1    Miao, Q.2    Liu, Y.M.3
  • 64
    • 66949171924 scopus 로고    scopus 로고
    • Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor
    • Miyara M, Yoshioka Y, Kitoh A, et al. Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity 2009;30:899-911.
    • (2009) Immunity , vol.30 , pp. 899-911
    • Miyara, M.1    Yoshioka, Y.2    Kitoh, A.3
  • 65
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel TJ, Coukos G, Zou L, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 2004;10:942-9.
    • (2004) Nat Med , vol.10 , pp. 942-949
    • Curiel, T.J.1    Coukos, G.2    Zou, L.3
  • 66
    • 33645286546 scopus 로고    scopus 로고
    • Regulatory T cells, tumour immunity and immunotherapy
    • Zou W. Regulatory T cells, tumour immunity and immunotherapy. Nat Rev Immunol 2006;6:295-307.
    • (2006) Nat Rev Immunol , vol.6 , pp. 295-307
    • Zou, W.1
  • 67
    • 33745261751 scopus 로고    scopus 로고
    • Specific recruitment of CC chemokine receptor 4-positive regulatory T cells in Hodgkin lymphoma fosters immune privilege
    • Ishida T, Ishii T, Inagaki A, et al. Specific recruitment of CC chemokine receptor 4-positive regulatory T cells in Hodgkin lymphoma fosters immune privilege. Cancer Res 2006;66:5716-22.
    • (2006) Cancer Res , vol.66 , pp. 5716-5722
    • Ishida, T.1    Ishii, T.2    Inagaki, A.3
  • 68
    • 84887081136 scopus 로고    scopus 로고
    • Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans
    • Sugiyama D, Nishikawa H,Maeda Y, et al. Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans. Proc Natl Acad Sci USA 2013;110:17945-50.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 17945-17950
    • Sugiyama, D.1    Nishikawa, H.2    Maeda, Y.3
  • 69
    • 77954721060 scopus 로고    scopus 로고
    • Regulatory T cells in tumor immunity
    • Nishikawa H, Sakaguchi S. Regulatory T cells in tumor immunity. Int J Cancer 2010;127:759-67.
    • (2010) Int J Cancer , vol.127 , pp. 759-767
    • Nishikawa, H.1    Sakaguchi, S.2
  • 70
    • 84931291785 scopus 로고    scopus 로고
    • Sialyl Lewis x (CD15s) identifies highly differentiated and most suppressive FOXP3high regulatory T cells in humans
    • Miyara M, Chader D, Sage E, et al. Sialyl Lewis x (CD15s) identifies highly differentiated and most suppressive FOXP3high regulatory T cells in humans. Proc Natl Acad Sci USA 2015;112:7225-30.
    • (2015) Proc Natl Acad Sci USA , vol.112 , pp. 7225-7230
    • Miyara, M.1    Chader, D.2    Sage, E.3
  • 71
    • 84928226005 scopus 로고    scopus 로고
    • The interaction of anticancer therapies with tumor-associated macrophages
    • Mantovani A, Allavena P. The interaction of anticancer therapies with tumor-associated macrophages. J Exp Med 2015;212:435-45.
    • (2015) J Exp Med , vol.212 , pp. 435-445
    • Mantovani, A.1    Allavena, P.2
  • 72
    • 84904406680 scopus 로고    scopus 로고
    • Tumor-associated macrophages: from mechanisms to therapy
    • Noy R, Pollard JW. Tumor-associated macrophages: from mechanisms to therapy. Immunity 2014;41:49-61.
    • (2014) Immunity , vol.41 , pp. 49-61
    • Noy, R.1    Pollard, J.W.2
  • 73
    • 84874499391 scopus 로고    scopus 로고
    • Polarization profiles of human M-CSF-generated macrophages and comparison of M1-markers in classically activated macrophages from GM-CSF and M-CSF origin
    • Jaguin M, Houlbert N, Fardel O, Lecureur V. Polarization profiles of human M-CSF-generated macrophages and comparison of M1-markers in classically activated macrophages from GM-CSF and M-CSF origin. Cell Immunol 2013;281:51-61.
