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Volumn 38, Issue 7, 2014, Pages 966-972

SALL4 immunoreactivity predicts prognosis in western hepatocellular carcinoma patients but is a rare event: A study of 236 cases

Author keywords

biomarker; immunostain; recurrence; stem cell; survival; transplantation

Indexed keywords

SALL4 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TUMOR MARKER;

EID: 84902549483     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0000000000000218     Document Type: Article
Times cited : (36)

References (52)
  • 2
    • 1642544603 scopus 로고    scopus 로고
    • Focus on hepatocellular carcinoma
    • Bruix J, Boix L, Sala M, et al. Focus on hepatocellular carcinoma. Cancer Cell. 2004;5: 215-219.
    • (2004) Cancer Cell , vol.5 , pp. 215-219
    • Bruix, J.1    Boix, L.2    Sala, M.3
  • 3
    • 40849124295 scopus 로고    scopus 로고
    • Novel advancements in the management of hepatocellular carcinoma in 2008
    • Llovet JM, Bruix J. Novel advancements in the management of hepatocellular carcinoma in 2008. J Hepatol. 2008;48(suppl 1):S20-S37.
    • (2008) J Hepatol , vol.48 , Issue.SUPPL. 1
    • Llovet, J.M.1    Bruix, J.2
  • 4
    • 60549106718 scopus 로고    scopus 로고
    • Major achievements in hepatocellular carcinoma
    • Bruix J, Llovet JM. Major achievements in hepatocellular carcinoma. Lancet. 2009;373: 614-616.
    • (2009) Lancet , vol.373 , pp. 614-616
    • Bruix, J.1    Llovet, J.M.2
  • 5
    • 77349086916 scopus 로고    scopus 로고
    • Two decades of advances in hepatocellular carcinoma research
    • Bruix J, Llovet JM. Two decades of advances in hepatocellular carcinoma research. Semin Liver Dis. 2010;30: 1-2.
    • (2010) Semin Liver Dis , vol.30 , pp. 1-2
    • Bruix, J.1    Llovet, J.M.2
  • 6
    • 79959323446 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Screening and staging
    • Sherman M. Hepatocellular carcinoma: screening and staging. Clin Liver Dis. 2011;15: 323-334.
    • (2011) Clin Liver Dis , vol.15 , pp. 323-334
    • Sherman, M.1
  • 7
    • 0038574308 scopus 로고    scopus 로고
    • Review article: Natural history and prognostic prediction of patients with hepatocellular carcinoma
    • Varela M, Sala M, Llovet JM, et al. Review article: natural history and prognostic prediction of patients with hepatocellular carcinoma. Aliment Pharmacol Ther. 2003;17(suppl 2): 98-102.
    • (2003) Aliment Pharmacol Ther , vol.17 , Issue.SUPPL. 2 , pp. 98-102
    • Varela, M.1    Sala, M.2    Llovet, J.M.3
  • 8
    • 34247549347 scopus 로고    scopus 로고
    • Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma
    • Wurmbach E, Chen YB, Khitrov G, et al. Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma. Hepatology. 2007;45: 938-947.
    • (2007) Hepatology , vol.45 , pp. 938-947
    • Wurmbach, E.1    Chen, Y.B.2    Khitrov, G.3
  • 9
    • 77951456114 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and hepatocellular carcinoma: A weighty connection
    • Starley BQ, Calcagno CJ, Harrison SA. Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection. Hepatology. 2010;51: 1820-1832.
    • (2010) Hepatology , vol.51 , pp. 1820-1832
    • Starley, B.Q.1    Calcagno, C.J.2    Harrison, S.A.3
  • 10
    • 79952231921 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma: An update
    • Bruix J, Sherman M. Management of hepatocellular carcinoma: an update. Hepatology. 2011;53: 1020-1022.
    • (2011) Hepatology , vol.53 , pp. 1020-1022
    • Bruix, J.1    Sherman, M.2
  • 11
    • 54449083925 scopus 로고    scopus 로고
    • Molecular targeted therapies in hepatocellular carcinoma
    • Llovet JM, Bruix J. Molecular targeted therapies in hepatocellular carcinoma. Hepatology. 2008;48: 1312-1327.
