-
1
-
-
84863078767
-
Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer
-
Baselga J, Campone M, Piccart M, et al: Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer.NEngl JMed 366:520-529, 2012
-
(2012)
NEngl JMed
, vol.366
, pp. 520-529
-
-
Baselga, J.1
Campone, M.2
Piccart, M.3
-
2
-
-
35948964043
-
Different prognostic roles of mutations in the helical and kinase domains of the PIK3CA gene in breast carcinomas
-
Barbareschi M, Buttitta F, Felicioni L, et al: Different prognostic roles of mutations in the helical and kinase domains of the PIK3CA gene in breast carcinomas. Clin Cancer Res 13:6064-6069, 2007
-
(2007)
Clin Cancer Res
, vol.13
, pp. 6064-6069
-
-
Barbareschi, M.1
Buttitta, F.2
Felicioni, L.3
-
3
-
-
84877028141
-
Comprehensive molecular portraits of human breast tumours
-
Cancer Genome Atlas Network: Comprehensive molecular portraits of human breast tumours. Nature 490:61-70, 2012
-
(2012)
Nature
, vol.490
, pp. 61-70
-
-
Cancer Genome Atlas Network1
-
4
-
-
84864395175
-
The favorable impact of PIK3CA mutations on survival: An analysis of 2587 patients with breast cancer
-
Dumont AG, Dumont SN, Trent JC: The favorable impact of PIK3CA mutations on survival: An analysis of 2587 patients with breast cancer. Chin J Cancer 31:327-334, 2012
-
(2012)
Chin J Cancer
, vol.31
, pp. 327-334
-
-
Dumont, A.G.1
Dumont, S.N.2
Trent, J.C.3
-
5
-
-
84862584058
-
Whole-genome analysis informs breast cancer response to aromatase inhibition
-
Ellis MJ, Ding L, Shen D, et al: Whole-genome analysis informs breast cancer response to aromatase inhibition. Nature 486:353-360, 2012
-
(2012)
Nature
, vol.486
, pp. 353-360
-
-
Ellis, M.J.1
Ding, L.2
Shen, D.3
-
6
-
-
83455162719
-
Variants on the promoter region of PTEN affect breast cancer progression and patient survival
-
Heikkinen T, Greco D, Pelttari LM, et al: Variants on the promoter region of PTEN affect breast cancer progression and patient survival. Breast Cancer Res 13:R130, 2011
-
(2011)
Breast Cancer Res
, vol.13
, pp. R130
-
-
Heikkinen, T.1
Greco, D.2
Pelttari, L.M.3
-
7
-
-
84877796247
-
Comprehensive analysis of PTEN status in breast carcinomas
-
Jones N, Bonnet F, Sfar S, et al: Comprehensive analysis of PTEN status in breast carcinomas. Int J Cancer 133:323-334, 2013
-
(2013)
Int J Cancer
, vol.133
, pp. 323-334
-
-
Jones, N.1
Bonnet, F.2
Sfar, S.3
-
8
-
-
77953422867
-
PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer
-
Loi S, Haibe-Kains B, Majjaj S, et al: PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer. Proc Natl Acad Sci U S A 107:10208-10213, 2010
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 10208-10213
-
-
Loi, S.1
Haibe-Kains, B.2
Majjaj, S.3
-
9
-
-
84861576201
-
The landscape of cancer genes and mutational processes in breast cancer
-
Stephens PJ, Tarpey PS, Davies H, et al: The landscape of cancer genes and mutational processes in breast cancer. Nature 486:400-404, 2012
-
(2012)
Nature
, vol.486
, pp. 400-404
-
-
Stephens, P.J.1
Tarpey, P.S.2
Davies, H.3
-
10
-
-
84887491073
-
Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing
-
Frampton GM, Fichtenholtz A, Otto GA, et al: Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing. Nat Biotechnol 31:1023-1031, 2013
-
(2013)
Nat Biotechnol
, vol.31
, pp. 1023-1031
-
-
Frampton, G.M.1
Fichtenholtz, A.2
Otto, G.A.3
-
11
-
-
84888391516
-
ESR1 ligandbinding domain mutations in hormone-resistant breast cancer
-
