Mitochondrial electron transport inhibition and viability of intraerythrocytic Plasmodium falciparum

Antimicrobial Agents and Chemotherapy

Volumn 54, Issue 12, 2010, Pages 5281-5287

  Painter, Heather J ^a,b   Morrisey, Joanne M ^a   Vaidya, Akhil B ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATOVAQUONE; PROGUANIL;

APOPTOSIS; ARTICLE; ELECTRON TRANSPORT; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; NUTRIENT UPTAKE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SCHIZONT;

ANTIMALARIALS; APOPTOSIS; ATOVAQUONE; ELECTRON TRANSPORT; ERYTHROCYTES; HEMOLYSIS; HUMANS; MITOCHONDRIA; PLASMODIUM FALCIPARUM;

EID: 78649672277     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00937-10     Document Type: Article

References (33)

1. Alkhalil, A., J. V. Cohn, M. A. Wagner, J. S. Cabrera, T. Rajapandi, and S. A. Desai. 2004. Plasmodium falciparum likely encodes the principal anion channel on infected human erythrocytes. Blood 104:4279-4286.
2. Baumeister, S., M. Winterberg, C. Duranton, S. M. Huber, F. Lang, K. Kirk, and K. Lingelbach. 2006. Evidence for the involvement of Plasmodium falciparum proteins in the formation of new permeability pathways in the erythrocyte membrane. Mol. Microbiol. 60:493-504.
3. Biagini, G. A., N. Fisher, N. Berry, P. A. Stocks, B. Meunier, D. P. Williams, R. Bonar-Law, P. G. Bray, A. Owen, P. M. O'Neill, and S. A. Ward. 2008. Acridinediones: selective and potent inhibitors of the malaria parasite mitochondrial bc1 complex. Mol. Pharmacol. 73:1347-1355.
4. Canfield, C. J., M. Pudney, and W. E. Gutteridge. 1995. Interactions of atovaquone with other antimalarial drugs against Plasmodium falciparum in vitro. Exp. Parasitol. 80:373-381.
5. Desai, S. A., S. M. Bezrukov, and J. Zimmerberg. 2000. A voltage-dependent channel involved in nutrient uptake by red blood cells infected with the malaria parasite. Nature 406:1001-1005.
6. Desjardins, R. E., C. J. Canfield, J. D. Haynes, and J. D. Chulay. 1979. Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique. Antimicrob. Agents Chemother. 16:710-718.
7. Edstein, M. D., S. Looareesuwan, C. Viravan, and D. E. Kyle. 1996. Pharmacokinetics of proguanil in malaria patients treated with proguanil plus atovaquone. Southeast Asian J. Trop. Med. Public Health 27:216-220.
8. Fry, M., and M. Pudney. 1992. Site of action of the antimalarial hydroxynaphthoquinone, 2-[trans-4-(4′-chlorophenyl) cyclohexyl]-3-hydroxy- 1,4-naphthoquinone (566C80). Biochem. Pharmacol. 43:1545-1553.
9. Gassis, S., and P. K. Rathod. 1996. Frequency of drug resistance in Plasmodium falciparum: a nonsynergistic combination of 5-fluoroorotate and atovaquone suppresses in vitro resistance. Antimicrob. Agents Chemother. 40:914-919.
10. Ginsburg, H., M. Krugliak, O. Eidelman, and Z. Ioav Cabantchik. 1983. New permeability pathways induced in membranes of Plasmodium falciparum infected erythrocytes. Mol. Biochem. Parasitol. 8:177-190.
11. Greenwood, B., and T. Mutabingwa. 2002. Malaria in 2002. Nature 415:670-672.
12. Haynes, J. D., and J. K. Moch. 2002. Automated synchronization of Plasmodium falciparum parasites by culture in a temperature-cycling incubator. Methods Mol. Med. 72:489-497.
13. Hudson, A. T., M. Dickins, C. D. Ginger, W. E. Gutteridge, T. Holdich, D. B. Hutchinson, M. Pudney, A. W. Randall, and V. S. Latter. 1991. 566C80: a potent broad spectrum anti-infective agent with activity against malaria and opportunistic infections in AIDS patients. Drugs Exp. Clin. Res. 17:427-435.
14. Kirk, K. 2001. Membrane transport in the malaria-infected erythrocyte. Physiol. Rev. 81:495-537.
15. Looareesuwan, S., C. Viravan, H. K. Webster, D. E. Kyle, D. B. Hutchinson, and C. J. Canfield. 1996. Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for treatment of acute uncomplicated malaria in Thailand. Am. J. Trop. Med. Hyg. 54:62-66.