    • (2008) Hepatology , vol.48 , pp. 1312-1327
    • Llovet, J.M.1    Bruix, J.2
  • 12
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet JM, Ricci S, Mazzaferro V, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 2008;359: 378-390.
    • (2008) N Engl J Med , vol.359 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 13
    • 69949129964 scopus 로고    scopus 로고
    • Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo
    • Newell P, Toffanin S, Villanueva A, et al. Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo. J Hepatol. 2009;51: 725-733.
    • (2009) J Hepatol , vol.51 , pp. 725-733
    • Newell, P.1    Toffanin, S.2    Villanueva, A.3
  • 14
    • 33845790499 scopus 로고    scopus 로고
    • A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis
    • Llovet JM, Chen Y, Wurmbach E, et al. A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis. Gastroenterology. 2006;131: 1758-1767.
    • (2006) Gastroenterology , vol.131 , pp. 1758-1767
    • Llovet, J.M.1    Chen, Y.2    Wurmbach, E.3
  • 15
    • 57349090407 scopus 로고    scopus 로고
    • Gene expression in fixed tissues and outcome in hepatocellular carcinoma
    • Hoshida Y, Villanueva A, Kobayashi M, et al. Gene expression in fixed tissues and outcome in hepatocellular carcinoma. N Engl J Med. 2008;359: 1995-2004.
    • (2008) N Engl J Med , vol.359 , pp. 1995-2004
    • Hoshida, Y.1    Villanueva, A.2    Kobayashi, M.3
  • 16
    • 77949875878 scopus 로고    scopus 로고
    • IGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage
    • Tovar V, Alsinet C, Villanueva A, et al. IGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage. J Hepatol. 2010;52: 550-559.
    • (2010) J Hepatol , vol.52 , pp. 550-559
    • Tovar, V.1    Alsinet, C.2    Villanueva, A.3
  • 17
    • 79955401037 scopus 로고    scopus 로고
    • Combining clinical, pathology, and gene expression data to predict recurrence of hepatocellular carcinoma
    • e1502
    • Villanueva A, Hoshida Y, Battiston C, et al. Combining clinical, pathology, and gene expression data to predict recurrence of hepatocellular carcinoma. Gastroenterology. 2011;140:1501-1512 e1502.
    • (2011) Gastroenterology , vol.140 , pp. 1501-1512
    • Villanueva, A.1    Hoshida, Y.2    Battiston, C.3
  • 18
    • 77952564300 scopus 로고    scopus 로고
    • The identification of stem cells in human liver diseases and hepatocellular carcinoma
    • Oliva J, French BA, Qing X, et al. The identification of stem cells in human liver diseases and hepatocellular carcinoma. Exp Mol Pathol. 2010;88: 331-340.
    • (2010) Exp Mol Pathol , vol.88 , pp. 331-340
    • Oliva, J.1    French, B.A.2    Qing, X.3
  • 19
    • 70349783082 scopus 로고    scopus 로고
    • CD133-positive hepatocellular carcinoma in an area endemic for hepatitis B virus infection
    • Yeh CT, Kuo CJ, Lai MW, et al. CD133-positive hepatocellular carcinoma in an area endemic for hepatitis B virus infection. BMC Cancer. 2009;9:324.
    • (2009) BMC Cancer , vol.9 , pp. 324
    • Yeh, C.T.1    Kuo, C.J.2    Lai, M.W.3
  • 20
    • 84863055429 scopus 로고    scopus 로고
    • Cancer stem cells generated by alcohol, diabetes, and hepatitis C virus
    • Machida K, Chen CL, Liu JC, et al. Cancer stem cells generated by alcohol, diabetes, and hepatitis C virus. J Gastroenterol Hepatol. 2012;27(suppl 2): 19-22.
    • (2012) J Gastroenterol Hepatol , vol.27 , Issue.SUPPL. 2 , pp. 19-22
    • Machida, K.1    Chen, C.L.2    Liu, J.C.3
  • 21
    • 80052031109 scopus 로고    scopus 로고
    • Human hepatic cancer stem cells are characterized by common stemness traits and diverse oncogenic pathways
    • Marquardt JU, Raggi C, Andersen JB, et al. Human hepatic cancer stem cells are characterized by common stemness traits and diverse oncogenic pathways. Hepatology. 2011;54: 1031-1042.
