-
1
-
-
0034767429
-
Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G
-
Andreassen PR, Lohez OD, Lacroix FB, Margolis RL. (2001). Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G. Mol Biol Cell 12: 1315-1328.
-
(2001)
Mol Biol Cell
, vol.12
, pp. 1315-1328
-
-
Andreassen, P.R.1
Lohez, O.D.2
Lacroix, F.B.3
Margolis, R.L.4
-
2
-
-
0034632717
-
Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
-
DOI 10.1038/35020592
-
Artandi SE, Chang S, Lee SL, Alson S, Gottlieb GJ, Chin L et al. (2000). Telomere dysfunction promotes non-reciprocal transloca-tions and epithelial cancers in mice. Nature 406: 641-645. (Pubitemid 30641052)
-
(2000)
Nature
, vol.406
, Issue.6796
, pp. 641-645
-
-
Artandl, S.E.1
Chang, S.2
Lee, S.-L.3
Alson, S.4
Gottlieb, G.J.5
Chin, L.6
DePinho, R.A.7
-
3
-
-
33749334018
-
A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization
-
DOI 10.1101/gad.1447006
-
Aylon Y, Michael D, Shmueli A, Yabuta N, Nojima H, Oren M. (2006). A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization. Genes Dev 20: 2687-2700. (Pubitemid 44498379)
-
(2006)
Genes and Development
, vol.20
, Issue.19
, pp. 2687-2700
-
-
Aylon, Y.1
Michael, D.2
Shmueli, A.3
Yabuta, N.4
Nojima, H.5
Oren, M.6
-
4
-
-
0042991379
-
Histone H2AX: A dosage-dependent suppressor of oncogenic translocations and tumors
-
DOI 10.1016/S0092-8674(03)00566-X
-
Bassing CH, Suh H, Ferguson DO, Chua KF, Manis J, Eckersdorff M et al. (2003). Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors. Cell 114: 359-370. (Pubitemid 36962934)
-
(2003)
Cell
, vol.114
, Issue.3
, pp. 359-370
-
-
Bassing, C.H.1
Suh, H.2
Ferguson, D.O.3
Chua, K.F.4
Manis, J.5
Eckersdorff, M.6
Gleason, M.7
Bronson, R.8
Lee, C.9
Alt, F.W.10
-
5
-
-
0025650332
-
Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: Aneuploidy and immortalization
-
Bischoff FZ, Yim SO, Pathak S, Grant G, Siciliano MJ, Giovanella BC et al. (1990). Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: aneuploidy and immortalization. Cancer Res 50: 7979-7984.
-
(1990)
Cancer Res
, vol.50
, pp. 7979-7984
-
-
Bischoff, F.Z.1
Yim, S.O.2
Pathak, S.3
Grant, G.4
Siciliano, M.J.5
Giovanella, B.C.6
-
6
-
-
33646437275
-
Prolonged mitosis versus tetraploid checkpoint: How p53 measures the duration of mitosis
-
Blagosklonny MV. (2006). Prolonged mitosis versus tetraploid checkpoint: how p53 measures the duration of mitosis. Cell Cycle 5: 971-975.
-
(2006)
Cell Cycle
, vol.5
, pp. 971-975
-
-
Blagosklonny, M.V.1
-
7
-
-
0029099361
-
Spontaneous and ionizing radiation-induced chromosomal abnormalities in p53-deficient mice
-
Bouffler SD, Kemp CJ, Balmain A, Cox R. (1995). Spontaneous and ionizing radiation-induced chromosomal abnormalities in p53-deficient mice. Cancer Res 55: 3883-3889.