    • (2013) Cell Immunol , vol.281 , pp. 51-61
    • Jaguin, M.1    Houlbert, N.2    Fardel, O.3    Lecureur, V.4
  • 75
    • 0028942668 scopus 로고
    • Mechanisms of immune suppression in patients with head and neck cancer:presence of CD34(+) cells which suppress immune functions within cancers that secrete granulocyte-macrophage colony-stimulating factor
    • Pak AS,Wright MA, Matthews JP, Collins SL, Petruzzelli GJ, Young MR. Mechanisms of immune suppression in patients with head and neck cancer:presence of CD34(+) cells which suppress immune functions within cancers that secrete granulocyte-macrophage colony-stimulating factor. Clin Cancer Res 1995;1:95-103.
    • (1995) Clin Cancer Res , vol.1 , pp. 95-103
    • Pak, A.S.1    Wright, M.A.2    Matthews, J.P.3    Collins, S.L.4    Petruzzelli, G.J.5    Young, M.R.6
  • 76
    • 0035164478 scopus 로고    scopus 로고
    • Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer
    • Almand B, Clark JI, Nikitina E, et al. Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer. J Immunol 2001;166:678-89.
    • (2001) J Immunol , vol.166 , pp. 678-689
    • Almand, B.1    Clark, J.I.2    Nikitina, E.3
  • 77
    • 63549105681 scopus 로고    scopus 로고
    • Sunitinib mediates reversal of myeloidderived suppressor cell accumulation in renal cell carcinoma patients
    • Ko JS, Zea AH, Rini BI, et al. Sunitinib mediates reversal of myeloidderived suppressor cell accumulation in renal cell carcinoma patients. Clin Cancer Res 2009;15:2148-57.
    • (2009) Clin Cancer Res , vol.15 , pp. 2148-2157
    • Ko, J.S.1    Zea, A.H.2    Rini, B.I.3
  • 78
    • 84884556145 scopus 로고    scopus 로고
    • History of myeloid-derived suppressor cells
    • Talmadge JE, Gabrilovich DI. History of myeloid-derived suppressor cells. Nat Rev Cancer 2013;13:739-52.
    • (2013) Nat Rev Cancer , vol.13 , pp. 739-752
    • Talmadge, J.E.1    Gabrilovich, D.I.2
  • 79
    • 78649586268 scopus 로고    scopus 로고
    • The biology of myeloid-derived suppressor cells:the blessing and the curse of morphological and functional heterogeneity
    • Youn JI, Gabrilovich DI. The biology of myeloid-derived suppressor cells:the blessing and the curse of morphological and functional heterogeneity. Eur J Immunol 2010;40:2969-75.
    • (2010) Eur J Immunol , vol.40 , pp. 2969-2975
    • Youn, J.I.1    Gabrilovich, D.I.2
  • 80
    • 77950944395 scopus 로고    scopus 로고
    • Macrophages, innate immunity and cancer: balance, tolerance, and diversity
    • Mantovani A, Sica A. Macrophages, innate immunity and cancer: balance, tolerance, and diversity. Curr Opin Immunol 2010;22:231-7.
    • (2010) Curr Opin Immunol , vol.22 , pp. 231-237
    • Mantovani, A.1    Sica, A.2
  • 81
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patientswithmetastaticmelanoma
    • Hodi FS, O'Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patientswithmetastaticmelanoma.NEngl J Med 2010;363:711-23.
    • (2010) NEngl J Med , vol.363 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 82
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • Robert C, Thomas L, Bondarenko I, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med 2011;364:2517-26.
    • (2011) N Engl J Med , vol.364 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3
  • 83
    • 84928917822 scopus 로고    scopus 로고
    • Pooled analysis of long-term survival data from phase II and phase III trials of ipilimumab in unresectable or metastatic melanoma
    • Schadendorf D, Hodi FS, Robert C, et al. Pooled analysis of long-term survival data from phase II and phase III trials of ipilimumab in unresectable or metastatic melanoma. J Clin Oncol 2015;33:1889-94.