    • (2011) Hepatology , vol.54 , pp. 1031-1042
    • Marquardt, J.U.1    Raggi, C.2    Andersen, J.B.3
  • 22
    • 33645742425 scopus 로고    scopus 로고
    • A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells
    • Lee JS, Heo J, Libbrecht L, et al. A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells. Nat Med. 2006;12: 410-416.
    • (2006) Nat Med , vol.12 , pp. 410-416
    • Lee, J.S.1    Heo, J.2    Libbrecht, L.3
  • 23
    • 0242609884 scopus 로고    scopus 로고
    • Cytokeratin 19 expression in hepatocellular carcinoma predicts early postoperative recurrence
    • Uenishi T, Kubo S, Yamamoto T, et al. Cytokeratin 19 expression in hepatocellular carcinoma predicts early postoperative recurrence. Cancer Sci. 2003;94: 851-857.
    • (2003) Cancer Sci , vol.94 , pp. 851-857
    • Uenishi, T.1    Kubo, S.2    Yamamoto, T.3
  • 24
    • 52449093970 scopus 로고    scopus 로고
    • Cytokeratin 10 and cytokeratin 19: Predictive markers for poor prognosis in hepatocellular carcinoma patients after curative resection
    • Yang XR, Xu Y, Shi GM, et al. Cytokeratin 10 and cytokeratin 19: predictive markers for poor prognosis in hepatocellular carcinoma patients after curative resection. Clin Cancer Res. 2008;14: 3850-3859.
    • (2008) Clin Cancer Res , vol.14 , pp. 3850-3859
    • Yang, X.R.1    Xu, Y.2    Shi, G.M.3
  • 25
    • 33749185394 scopus 로고    scopus 로고
    • SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice
    • Ma Y, Cui W, Yang J, et al. SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice. Blood. 2006;108: 2726-2735.
    • (2006) Blood , vol.108 , pp. 2726-2735
    • Ma, Y.1    Cui, W.2    Yang, J.3
  • 26
    • 33751215123 scopus 로고    scopus 로고
    • Differential expression of the novel oncogene, SALL4, in lymphoma, plasma cell myeloma, and acute lymphoblastic leukemia
    • Cui W, Kong NR, Ma Y, et al. Differential expression of the novel oncogene, SALL4, in lymphoma, plasma cell myeloma, and acute lymphoblastic leukemia. Mod Pathol. 2006;19: 1585-1592.
    • (2006) Mod Pathol , vol.19 , pp. 1585-1592
    • Cui, W.1    Kong, N.R.2    Ma, Y.3
  • 27
    • 67649562737 scopus 로고    scopus 로고
    • SALL4 is a novel diagnostic marker for testicular germ cell tumors
    • Cao D, Li J, Guo CC, et al. SALL4 is a novel diagnostic marker for testicular germ cell tumors. Am J Surg Pathol. 2009;33: 1065-1077.
    • (2009) Am J Surg Pathol , vol.33 , pp. 1065-1077
    • Cao, D.1    Li, J.2    Guo, C.C.3
  • 28
    • 84876121571 scopus 로고    scopus 로고
    • Sal-like protein 4 (SALL4), a stem cell biomarker in liver cancers
    • Oikawa T, Kamiya A, Zeniya M, et al. Sal-like protein 4 (SALL4), a stem cell biomarker in liver cancers. Hepatology. 2013;57: 1469-1483.
    • (2013) Hepatology , vol.57 , pp. 1469-1483
    • Oikawa, T.1    Kamiya, A.2    Zeniya, M.3
  • 29
    • 84878887042 scopus 로고    scopus 로고
    • Oncofetal gene SALL4 in aggressive hepatocellular carcinoma
    • Yong KJ, Gao C, Lim JS, et al. Oncofetal gene SALL4 in aggressive hepatocellular carcinoma. N Engl J Med. 2013;368: 2266-2276.