-
(1995)
Cancer Res
, vol.55
, pp. 3883-3889
-
-
Bouffler, S.D.1
Kemp, C.J.2
Balmain, A.3
Cox, R.4
-
8
-
-
0032553485
-
2 arrest after DNA damage
-
Bunz F, Dutriaux A, Lengauer C, Waldman T, Zhou S, Brown JP et al. (1998). Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 282: 1497-1501. (Pubitemid 28538613)
-
(1998)
Science
, vol.282
, Issue.5393
, pp. 1497-1501
-
-
Bunz, F.1
Dutriaux, A.2
Lengauer, C.3
Waldman, T.4
Zhou, S.5
Brown, J.P.6
Sedivy, J.M.7
Kinzler, K.W.8
Vogelstein, B.9
-
9
-
-
0036169078
-
Targeted inactivation of p53 in human cells does not result in aneuploidy
-
Bunz F, Fauth C, Speicher MR, Dutriaux A, Sedivy JM, Kinzler KW et al. (2002). Targeted inactivation of p53 in human cells does not result in aneuploidy. Cancer Res 62: 1129-1133. (Pubitemid 34160298)
-
(2002)
Cancer Research
, vol.62
, Issue.4
, pp. 1129-1133
-
-
Bunz, F.1
Fauth, C.2
Speicher, M.R.3
Dutriaux, A.4
Sedivy, J.M.5
Kinzler, K.W.6
Vogelstein, B.7
Lengauer, C.8
-
10
-
-
0032701521
-
Disruption of p53 in human cancer cells alters the responses to therapeutic agents
-
Bunz F, Hwang PM, Torrance C, Waldman T, Zhang Y, Dillehay L et al. (1999). Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J Clin Invest 104: 263-269.
-
(1999)
J Clin Invest
, vol.104
, pp. 263-269
-
-
Bunz, F.1
Hwang, P.M.2
Torrance, C.3
Waldman, T.4
Zhang, Y.5
Dillehay, L.6
-
11
-
-
33745756364
-
Apoptosis regulation in tetraploid cancer cells
-
DOI 10.1038/sj.emboj.7601127, PII 7601127
-
Castedo M, Coquelle A, Vivet S, Vitale I, Kauffmann A, Dessen P et al. (2006). Apoptosis regulation in tetraploid cancer cells. EMBO J 25: 2584-2595. (Pubitemid 44012240)
-
(2006)
EMBO Journal
, vol.25
, Issue.11
, pp. 2584-2595
-
-
Castedo, M.1
Coquelle, A.2
Vivet, S.3
Vitale, I.4
Kauffmann, A.5
Dessen, P.6
Pequignot, M.O.7
Casares, N.8
Valent, A.9
Mouhamad, S.10
Schmitt, E.11
Modjtahedi, N.12
Vainchenker, W.13
Zitvogel, L.14
Lazar, V.15
Garrido, C.16
Kroemer, G.17
-
12
-
-
47049109949
-
The kinetics of p53 activation versus cyclin e accumulation underlies the relationship between the spindle-assembly checkpoint and the postmitotic checkpoint
-
Chan YW, On KF, Chan WM, Wong W, Siu HO, Hau PM et al. (2008). The kinetics of p53 activation versus cyclin E accumulation underlies the relationship between the spindle-assembly checkpoint and the postmitotic checkpoint. J Biol Chem 283: 15716-15723.
-
(2008)
J Biol Chem
, vol.283
, pp. 15716-15723
-
-
Chan, Y.W.1
On, K.F.2
Chan, W.M.3
Wong, W.4
Siu, H.O.5
Hau, P.M.6
-
13
-
-
0028913739
-
A p53-dependent mouse spindle checkpoint
-
Cross SM, Sanchez CA, Morgan CA, Schimke MK, Ramel S, Idzerda RL et al. (1995). A p53-dependent mouse spindle checkpoint. Science 267: 1353-1356.
-
(1995)
Science
, vol.267
, pp. 1353-1356
-
-
Cross, S.M.1
Sanchez, C.A.2
Morgan, C.A.3
Schimke, M.K.4
Ramel, S.5
Idzerda, R.L.6
-
14
-
-
0033669763
-
Specific patterns of chromosomal abnormalities are associated with RER status in sporadic colorectal cancer
-
Curtis LJ, Georgiades IB, White S, Bird CC, Harrison DJ, Wyllie AH. (2000). Specific patterns of chromosomal abnormalities are associated with RER status in sporadic colorectal cancer. J Pathol 192: 440-445.
-
(2000)
J Pathol
, vol.192
, pp. 440-445
-
-
Curtis, L.J.1
Georgiades, I.B.2
White, S.3
Bird, C.C.4
Harrison, D.J.5
Wyllie, A.H.6
-
15
-
-
37549010631
-
Human cancer cells commonly acquire DNA damage during mitotic arrest
-
Dalton WB, Nandan MO, Moore RT, Yang VW. (2007). Human cancer cells commonly acquire DNA damage during mitotic arrest. Cancer Res 67: 11487-11492.
