A second target of the antimalarial and antibacterial agent fosmidomycin revealed by cellular metabolic profiling

Biochemistry

Volumn 50, Issue 17, 2011, Pages 3570-3577

  Zhang, Baichen ^a   Watts, Kristin M ^b   Hodge, Dana ^b   Kemp, Lisa M ^b   Hunstad, David A ^b   Hicks, Leslie M ^a   Odom, Audrey R ^b  

^a DONALD DANFORTH PLANT SCIENCE CENTER   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-MICROBIAL AGENT; ANTIBACTERIAL AGENT; ANTIMICROBIAL DRUG; ANTIPARASITIC DRUGS; BIOLOGICAL EFFECTS; BIOLOGICAL SAMPLES; CLINICAL TRIAL; COMBINATION THERAPY; DEOXYXYLULOSE PHOSPHATES; E. COLI; ESCHERICHIA COLI BACTERIA; EUBACTERIA; FALCIPARUM MALARIA; GRAM-NEGATIVE BACTERIA; GROWTH INHIBITION; IN-VITRO; IN-VIVO; ISOPRENOID BIOSYNTHESIS; ISOPRENOID METABOLISM; ISOPRENOIDS; METABOLIC PROFILING; MEVALONATE; NONMEVALONATE PATHWAY; OVER-EXPRESSION; PATHOGENIC ORGANISMS; PLASMODIUM FALCIPARUM; REDUCTOISOMERASE; URGENT PROBLEMS;

BACTERIA; BACTERIOLOGY; BIOCHEMISTRY; BIOSYNTHESIS; ENZYMES; ESCHERICHIA COLI; HEALTH CARE; LIPIDS; MALARIA CONTROL; MASS SPECTROMETRY; METABOLITES; PHYSIOLOGY;

METABOLISM;

DEOXYXYLULOSE PHOSPHATE REDUCTOISOMERASE; FOSMIDOMYCIN; ISOMERASE; ISOPRENOID; METHYLERYTHRITOL PHOSPHATE CYTIDYLTRANSFERASE; TRANSFERASE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; BIOSYNTHESIS; ESCHERICHIA COLI; GROWTH INHIBITION; IN VIVO STUDY; MASS SPECTROMETRY; METABOLISM; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ALDOSE-KETOSE ISOMERASES; ANTI-BACTERIAL AGENTS; ANTIMALARIALS; CHROMATOGRAPHY, LIQUID; CULTURE MEDIA; DRUG RESISTANCE, MICROBIAL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FOSFOMYCIN; MEVALONIC ACID; MULTIENZYME COMPLEXES; OXIDOREDUCTASES; PLASMODIUM FALCIPARUM; TANDEM MASS SPECTROMETRY; TERPENES;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA; PLASMODIUM FALCIPARUM;

EID: 79955399200     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200113y     Document Type: Article

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