Polarization profiles of human M-CSF-generated macrophages and comparison of M1-markers in classically activated macrophages from GM-CSF and M-CSF origin

Cellular Immunology

Volumn 281, Issue 1, 2013, Pages 51-61

  Jaguin, Marie ^a   Houlbert, Noémie ^a   Fardel, Olivier ^a,b   Lecureur, Valérie ^a  

^a UNIVERSITÉ DE RENNES 1   (France)

^b RENNES UNIVERSITY HOSPITAL   (France)

Author keywords

Cytokine chemokine; M CSF; Macrophage; Markers; Polarization; Transcription factors

Indexed keywords

B7 ANTIGEN; CD200 RECEPTOR; CHEMOKINE RECEPTOR CCR7; COLONY STIMULATING FACTOR 1; CXCL11 CHEMOKINE; EARLY GROWTH RESPONSE FACTOR 1; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 1; INTERFERON REGULATORY FACTOR 3; INTERFERON REGULATORY FACTOR 4; INTERFERON REGULATORY FACTOR 5; INTERFERON REGULATORY FACTOR 7; INTERLEUKIN 10; INTERLEUKIN 12P35; INTERLEUKIN 12P40; INTERLEUKIN 1BETA; INTERLEUKIN 4; KRUPPEL LIKE FACTOR 4; MACROPHAGE DERIVED CHEMOKINE; MANNOSE RECEPTOR; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RANTES; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL DIFFERENTIATION; CYTOKINE RELEASE; FLOW CYTOMETRY; GENOMICS; HUMAN; HUMAN CELL; MACROPHAGE; NONHUMAN; PHENOTYPE; POLARIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTIGENS, CD80; ANTIGENS, SURFACE; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELLS, CULTURED; CHEMOKINES; CYTOKINES; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-4; LECTINS, C-TYPE; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; MACROPHAGE COLONY-STIMULATING FACTOR; MACROPHAGES; MANNOSE-BINDING LECTINS; RECEPTORS, CELL SURFACE; RNA, MESSENGER;

EID: 84874499391     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2013.01.010     Document Type: Article

References (40)