-
(2007)
Cancer Res
, vol.67
, pp. 11487-11492
-
-
Dalton, W.B.1
Nandan, M.O.2
Moore, R.T.3
Yang, V.W.4
-
16
-
-
74949115115
-
The role of prolonged mitotic checkpoint activation in the formation and treatment of cancer
-
Dalton WB, Yang VW. (2009). The role of prolonged mitotic checkpoint activation in the formation and treatment of cancer. Future Oncol 5: 1363-1370.
-
(2009)
Future Oncol
, vol.5
, pp. 1363-1370
-
-
Dalton, W.B.1
Yang, V.W.2
-
17
-
-
0032903791
-
Chromosomal gains and losses in primary colorectal carcinomas detected by CGH and their associations with tumour DNA ploidy, genotypes and phenotypes
-
DOI 10.1038/sj.bjc.6690388
-
De Angelis PM, Clausen OP, Schjolberg A, Stokke T. (1999). Chromosomal gains and losses in primary colorectal carcinomas detected by CGH and their associations with tumour DNA ploidy, genotypes and phenotypes. Br J Cancer 80: 526-535. (Pubitemid 29213210)
-
(1999)
British Journal of Cancer
, vol.80
, Issue.3-4
, pp. 526-535
-
-
De Angelis, P.1
Clausen, O.P.F.2
Schjolberg, A.3
Stokke, T.4
-
18
-
-
0030929838
-
DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function
-
Di Leonardo A, Khan SH, Linke SP, Greco V, Seidita G, Wahl GM. (1997). DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function. Cancer Res 57: 1013-1019. (Pubitemid 27138591)
-
(1997)
Cancer Research
, vol.57
, Issue.6
, pp. 1013-1019
-
-
Leonardo, A.D.1
Khan, S.H.2
Linke, S.P.3
Greco, V.4
Seidita, G.5
Wahl, G.M.6
-
19
-
-
0032514366
-
Chromosome number and structure both are markedly stable in RER colorectal cancers and are not destabilized by mutation of p53
-
Eshleman JR, Casey G, Kochera ME, Sedwick WD, Swinler SE, Veigl ML et al. (1998). Chromosome number and structure both are markedly stable in RER colorectal cancers and are not destabilized by mutation of p53. Oncogene 17: 719-725. (Pubitemid 28412492)
-
(1998)
Oncogene
, vol.17
, Issue.6
, pp. 719-725
-
-
Eshleman, J.R.1
Casey, G.2
Kochera, M.E.3
Sedwick, W.D.4
Swinler, S.E.5
Veigl, M.L.6
Willson, J.K.V.7
Schwartz, S.8
Markowitz, S.D.9
-
20
-
-
27144507868
-
Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells
-
DOI 10.1038/nature04217, PII N04217
-
Fujiwara T, Bandi M, Nitta M, Ivanova EV, Bronson RT, Pellman D. (2005). Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells. Nature 437: 1043-1047. (Pubitemid 41486987)
-
(2005)
Nature
, vol.437
, Issue.7061
, pp. 1043-1047
-
-
Fujiwara, T.1
Bandi, M.2
Nitta, M.3
Ivanova, E.V.4
Bronson, R.T.5
Pellman, D.6
-
21
-
-
0035860132
-
Inactivation of wild-type p53 by a dominant negative mutant renders MCF-7 cells resistant to tubulin-binding agent cytotoxicity
-
DOI 10.1054/bjoc.2001.2017
-
Galmarini CM, Falette N, Tabone E, Levrat C, Britten R, Voorzanger-Rousselot N et al. (2001). Inactivation of wild-type p53 by a dominant negative mutant renders MCF-7 cells resistant to tubulin-binding agent cytotoxicity. Br J Cancer 85: 902-908. (Pubitemid 33010560)
-
(2001)
British Journal of Cancer
, vol.85
, Issue.6
, pp. 902-908
-
-
Galmarini, C.M.1
Falette, N.2
Tabone, E.3
Levrat, C.4
Britten, R.5
Voorzanger-Rousselot, N.6
Roesch-Gateau, O.7
Vanier-Viornery, A.8
Puisieux, A.9
Dumontet, C.10
-
22
-
-
35548935096
-