    • (2013) N Engl J Med , vol.368 , pp. 2266-2276
    • Yong, K.J.1    Gao, C.2    Lim, J.S.3
  • 30
    • 67549105495 scopus 로고    scopus 로고
    • SALL4 is a novel sensitive and specific marker of ovarian primitive germ cell tumors and is particularly useful in distinguishing yolk sac tumor from clear cell carcinoma
    • Cao D, Guo S, Allan RW, et al. SALL4 is a novel sensitive and specific marker of ovarian primitive germ cell tumors and is particularly useful in distinguishing yolk sac tumor from clear cell carcinoma. Am J Surg Pathol. 2009;33: 894-904.
    • (2009) Am J Surg Pathol , vol.33 , pp. 894-904
    • Cao, D.1    Guo, S.2    Allan, R.W.3
  • 31
    • 84870938494 scopus 로고    scopus 로고
    • CDX1 confers intestinal phenotype on gastric epithelial cells via induction of stemnessassociated reprogramming factors SALL4 and KLF5
    • Fujii Y, Yoshihashi K, Suzuki H, et al. CDX1 confers intestinal phenotype on gastric epithelial cells via induction of stemnessassociated reprogramming factors SALL4 and KLF5. Proc Natl Acad Sci USA. 2012;109: 20584-20589.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 20584-20589
    • Fujii, Y.1    Yoshihashi, K.2    Suzuki, H.3
  • 32
    • 34547495258 scopus 로고    scopus 로고
    • Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells
    • Yang J, Chai L, Liu F, et al. Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells. Proc Natl Acad Sci USA. 2007; 104: 10494-10499.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 10494-10499
    • Yang, J.1    Chai, L.2    Liu, F.3
  • 33
    • 50949096867 scopus 로고    scopus 로고
    • SALL4 is a key regulator of survival and apoptosis in human leukemic cells
    • Yang J, Chai L, Gao C, et al. SALL4 is a key regulator of survival and apoptosis in human leukemic cells. Blood. 2008;112: 805-813.
    • (2008) Blood , vol.112 , pp. 805-813
    • Yang, J.1    Chai, L.2    Gao, C.3
  • 34
    • 79952338489 scopus 로고    scopus 로고
    • SALL4 is essential for cancer cell proliferation and is overexpressed at early clinical stages in breast cancer
    • Kobayashi D, Kuribayshi K, Tanaka M, et al. SALL4 is essential for cancer cell proliferation and is overexpressed at early clinical stages in breast cancer. Int J Oncol. 2011;38: 933-939.
    • (2011) Int J Oncol , vol.38 , pp. 933-939
    • Kobayashi, D.1    Kuribayshi, K.2    Tanaka, M.3
  • 35
    • 79960831107 scopus 로고    scopus 로고
    • Overexpression of SALL4 in lung cancer and its importance in cell proliferation
    • Kobayashi D, Kuribayashi K, Tanaka M, et al. Overexpression of SALL4 in lung cancer and its importance in cell proliferation. Oncol Rep. 2011;26: 965-970.
    • (2011) Oncol Rep , vol.26 , pp. 965-970
    • Kobayashi, D.1    Kuribayashi, K.2    Tanaka, M.3
  • 36
    • 77950196211 scopus 로고    scopus 로고
    • SALL4 represents fetal gut differentiation of gastric cancer, and is diagnostically useful in distinguishing hepatoid gastric carcinoma from hepatocellular carcinoma
    • Ushiku T, Shinozaki A, Shibahara J, et al. SALL4 represents fetal gut differentiation of gastric cancer, and is diagnostically useful in distinguishing hepatoid gastric carcinoma from hepatocellular carcinoma. Am J Surg Pathol. 2010;34: 533-540.
    • (2010) Am J Surg Pathol , vol.34 , pp. 533-540
    • Ushiku, T.1    Shinozaki, A.2    Shibahara, J.3
  • 37
    • 84867841878 scopus 로고    scopus 로고
    • Alpha-Fetoprotein-producing gastric carcinoma and combined hepatocellular and cholangiocarcinoma show similar morphology but different histogenesis with respect to SALL4 expression
    • Ikeda H, Sato Y, Yoneda N, et al. alpha-Fetoprotein-producing gastric carcinoma and combined hepatocellular and cholangiocarcinoma show similar morphology but different histogenesis with respect to SALL4 expression. Hum Pathol. 2012;43: 1955-1963.