1. Akagawa K.S. Functional heterogeneity of colony-stimulating factor-induced human monocyte-derived macrophages. Int. J. Hematol. 2002, 76:27-34.
2. Akagawa K.S., Komuro I., Kanazawa H., Yamazaki T., Mochida K., Kishi F. Functional heterogeneity of colony-stimulating factor-induced human monocyte-derived macrophages. Respirology 2006, (Suppl. 11):6-32.
3. Biswas S.K., Mantovani A. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat. Immunol. 2010, 11:889-896.
4. Gordon S. Alternative activation of macrophages. Nat. Rev. Immunol. 2003, 3:23-35.
5. Raes G., Van den Bergh R., De Baetselier P., Ghassabeh G.H., Scotton C., Locati M., Mantovani A., Sozzani S. Arginase-1 and Ym1 are markers for murine, but not human, alternatively activated myeloid cells. J. Immunol. 2005, 174:6561-6562.
6. Lacey D.C., Achuthan A., Fleetwood A.J., Dinh H., Roiniotis J., Scholz G.M., Chang M.W., Beckman S.K., Cook A.D., Hamilton J.A. Defining GM-CSF- and macrophage-CSF-dependent macrophage responses by in vitro models. J. Immunol. 2012, 188:5752-5765.
7. Fleetwood A.J., Lawrence T., Hamilton J.A., Cook A.D. Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammation. J. Immunol. 2007, 178:5245-5252.
8. Fleetwood A.J., Dinh H., Cook A.D., Hertzog P.J., Hamilton J.A. GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on type I interferon signaling. J. Leukocyte Biol. 2009, 86:411-421.
9. Verreck F.A., de Boer T., Langenberg D.M., Hoeve M.A., Kramer M., Vaisberg E., Kastelein R., Kolk A., de Waal-Malefyt R., Ottenhoff T.H. Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco) bacteria. Proc. Natl. Acad. Sci. USA 2004, 101:4560-4565.
10. Van Grevenynghe J., Rion S., Le Ferrec E., Le Vee M., Amiot L., Fauchet R., Fardel O. Polycyclic aromatic hydrocarbons inhibit differentiation of human monocytes into macrophages. J. Immunol. 2003, 170:2374-2381.
11. Martinez F.O., Gordon S., Locati M., Mantovani A. Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression. J. Immunol. 2006, 177:7303-7311.
12. World Medical Association Declaration of Helsinki Recommendations guiding physicians in biomedical research involving human subjects. Cardiovasc. Res. 1997, 35:2-3.
13. Podechard N., Lecureur V., Le Ferrec E., Guenon I., Sparfel L., Gilot D., Gordon J.R., Lagente V., Fardel O. Interleukin-8 induction by the environmental contaminant benzo(a)pyrene is aryl hydrocarbon receptor-dependent and leads to lung inflammation. Toxicol. Lett. 2008, 177:130-137.
14. Hashimoto S., Suzuki T., Dong H.Y., Yamazaki N., Matsushima K. Serial analysis of gene expression in human monocytes and macrophages. Blood 1999, 94:837-844.
15. Mantovani A., Sica A., Sozzani S., Allavena P., Vecchi A., Locati M. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 2004, 25:677-686.
16. Ambarus C.A., Krausz S., Van Eijk M., Hamann J., Radstake T.R., Reedquist K.A., Tak P.P., Baeten D.L. Systematic validation of specific phenotypic markers for in vitro polarized human macrophages. J. Immunol. Methods 2012, 375:196-206.
17. Vannier E., Miller L.C., Dinarello C.A. Coordinated antiinflammatory effects of interleukin 4: interleukin 4 suppresses interleukin 1 production but up-regulates gene expression and synthesis of interleukin 1 receptor antagonist. Proc. Natl. Acad. Sci. USA 1992, 89:4076-4080.
18. Di Rosa M., Malaguarnera G., De Gregorio C., Drago F., Malaguarnera L. Evaluation of CHI3L-1 and CHIT-1 Expression in Differentiated and Polarized Macrophages. Inflammation 2012.
19. Dror N., Alter-Koltunoff M., Azriel A., Amariglio N., Jacob-Hirsch J., Zeligson S., Morgenstern A., Tamura T., Hauser H., Rechavi G., Ozato K., Levi B.Z. Identification of IRF-8 and IRF-1 target genes in activated macrophages. Mol. Immunol. 2007, 44:338-346.
20. Nagamura-Inoue T., Tamura T., Ozato K. Transcription factors that regulate growth and differentiation of myeloid cells. Int. Rev. Immunol. 2001, 20:83-105.
21. Friedman A.D. Transcriptional regulation of granulocyte and monocyte development. Oncogene 2002, 21:3377-3390.
