메뉴 건너뛰기




Volumn 29, Issue 13, 2010, Pages 1929-1940

P53 suppresses structural chromosome instability after mitotic arrest in human cells

Author keywords

Cell cycle arrest; Chromosomal instability; DNA damage; Mitotic checkpoint; P53; Polypoidization

Indexed keywords

BLEBBISTATIN; DIHYDROCYTOCHALASIN B; MICRORNA; NOCODAZOLE; PROTEIN P53;

EID: 77950521355     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.477     Document Type: Article
Times cited : (36)

References (76)
  • 1
    • 0034767429 scopus 로고    scopus 로고
    • Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G
    • Andreassen PR, Lohez OD, Lacroix FB, Margolis RL. (2001). Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G. Mol Biol Cell 12: 1315-1328.
    • (2001) Mol Biol Cell , vol.12 , pp. 1315-1328
    • Andreassen, P.R.1    Lohez, O.D.2    Lacroix, F.B.3    Margolis, R.L.4
  • 2
    • 0034632717 scopus 로고    scopus 로고
    • Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
    • DOI 10.1038/35020592
    • Artandi SE, Chang S, Lee SL, Alson S, Gottlieb GJ, Chin L et al. (2000). Telomere dysfunction promotes non-reciprocal transloca-tions and epithelial cancers in mice. Nature 406: 641-645. (Pubitemid 30641052)
    • (2000) Nature , vol.406 , Issue.6796 , pp. 641-645
    • Artandl, S.E.1    Chang, S.2    Lee, S.-L.3    Alson, S.4    Gottlieb, G.J.5    Chin, L.6    DePinho, R.A.7
  • 3
    • 33749334018 scopus 로고    scopus 로고
    • A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization
    • DOI 10.1101/gad.1447006
    • Aylon Y, Michael D, Shmueli A, Yabuta N, Nojima H, Oren M. (2006). A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization. Genes Dev 20: 2687-2700. (Pubitemid 44498379)
    • (2006) Genes and Development , vol.20 , Issue.19 , pp. 2687-2700
    • Aylon, Y.1    Michael, D.2    Shmueli, A.3    Yabuta, N.4    Nojima, H.5    Oren, M.6
  • 5
    • 0025650332 scopus 로고
    • Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: Aneuploidy and immortalization
    • Bischoff FZ, Yim SO, Pathak S, Grant G, Siciliano MJ, Giovanella BC et al. (1990). Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: aneuploidy and immortalization. Cancer Res 50: 7979-7984.
    • (1990) Cancer Res , vol.50 , pp. 7979-7984
    • Bischoff, F.Z.1    Yim, S.O.2    Pathak, S.3    Grant, G.4    Siciliano, M.J.5    Giovanella, B.C.6
  • 6
    • 33646437275 scopus 로고    scopus 로고
    • Prolonged mitosis versus tetraploid checkpoint: How p53 measures the duration of mitosis
    • Blagosklonny MV. (2006). Prolonged mitosis versus tetraploid checkpoint: how p53 measures the duration of mitosis. Cell Cycle 5: 971-975.
    • (2006) Cell Cycle , vol.5 , pp. 971-975
    • Blagosklonny, M.V.1
  • 7
    • 0029099361 scopus 로고
    • Spontaneous and ionizing radiation-induced chromosomal abnormalities in p53-deficient mice
    • Bouffler SD, Kemp CJ, Balmain A, Cox R. (1995). Spontaneous and ionizing radiation-induced chromosomal abnormalities in p53-deficient mice. Cancer Res 55: 3883-3889.
    • (1995) Cancer Res , vol.55 , pp. 3883-3889
    • Bouffler, S.D.1    Kemp, C.J.2    Balmain, A.3    Cox, R.4
  • 10
    • 0032701521 scopus 로고    scopus 로고
    • Disruption of p53 in human cancer cells alters the responses to therapeutic agents
    • Bunz F, Hwang PM, Torrance C, Waldman T, Zhang Y, Dillehay L et al. (1999). Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J Clin Invest 104: 263-269.
