Chromosome instability accounts for reverse metastatic outcomes of pediatric and adult synovial sarcomas

Journal of Clinical Oncology

Volumn 31, Issue 5, 2013, Pages 608-615

  Lagarde, Pauline ^a,b   Przybyl, Joanna ^f,g   Brulard, Céline ^a   Pérot, Gaëlle ^a,b   Pierron, Gaelle ^d   Delattre, Olivier ^d   Sciot, Raf ^g   Wozniak, Agnieszka ^g   Schöffski, Patrick ^g   Terrier, Philippe ^e   Neuville, Agnès ^a,b   Coindre, Jean Michel ^a,b,c   Italiano, Antoine ^b   Orbach, Daniel ^d   Debiec Rychter, Maria ^g   Chibon, Frédéric ^a,b  

^a INSERM   (France)

^b INSTITUT BERGONIÉ   (France)

^c UNIVERSITÉ DE BORDEAUX   (France)

^d INSTITUT CURIE   (France)

^e INSTITUT GUSTAVE ROUSSY   (France)

^f Final approval of the article   (Poland)

^g UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CANCER PROGNOSIS; CHROMOSOMAL INSTABILITY; CLINICAL EFFECTIVENESS; FEMALE; GENE DOSAGE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION; HUMAN; HUMAN GENOME; MAJOR CLINICAL STUDY; MALE; METASTASIS; PRIORITY JOURNAL; SYNOVIAL SARCOMA;

ADOLESCENT; ADULT; CARRIER PROTEINS; CELL CYCLE PROTEINS; CHILD; CHROMOSOMAL INSTABILITY; DNA COPY NUMBER VARIATIONS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KAPLAN-MEIER ESTIMATE; KINESIN; MALE; NUCLEAR PROTEINS; ONCOGENE PROTEINS; PROGNOSIS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SARCOMA, SYNOVIAL; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84875466344     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2012.46.0147     Document Type: Article

References (33)

