Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age-related macular degeneration

EMBO Molecular Medicine

Volumn 7, Issue 2, 2015, Pages 211-226

  Levy, Olivier ^a,b,c   Calippe, Bertrand ^a,b,c   Lavalette, Sophie ^a,b,c   Hu, Shulong J ^a,b,c   Raoul, William ^a,b,c   Dominguez, Elisa ^a,b,c   Housset, Michael ^a,b,c   Paques, Michel ^a,b,c   Sahel, José Alain ^a,b,c   Bemelmans, Alexis Pierre ^a,b,c,d,e   Combadiere, Christophe ^a,b,f   Guillonneau, Xavier ^a,b,c   Sennlaub, Florian ^a,b,c  

^a INSERM   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c CENTRE HOSPITALIER NATIONAL D OPHTALMOLOGIE DES QUINZE VINGTS   (France)

^d INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

^e CNRS   (France)

^f Assistance publique Hôpitaux de Paris   (France)

Author keywords

Age related macular degeneration; Apolipoprotein E; Interleukin 6; Mononuclear phagocyte; Neuroinflammation

Indexed keywords

APOLIPOPROTEIN E; CD14 ANTIGEN; FAS LIGAND; INTERLEUKIN 6; TOLL LIKE RECEPTOR 2; CHEMOKINE RECEPTOR; CX3CR1 PROTEIN, MOUSE;

AGE RELATED MACULAR DEGENERATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SURVIVAL; CHRONIC INFLAMMATION; CONTROLLED STUDY; HUMAN; INNATE IMMUNITY; MALE; MONONUCLEAR PHAGOCYTE; MOUSE; NONHUMAN; PHOTORECEPTOR; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUBRETINAL MONONUCLEAR PHAGOCYTE; SUBRETINAL NEOVASCULARIZATION; ANIMAL; CYTOLOGY; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; MACULAR DEGENERATION; PATHOPHYSIOLOGY; PHAGOCYTE; RETINAL PIGMENT EPITHELIUM;

ANIMALS; APOLIPOPROTEINS E; CELL SURVIVAL; CHOROIDAL NEOVASCULARIZATION; FAS LIGAND PROTEIN; HUMANS; INTERLEUKIN-6; MACULAR DEGENERATION; MALE; MICE; MICE, KNOCKOUT; PHAGOCYTES; RECEPTORS, CHEMOKINE; RETINAL PIGMENT EPITHELIUM;

EID: 84922008795     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.15252/emmm.201404524     Document Type: Article

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