    • (1999) J Clin Invest , vol.104 , pp. 263-269
    • Bunz, F.1    Hwang, P.M.2    Torrance, C.3    Waldman, T.4    Zhang, Y.5    Dillehay, L.6
  • 12
    • 47049109949 scopus 로고    scopus 로고
    • The kinetics of p53 activation versus cyclin e accumulation underlies the relationship between the spindle-assembly checkpoint and the postmitotic checkpoint
    • Chan YW, On KF, Chan WM, Wong W, Siu HO, Hau PM et al. (2008). The kinetics of p53 activation versus cyclin E accumulation underlies the relationship between the spindle-assembly checkpoint and the postmitotic checkpoint. J Biol Chem 283: 15716-15723.
    • (2008) J Biol Chem , vol.283 , pp. 15716-15723
    • Chan, Y.W.1    On, K.F.2    Chan, W.M.3    Wong, W.4    Siu, H.O.5    Hau, P.M.6
  • 14
    • 0033669763 scopus 로고    scopus 로고
    • Specific patterns of chromosomal abnormalities are associated with RER status in sporadic colorectal cancer
    • Curtis LJ, Georgiades IB, White S, Bird CC, Harrison DJ, Wyllie AH. (2000). Specific patterns of chromosomal abnormalities are associated with RER status in sporadic colorectal cancer. J Pathol 192: 440-445.
    • (2000) J Pathol , vol.192 , pp. 440-445
    • Curtis, L.J.1    Georgiades, I.B.2    White, S.3    Bird, C.C.4    Harrison, D.J.5    Wyllie, A.H.6
  • 15
    • 37549010631 scopus 로고    scopus 로고
    • Human cancer cells commonly acquire DNA damage during mitotic arrest
    • Dalton WB, Nandan MO, Moore RT, Yang VW. (2007). Human cancer cells commonly acquire DNA damage during mitotic arrest. Cancer Res 67: 11487-11492.
    • (2007) Cancer Res , vol.67 , pp. 11487-11492
    • Dalton, W.B.1    Nandan, M.O.2    Moore, R.T.3    Yang, V.W.4
  • 16
    • 74949115115 scopus 로고    scopus 로고
    • The role of prolonged mitotic checkpoint activation in the formation and treatment of cancer
    • Dalton WB, Yang VW. (2009). The role of prolonged mitotic checkpoint activation in the formation and treatment of cancer. Future Oncol 5: 1363-1370.
    • (2009) Future Oncol , vol.5 , pp. 1363-1370
    • Dalton, W.B.1    Yang, V.W.2
  • 17
    • 0032903791 scopus 로고    scopus 로고
    • Chromosomal gains and losses in primary colorectal carcinomas detected by CGH and their associations with tumour DNA ploidy, genotypes and phenotypes
    • DOI 10.1038/sj.bjc.6690388
    • De Angelis PM, Clausen OP, Schjolberg A, Stokke T. (1999). Chromosomal gains and losses in primary colorectal carcinomas detected by CGH and their associations with tumour DNA ploidy, genotypes and phenotypes. Br J Cancer 80: 526-535. (Pubitemid 29213210)
    • (1999) British Journal of Cancer , vol.80 , Issue.3-4 , pp. 526-535
    • De Angelis, P.1    Clausen, O.P.F.2    Schjolberg, A.3    Stokke, T.4
  • 18
    • 0030929838 scopus 로고    scopus 로고
    • DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function
    • Di Leonardo A, Khan SH, Linke SP, Greco V, Seidita G, Wahl GM. (1997). DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function. Cancer Res 57: 1013-1019. (Pubitemid 27138591)
    • (1997) Cancer Research , vol.57 , Issue.6 , pp. 1013-1019
    • Leonardo, A.D.1    Khan, S.H.2    Linke, S.P.3    Greco, V.4    Seidita, G.5    Wahl, G.M.6