    • (2012) Hum Pathol , vol.43 , pp. 1955-1963
    • Ikeda, H.1    Sato, Y.2    Yoneda, N.3
  • 38
    • 71149088322 scopus 로고    scopus 로고
    • Diagnostic utility of SALL4 in primary germ cell tumors of the central nervous system: A study of 77 cases
    • Mei K, Liu A, Allan RW, et al. Diagnostic utility of SALL4 in primary germ cell tumors of the central nervous system: a study of 77 cases. Mod Pathol. 2009;22: 1628-1636.
    • (2009) Mod Pathol , vol.22 , pp. 1628-1636
    • Mei, K.1    Liu, A.2    Allan, R.W.3
  • 39
    • 69149097964 scopus 로고    scopus 로고
    • Mutational analysis of SAL-Like 4 (SALL4) in Han Chinese women with premature ovarian failure
    • Wang B, Li L, Ni F, et al. Mutational analysis of SAL-Like 4 (SALL4) in Han Chinese women with premature ovarian failure. Mol Hum Reprod. 2009;15: 557-562.
    • (2009) Mol Hum Reprod , vol.15 , pp. 557-562
    • Wang, B.1    Li, L.2    Ni, F.3
  • 40
    • 70349684394 scopus 로고    scopus 로고
    • Diagnostic utility of SALL4 in extragonadal yolk sac tumors: An immunohistochemical study of 59 cases with comparison to placental-like alkaline phosphatase, alphafetoprotein, and glypican-3
    • Wang F, Liu A, Peng Y, et al. Diagnostic utility of SALL4 in extragonadal yolk sac tumors: an immunohistochemical study of 59 cases with comparison to placental-like alkaline phosphatase, alphafetoprotein, and glypican-3. Am J Surg Pathol. 2009;33: 1529-1539.
    • (2009) Am J Surg Pathol , vol.33 , pp. 1529-1539
    • Wang, F.1    Liu, A.2    Peng, Y.3
  • 41
    • 67649220203 scopus 로고    scopus 로고
    • SALL4 is a novel sensitive and specific marker for metastatic germ cell tumors, with particular utility in detection of metastatic yolk sac tumors
    • Cao D, Humphrey PA, Allan RW. SALL4 is a novel sensitive and specific marker for metastatic germ cell tumors, with particular utility in detection of metastatic yolk sac tumors. Cancer. 2009;115: 2640-2651.
    • (2009) Cancer , vol.115 , pp. 2640-2651
    • Cao, D.1    Humphrey, P.A.2    Allan, R.W.3
  • 42
    • 79956079665 scopus 로고    scopus 로고
    • Does the hepatitis B antigen HBx promote the appearance of liver cancer stem cells?
    • Arzumanyan A, Friedman T, Ng IO, et al. Does the hepatitis B antigen HBx promote the appearance of liver cancer stem cells? Cancer Res. 2011;71: 3701-3708.
    • (2011) Cancer Res , vol.71 , pp. 3701-3708
    • Arzumanyan, A.1    Friedman, T.2    Ng, I.O.3
  • 43
    • 84155180684 scopus 로고    scopus 로고
    • Hepatitis B virus X (HBx) induces tumorigenicity of hepatic progenitor cells in 3, 5-diethoxycarbonyl- 1, 4-dihydrocollidine-treated HBx transgenic mice
    • Wang C, Yang W, Yan HX, et al. Hepatitis B virus X (HBx) induces tumorigenicity of hepatic progenitor cells in 3, 5-diethoxycarbonyl- 1, 4-dihydrocollidine-treated HBx transgenic mice. Hepatology. 2012;55: 108-120.
    • (2012) Hepatology , vol.55 , pp. 108-120
    • Wang, C.1    Yang, W.2    Yan, H.X.3
  • 44
    • 84866520281 scopus 로고    scopus 로고
    • Parallel induction of cell proliferation and inhibition of cell differentiation in hepatic progenitor cells by hepatitis B virus X gene
    • Huang J, Shen L, Lu Y, et al. Parallel induction of cell proliferation and inhibition of cell differentiation in hepatic progenitor cells by hepatitis B virus X gene. Int J Mol Med. 2012;30: 842-848.