16. Nyakeriga, A. M., H. Perlmann, M. Hagstedt, K. Berzins, M. Troye- Blomberg, B. Zhivotovsky, P. Perlmann, and A. Grandien. 2006. Drug-induced death of the asexual blood stages of Plasmodium falciparum occurs without typical signs of apoptosis. Microbes Infect. 8:1560-1568.
17. Olszewski, K. L., M. W. Mather, J. M. Morrisey, B. A. Garcia, A. B. Vaidya, J. D. Rabinowitz, and M. Llinas. 2010. Branched tricarboxylic acid metabolism in Plasmodium falciparum. Nature 466:774-778.
18. Painter, H. J., J. M. Morrisey, M. W. Mather, and A. B. Vaidya. 2007. Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum. Nature 446:88-91.
19. Rathod, P. K., T. McErlean, and P.-C. Lee. 1997. Variations in frequencies of drug resistance in Plasmodium falciparum. Proc. Natl. Acad. Sci. U. S. A. 94:9389-9393.
20. Rodrigues, T., F. Lopes, and R. Moreira. 2010. Inhibitors of the mitochondrial electron transport chain and de novo pyrimidine biosynthesis as antimalarials: the present status. Curr. Med. Chem. 17:929-956.
21. Sachs, J., and P. Malaney. 2002. The economic and social burden of malaria. Nature 415:680-685.
22. Shock, J. L., K. F. Fischer, and J. L. Derisi. 2007. Whole-genome analysis of mRNA decay in Plasmodium falciparum reveals a global lengthening of mRNA half-life during the intra-erythrocytic development cycle. Genome Biol. 8:R134.
23. Skinner, T. S., L. S. Manning, W. A. Johnston, and T. M. E. Davis. 1996. In vitro stage-specific sensitivity of Plasmodium falciparum to quinine and artemisinin drugs. Int. J. Parasitol. 26:519-525.
24. Srivastava, I. K., H. Rottenberg, and A. B. Vaidya. 1997. Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malarial parasite. J. Biol. Chem. 272:3961-3966.
25. Srivastava, I. K., and A. B. Vaidya. 1999. A mechanism for the synergistic antimalarial action of atovaquone and proguanil. Antimicrob. Agents Chemother. 43:1334-1339.
26. Staines, H. M., A. Alkhalil, R. J. Allen, H. R. De Jonge, E. Derbyshire, S. Egee, H. Ginsburg, D. A. Hill, S. M. Huber, K. Kirk, F. Lang, G. Lisk, E. Oteng, A. D. Pillai, K. Rayavara, S. Rouhani, K. J. Saliba, C. Shen, T. Solomon, S. L. Y. Thomas, P. Verloo, and S. A. Desai. 2007. Electrophysiological studies of malaria parasite-infected erythrocytes: current status. Int. J. Parasitol. 37:475-482.
27. ter Kuile, F., N. J. White, P. Holloway, G. Pasvol, and S. Krishna. 1993. Plasmodium falciparum: in vitro studies of the pharmacodynamic properties of drugs used for the treatment of severe malaria. Exp. Parasitol. 76:85-95.
28. Thapar, M. M., J. P. Gil, and A. Bjorkman. 2005. In vitro recrudescence of Plasmodium falciparum parasites suppressed to dormant state by atovaquone alone and in combination with proguanil. Trans. R. Soc. Trop. Med. Hyg. 99:62-70.
29. Trager, W., and J. B. Jensen. 1976. Human malaria parasites in continuous culture. Science 193:673-675.
30. Vaidya, A. B., and M. W. Mather. 2009. Mitochondrial evolution and functions in malaria parasites. Annu. Rev. Microbiol. 63:249-267.
31. Winter, R. W., J. X. Kelly, M. J. Smilkstein, R. Dodean, G. C. Bagby, R. K. Rathbun, J. I. Levin, D. Hinrichs, and M. K. Riscoe. 2006. Evaluation and lead optimization of anti-malarial acridones. Exp. Parasitol. 114:47-56.
32. Winter, R. W., J. X. Kelly, M. J. Smilkstein, R. Dodean, D. Hinrichs, and M. K. Riscoe. 2008. Antimalarial quinolones: synthesis, potency, and mechanistic studies. Exp. Parasitol. 118:487-497.
33. Yayon, A., J. A. V. Waa, M. Yayon, T. G. Geary, and J. B. Jensen. 1983. Stage-dependent effects of chloroquine on Plasmodium falciparum in vitro. J. Eukaryot. Microbiol. 30:642-647.