  • 20
    • 27144507868 scopus 로고    scopus 로고
    • Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells
    • DOI 10.1038/nature04217, PII N04217
    • Fujiwara T, Bandi M, Nitta M, Ivanova EV, Bronson RT, Pellman D. (2005). Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells. Nature 437: 1043-1047. (Pubitemid 41486987)
    • (2005) Nature , vol.437 , Issue.7061 , pp. 1043-1047
    • Fujiwara, T.1    Bandi, M.2    Nitta, M.3    Ivanova, E.V.4    Bronson, R.T.5    Pellman, D.6
  • 22
    • 35548935096 scopus 로고    scopus 로고
    • Limiting the proliferation of polyploid cells
    • DOI 10.1016/j.cell.2007.10.024, PII S0092867407013426
    • Ganem NJ, Pellman D. (2007). Limiting the proliferation of polyploid cells. Cell 131: 437-440. (Pubitemid 350007703)
    • (2007) Cell , vol.131 , Issue.3 , pp. 437-440
    • Ganem, N.J.1    Pellman, D.2
  • 23
  • 26
    • 0015256217 scopus 로고
    • Chromosome pulverization in micronuclei induced by tritiated thymidine
    • Ikeuchi T, Weinfeld H, Sandberg AA. (1972). Chromosome pulverization in micronuclei induced by tritiated thymidine. J Cell Biol 52: 97-104.
    • (1972) J Cell Biol , vol.52 , pp. 97-104
    • Ikeuchi, T.1    Weinfeld, H.2    Sandberg, A.A.3
  • 28
    • 0014105051 scopus 로고
    • Chromosome pulverization in human binucleate cells following colcemid treatment
    • Kato H, Sandberg AA. (1967). Chromosome pulverization in human binucleate cells following colcemid treatment. J Cell Biol 34: 35-45.
    • (1967) J Cell Biol , vol.34 , pp. 35-45
    • Kato, H.1    Sandberg, A.A.2
  • 29
    • 20544463659 scopus 로고    scopus 로고
    • Partial downregulation of MAD1 causes spindle checkpoint inactivation and aneuploidy, but does not confer resistance towards taxol
    • DOI 10.1038/sj.onc.1208589
    • Kienitz A, Vogel C, Morales I, Muller R, Bastians H. (2005). Partial downregulation of MAD1 causes spindle checkpoint inactivation and aneuploidy, but does not confer resistance towards taxol. Oncogene 24: 4301-4310. (Pubitemid 40961783)
    • (2005) Oncogene , vol.24 , Issue.26 , pp. 4301-4310
    • Kienitz, A.1    Vogel, C.2    Morales, I.3    Muller, R.4    Bastians, H.5
  • 31
    • 23944504305 scopus 로고    scopus 로고
    • TP53 mutations are associated with a particular pattern of genomic imbalances in breast carcinomas
    • DOI 10.1002/path.1812
    • Kleivi K, Diep CB, Pandis N, Heim S, Teixeira MR, Lothe RA. (2005). TP53 mutations are associated with a particular pattern of genomic imbalances in breast carcinomas. J Pathol 207: 14-19. (Pubitemid 41200709)
    • (2005) Journal of Pathology , vol.207 , Issue.1 , pp. 14-19
    • Kleivi, K.1    Diep, C.B.2    Pandis, N.3    Heim, S.4    Teixeira, M.R.5    Lothe, R.A.6
  • 33
    • 0029005842 scopus 로고
    • Genomic stability and wild-type p53 function of lymphoblastoid cells with germ-line p53 mutation
    • Lalle P, Moyret-Lalle C, Wang Q, Vialle JM, Navarro C, Bressac-de Paillerets B et al. (1995). Genomic stability and wild-type p53 function of lymphoblastoid cells with germ-line p53 mutation. Oncogene 10: 2447-2454.