    • (2015) J Clin Oncol , vol.33 , pp. 1889-1894
    • Schadendorf, D.1    Hodi, F.S.2    Robert, C.3
  • 84
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012;366:2443-54.
    • (2012) N Engl J Med , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 85
    • 84879759020 scopus 로고    scopus 로고
    • Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
    • Hamid O, Robert C, Daud A, et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med 2013;369:134-44.
    • (2013) N Engl J Med , vol.369 , pp. 134-144
    • Hamid, O.1    Robert, C.2    Daud, A.3
  • 86
    • 84929361060 scopus 로고    scopus 로고
    • Survival, durable response, and long-term safety in patients with previously treated advanced renal cell carcinoma receiving nivolumab
    • McDermott DF, Drake CG, Sznol M, et al. Survival, durable response, and long-term safety in patients with previously treated advanced renal cell carcinoma receiving nivolumab. J Clin Oncol 2015;33:2013-20.
    • (2015) J Clin Oncol , vol.33 , pp. 2013-2020
    • McDermott, D.F.1    Drake, C.G.2    Sznol, M.3
  • 87
    • 84936749833 scopus 로고    scopus 로고
    • Overall survival and long-term safety of nivolumab (anti-programmed death 1 antibody, BMS-936558, ONO-4538) in patients with previously treated advanced non-small-cell lung cancer
    • Gettinger SN, Horn L, Gandhi L, et al. Overall survival and long-term safety of nivolumab (anti-programmed death 1 antibody, BMS-936558, ONO-4538) in patients with previously treated advanced non-small-cell lung cancer. J Clin Oncol 2015;33:2004-12.
    • (2015) J Clin Oncol , vol.33 , pp. 2004-2012
    • Gettinger, S.N.1    Horn, L.2    Gandhi, L.3
  • 88
    • 84929572937 scopus 로고    scopus 로고
    • Nivolumab for metastatic renal cell carcinoma: results of a randomized phase II trial
    • Motzer RJ, Rini BI, McDermott DF, et al. Nivolumab for metastatic renal cell carcinoma: results of a randomized phase II trial. J Clin Oncol 2015;33:1430-7.
    • (2015) J Clin Oncol , vol.33 , pp. 1430-1437
    • Motzer, R.J.1    Rini, B.I.2    McDermott, D.F.3
  • 89
    • 84898973055 scopus 로고    scopus 로고
    • Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab
    • Topalian SL, Sznol M, McDermott DF, et al. Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab. J Clin Oncol 2014;32:1020-30.
    • (2014) J Clin Oncol , vol.32 , pp. 1020-1030
    • Topalian, S.L.1    Sznol, M.2    McDermott, D.F.3
  • 90
    • 84929481480 scopus 로고    scopus 로고
    • Pembrolizumab for the treatment of non-small-cell lung cancer
    • Garon EB, Rizvi NA, Hui R, et al. Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med 2015;372:2018-28.
    • (2015) N Engl J Med , vol.372 , pp. 2018-2028
    • Garon, E.B.1    Rizvi, N.A.2    Hui, R.3
  • 91
    • 84925222119 scopus 로고    scopus 로고
    • Nivolumab in previously untreated melanoma without BRAF mutation
    • Robert C, Long GV, Brady B, et al. Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med 2015;372:320-30.
    • (2015) N Engl J Med , vol.372 , pp. 320-330
    • Robert, C.1    Long, G.V.2    Brady, B.3
  • 92
    • 84931083080 scopus 로고    scopus 로고
    • Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial
    • Weber JS, D'Angelo SP, Minor D, et al. Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial. Lancet Oncol 2015;16:375-84.
    • (2015) Lancet Oncol , vol.16 , pp. 375-384
    • Weber, J.S.1    D'Angelo, S.P.2    Minor, D.3
  • 93
    • 84936791837 scopus 로고    scopus 로고
    • Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer
    • Brahmer J,Reckamp KL, Baas P, et al. Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N Engl JMed 2015;373:123-35.