Limiting the proliferation of polyploid cells
-
DOI 10.1016/j.cell.2007.10.024, PII S0092867407013426
-
Ganem NJ, Pellman D. (2007). Limiting the proliferation of polyploid cells. Cell 131: 437-440. (Pubitemid 350007703)
-
(2007)
Cell
, vol.131
, Issue.3
, pp. 437-440
-
-
Ganem, N.J.1
Pellman, D.2
-
23
-
-
34047274772
-
Tetraploidy, aneuploidy and cancer
-
DOI 10.1016/j.gde.2007.02.011, PII S0959437X07000378, Chromosomes and Expression Mechanisms
-
Ganem NJ, Storchova Z, Pellman D. (2007). Tetraploidy, aneuploidy and cancer. Curr Opin Genet Dev 17: 157-162. (Pubitemid 46551722)
-
(2007)
Current Opinion in Genetics and Development
, vol.17
, Issue.2
, pp. 157-162
-
-
Ganem, N.J.1
Storchova, Z.2
Pellman, D.3
-
24
-
-
44049086505
-
DNA synthesis from unbalanced nucleotide pools causes limited DNA damage that triggers ATR-CHK1-dependent p53 activation
-
DOI 10.1073/pnas.0802080105
-
Hastak K, Paul RK, Agarwal MK, Thakur VS, Amin AR, Agrawal S et al. (2008). DNA synthesis from unbalanced nucleotide pools causes limited DNA damage that triggers ATR-CHK1-dependent p53 activation. Proc Natl Acad Sci USA 105: 6314-6319. (Pubitemid 351758343)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.17
, pp. 6314-6319
-
-
Hastak, K.1
Paul, R.K.2
Agarwal, M.K.3
Thakur, V.S.4
Amin, A.R.M.R.5
Agrawal, S.6
Sramkoski, R.M.7
Jacobberger, J.W.8
Jackson, M.W.9
Stark, G.R.10
Agarwal, M.L.11
-
25
-
-
4043093341
-
Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control
-
DOI 10.1038/nature02820
-
Hernando E, Nahle Z, Juan G, Diaz-Rodriguez E, Alaminos M, Hemann M et al. (2004). Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control. Nature 430: 797-802. (Pubitemid 39071352)
-
(2004)
Nature
, vol.430
, Issue.7001
, pp. 797-802
-
-
Hernando, E.1
Nahle, Z.2
Juan, G.3
Diaz-Rodriguez, E.4
Alaminos, M.5
Hemann, M.6
Michel, L.7
Mittal, V.8
Gerald, W.9
Benezra, R.10
Lowe, S.W.11
Cordon-Cardo, C.12
-
26
-
-
0015256217
-
Chromosome pulverization in micronuclei induced by tritiated thymidine
-
Ikeuchi T, Weinfeld H, Sandberg AA. (1972). Chromosome pulverization in micronuclei induced by tritiated thymidine. J Cell Biol 52: 97-104.
-
(1972)
J Cell Biol
, vol.52
, pp. 97-104
-
-
Ikeuchi, T.1
Weinfeld, H.2
Sandberg, A.A.3
-
27
-
-
9144230626
-
Chromosomal comparative genomic hybridization abnormalities in early- and late-onset human breast cancers: Correlation with disease progression and TP53 mutations
-
DOI 10.1016/S0165-4608(03)00205-X
-
Jong YJ, Li LH, Tsou MH, Chen YJ, Cheng SH, Wang-Wuu S et al. (2004). Chromosomal comparative genomic hybridization abnormalities in early-and late-onset human breast cancers: correlation with disease progression and TP53 mutations. Cancer Genet Cytogenet 148: 55-65. (Pubitemid 38018881)
-
(2004)
Cancer Genetics and Cytogenetics
, vol.148
, Issue.1
, pp. 55-65
-
-
Jong, Y.-J.1
Li, L.-H.2
Tsou, M.-H.3
Chen, Y.-J.4
Cheng, S.H.5
Wang-Wuu, S.6
Tsai, S.-F.7
Chen, C.-M.8
Huang, A.T.9
Hsu, M.-T.10
Lin, C.-H.11
-
28
-
-
0014105051
-
Chromosome pulverization in human binucleate cells following colcemid treatment
-
Kato H, Sandberg AA. (1967). Chromosome pulverization in human binucleate cells following colcemid treatment. J Cell Biol 34: 35-45.