    • (1995) Oncogene , vol.10 , pp. 2447-2454
    • Lalle, P.1    Moyret-Lalle, C.2    Wang, Q.3    Vialle, J.M.4    Navarro, C.5    Bressac-De Paillerets, B.6
  • 34
    • 0031931414 scopus 로고    scopus 로고
    • Characterization of the p53-dependent postmitotic checkpoint following spindle disruption
    • Lanni JS, Jacks T. (1998). Characterization of the p53-dependent postmitotic checkpoint following spindle disruption. Mol Cell Biol 18: 1055-1064. (Pubitemid 28063440)
    • (1998) Molecular and Cellular Biology , vol.18 , Issue.2 , pp. 1055-1064
    • Lanni, J.S.1    Jacks, T.2
  • 35
    • 0029964158 scopus 로고    scopus 로고
    • 1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage
    • Linke SP, Clarkin KC, Di Leonardo A, Tsou A, Wahl GM. (1996). A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. Genes Dev 10: 934-947. (Pubitemid 26138705)
    • (1996) Genes and Development , vol.10 , Issue.8 , pp. 934-947
    • Linke, S.P.1    Clarkin, K.C.2    Di Leonardo, A.3    Tsou, A.4    Wahl, G.M.5
  • 36
    • 62449278758 scopus 로고    scopus 로고
    • Targeting p53 for enhanced radio-and chemo-sensitivity
    • Lu C, El-Deiry WS. (2009). Targeting p53 for enhanced radio-and chemo-sensitivity. Apoptosis 14: 597-606.
    • (2009) Apoptosis , vol.14 , pp. 597-606
    • Lu, C.1    El-Deiry, W.S.2
  • 38
    • 0029658664 scopus 로고    scopus 로고
    • Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage
    • Minn AJ, Boise LH, Thompson CB. (1996). Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage. Genes Dev 10: 2621-2631.
    • (1996) Genes Dev , vol.10 , pp. 2621-2631
    • Minn, A.J.1    Boise, L.H.2    Thompson, C.B.3
  • 40
    • 33746558541 scopus 로고    scopus 로고
    • Telomere dysfunction and loss of p53 cooperate in defective mitotic segregation of chromosomes in cancer cells
    • DOI 10.1038/sj.onc.1209486, PII 1209486
    • Pantic M, Zimmermann S, Daly E, Opitz OG, Popp S, Boukamp P et al. (2006). Telomere dysfunction and loss of p53 cooperate in defective mitotic segregation of chromosomes in cancer cells. Oncogene 25: 4413-4420. (Pubitemid 44141629)
    • (2006) Oncogene , vol.25 , Issue.32 , pp. 4413-4420
    • Pantic, M.1    Zimmermann, S.2    El Daly, H.3    Opitz, O.G.4    Popp, S.5    Boukamp, P.6    Martens, U.M.7
  • 41
    • 29144456625 scopus 로고    scopus 로고
    • Securin is not required for chromosomal stability in human cells
    • DOI 10.1371/journal.pbio.0030416, e416
    • Pfleghaar K, Heubes S, Cox J, Stemmann O, Speicher MR. (2005). Securin is not required for chromosomal stability in human cells. PLoS Biol 3: e416. (Pubitemid 41796339)
    • (2005) PLoS Biology , vol.3 , Issue.12 , pp. 1-8
    • Pfleghaar, K.1    Heubes, S.2    Cox, J.3    Stemmann, O.4    Speicher, M.R.5
  • 42
    • 33846209076 scopus 로고    scopus 로고
    • Sustained mitotic block elicits DNA breaks: One-step alteration of ploidy and chromosome integrity in mammalian cells
    • DOI 10.1038/sj.onc.1209787, PII 1209787
    • Quignon F, Rozier L, Lachages AM, Bieth A, Simili M, Debatisse M. (2007). Sustained mitotic block elicits DNA breaks: one-step alteration of ploidy and chromosome integrity in mammalian cells. Oncogene 26: 165-172. (Pubitemid 46095728)
    • (2007) Oncogene , vol.26 , Issue.2 , pp. 165-172
    • Quignon, F.1    Rozier, L.2    Lachages, A.-M.3    Bieth, A.4    Simili, M.5    Debatisse, M.6