22. Liao X., Sharma N., Kapadia F., Zhou G., Lu Y., Hong H., Paruchuri K., Mahabeleshwar G.H., Dalmas E., Venteclef N., Flask C.A., Kim J., Doreian B.W., Lu K.Q., Kaestner K.H., Hamik A., Clement K., Jain M.K. Kruppel-like factor 4 regulates macrophage polarization. J. Clin. Invest. 2011, 121:2736-2749.
23. Solinas G., Schiarea S., Liguori M., Fabbri M., Pesce S., Zammataro L., Pasqualini F., Nebuloni M., Chiabrando C., Mantovani A., Allavena P. Tumor-conditioned macrophages secrete migration-stimulating factor: a new marker for M2-polarization, influencing tumor cell motility. J. Immunol. 2010, 185:642-652.
24. Verreck F.A., de Boer T., Langenberg D.M., Van der Zanden L., Ottenhoff T.H. Phenotypic and functional profiling of human proinflammatory type-1 and anti-inflammatory type-2 macrophages in response to microbial antigens and IFN-gamma- and CD40L-mediated costimulation. J. Leukocyte Biol. 2006, 79:285-293.
25. Sica A., Mantovani A. Macrophage plasticity and polarization: in vivo veritas. J. Clin. Invest. 2012, 122:787-795.
26. Feinberg M.W., Cao Z., Wara A.K., Lebedeva M.A., Senbanerjee S., Jain M.K. Kruppel-like factor 4 is a mediator of proinflammatory signaling in macrophages. J. Biol. Chem. 2005, 280:38247-38258.
27. Rehli M., Sulzbacher S., Pape S., Ravasi T., Wells C.A., Heinz S., Sollner L., El Chartouni C., Krause S.W., Steingrimsson E., Hume D.A., Andreesen R. Transcription factor Tfec contributes to the IL-4-inducible expression of a small group of genes in mouse macrophages including the granulocyte colony-stimulating factor receptor. J. Immunol. 2005, 174:7111-7122.
28. Bouhlel M.A., Derudas B., Rigamonti E., Dievart R., Brozek J., Haulon S., Zawadzki C., Jude B., Torpier G., Marx N., Staels B., Chinetti-Gbaguidi G. PPARgamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties. Cell Metab. 2007, 6:137-143.
29. Krausgruber T., Blazek K., Smallie T., Alzabin S., Lockstone H., Sahgal N., Hussell T., Feldmann M., Udalova I.A. IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses. Nat. Immunol. 2011, 12:231-238.
30. Satoh T., Takeuchi O., Vandenbon A., Yasuda K., Tanaka Y., Kumagai Y., Miyake T., Matsushita K., Okazaki T., Saitoh T., Honma K., Matsuyama T., Yui K., Tsujimura T., Standley D.M., Nakanishi K., Nakai K., Akira S. The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection. Nat. Immunol. 2010, 11:936-944.
31. El Chartouni C., Schwarzfischer L., Rehli M. Interleukin-4 induced interferon regulatory factor (Irf) four participates in the regulation of alternative macrophage priming. Immunobiology 2010, 215:821-825.
32. Lehtonen A., Veckman V., Nikula T., Lahesmaa R., Kinnunen L., Matikainen S., Julkunen I. Differential expression of IFN regulatory factor four gene in human monocyte-derived dendritic cells and macrophages. J. Immunol. 2005, 175:6570-6579.
33. Mullins D.W., Martins R.S., Elgert K.D. Tumor-derived cytokines dysregulate macrophage interferon-gamma responsiveness and interferon regulatory factor-8 expression. Exp. Biol. Med. (Maywood) 2003, 228:270-277.
34. Wang I.M., Contursi C., Masumi A., Ma X., Trinchieri G., Ozato K. An IFN-gamma-inducible transcription factor, IFN consensus sequence binding protein (ICSBP), stimulates IL-12 p40 expression in macrophages. J. Immunol. 2000, 165:271-279.
35. Lawrence T., Natoli G. Transcriptional regulation of macrophage polarization: enabling diversity with identity. Nat. Rev. Immunol. 2011, 11:750-761.
36. Kawai T., Takeuchi O., Fujita T., Inoue J., Muhlradt P.F., Sato S., Hoshino K., Akira S. Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J. Immunol. 2001, 167:5887-5894.
37. Murray P.J., Wynn T.A. Obstacles and opportunities for understanding macrophage polarization. J. Leukocyte Biol. 2011, 89:557-563.
38. Chroneos Z., Shepherd V.L. Differential regulation of the mannose and SP-A receptors on macrophages. Am. J. Physiol. 1995, 269:6-721.
39. Di Rosa M., Musumeci M., Scuto A., Musumeci S., Malaguarnera L. Effect of interferon-gamma, interleukin-10, lipopolysaccharide and tumor necrosis factor-alpha on chitotriosidase synthesis in human macrophages. Clin. Chem. Lab. Med. 2005, 43:499-502.
40. Martinez F.O., Helming L., Gordon S. Alternative activation of macrophages: an immunologic functional perspective. Annu. Rev. Immunol. 2009, 27:451-483.