Targeting translocator protein (18 kDa) (TSPO) dampens pro-inflammatory microglia reactivity in the retina and protects from degeneration

Journal of Neuroinflammation

Volumn 12, Issue 1, 2015, Pages

  Scholz, Rebecca ^a   Caramoy, Albert ^a   Bhuckory, Mohajeet B ^b   Rashid, Khalid ^a   Chen, Mei ^b   Xu, Heping ^b   Grimm, Christian ^c   Langmann, Thomas ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Age related macular degeneration; Light damage; Microglia; Photoreceptors; Retinal degeneration; Translocator protein (18 kDa) (TSPO)

Indexed keywords

CARRIER PROTEIN; EMAPUNIL; RETINA S ANTIGEN; TRANSLOCATOR PROTEIN; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID RECEPTOR; BZRP PROTEIN, MOUSE; N-BENZYL-N-ETHYL-2-(7,8-DIHYDRO-7-METHYL-8-OXO-2-PHENYL-9H-PURIN-9-YL)ACETAMIDE; PURINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; EYE PROTECTION; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; GLIOSIS; IMMUNOREACTIVITY; LIGHT EXPOSURE; MALE; MICROGLIA; MOLECULAR WEIGHT; MORPHOMETRICS; MOUSE; MUELLER CELL; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; OPTICAL COHERENCE TOMOGRAPHY; PHOTORECEPTOR CELL; PIGMENT EPITHELIUM; PROTEIN EXPRESSION; PROTEIN TARGETING; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RETINA DEGENERATION; RETINA DETACHMENT; TREATMENT OUTCOME; TUNEL ASSAY; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; DISEASE MODEL; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; METABOLISM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INFLAMMATION; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROGLIA; PURINES; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, GABA; RETINAL DEGENERATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 84959214289     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-015-0422-5     Document Type: Article

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