    • (2015) N Engl JMed , vol.373 , pp. 123-135
    • Brahmer, J.1    Reckamp, K.L.2    Baas, P.3
  • 94
    • 84936147067 scopus 로고    scopus 로고
    • Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
    • Larkin J, Chiarion-Sileni V,Gonzalez R, et al. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. NEngl J Med 2015;373:23-34.
    • (2015) NEngl J Med , vol.373 , pp. 23-34
    • Larkin, J.1    Chiarion-Sileni, V.2    Gonzalez, R.3
  • 95
    • 84891373595 scopus 로고    scopus 로고
    • Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: a single group, open-label, phase 2 trial
    • Westin JR, Chu F, Zhang M, et al. Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: a single group, open-label, phase 2 trial. Lancet Oncol 2014;15:69-77.
    • (2014) Lancet Oncol , vol.15 , pp. 69-77
    • Westin, J.R.1    Chu, F.2    Zhang, M.3
  • 96
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer JR, Tykodi SS, Chow LQ, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 2012;366:2455-65.
    • (2012) N Engl J Med , vol.366 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3
  • 97
    • 84923078390 scopus 로고    scopus 로고
    • MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer
    • Powles T, Eder JP, Fine GD, et al. MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer. Nature 2014;515:558-62.
    • (2014) Nature , vol.515 , pp. 558-562
    • Powles, T.1    Eder, J.P.2    Fine, G.D.3
  • 98
    • 84920956735 scopus 로고    scopus 로고
    • Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
    • Herbst RS, Soria JC, Kowanetz M, et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature 2014;515:563-7.
    • (2014) Nature , vol.515 , pp. 563-567
    • Herbst, R.S.1    Soria, J.C.2    Kowanetz, M.3
  • 99
    • 84962032966 scopus 로고    scopus 로고
    • Identification and characterization of MEDI4736, an antagonistic anti-PD-L1 monoclonal antibody
    • Stewart R, Morrow M, Hammond SA, et al. Identification and characterization of MEDI4736, an antagonistic anti-PD-L1 monoclonal antibody. Cancer Immunol Res 2015;3:1052-62.
    • (2015) Cancer Immunol Res , vol.3 , pp. 1052-1062
    • Stewart, R.1    Morrow, M.2    Hammond, S.A.3
  • 100
    • 84951279998 scopus 로고    scopus 로고
    • Antibody-dependent cellular cytotoxicity activity of a novel anti-PD-L1 antibody avelumab (MSB0010718C) on human tumor cells
    • Boyerinas B, Jochems C, Fantini M, et al. Antibody-dependent cellular cytotoxicity activity of a novel anti-PD-L1 antibody avelumab (MSB0010718C) on human tumor cells. Cancer Immunol Res 2015;3:1148-57.
    • (2015) Cancer Immunol Res , vol.3 , pp. 1148-1157
    • Boyerinas, B.1    Jochems, C.2    Fantini, M.3
  • 101
    • 84929481482 scopus 로고    scopus 로고
    • Nivolumab and ipilimumab versus ipilimumab in untreated melanoma
    • Postow MA, Chesney J, Pavlick AC, et al. Nivolumab and ipilimumab versus ipilimumab in untreated melanoma. N Engl J Med 2015;372:2006-17.
    • (2015) N Engl J Med , vol.372 , pp. 2006-2017
    • Postow, M.A.1    Chesney, J.2    Pavlick, A.C.3
  • 102
    • 84929481481 scopus 로고    scopus 로고
    • Pembrolizumab versus Ipilimumab in Advanced Melanoma
    • Robert C, Schachter J, Long GV, et al. Pembrolizumab versus Ipilimumab in Advanced Melanoma. N Engl J Med 2015;372:2521-32.
    • (2015) N Engl J Med , vol.372 , pp. 2521-2532
    • Robert, C.1    Schachter, J.2    Long, G.V.3
  • 103
    • 0033168037 scopus 로고    scopus 로고
    • Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody
    • Onizuka S, Tawara I, Shimizu J, Sakaguchi S, Fujita T, Nakayama E. Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody. Cancer Res 1999;59:3128-33.
