Akt switches TopBP1 function from checkpoint activation to transcriptional regulation through phosphoserine binding-mediated oligomerization

Molecular and Cellular Biology

Volumn 33, Issue 23, 2013, Pages 4685-4700

  Liu, Kang ^a   Graves, Joshua D ^a   Scott, Jessica D ^a   Li, Rongbao ^b   Lin, Weei Chin ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; COMPLEMENTARY DNA; HYDROXYUREA; LUCIFERASE; PEPTIDE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOSERINE; PROTEIN KINASE B; PROTEIN P53; RNA; TOPOISOMERASE IIBETA BINDING PROTEIN 1; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG; 8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; AKT1 PROTEIN, HUMAN; CARRIER PROTEIN; DNA BINDING PROTEIN; E2F1 PROTEIN, HUMAN; FUSED HETEROCYCLIC RINGS; NUCLEAR PROTEIN; SERINE; TOPBP1 PROTEIN, HUMAN; CHROMATIN; PROTEIN BINDING;

ADENOVIRUS; ARTICLE; CELL CULTURE; CELL CYCLE CHECKPOINT; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; FAST PROTEIN LIQUID CHROMATOGRAPHY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; OLIGOMERIZATION; PLASMID; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; REAL TIME POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; WESTERN BLOTTING; AMINO ACID SUBSTITUTION; CELL STRAIN HEK293; CHEMISTRY; CHROMATIN; DRUG ANTAGONISM; GENE EXPRESSION REGULATION; METABOLISM; MOLECULAR DYNAMICS; PHOSPHORYLATION; PHYSIOLOGICAL STRESS; PHYSIOLOGY; PROTEIN MULTIMERIZATION; PROTEIN PROCESSING; TUMOR CELL LINE; ANTAGONISTS AND INHIBITORS; HEK293 CELL LINE;

AMINO ACID SUBSTITUTION; CARRIER PROTEINS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CHROMATIN; DNA-BINDING PROTEINS; E2F1 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; HEK293 CELLS; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; HYDROXYUREA; MOLECULAR DYNAMICS SIMULATION; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN MULTIMERIZATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; SERINE; STRESS, PHYSIOLOGICAL; TRANSCRIPTION, GENETIC;

EID: 84891709489     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.00373-13     Document Type: Article

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