    • (2012) Int J Mol Med , vol.30 , pp. 842-848
    • Huang, J.1    Shen, L.2    Lu, Y.3
  • 45
    • 79952230767 scopus 로고    scopus 로고
    • Epithelial cell adhesion molecule (EpCAM) marks hepatocytes newly derived from stem/progenitor cells in humans
    • Yoon SM, Gerasimidou D, Kuwahara R, et al. Epithelial cell adhesion molecule (EpCAM) marks hepatocytes newly derived from stem/progenitor cells in humans. Hepatology. 2011;53: 964-973.
    • (2011) Hepatology , vol.53 , pp. 964-973
    • Yoon, S.M.1    Gerasimidou, D.2    Kuwahara, R.3
  • 46
    • 84862769727 scopus 로고    scopus 로고
    • Interleukin-22 promotes proliferation of liver stem/progenitor cells in mice and patients with chronic hepatitis B virus infection
    • e187
    • Feng D, Kong X, Weng H, et al. Interleukin-22 promotes proliferation of liver stem/progenitor cells in mice and patients with chronic hepatitis B virus infection. Gastroenterology. 2012;143:188-198 e187.
    • (2012) Gastroenterology , vol.143 , pp. 188-198
    • Feng, D.1    Kong, X.2    Weng, H.3
  • 47
    • 48549084860 scopus 로고    scopus 로고
    • Stem-like cells in hepatitis B virusassociated cirrhotic livers and adjacent tissue to hepatocellular carcinomas possess the capacity of tumorigenicity
    • Sun YL, Yin SY, Xie HY, et al. Stem-like cells in hepatitis B virusassociated cirrhotic livers and adjacent tissue to hepatocellular carcinomas possess the capacity of tumorigenicity. J Gastroenterol Hepatol. 2008;23: 1280-1286.
    • (2008) J Gastroenterol Hepatol , vol.23 , pp. 1280-1286
    • Sun, Y.L.1    Yin, S.Y.2    Xie, H.Y.3
  • 48
    • 81255200425 scopus 로고    scopus 로고
    • Hepatitis C virus-induced cancer stem cell-like signatures in cell culture and murine tumor xenografts
    • Ali N, Allam H, May R, et al. Hepatitis C virus-induced cancer stem cell-like signatures in cell culture and murine tumor xenografts. J Virol. 2011;85: 12292-12303.
    • (2011) J Virol , vol.85 , pp. 12292-12303
    • Ali, N.1    Allam, H.2    May, R.3
  • 49
    • 77954045897 scopus 로고    scopus 로고
    • Intermediate hepatobiliary cells predict an increased risk of hepatocarcinogenesis in patients with hepatitis C virus-related cirrhosis
    • e332
    • Ziol M, Nault JC, Aout M, et al. Intermediate hepatobiliary cells predict an increased risk of hepatocarcinogenesis in patients with hepatitis C virus-related cirrhosis. Gastroenterology. 2010;139: 335-343 e332.
    • (2010) Gastroenterology , vol.139 , pp. 335-343
    • Ziol, M.1    Nault, J.C.2    Aout, M.3
  • 50
    • 78649641423 scopus 로고    scopus 로고
    • Viral factors induce Hedgehog pathway activation in humans with viral hepatitis, cirrhosis, and hepatocellular carcinoma
    • Pereira Tde A, Witek RP, Syn WK, et al. Viral factors induce Hedgehog pathway activation in humans with viral hepatitis, cirrhosis, and hepatocellular carcinoma. Lab Invest. 2010;90: 1690-1703.
    • (2010) Lab Invest , vol.90 , pp. 1690-1703
    • Pereira Tde, A.1    Witek, R.P.2    Syn, W.K.3
  • 51
    • 60849102149 scopus 로고    scopus 로고
    • Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog
    • Machida K, Tsukamoto H, Mkrtchyan H, et al. Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog. Proc Natl Acad Sci USA. 2009;106: 1548-1553.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 1548-1553
    • Machida, K.1    Tsukamoto, H.2    Mkrtchyan, H.3
  • 52
    • 79953277497 scopus 로고    scopus 로고
    • TLRs, alcohol, HCV, and tumorigenesis
    • Machida K. TLRs, alcohol, HCV, and tumorigenesis. Gastroenterol Res Pract. 2010;2010:518674.
    • (2010) Gastroenterol Res Pract , vol.2010 , pp. 518674
    • Machida, K.1


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