-
(1967)
J Cell Biol
, vol.34
, pp. 35-45
-
-
Kato, H.1
Sandberg, A.A.2
-
29
-
-
20544463659
-
Partial downregulation of MAD1 causes spindle checkpoint inactivation and aneuploidy, but does not confer resistance towards taxol
-
DOI 10.1038/sj.onc.1208589
-
Kienitz A, Vogel C, Morales I, Muller R, Bastians H. (2005). Partial downregulation of MAD1 causes spindle checkpoint inactivation and aneuploidy, but does not confer resistance towards taxol. Oncogene 24: 4301-4310. (Pubitemid 40961783)
-
(2005)
Oncogene
, vol.24
, Issue.26
, pp. 4301-4310
-
-
Kienitz, A.1
Vogel, C.2
Morales, I.3
Muller, R.4
Bastians, H.5
-
30
-
-
4644278514
-
Function of Drg1/Rit42 in p53-dependent mitotic spindle checkpoint
-
DOI 10.1074/jbc.M400781200
-
Kim KT, Ongusaha PP, Hong YK, Kurdistani SK, Nakamura M, Lu KP et al. (2004). Function of Drg1/Rit42 in p53-dependent mitotic spindle checkpoint. J Biol Chem 279: 38597-38602. (Pubitemid 39296014)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.37
, pp. 38597-38602
-
-
Kim, K.-T.1
Ongusaha, P.P.2
Hong, Y.-K.3
Kurdisiani, S.K.4
Nakamura, M.5
Lu, K.P.6
Lee, S.W.7
-
31
-
-
23944504305
-
TP53 mutations are associated with a particular pattern of genomic imbalances in breast carcinomas
-
DOI 10.1002/path.1812
-
Kleivi K, Diep CB, Pandis N, Heim S, Teixeira MR, Lothe RA. (2005). TP53 mutations are associated with a particular pattern of genomic imbalances in breast carcinomas. J Pathol 207: 14-19. (Pubitemid 41200709)
-
(2005)
Journal of Pathology
, vol.207
, Issue.1
, pp. 14-19
-
-
Kleivi, K.1
Diep, C.B.2
Pandis, N.3
Heim, S.4
Teixeira, M.R.5
Lothe, R.A.6
-
32
-
-
33644517511
-
Use of a chemically modified antisense oligonucleotide library to identify and validate Eg5 (kinesin-like 1) as a target for antineoplastic drug development
-
DOI 10.1158/0008-5472.CAN-05-1531
-
Koller E, Propp S, Zhang H, Zhao C, Xiao X, Chang M et al. (2006). Use of a chemically modified antisense oligonucleotide library to identify and validate Eg5 (kinesin-like 1) as a target for anti-neoplastic drug development. Cancer Res 66: 2059-2066. (Pubitemid 43294914)
-
(2006)
Cancer Research
, vol.66
, Issue.4
, pp. 2059-2066
-
-
Koller, E.1
Propp, S.2
Zhang, H.3
Zhao, C.4
Xiao, X.5
Chang, M.6
Hirsch, S.A.7
Shepard, P.J.8
Koo, S.9
Murphy, C.10
Glazer, R.I.11
Dean, N.M.12
-
33
-
-
0029005842
-
Genomic stability and wild-type p53 function of lymphoblastoid cells with germ-line p53 mutation
-
Lalle P, Moyret-Lalle C, Wang Q, Vialle JM, Navarro C, Bressac-de Paillerets B et al. (1995). Genomic stability and wild-type p53 function of lymphoblastoid cells with germ-line p53 mutation. Oncogene 10: 2447-2454.