  • 44
    • 7744233719 scopus 로고    scopus 로고
    • Stuck in division or passing through: What happens when cells cannot satisfy the spindle assembly checkpoint
    • DOI 10.1016/j.devcel.2004.09.002, PII S1534580704003016
    • Rieder CL, Maiato H. (2004). Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpoint. Dev Cell 7: 637-651. (Pubitemid 39462685)
    • (2004) Developmental Cell , vol.7 , Issue.5 , pp. 637-651
    • Rieder, C.L.1    Maiato, H.2
  • 45
    • 0032861343 scopus 로고    scopus 로고
    • Megabase chromatin domains involved in DNA double-strand breaks in vivo
    • DOI 10.1083/jcb.146.5.905
    • Rogakou EP, Boon C, Redon C, Bonner WM. (1999). Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol 146: 905-916. (Pubitemid 29430435)
    • (1999) Journal of Cell Biology , vol.146 , Issue.5 , pp. 905-915
    • Rogakou, E.P.1    Boon, C.2    Redon, C.3    Bonner, W.M.4
  • 46
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-stranded breaks induce histone H2AX phosphoryla-tion on serine 139
    • Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. (1998). DNA double-stranded breaks induce histone H2AX phosphoryla-tion on serine 139. J Biol Chem 273: 5858-5868.
    • (1998) J Biol Chem , vol.273 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4    Bonner, W.M.5
  • 47
    • 0017252257 scopus 로고
    • Classification and relationships of induced chromosomal structual changes
    • Savage JR. (1976). Classification and relationships of induced chromosomal structual changes. J Med Genet 13: 103-122.
    • (1976) J Med Genet , vol.13 , pp. 103-122
    • Savage, J.R.1
  • 48
    • 44849127993 scopus 로고    scopus 로고
    • Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5
    • Shi J, Orth JD, Mitchison T. (2008). Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5. Cancer Res 68: 3269-3276.
    • (2008) Cancer Res , vol.68 , pp. 3269-3276
    • Shi, J.1    Orth, J.D.2    Mitchison, T.3
  • 49
    • 34247329362 scopus 로고    scopus 로고
    • P53 gain-of-function cancer mutants induce genetic instability by inactivating ATM
    • DOI 10.1038/ncb1571, PII NCB1571
    • Song H, Hollstein M, Xu Y. (2007). p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM. Nat Cell Biol 9: 573-580. (Pubitemid 46696539)
    • (2007) Nature Cell Biology , vol.9 , Issue.5 , pp. 573-580
    • Song, H.1    Hollstein, M.2    Xu, Y.3
  • 53
    • 2942642800 scopus 로고    scopus 로고
    • Triggering p53 after cytokinesis failure
    • Stukenberg PT. (2004). Triggering p53 after cytokinesis failure. J Cell Biol 165: 607-608.
    • (2004) J Cell Biol , vol.165 , pp. 607-608
    • Stukenberg, P.T.1
  • 56
    • 0025883614 scopus 로고
    • Monoclonal antibody CC-3 recognizes phosphoproteins in interphase and mitotic cells
    • Thibodeau A, Vincent M. (1991). Monoclonal antibody CC-3 recognizes phosphoproteins in interphase and mitotic cells. Exp Cell Res 195: 145-153. (Pubitemid 121006305)
    • (1991) Experimental Cell Research , vol.195 , Issue.1 , pp. 145-153
    • Thibodeau, A.1    Vincent, M.2
  • 57
    • 40849096242 scopus 로고    scopus 로고
    • Examining the link between chromosomal instability and aneuploidy in human cells
    • Thompson SL, Compton DA. (2008). Examining the link between chromosomal instability and aneuploidy in human cells. J Cell Biol 180: 665-672.
