메뉴 건너뛰기




Volumn 19, Issue 18, 2013, Pages 4917-4924

Molecular pathways: Coexpression of immune checkpoint molecules: Signaling pathways and implications for cancer immunotherapy

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INTERLEUKIN 2; IPILIMUMAB; LAMBROLIZUMAB; MK 3475; NIVOLUMAB; PIDILIZUMAB; PROGRAMMED DEATH 1 RECEPTOR; TICILIMUMAB; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84884561907     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-12-1972     Document Type: Article
Times cited : (232)

References (53)
  • 1
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012;12:252-64.
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 2
    • 34247884612 scopus 로고    scopus 로고
    • The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection
    • Sharpe AH, Wherry EJ, Ahmed R, Freeman GJ. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nat Immunol 2007;8:239-45.
    • (2007) Nat Immunol , vol.8 , pp. 239-245
    • Sharpe, A.H.1    Wherry, E.J.2    Ahmed, R.3    Freeman, G.J.4
  • 5
    • 84879759020 scopus 로고    scopus 로고
    • Safety and tumor responses with lambrolizumab (Anti-PD-1) in melanoma
    • Hamid O, Robert C, Daud A, Hodi FS, Hwu W-J, Kefford R, et al. Safety and tumor responses with lambrolizumab (Anti-PD-1) in melanoma. N Engl J Med 2013;369:134-44.
    • (2013) N Engl J Med , vol.369 , pp. 134-144
    • Hamid, O.1    Robert, C.2    Daud, A.3    Hodi, F.S.4    Hwu, W.-J.5    Kefford, R.6
  • 7
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA-4 blockade
    • Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science 1996;271:1734-6.
    • (1996) Science , vol.271 , pp. 1734-1736
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 8
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    • Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 1995;3:541-7.
    • (1995) Immunity , vol.3 , pp. 541-547
    • Tivol, E.A.1    Borriello, F.2    Schweitzer, A.N.3    Lynch, W.P.4    Bluestone, J.A.5    Sharpe, A.H.6
  • 10
  • 13
    • 2442585121 scopus 로고    scopus 로고
    • Coinhibitory molecules of the B7-CD28 family in the control of T-cell immunity
    • Chen L. Coinhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nat Rev Immunol 2004;4:336-47.
    • (2004) Nat Rev Immunol , vol.4 , pp. 336-347
    • Chen, L.1
  • 15
    • 0031685190 scopus 로고    scopus 로고
    • Immunological studies on PD-1 deficient mice: Implication of PD-1 as a negative regulator for B cell responses
    • Nishimura H, Minato N, Nakano T, Honjo T. Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses. Int Immunol 1998;10:1563-72.
    • (1998) Int Immunol , vol.10 , pp. 1563-1572
    • Nishimura, H.1    Minato, N.2    Nakano, T.3    Honjo, T.4
  • 17
    • 34447646310 scopus 로고    scopus 로고
    • Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses
    • Butte MJ, Keir ME, Phamduy TB, Sharpe AH, Freeman GJ. Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity 2007;27:111-22.
    • (2007) Immunity , vol.27 , pp. 111-122
    • Butte, M.J.1    Keir, M.E.2    Phamduy, T.B.3    Sharpe, A.H.4    Freeman, G.J.5
  • 18
    • 3142688997 scopus 로고    scopus 로고
    • SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation
    • Chemnitz JM, Parry RV, Nichols KE, June CH, Riley JL. SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation. J Immunol 2004;173:945-54.
    • (2004) J Immunol , vol.173 , pp. 945-954
    • Chemnitz, J.M.1    Parry, R.V.2    Nichols, K.E.3    June, C.H.4    Riley, J.L.5
  • 19
    • 4444317516 scopus 로고    scopus 로고
    • PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta
    • Sheppard KA, Fitz LJ, Lee JM, Benander C, George JA, Wooters J, et al. PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta. FEBS Lett 2004;574:37-41.
    • (2004) FEBS Lett , vol.574 , pp. 37-41
    • Sheppard, K.A.1    Fitz, L.J.2    Lee, J.M.3    Benander, C.4    George, J.A.5    Wooters, J.6
  • 20
    • 65349118810 scopus 로고    scopus 로고
    • PD-1 signaling in primary T cells
    • Riley JL. PD-1 signaling in primary T cells. Immunol Rev 2009;229:114-25.