1. Fletcher CD: The evolving classification of soft tissue tumours: An update based on the new WHO classification. Histopathology 48: 3-12, 2006
2. Sultan I, Rodriguez-Galindo C, Saab R, et al: Comparing children and adults with synovial sarcoma in the Surveillance, Epidemiology, and End Results program, 1983 to 2005: An analysis of 1268 patients. Cancer 115: 3537-3547, 2009
3. Clark J, Rocques PJ, Crew AJ, et al: Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma. Nat Genet 7: 502-508, 1994 (Pubitemid 24308337)
4. Crew AJ, Clark J, Fisher C, et al: Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma. EMBO J 14: 2333-2340, 1995
5. Antonescu CR, Kawai A, Leung DH, et al: Strong association of SYT-SSX fusion type and morphologic epithelial differentiation in synovial sarcoma. Diagn Mol Pathol 9: 1-8, 2000 (Pubitemid 30131955)
6. Canter RJ, Qin LX, Maki RG, et al: A synovial sarcoma-specific preoperative nomogram supports a survival benefit to ifosfamide-based chemotherapy and improves risk stratification for patients. Clin Cancer Res 14: 8191-8197, 2008
7. Guillou L, Benhattar J, Bonichon F, et al: Histologic grade, but not SYT-SSX fusion type, is an important prognostic factor in patients with synovial sarcoma: A multicenter, retrospective analysis. J Clin Oncol 22: 4040-4050, 2004 (Pubitemid 41185173)
8. Kawai A, Woodruff J, Healey JH, et al: SYTSSX gene fusion as a determinant of morphology and prognosis in synovial sarcoma. N Engl J Med 338: 153-160, 1998 (Pubitemid 28041862)
9. Nakagawa Y, Numoto K, Yoshida A, et al: Chromosomal and genetic imbalances in synovial sarcoma detected by conventional and microarray comparative genomic hybridization. J Cancer Res Clin Oncol 132: 444-450, 2006
10. Skytting BT, Szymanska J, Aalto Y, et al: Clinical importance of genomic imbalances in synovial sarcoma evaluated by comparative genomic hybridization. Cancer Genet Cytogenet 115: 39-46, 1999 (Pubitemid 29505217)
11. Szymanska J, Serra M, Skytting B, et al: Genetic imbalances in 67 synovial sarcomas evaluated by comparative genomic hybridization. Genes Chromosomes Cancer 23: 213-219, 1998 (Pubitemid 28465637)
12. Chibon F, Lagarde P, Salas S, et al: Validated prediction of clinical outcome in sarcomas and multiple types of cancer on the basis of a gene expression signature related to genome complexity. Nat Med 16: 781-787, 2010
13. Lagarde P, Pérot G, Kauffmann A, et al: Mitotic checkpoints and chromosome instability are strong predictors of clinical outcome in gastrointestinal stromal tumors. Clin Cancer Res 18: 826-838, 2012
14. Pérot G, Chibon F, Montero A, et al: Constant p53 pathway inactivation in a large series of soft tissue sarcomas with complex genetics. Am J Pathol 177: 2080-2090, 2010
15. Panagopoulos I, Mertens F, Isaksson M, et al: Clinical impact of molecular and cytogenetic findings in synovial sarcoma. Genes Chromosomes Cancer 31: 362-372, 2001 (Pubitemid 32622713)
16. Pérot G, Croce S, Ribeiro A, et al: MED12 alterations in both human benign and malignant uterine soft tissue tumors. PLoS One 7:e40015, 2012
17. Bertucci F, Finetti P, Sabatier R, et al: The CINSARC signature: Prognostic and predictive of response to chemotherapy? Cell Cycle 9: 4025-4027, 2010
18. Allander SV, Illei PB, Chen Y, et al: Expression profiling of synovial sarcoma by cDNA microarrays: Association of ERBB2, IGFBP2, and ELF3 with epithelial differentiation. Am J Pathol 161: 1587-1595, 2002 (Pubitemid 35265519)
19. Fernebro J, Francis P, Edén P, et al: Gene expression profiles relate to SS18/SSX fusion type in synovial sarcoma. Int J Cancer 118: 1165-1172, 2006 (Pubitemid 43185603)
20. Francis P, Namlos HM, Muller C, et al: Diagnostic and prognostic gene expression signatures in 177 soft tissue sarcomas: Hypoxia-induced transcription profile signifies metastatic potential. BMC Genomics 8:73, 2007
21. Nagayama S, Katagiri T, Tsunoda T, et al: Genome-wide analysis of gene expression in synovial sarcomas using a cDNA microarray. Cancer Res 62: 5859-5866, 2002 (Pubitemid 35204746)
22. Nakayama R, Mitani S, Nakagawa T, et al: Gene expression profiling of synovial sarcoma: Distinct signature of poorly differentiated type. Am J Surg Pathol 34: 1599-1607, 2010
23. Nielsen TO, West RB, Linn SC, et al: Molecular characterisation of soft tissue tumours: A gene expression study. Lancet 359: 1301-1307, 2002 (Pubitemid 34310636)
24. Corson TW, Zhu CQ, Lau SK, et al: KIF14 messenger RNA expression is independently prognostic for outcome in lung cancer. Clin Cancer Res 13: 3229-3234, 2007 (Pubitemid 46944906)
25. Corson TW, Gallie BL: KIF14 mRNA expression is a predictor of grade and outcome in breast cancer. Int J Cancer 119: 1088-1094, 2006 (Pubitemid 44116918)
26. Thériault BL, Pajovic S, Bernardini MQ, et al: Kinesin family member 14: an independent prognostic marker and potential therapeutic target for ovarian cancer. Int J Cancer 130: 1844-1854, 2012
27. Kim TM, Yim SH, Shin SH, et al: Clinical implication of recurrent copy number alterations in hepatocellular carcinoma and putative oncogenes in recurrent gains on 1q. Int J Cancer 123: 2808-2815, 2008
28. Gruneberg U, Neef R, Li X, et al: KIF14 and citron kinase act together to promote efficient cytokinesis. J Cell Biol 172: 363-372, 2006 (Pubitemid 43187933)
29. Carleton M, Mao M, Biery M, et al: RNA interference-mediated silencing of mitotic kinesin KIF14 disrupts cell cycle progression and induces cytokinesis failure. Mol Cell Biol 26: 3853-3863, 2006 (Pubitemid 43726402)
30. Balogh Z, Szemlaky Z, Szendroi M, et al: Correlation between DNA ploidy, metaphase highresolution comparative genomic hybridization results and clinical outcome of synovial sarcoma. Diagn Pathol 6:107, 2011
31. Trinkle-Mulcahy L, Andersen J, Lam YW, et al: Repo-Man recruits PP1 gamma to chromatin and is essential for cell viability. J Cell Biol 172: 679-692, 2006
32. Vagnarelli P, Ribeiro S, Sennels L, et al: Repo- Man coordinates chromosomal reorganization with nuclear envelope reassembly during mitotic exit. Dev Cell 21: 328-342, 2011
33. Wurzenberger C, Held M, Lampson MA, et al: Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores. J Cell Biol 198: 173-183, 2012