Production of the forskolin precursor 11β-hydroxy-manoyl oxide in yeast using surrogate enzymatic activities

Microbial Cell Factories

Volumn 15, Issue 1, 2016, Pages

  Ignea, Codruta ^a   Ioannou, Efstathia ^b   Georgantea, Panagiota ^b   Trikka, Fotini A ^c   Athanasakoglou, Anastasia ^a   Loupassaki, Sofia ^d   Roussis, Vassilios ^b   Makris, Antonios M ^c   Kampranis, Sotirios C ^a  

^a UNIVERSITY OF CRETE   (Greece)

^b UNIVERSITY OF ATHENS   (Greece)

^c INFORMATION TECHNOLOGIES INSTITUTE   (Greece)

^d MEDITERRANEAN AGRONOMIC INSTITUTE OF CHANIA   (Greece)

Author keywords

Cytochrome P450; Isoprenoid; Metabolic engineering; Natural products; Terpene

Indexed keywords

11BETA HYDROXY MANOYL OXIDE; CYP76AH24 PROTEIN; DITERPENE SYNTHASE; ENZYME; FORSKOLIN; GLUTAMATE DEHYDROGENASE (NADP); MONOCARBOXYLATE TRANSPORTER 1; NADP(+) DEPENDENT GLUTAMATE DEHYDROGENASE 1; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG; WHI2 PROTEIN; ABIETANE DERIVATIVE; CARNOSIC ACID; DITERPENE; MANOYL OXIDE; MEVALONIC ACID; TERPENE; TERPENE SYNTHASE; TRANSFERASE;

ARTICLE; BIOSYNTHESIS; CHASSIS ENGINEERING; CONTROLLED STUDY; ENGINEERING; ENZYME ACTIVITY; GENE DELETION; HETEROZYGOTE; HYDROXYLATION; NONHUMAN; OXIDATION; SALVIA; SALVIA POMIFERA; YEAST; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; KINETICS; METABOLISM; OXIDATION REDUCTION REACTION; SACCHAROMYCES CEREVISIAE;

ALKYL AND ARYL TRANSFERASES; BIOSYNTHETIC PATHWAYS; COLFORSIN; DITERPENES; DITERPENES, ABIETANE; KINETICS; MEVALONIC ACID; OXIDATION-REDUCTION; SACCHAROMYCES CEREVISIAE; SUBSTRATE SPECIFICITY; TERPENES;

EID: 84959192827     PISSN: None     EISSN: 14752859     Source Type: Journal    
DOI: 10.1186/s12934-016-0440-8     Document Type: Article

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