Toy W, Shen Y, Won H, et al: ESR1 ligandbinding domain mutations in hormone-resistant breast cancer. Nat Genet 45:1439-1445, 2013
-
(2013)
Nat Genet
, vol.45
, pp. 1439-1445
-
-
Toy, W.1
Shen, Y.2
Won, H.3
-
12
-
-
84867333656
-
Genome sequencing identifies a basis for everolimus sensitivity
-
Iyer G, Hanrahan AJ, Milowsky MI, et al: Genome sequencing identifies a basis for everolimus sensitivity. Science 338:221, 2012
-
(2012)
Science
, vol.338
, pp. 221
-
-
Iyer, G.1
Hanrahan, A.J.2
Milowsky, M.I.3
-
13
-
-
84898732516
-
Tumor genetic analyses of patientswith metastatic renal cell carcinoma and extended benefit from mTOR inhibitor therapy
-
Voss MH, Hakimi AA, Pham CG, et al: Tumor genetic analyses of patientswith metastatic renal cell carcinoma and extended benefit from mTOR inhibitor therapy. Clin Cancer Res 20:1955-1964, 2014
-
(2014)
Clin Cancer Res
, vol.20
, pp. 1955-1964
-
-
Voss, M.H.1
Hakimi, A.A.2
Pham, C.G.3
-
14
-
-
84906805668
-
Luminal B breast cancer: Molecular characterization, clinical management, and future perspectives
-
Ades F, Zardavas D, Bozovic-Spasojevic I, et al: Luminal B breast cancer: Molecular characterization, clinical management, and future perspectives. J Clin Oncol 32:2794-2803, 2014
-
(2014)
J Clin Oncol
, vol.32
, pp. 2794-2803
-
-
Ades, F.1
Zardavas, D.2
Bozovic-Spasojevic, I.3
-
15
-
-
33748286796
-
A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers
-
Carter SL, Eklund AC, Kohane IS, et al: A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers. Nat Genet 38:1043-1048, 2006
-
(2006)
Nat Genet
, vol.38
, pp. 1043-1048
-
-
Carter, S.L.1
Eklund, A.C.2
Kohane, I.S.3
-
16
-
-
0037837441
-
Chromosomal instability rather than p53 mutation is associated with response to neoadjuvant cisplatinbased chemotherapy in gastric carcinoma
-
Ott K, Vogelsang H, Mueller J, et al: Chromosomal instability rather than p53 mutation is associated with response to neoadjuvant cisplatinbased chemotherapy in gastric carcinoma. Clin Cancer Res 9:2307-2315, 2003
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2307-2315
-
-
Ott, K.1
Vogelsang, H.2
Mueller, J.3
-
17
-
-
84874458031
-
The CIN4 chromosomal instability qPCR classifier defines tumor aneuploidy and stratifies outcome in grade 2 breast cancer
-
Szasz AM, Li Q, Eklund AC, et al: The CIN4 chromosomal instability qPCR classifier defines tumor aneuploidy and stratifies outcome in grade 2 breast cancer. PLoS One 8:e56707, 2013
-
(2013)
PLoS One
, vol.8
-
-
Szasz, A.M.1
Li, Q.2
Eklund, A.C.3
-
18
-
-
84858842073
-
Tumor genetic testing for patient selection in phase i clinical trials: The case of PI3K inhibitors
-
Juric D, Baselga J: Tumor genetic testing for patient selection in phase I clinical trials: The case of PI3K inhibitors. J Clin Oncol 30:765-766, 2012
-
(2012)
J Clin Oncol
, vol.30
, pp. 765-766
-
-
Juric, D.1
Baselga, J.2
-
19
-
-
66849136781
-
Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer
-
Baselga J, Semiglazov V, van Dam P, et al: Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer. J Clin Oncol 27:2630-2637, 2009
-
(2009)
J Clin Oncol
, vol.27
, pp. 2630-2637
-
-
Baselga, J.1
Semiglazov, V.2
Van Dam, P.3
-
20
-
-
84859169877
-
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
-
Barretina J, Caponigro G, Stransky N, et al: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 483: 603-607, 2012
-
(2012)
Nature
, vol.483
, pp. 603-607
-
-
Barretina, J.1
Caponigro, G.2
Stransky, N.3
-
21
-
-
84866544615
-
Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110alpha (PIK3CA)
-
Burke JE, Perisic O, Masson GR, et al: Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110alpha (PIK3CA). Proc Natl Acad Sci U S A 109:15259-15264, 2012
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 15259-15264
-
-
Burke, J.E.1
Perisic, O.2
Masson, G.R.3
-
22
-
-
84864509652
-
FGFR1 is amplified during the progression of in situ to invasive breast carcinoma
-
Jang MH, Kim EJ, Choi Y, et al: FGFR1 is amplified during the progression of in situ to invasive breast carcinoma. Breast Cancer Res 14:R115, 2012
-
(2012)
Breast Cancer Res
, vol.14
, pp. R115
-
-
Jang, M.H.1
Kim, E.J.2
Choi, Y.3
-
23
-
-
77950278598
-
FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer
-
Turner N, Pearson A, Sharpe R, et al: FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer. Cancer Res 70:2085-2094, 2010
-
(2010)
Cancer Res
, vol.70
, pp. 2085-2094
-
-
Turner, N.1
Pearson, A.2
Sharpe, R.3
-
24
-
-
80051558985
-
High-resolution genomic analysis of the 11q13 amplicon in breast cancers identifies synergy with 8p12 amplification, involving the mTOR targets S6K2 and 4EBP1
-
Karlsson E, Waltersson MA, Bostner J, et al: High-resolution genomic analysis of the 11q13 amplicon in breast cancers identifies synergy with 8p12 amplification, involving the mTOR targets S6K2 and 4EBP1. Genes Chromosomes Cancer 50:775-787, 2011
-
(2011)
Genes Chromosomes Cancer
, vol.50
, pp. 775-787
-
-
Karlsson, E.1
Waltersson, M.A.2
Bostner, J.3
-
25
-
-
67349202517
-
Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate with two major pathways in oncogenesis
-
Kwek SS, Roy R, Zhou H, et al: Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate with two major pathways in oncogenesis. Oncogene 28:1892-1903, 2009
-
(2009)
Oncogene
, vol.28
, pp. 1892-1903
-
-
Kwek, S.S.1
Roy, R.2
Zhou, H.3
-
26
-
-
33947422035
-
Coamplification of 8p12 and 11q13 in breast cancers is not the result of a single genomic event
-
Paterson AL, Pole JC, Blood KA, et al: Coamplification of 8p12 and 11q13 in breast cancers is not the result of a single genomic event. Genes Chromosomes Cancer 46:427-439, 2007
-
(2007)
Genes Chromosomes Cancer
, vol.46
, pp. 427-439
-
-
Paterson, A.L.1
Pole, J.C.2
Blood, K.A.3
-
27
-
-
84879859652
-
Targeting FGFR with dovitinib (TKI258): Preclinical and clinical data in breast cancer
-
Andre F, Bachelot T, Campone M, et al: Targeting FGFR with dovitinib (TKI258): Preclinical and clinical data in breast cancer. Clin Cancer Res 19: 3693-3702, 2013
-
(2013)
Clin Cancer Res
, vol.19
, pp. 3693-3702
-
-
Andre, F.1
Bachelot, T.2
Campone, M.3
-
28
-
-
84874088896
-
Significant antitumor activity of E-3810, a novel FGFR and VEGFR inhibitor, in patients with FGFR1 amplified breast cancer
-
(abstr 319O)
-
Dienstmann R, Andre F, Soria J, et al: Significant antitumor activity of E-3810, a novel FGFR and VEGFR inhibitor, in patients with FGFR1 amplified breast cancer. Ann Oncol 23:ix116-ix117, 2012 (abstr 319O)
-
(2012)
Ann Oncol
, vol.23
, pp. ix116-ix117
-
-
Dienstmann, R.1
Andre, F.2
Soria, J.3
-
29
-
-
78049261497
-
Targeting chromosomal instability and tumour heterogeneity in HER2-positive breast cancer
-
Burrell RA, Juul N, Johnston SR, et al: Targeting chromosomal instability and tumour heterogeneity in HER2-positive breast cancer. J Cell Biochem 111:782-790, 2010
-
(2010)
J Cell Biochem
, vol.111
, pp. 782-790
-
-
Burrell, R.A.1
Juul, N.2
Johnston, S.R.3