    • (2009) Immunol Rev , vol.229 , pp. 114-125
    • Riley, J.L.1
  • 21
    • 0041845131 scopus 로고    scopus 로고
    • Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism
    • Blazar BR, Carreno BM, Panoskaltsis-Mortari A, Carter L, Iwai Y, Yagita H, et al. Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism. J Immunol 171:1272-7.
    • J Immunol , vol.171 , pp. 1272-1277
    • Blazar, B.R.1    Carreno, B.M.2    Panoskaltsis-Mortari, A.3    Carter, L.4    Iwai, Y.5    Yagita, H.6
  • 24
    • 0026681864 scopus 로고
    • Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens
    • Baixeras E, Huard B, Miossec C, Jitsukawa S, Martin M, Hercend T, et al. Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens. J Exp Med 1992;176:327-37.
    • (1992) J Exp Med , vol.176 , pp. 327-337
    • Baixeras, E.1    Huard, B.2    Miossec, C.3    Jitsukawa, S.4    Martin, M.5    Hercend, T.6
  • 25
    • 0029873311 scopus 로고    scopus 로고
    • LAG-3 is not responsible for selecting T helper cells in CD4-deficient mice
    • Miyazaki T, Dierich A, Benoist C, Mathis D. LAG-3 is not responsible for selecting T helper cells in CD4-deficient mice. Int Immunol 1996;8:725-9.
    • (1996) Int Immunol , vol.8 , pp. 725-729
    • Miyazaki, T.1    Dierich, A.2    Benoist, C.3    Mathis, D.4
  • 26
    • 36048963838 scopus 로고    scopus 로고
    • LAG-3 regulates CD8+ T cell accumulation and effector function in murine self-and tumor-tolerance systems
    • Grosso JF, Kelleher CC, Harris TJ, Maris CH, Hipkiss EL, De Marzo A, et al. LAG-3 regulates CD8+ T cell accumulation and effector function in murine self-and tumor-tolerance systems. J Clin Invest 2007;117:3383-92.
    • (2007) J Clin Invest , vol.117 , pp. 3383-3392
    • Grosso, J.F.1    Kelleher, C.C.2    Harris, T.J.3    Maris, C.H.4    Hipkiss, E.L.5    De Marzo, A.6
  • 28
    • 0038068048 scopus 로고    scopus 로고
    • The CD4-related molecule, LAG-3(CD223), regulates the expansion of activated T cells
    • Workman CJ, Vignali DA. The CD4-related molecule, LAG-3(CD223), regulates the expansion of activated T cells. Eur J Immunol 2003;33:970-9.
    • (2003) Eur J Immunol , vol.33 , pp. 970-979
    • Workman, C.J.1    Vignali, D.A.2
  • 30
    • 0242708767 scopus 로고    scopus 로고
    • Tim-3 inhibits T helper type 1-mediated auto-and alloimmune responses and promotes immunological tolerance
    • Sanchez-Fueyo A, Tian J, Picarella D, Domenig C, Zheng XX, Sabatos CA, et al. Tim-3 inhibits T helper type 1-mediated auto-and alloimmune responses and promotes immunological tolerance. Nat Immunol 2003;4:1093-101.
    • (2003) Nat Immunol , vol.4 , pp. 1093-1101
    • Sanchez-Fueyo, A.1    Tian, J.2    Picarella, D.3    Domenig, C.4    Zheng, X.X.5    Sabatos, C.A.6
  • 31
    • 0037203867 scopus 로고    scopus 로고
    • Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease
    • Monney L, Sabatos CA, Gaglia JL, Ryu A, Waldner H, Chernova T, et al. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 2002;415:536-41.
    • (2002) Nature , vol.415 , pp. 536-541
    • Monney, L.1    Sabatos, C.A.2    Gaglia, J.L.3    Ryu, A.4    Waldner, H.5    Chernova, T.6
  • 34
    • 84868669212 scopus 로고    scopus 로고
    • Bat3 promotes T cell responses and autoimmunity by repressing Tim-3-mediated cell death and exhaustion
    • Rangachari M, Zhu C, Sakuishi K, Xiao S, Karman J, Chen A, et al. Bat3 promotes T cell responses and autoimmunity by repressing Tim-3-mediated cell death and exhaustion. Nat Med 2012;18:1394-400.