    • (1999) Cancer Res , vol.59 , pp. 3128-3133
    • Onizuka, S.1    Tawara, I.2    Shimizu, J.3    Sakaguchi, S.4    Fujita, T.5    Nakayama, E.6
  • 104
    • 47549114487 scopus 로고    scopus 로고
    • Combinations of tumor-specific CD8+ CTLs and anti-CD25 mAb provide improved immunotherapy
    • Ohmura Y, Yoshikawa K, Saga S, Ueda R, Kazaoka Y, Yamada S. Combinations of tumor-specific CD8+ CTLs and anti-CD25 mAb provide improved immunotherapy. Oncol Rep 2008;19:1265-70.
    • (2008) Oncol Rep , vol.19 , pp. 1265-1270
    • Ohmura, Y.1    Yoshikawa, K.2    Saga, S.3    Ueda, R.4    Kazaoka, Y.5    Yamada, S.6
  • 105
    • 77958056009 scopus 로고    scopus 로고
    • Dendritic cell vaccination in combination with anti-CD25 monoclonal antibody treatment: a phase I/II study in metastatic melanoma patients
    • Jacobs JF, Punt CJ, Lesterhuis WJ, et al. Dendritic cell vaccination in combination with anti-CD25 monoclonal antibody treatment: a phase I/II study in metastatic melanoma patients. Clin Cancer Res 2010;16:5067-78.
    • (2010) Clin Cancer Res , vol.16 , pp. 5067-5078
    • Jacobs, J.F.1    Punt, C.J.2    Lesterhuis, W.J.3
  • 106
    • 84855338629 scopus 로고    scopus 로고
    • Regulatory T cells in melanoma: the final hurdle towards effective immunotherapy?
    • Jacobs JF, Nierkens S, Figdor CG, de Vries IJ, Adema GJ. Regulatory T cells in melanoma: the final hurdle towards effective immunotherapy? Lancet Oncol 2012;13:e32-42.
    • (2012) Lancet Oncol , vol.13 , pp. e32-42
    • Jacobs, J.F.1    Nierkens, S.2    Figdor, C.G.3    de Vries, I.J.4    Adema, G.J.5
  • 107
    • 84863393084 scopus 로고    scopus 로고
    • Defucosylated anti-CCR4 monoclonal antibody (KW-0761) for relapsed adult T-cell leukemia-lymphoma: a multicenter phase II study
    • Ishida T, Joh T, Uike N, et al. Defucosylated anti-CCR4 monoclonal antibody (KW-0761) for relapsed adult T-cell leukemia-lymphoma: a multicenter phase II study. J Clin Oncol 2012;30:837-42.
    • (2012) J Clin Oncol , vol.30 , pp. 837-842
    • Ishida, T.1    Joh, T.2    Uike, N.3
  • 108
    • 84876414545 scopus 로고    scopus 로고
    • Stevens-Johnson Syndrome associated with mogamulizumab treatment of adult T-cell leukemia/lymphoma
    • Ishida T, Ito A, Sato F, et al. Stevens-Johnson Syndrome associated with mogamulizumab treatment of adult T-cell leukemia/lymphoma. Cancer Sci 2013;104:647-50.
    • (2013) Cancer Sci , vol.104 , pp. 647-650
    • Ishida, T.1    Ito, A.2    Sato, F.3
  • 109
    • 84867232118 scopus 로고    scopus 로고
    • Tax is a potential molecular target for immunotherapy of adult T-cell leukemia/lymphoma
    • Suzuki S, Masaki A, Ishida T, et al. Tax is a potential molecular target for immunotherapy of adult T-cell leukemia/lymphoma. Cancer Sci 2012;103:1764-73.
    • (2012) Cancer Sci , vol.103 , pp. 1764-1773
    • Suzuki, S.1    Masaki, A.2    Ishida, T.3
  • 110
    • 84945978548 scopus 로고    scopus 로고
    • Phase Ia Study of FoxP3+ CD4 Treg depletion by infusion of a humanized anti-CCR4 antibody, KW-0761, in cancer patients
    • Kurose K, Ohue Y, Wada H, et al. Phase Ia Study of FoxP3+ CD4 Treg depletion by infusion of a humanized anti-CCR4 antibody, KW-0761, in cancer patients. Clin Cancer Res 2015;21:4327-36.