    • (2008) J Cell Biol , vol.180 , pp. 665-672
    • Thompson, S.L.1    Compton, D.A.2
  • 58
    • 13444261036 scopus 로고    scopus 로고
    • Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability
    • DOI 10.1242/jcs.01556
    • Tighe A, Johnson VL, Taylor SS. (2004). Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability. J Cell Sci 117: 6339-6353. (Pubitemid 40214561)
    • (2004) Journal of Cell Science , vol.117 , Issue.26 , pp. 6339-6353
    • Tighe, A.1    Johnson, V.L.2    Taylor, S.S.3
  • 59
    • 33845270990 scopus 로고    scopus 로고
    • Regulating the p53 pathway: In vitro hypotheses, in vivo veritas
    • DOI 10.1038/nrc2012, PII NRC2012
    • Toledo F, Wahl GM. (2006). Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat Rev Cancer 6: 909-923. (Pubitemid 44862676)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.12 , pp. 909-923
    • Toledo, F.1    Wahl, G.M.2
  • 60
    • 2942679807 scopus 로고    scopus 로고
    • Cell cycle progression after cleavage failure: Mammalian somatic cells do not possess a tetraploidy checkpoint
    • DOI 10.1083/jcb.200403014
    • Uetake Y, Sluder G. (2004). Cell cycle progression after cleavage failure: mammalian somatic cells do not possess a 'tetraploidy checkpoint'. J Cell Biol 165: 609-615. (Pubitemid 38765762)
    • (2004) Journal of Cell Biology , vol.165 , Issue.5 , pp. 609-615
    • Uetake, Y.1    Sluder, G.2
  • 61
    • 36549024010 scopus 로고    scopus 로고
    • Cell-Cycle Progression without an Intact Microtubule Cytoskeleton
    • DOI 10.1016/j.cub.2007.10.065, PII S0960982207021975
    • Uetake Y, Sluder G. (2007). Cell-cycle progression without an intact microtuble cytoskeleton. Curr Biol 17: 2081-2086. (Pubitemid 350180474)
    • (2007) Current Biology , vol.17 , Issue.23 , pp. 2081-2086
    • Uetake, Y.1    Sluder, G.2
  • 62
    • 0035289717 scopus 로고    scopus 로고
    • Chromosomal stability and the DNA double-stranded break connection
    • DOI 10.1038/35056049
    • van Gent DC, Hoeijmakers JH, Kanaar R. (2001). Chromosomal stability and the DNA double-stranded break connection. Nat Rev Genet 2: 196-206. (Pubitemid 33674018)
    • (2001) Nature Reviews Genetics , vol.2 , Issue.3 , pp. 196-206
    • Van Gent, D.C.1    Hoeijmakers, J.H.J.2    Kanaar, R.3
  • 63
    • 4644281946 scopus 로고    scopus 로고
    • Crosstalk of the mitotic spindle assembly checkpoint with p53 to prevent polyploidy
    • DOI 10.1038/sj.onc.1207860
    • Vogel C, Kienitz A, Hofmann I, Muller R, Bastians H. (2004). Crosstalk of the mitotic spindle assembly checkpoint with p53 to prevent polyploidy. Oncogene 23: 6845-6853. (Pubitemid 39279985)
    • (2004) Oncogene , vol.23 , Issue.41 , pp. 6845-6853
    • Vogel, C.1    Kienitz, A.2    Hofmann, I.3    Muller, R.4    Bastians, H.5
  • 65
    • 0036674617 scopus 로고    scopus 로고
    • Live or let die: The cell's response to p53
    • DOI 10.1038/nrc864
    • Vousden KH, Lu X. (2002). Live or let die: the cell's response to p53. Nat Rev Cancer 2: 594-604. (Pubitemid 37328926)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.8 , pp. 594-604
    • Vousden, K.H.1    Lu, X.2
  • 68
    • 33846065784 scopus 로고    scopus 로고
    • Aneuploidy Acts Both Oncogenically and as a Tumor Suppressor
    • DOI 10.1016/j.ccr.2006.12.003, PII S1535610806003680
    • Weaver BA, Silk AD, Montagna C, Verdier-Pinard P, Cleveland DW. (2007). Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell 11: 25-36. (Pubitemid 46070223)
    • (2007) Cancer Cell , vol.11 , Issue.1 , pp. 25-36
    • Weaver, B.A.A.1    Silk, A.D.2    Montagna, C.3    Verdier-Pinard, P.4    Cleveland, D.W.5
  • 70
    • 25444533618 scopus 로고    scopus 로고
    • Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure
    • DOI 10.1186/1471-2121-6-6
    • Wong C, Stearns T. (2005). Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure. BMC Cell Biol 6: 6. (Pubitemid 41357630)
    • (2005) BMC Cell Biology , vol.6 , pp. 6
    • Wong, C.1    Stearns, T.2
  • 71
    • 0029328641 scopus 로고
    • Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway
    • Woods CM, Zhu J, McQueney PA, Bollag D, Lazarides E. (1995). Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway. Mol Med 1: 506-526.