    • (2012) Nat Med , vol.18 , pp. 1394-1400
    • Rangachari, M.1    Zhu, C.2    Sakuishi, K.3    Xiao, S.4    Karman, J.5    Chen, A.6
  • 36
    • 57849168934 scopus 로고    scopus 로고
    • Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
    • Blackburn SD, Shin H, Haining WN, Zou T, Workman CJ, Polley A, et al. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol 2009;10:29-37.
    • (2009) Nat Immunol , vol.10 , pp. 29-37
    • Blackburn, S.D.1    Shin, H.2    Haining, W.N.3    Zou, T.4    Workman, C.J.5    Polley, A.6
  • 38
    • 67449155868 scopus 로고    scopus 로고
    • Functionally distinct LAG-3 and PD-1 subsets on activated and chronically stimulated CD8 T cells
    • Grosso JF, Goldberg MV, Getnet D, Bruno TC, Yen HR, Pyle KJ, et al. Functionally distinct LAG-3 and PD-1 subsets on activated and chronically stimulated CD8 T cells. J Immunol 2009;182:6659-69.
    • (2009) J Immunol , vol.182 , pp. 6659-6669
    • Grosso, J.F.1    Goldberg, M.V.2    Getnet, D.3    Bruno, T.C.4    Yen, H.R.5    Pyle, K.J.6
  • 39
    • 84855911057 scopus 로고    scopus 로고
    • Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage plasmodium infection
    • Butler NS, Moebius J, Pewe LL, Traore B, Doumbo OK, Tygrett LT, et al. Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage plasmodium infection. Nat Immunol 2012;13:188-95.
    • (2012) Nat Immunol , vol.13 , pp. 188-195
    • Butler, N.S.1    Moebius, J.2    Pewe, L.L.3    Traore, B.4    Doumbo, O.K.5    Tygrett, L.T.6
  • 40
    • 84886583217 scopus 로고    scopus 로고
    • Activity of anti-PD-1 in murine tumor models: Role of "host" PD-L1 and synergistic effect of anti-PD-1 and anti-CTLA-4
    • Korman A, Chen B, Wang C, Wu L, Cardarelli P, Selby M. Activity of anti-PD-1 in murine tumor models: role of "host" PD-L1 and synergistic effect of anti-PD-1 and anti-CTLA-4. J Immunol 2007;178:48.37.
    • (2007) J Immunol , vol.178 , pp. 4837
    • Korman, A.1    Chen, B.2    Wang, C.3    Wu, L.4    Cardarelli, P.5    Selby, M.6
  • 41
    • 77749279776 scopus 로고    scopus 로고
    • PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
    • Curran MA, Montalvo W, Yagita H, Allison JP. PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors. Proc Natl Acad Sci U S A 2010;107:4275-80.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 4275-4280
    • Curran, M.A.1    Montalvo, W.2    Yagita, H.3    Allison, J.P.4
  • 43
    • 84879104519 scopus 로고    scopus 로고
    • Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T cell rejection function in tumors
    • Duraiswamy J, Kaluza KM, Freeman GJ, Coukos G. Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T cell rejection function in tumors. Cancer Res 2013;73:3591-603.
    • (2013) Cancer Res , vol.73 , pp. 3591-3603
    • Duraiswamy, J.1    Kaluza, K.M.2    Freeman, G.J.3    Coukos, G.4
  • 44
    • 77957744369 scopus 로고    scopus 로고
    • Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
    • Sakuishi K, Apetoh L, Sullivan JM, Blazar BR, Kuchroo VK, Anderson AC. Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity. J Exp Med 2010;207:2187-94.
    • (2010) J Exp Med , vol.207 , pp. 2187-2194
    • Sakuishi, K.1    Apetoh, L.2    Sullivan, J.M.3    Blazar, B.R.4    Kuchroo, V.K.5    Anderson, A.C.6
  • 45
    • 84863115998 scopus 로고    scopus 로고
    • Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape
    • Woo SR, Turnis ME, Goldberg MV, Bankoti J, Selby M, Nirschl CJ, et al. Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape. Cancer Res 2012;72:917-27.
    • (2012) Cancer Res , vol.72 , pp. 917-927
    • Woo, S.R.1    Turnis, M.E.2    Goldberg, M.V.3    Bankoti, J.4    Selby, M.5    Nirschl, C.J.6
  • 46
    • 79951684125 scopus 로고    scopus 로고
    • PD-1 and LAG-3 inhibitory coreceptors act synergistically to prevent autoimmunity in mice
    • Okazaki T, Okazaki IM, Wang J, Sugiura D, Nakaki F, Yoshida T, et al. PD-1 and LAG-3 inhibitory coreceptors act synergistically to prevent autoimmunity in mice. J Exp Med 2011;208:395-407.