    • (2015) Clin Cancer Res , vol.21 , pp. 4327-4336
    • Kurose, K.1    Ohue, Y.2    Wada, H.3
  • 111
    • 84884271914 scopus 로고    scopus 로고
    • Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma
    • Simpson TR, Li F, Montalvo-Ortiz W, et al. Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma. J Exp Med 2013;210:1695-710.
    • (2013) J Exp Med , vol.210 , pp. 1695-1710
    • Simpson, T.R.1    Li, F.2    Montalvo-Ortiz, W.3
  • 112
    • 84929192743 scopus 로고    scopus 로고
    • Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients
    • Romano E, Kusio-Kobialka M, Foukas PG, et al. Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients. Proc Natl Acad Sci USA 2015;112:6140-5.
    • (2015) Proc Natl Acad Sci USA , vol.112 , pp. 6140-6145
    • Romano, E.1    Kusio-Kobialka, M.2    Foukas, P.G.3
  • 113
    • 84901281224 scopus 로고    scopus 로고
    • Chemotherapeutic targeting of cancer-induced immunosuppressive cells
    • Alizadeh D, Larmonier N. Chemotherapeutic targeting of cancer-induced immunosuppressive cells. Cancer Res 2014;74:2663-8.
    • (2014) Cancer Res , vol.74 , pp. 2663-2668
    • Alizadeh, D.1    Larmonier, N.2
  • 114
    • 84863924314 scopus 로고    scopus 로고
    • Regulatory T-cell modulation using cyclophosphamide in vaccine approaches: a current perspective
    • Le DT, Jaffee EM. Regulatory T-cell modulation using cyclophosphamide in vaccine approaches: a current perspective. Cancer Res 2012;72:3439-44.
    • (2012) Cancer Res , vol.72 , pp. 3439-3444
    • Le, D.T.1    Jaffee, E.M.2
  • 115
    • 54049093133 scopus 로고    scopus 로고
    • Differential impairment of regulatory T cells rather than effector T cells by paclitaxel-based chemotherapy
    • Zhang L, Dermawan K, Jin M, et al. Differential impairment of regulatory T cells rather than effector T cells by paclitaxel-based chemotherapy. Clin Immunol 2008;129:219-29.
    • (2008) Clin Immunol , vol.129 , pp. 219-229
    • Zhang, L.1    Dermawan, K.2    Jin, M.3
  • 116
    • 84876678701 scopus 로고    scopus 로고
    • Low-dose gemcitabine depletes regulatory T cells and improves survival in the orthotopic Panc02 model of pancreatic cancer
    • Shevchenko I, Karakhanova S, Soltek S, et al. Low-dose gemcitabine depletes regulatory T cells and improves survival in the orthotopic Panc02 model of pancreatic cancer. Int J Cancer 2013;133:98-107.
    • (2013) Int J Cancer , vol.133 , pp. 98-107
    • Shevchenko, I.1    Karakhanova, S.2    Soltek, S.3
  • 117
    • 33747888406 scopus 로고    scopus 로고
    • Efficacy of GM-CSF-producing tumor vaccine after docetaxel chemotherapy in mice bearing established Lewis lung carcinoma
    • Chu Y, Wang LX, Yang G, et al. Efficacy of GM-CSF-producing tumor vaccine after docetaxel chemotherapy in mice bearing established Lewis lung carcinoma. J Immunother 2006;29:367-80.
    • (2006) J Immunother , vol.29 , pp. 367-380
    • Chu, Y.1    Wang, L.X.2    Yang, G.3
  • 118
    • 15944410592 scopus 로고    scopus 로고
    • Inhibition of CD4(+)25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide
    • Lutsiak ME, Semnani RT, De Pascalis R, Kashmiri SV, Schlom J, Sabzevari H. Inhibition of CD4(+)25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide. Blood 2005;105:2862-8.