-
30
-
-
84878546031
-
Taxane benefit in breast cancer - A role for grade and chromosomal stability
-
A'Hern RP, Jamal-Hanjani M, Szasz AM, et al: Taxane benefit in breast cancer-a role for grade and chromosomal stability. Nat Rev Clin Oncol 10: 357-364, 2013
-
(2013)
Nat Rev Clin Oncol
, vol.10
, pp. 357-364
-
-
A'Hern, R.P.1
Jamal-Hanjani, M.2
Szasz, A.M.3
-
31
-
-
39749108733
-
High-resolution aCGH and expression profiling identifies a novel genomic subtype of ER negative breast cancer
-
Chin SF, Teschendorff AE, Marioni JC, et al: High-resolution aCGH and expression profiling identifies a novel genomic subtype of ER negative breast cancer. Genome Biol 8:R215, 2007
-
(2007)
Genome Biol
, vol.8
, pp. R215
-
-
Chin, S.F.1
Teschendorff, A.E.2
Marioni, J.C.3
-
32
-
-
84879266916
-
A novel measure of chromosome instability can account for prognostic difference in multiple myeloma
-
Chung TH, Mulligan G, Fonseca R, et al: A novel measure of chromosome instability can account for prognostic difference in multiple myeloma. PLoS One 8:e66361, 2013
-
(2013)
PLoS One
, vol.8
-
-
Chung, T.H.1
Mulligan, G.2
Fonseca, R.3
-
33
-
-
84856513068
-
Mitotic checkpoints and chromosome instability are strong predictors of clinical outcome in gastrointestinal stromal tumors
-
Lagarde P, Perot G, Kauffmann A, et al: Mitotic checkpoints and chromosome instability are strong predictors of clinical outcome in gastrointestinal stromal tumors. Clin Cancer Res 18: 826-838, 2012
-
(2012)
Clin Cancer Res
, vol.18
, pp. 826-838
-
-
Lagarde, P.1
Perot, G.2
Kauffmann, A.3
-
34
-
-
77954535843
-
Validated prediction of clinical outcome in sarcomas and multiple types of cancer on the basis of a gene expression signature related to genome complexity
-
Chibon F, Lagarde P, Salas S, et al: Validated prediction of clinical outcome in sarcomas and multiple types of cancer on the basis of a gene expression signature related to genome complexity. Nat Med 16:781-787, 2010
-
(2010)
Nat Med
, vol.16
, pp. 781-787
-
-
Chibon, F.1
Lagarde, P.2
Salas, S.3
-
35
-
-
84875466344
-
Chromosome instability accounts for reverse metastatic outcomes of pediatric and adult synovial sarcomas
-
Lagarde P, Przybyl J, Brulard C, et al: Chromosome instability accounts for reverse metastatic outcomes of pediatric and adult synovial sarcomas. J Clin Oncol 31:608-615, 2013
-
(2013)
J Clin Oncol
, vol.31
, pp. 608-615
-
-
Lagarde, P.1
Przybyl, J.2
Brulard, C.3
-
36
-
-
0031669861
-
P53 mutations and DNA ploidy in colorectal adenocarcinomas
-
Campomenosi P, Assereto P, Bogliolo M, et al: p53 mutations and DNA ploidy in colorectal adenocarcinomas. Anal Cell Pathol 17:1-12, 1998
-
(1998)
Anal Cell Pathol
, vol.17
, pp. 1-12
-
-
Campomenosi, P.1
Assereto, P.2
Bogliolo, M.3
-
37
-
-
77950521355
-
P53 suppresses structural chromosome instability after mitotic arrest in human cells
-
Dalton WB, Yu B, Yang VW: p53 suppresses structural chromosome instability after mitotic arrest in human cells. Oncogene 29:1929-1940, 2010
-
(2010)
Oncogene
, vol.29
, pp. 1929-1940
-
-
Dalton, W.B.1
Yu, B.2
Yang, V.W.3
-
38
-
-
0034691217
-
Chromosome instability contributes to loss of heterozygosity inmice lacking p53
-
Shao C, Deng L, Henegariu O, et al: Chromosome instability contributes to loss of heterozygosity inmice lacking p53. Proc Natl Acad Sci U S A 97:7405-7410, 2000
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 7405-7410
-
-
Shao, C.1
Deng, L.2
Henegariu, O.3
|