    • (1995) Mol Med , vol.1 , pp. 506-526
    • Woods, C.M.1    Zhu, J.2    McQueney, P.A.3    Bollag, D.4    Lazarides, E.5
  • 72
    • 4544381708 scopus 로고    scopus 로고
    • Regulation of Bax activation and apoptotic response to microtubule-damaging agents by p53 transcription-dependent and -independent pathways
    • DOI 10.1074/jbc.M401530200
    • Yamaguchi H, Chen J, Bhalla K, Wang HG. (2004). Regulation of Bax activation and apoptotic response to microtubule-damaging agents by p53 transcription-dependent and-independent pathways. J Biol Chem 279: 39431-39437. (Pubitemid 39258208)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.38 , pp. 39431-39437
    • Yamaguchi, H.1    Chen, J.2    Bhalla, K.3    Wang, H.-G.4
  • 73
    • 44649126775 scopus 로고    scopus 로고
    • Extra centrosomes and/or chromosomes prolong mitosis in human cells
    • DOI 10.1038/ncb1738, PII NCB1738
    • Yang Z, Loncarek J, Khodjakov A, Rieder CL. (2008). Extra centrosomes and/or chromosomes prolong mitosis in human cells. Nat Cell Biol 10: 748-751. (Pubitemid 351772940)
    • (2008) Nature Cell Biology , vol.10 , Issue.6 , pp. 748-751
    • Yang, Z.1    Loncarek, J.2    Khodjakov, A.3    Rieder, C.L.4
  • 74
    • 21244499737 scopus 로고    scopus 로고
    • Kruppel-like factor 4 prevents centrosome amplification following gamma-irradiation-induced DNA damage
    • Yoon HS, Ghaleb AM, Nandan MO, Hisamuddin IM, Dalton WB, Yang VW. (2005). Kruppel-like factor 4 prevents centrosome amplification following gamma-irradiation-induced DNA damage. Oncogene 24: 4017-4025.
    • (2005) Oncogene , vol.24 , pp. 4017-4025
    • Yoon, H.S.1    Ghaleb, A.M.2    Nandan, M.O.3    Hisamuddin, I.M.4    Dalton, W.B.5    Yang, V.W.6
  • 75
    • 0037113913 scopus 로고    scopus 로고
    • Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells
    • DOI 10.1074/jbc.M203214200
    • Zhang H, Shi X, Zhang QJ, Hampong M, Paddon H, Wahyuningsih D et al. (2002). Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells. J Biol Chem 277: 43648-43658. (Pubitemid 36157780)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.46 , pp. 43648-43658
    • Zhang, H.1    Shi, X.2    Zhang, Q.-J.3    Hampong, M.4    Paddon, H.5    Wahyuningsih, D.6    Pelech, S.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.