    • (2011) J Exp Med , vol.208 , pp. 395-407
    • Okazaki, T.1    Okazaki, I.M.2    Wang, J.3    Sugiura, D.4    Nakaki, F.5    Yoshida, T.6
  • 47
    • 77954674575 scopus 로고    scopus 로고
    • Coexpression of PD-1, 2B4, CD160, and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation
    • Bengsch B, Seigel B, Ruhl M, Timm J, Kuntz M, Blum HE, et al. Coexpression of PD-1, 2B4, CD160, and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation. PLoS Pathog 2010;6:e1000947.
    • (2010) PLoS Pathog , vol.6
    • Bengsch, B.1    Seigel, B.2    Ruhl, M.3    Timm, J.4    Kuntz, M.5    Blum, H.E.6
  • 48
    • 78649903057 scopus 로고    scopus 로고
    • Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence and its blockade restores hepatocyte-directed in vitro cytotoxicity
    • McMahan RH, Golden-Mason L, Nishimura MI, McMahon BJ, Kemper M, Allen TM, et al. Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence and its blockade restores hepatocyte-directed in vitro cytotoxicity. J Clin Invest 2010;120:4546-57.
    • (2010) J Clin Invest , vol.120 , pp. 4546-4557
    • McMahan, R.H.1    Golden-Mason, L.2    Nishimura, M.I.3    McMahon, B.J.4    Kemper, M.5    Allen, T.M.6
  • 49
    • 79955955402 scopus 로고    scopus 로고
    • Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+T-cell exhaustion in HIV infection
    • Yamamoto T, Price DA, Casazza JP, Ferrari G, Chattopadhyay PK, Roederer M, et al. Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+T-cell exhaustion in HIV infection. Blood 2011;117:4805-15.
    • (2011) Blood , vol.117 , pp. 4805-4815
    • Yamamoto, T.1    Price, D.A.2    Casazza, J.P.3    Ferrari, G.4    Chattopadhyay, P.K.5    Roederer, M.6
  • 50
    • 77952343328 scopus 로고    scopus 로고
    • Tumor-infiltrating NY-ESO-1-specificCD8+T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer
    • Matsuzaki J, Gnjatic S, Mhawech-Fauceglia P, Beck A, Miller A, Tsuji T, et al. Tumor-infiltrating NY-ESO-1-specificCD8+T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer. Proc Natl Acad Sci U S A 2010;107:7875-80.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 7875-7880
    • Matsuzaki, J.1    Gnjatic, S.2    Mhawech-Fauceglia, P.3    Beck, A.4    Miller, A.5    Tsuji, T.6
  • 51
    • 77957723967 scopus 로고    scopus 로고
    • Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+T cell dysfunction in melanoma patients
    • Fourcade J, Sun Z, Benallaoua M, Guillaume P, Luescher IF, Sander C, et al. Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+T cell dysfunction in melanoma patients. J Exp Med 2010;207:2175-86.
    • (2010) J Exp Med , vol.207 , pp. 2175-2186
    • Fourcade, J.1    Sun, Z.2    Benallaoua, M.3    Guillaume, P.4    Luescher, I.F.5    Sander, C.6
  • 52
    • 84856733781 scopus 로고    scopus 로고
    • Extended coexpression of inhibitory receptors by human CD8 T-cells depending on differentiation, antigen-specificity and anatomical localization
    • Baitsch L, Legat A, Barba L, Fuertes Marraco SA, Rivals JP, Baumgaertner P, et al. Extended coexpression of inhibitory receptors by human CD8 T-cells depending on differentiation, antigen-specificity and anatomical localization. PLoS ONE 2012;7:e30852.
    • (2012) PLoS ONE , vol.7
    • Baitsch, L.1    Legat, A.2    Barba, L.3    Fuertes Marraco, S.A.4    Rivals, J.P.5    Baumgaertner, P.6
  • 53
    • 34347389213 scopus 로고    scopus 로고
    • Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells
    • Goldberg MV, Maris CH, Hipkiss EL, Flies AS, Zhen L, Tuder RM, et al. Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells. Blood 2007;110:186-92.
    • (2007) Blood , vol.110 , pp. 186-192
    • Goldberg, M.V.1    Maris, C.H.2    Hipkiss, E.L.3    Flies, A.S.4    Zhen, L.5    Tuder, R.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.