    • (2005) Blood , vol.105 , pp. 2862-2868
    • Lutsiak, M.E.1    Semnani, R.T.2    De Pascalis, R.3    Kashmiri, S.V.4    Schlom, J.5    Sabzevari, H.6
  • 119
    • 79151475547 scopus 로고    scopus 로고
    • Selective impairment of CD4 +CD25+Foxp3+ regulatory T cells by paclitaxel is explained by Bcl-2/ Bax mediated apoptosis
    • Liu N, Zheng Y, Zhu Y, Xiong S, Chu Y. Selective impairment of CD4 +CD25+Foxp3+ regulatory T cells by paclitaxel is explained by Bcl-2/ Bax mediated apoptosis. Int Immunopharmacol 2011;11:212-9.
    • (2011) Int Immunopharmacol , vol.11 , pp. 212-219
    • Liu, N.1    Zheng, Y.2    Zhu, Y.3    Xiong, S.4    Chu, Y.5
  • 120
    • 67349107194 scopus 로고    scopus 로고
    • The anti-cancer agents lenalidomide and pomalidomide inhibit the proliferation and function of T regulatory cells
    • Galustian C, Meyer B, Labarthe MC, et al. The anti-cancer agents lenalidomide and pomalidomide inhibit the proliferation and function of T regulatory cells. Cancer Immunol Immunother 2009;58:1033-45.
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 1033-1045
    • Galustian, C.1    Meyer, B.2    Labarthe, M.C.3
  • 121
    • 78149281950 scopus 로고    scopus 로고
    • A decrease of regulatory T cells correlates with overall survival after sunitinib-based antiangiogenic therapy in metastatic renal cancer patients
    • Adotevi O, Pere H, Ravel P, et al. A decrease of regulatory T cells correlates with overall survival after sunitinib-based antiangiogenic therapy in metastatic renal cancer patients. J Immunother 2010;33:991-8.
    • (2010) J Immunother , vol.33 , pp. 991-998
    • Adotevi, O.1    Pere, H.2    Ravel, P.3
  • 122
    • 84872593848 scopus 로고    scopus 로고
    • VEGFA-VEGFR pathway blockade inhibits tumor induced regulatory T-cell proliferation in colorectal cancer
    • Terme M, Pernot S, Marcheteau E, et al. VEGFA-VEGFR pathway blockade inhibits tumor induced regulatory T-cell proliferation in colorectal cancer. Cancer Res 2013;73:539-49.
    • (2013) Cancer Res , vol.73 , pp. 539-549
    • Terme, M.1    Pernot, S.2    Marcheteau, E.3
  • 123
    • 79961125367 scopus 로고    scopus 로고
    • Sorafenib reduces the percentage of tumour infiltrating regulatory T cells in renal cell carcinoma patients
    • Desar IM, Jacobs JH, Hulsbergen-vandeKaa CA, et al. Sorafenib reduces the percentage of tumour infiltrating regulatory T cells in renal cell carcinoma patients. Int J Cancer 2011;129:507-12.
    • (2011) Int J Cancer , vol.129 , pp. 507-512
    • Desar, I.M.1    Jacobs, J.H.2    Hulsbergen-VandeKaa, C.A.3
  • 124
    • 58149187113 scopus 로고    scopus 로고
    • Imatinib mesylate inhibits CD4 CD25 regulatory T cell activity and enhances active immunotherapy against BCR-ABLtumors
    • Larmonier N, Janikashvili N, LaCasse CJ, et al. Imatinib mesylate inhibits CD4 CD25 regulatory T cell activity and enhances active immunotherapy against BCR-ABLtumors. J Immunol 2008;181:6955-63.
    • (2008) J Immunol , vol.181 , pp. 6955-6963
    • Larmonier, N.1    Janikashvili, N.2    LaCasse, C.J.3
  • 125
    • 84870533238 scopus 로고    scopus 로고
    • Antitumor T cell responses contribute to the effects of dasatinib on c-KIT mutant murine mastocytoma and are potentiated by anti-OX40
    • Yang Y, Liu C, Peng W, et al. Antitumor T cell responses contribute to the effects of dasatinib on c-KIT mutant murine mastocytoma and are potentiated by anti-OX40. Blood 2012;120:4533-43.
    • (2012) Blood , vol.120 , pp. 4533-4543
    • Yang, Y.1    Liu, C.2    Peng, W.3
  • 126
    • 84862120892 scopus 로고    scopus 로고
    • Paclitaxel promotes differentiation of myeloid-derived suppressor cells into dendritic cells in vitro in a TLR4-independent manner
    • Michels T, Shurin GV, Naiditch H, Sevko A, Umansky V, Shurin MR. Paclitaxel promotes differentiation of myeloid-derived suppressor cells into dendritic cells in vitro in a TLR4-independent manner. J Immunotoxicol 2012;9:292-300.
    • (2012) J Immunotoxicol , vol.9 , pp. 292-300
    • Michels, T.1    Shurin, G.V.2    Naiditch, H.3    Sevko, A.4    Umansky, V.5    Shurin, M.R.6
  • 127
    • 84892686102 scopus 로고    scopus 로고
    • Doxorubicin eliminates myeloidderived suppressor cells and enhances the efficacy of adoptive T-cell transfer in breast cancer
    • Alizadeh D, Trad M, Hanke NT, et al. Doxorubicin eliminates myeloidderived suppressor cells and enhances the efficacy of adoptive T-cell transfer in breast cancer. Cancer Res 2014;74:104-18.
    • (2014) Cancer Res , vol.74 , pp. 104-118
    • Alizadeh, D.1    Trad, M.2    Hanke, N.T.3
  • 128
    • 77956680680 scopus 로고    scopus 로고
    • A novel chemoimmunomodulating property of docetaxel: suppression of myeloidderived suppressor cells in tumor bearers
    • Kodumudi KN,Woan K, Gilvary DL, Sahakian E,Wei S, Djeu JY. A novel chemoimmunomodulating property of docetaxel: suppression of myeloidderived suppressor cells in tumor bearers. Clin Cancer Res 2010;16:4583-94.
    • (2010) Clin Cancer Res , vol.16 , pp. 4583-4594
    • Kodumudi, K.N.1    Woan, K.2    Gilvary, D.L.3    Sahakian, E.4    Wei, S.5    Djeu, J.Y.6
  • 129
    • 65549129226 scopus 로고    scopus 로고
    • Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells
    • Xin H, Zhang C, Herrmann A, Du Y, Figlin R, Yu H. Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells. Cancer Res 2009;69:2506-13.
    • (2009) Cancer Res , vol.69 , pp. 2506-2513
    • Xin, H.1    Zhang, C.2    Herrmann, A.3    Du, Y.4    Figlin, R.5    Yu, H.6
  • 131
    • 84938350452 scopus 로고    scopus 로고
    • Combination cancer immunotherapy and new immunomodulatory targets
    • Mahoney KM, Rennert PD, Freeman GJ. Combination cancer immunotherapy and new immunomodulatory targets. Nat Rev Drug Discov 2015;14:561-84.
    • (2015) Nat Rev Drug Discov , vol.14 , pp. 561-584
    • Mahoney, K.M.1    Rennert, P.D.2    Freeman, G.J.3
  • 132
    • 84880706152 scopus 로고    scopus 로고
    • Oncology meets immunology: the cancer-immunity cycle
    • Chen DS, Mellman I. Oncology meets immunology: the cancer-immunity cycle. Immunity 2013;391:1-10.
    • (2013) Immunity , vol.391 , pp. 1-10
    • Chen, D.S.1    Mellman, I.2
  • 133
    • 84890814629 scopus 로고    scopus 로고
    • Breakthrough of the year 2013. Cancer immunotherapy
    • Couzin-Frankel J. Breakthrough of the year 2013. Cancer immunotherapy. Science 2013;342:1432-3.
    • (2013) Science , vol.342 , pp. 1432-1433
    • Couzin-Frankel, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.