-
(1995)
Oncogene
, vol.10
, pp. 2447-2454
-
-
Lalle, P.1
Moyret-Lalle, C.2
Wang, Q.3
Vialle, J.M.4
Navarro, C.5
Bressac-De Paillerets, B.6
-
34
-
-
0031931414
-
Characterization of the p53-dependent postmitotic checkpoint following spindle disruption
-
Lanni JS, Jacks T. (1998). Characterization of the p53-dependent postmitotic checkpoint following spindle disruption. Mol Cell Biol 18: 1055-1064. (Pubitemid 28063440)
-
(1998)
Molecular and Cellular Biology
, vol.18
, Issue.2
, pp. 1055-1064
-
-
Lanni, J.S.1
Jacks, T.2
-
35
-
-
0029964158
-
1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage
-
Linke SP, Clarkin KC, Di Leonardo A, Tsou A, Wahl GM. (1996). A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. Genes Dev 10: 934-947. (Pubitemid 26138705)
-
(1996)
Genes and Development
, vol.10
, Issue.8
, pp. 934-947
-
-
Linke, S.P.1
Clarkin, K.C.2
Di Leonardo, A.3
Tsou, A.4
Wahl, G.M.5
-
36
-
-
62449278758
-
Targeting p53 for enhanced radio-and chemo-sensitivity
-
Lu C, El-Deiry WS. (2009). Targeting p53 for enhanced radio-and chemo-sensitivity. Apoptosis 14: 597-606.
-
(2009)
Apoptosis
, vol.14
, pp. 597-606
-
-
Lu, C.1
El-Deiry, W.S.2
-
37
-
-
33745149291
-
P53 regulates mitochondrial respiration
-
DOI 10.1126/science.1126863
-
Matoba S, Kang JG, Patino WD, Wragg A, Boehm M, Gavrilova O et al. (2006). p53 regulates mitochondrial respiration. Science 312: 1650-1653. (Pubitemid 43902663)
-
(2006)
Science
, vol.312
, Issue.5780
, pp. 1650-1653
-
-
Matoba, S.1
Kang, J.-G.2
Patino, W.D.3
Wragg, A.4
Boehm, M.5
Gavrilova, O.6
Hurley, P.J.7
Bunz, F.8
Hwang, P.M.9
-
38
-
-
0029658664
-
Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage
-
Minn AJ, Boise LH, Thompson CB. (1996). Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage. Genes Dev 10: 2621-2631.
-
(1996)
Genes Dev
, vol.10
, pp. 2621-2631
-
-
Minn, A.J.1
Boise, L.H.2
Thompson, C.B.3
-
39
-
-
33847390640
-
One, two, three-p53, p63, p73 and chemosensi-tivity
-
Muller M, Schleithoff ES, Stremmel W, Melino G, Krammer PH, Schilling T. (2006). One, two, three-p53, p63, p73 and chemosensi-tivity. Drug Resist Updat 9: 288-306.
-
(2006)
Drug Resist Updat
, vol.9
, pp. 288-306
-
-
Muller, M.1
Schleithoff, E.S.2
Stremmel, W.3
Melino, G.4
Krammer, P.H.5
Schilling, T.6
-
40
-
-
33746558541
-
Telomere dysfunction and loss of p53 cooperate in defective mitotic segregation of chromosomes in cancer cells
-
DOI 10.1038/sj.onc.1209486, PII 1209486
-
Pantic M, Zimmermann S, Daly E, Opitz OG, Popp S, Boukamp P et al. (2006). Telomere dysfunction and loss of p53 cooperate in defective mitotic segregation of chromosomes in cancer cells. Oncogene 25: 4413-4420. (Pubitemid 44141629)
-
(2006)
Oncogene
, vol.25
, Issue.32
, pp. 4413-4420
-
-
Pantic, M.1
Zimmermann, S.2
El Daly, H.3
Opitz, O.G.4
Popp, S.5
Boukamp, P.6
Martens, U.M.7
-
41
-
-
29144456625
-
Securin is not required for chromosomal stability in human cells
-
DOI 10.1371/journal.pbio.0030416, e416
-
Pfleghaar K, Heubes S, Cox J, Stemmann O, Speicher MR. (2005). Securin is not required for chromosomal stability in human cells. PLoS Biol 3: e416. (Pubitemid 41796339)
-
(2005)
PLoS Biology
, vol.3
, Issue.12
, pp. 1-8
-
-
Pfleghaar, K.1
Heubes, S.2
Cox, J.3
Stemmann, O.4
Speicher, M.R.5
-
42
-
-
33846209076
-
Sustained mitotic block elicits DNA breaks: One-step alteration of ploidy and chromosome integrity in mammalian cells
-
DOI 10.1038/sj.onc.1209787, PII 1209787
-
Quignon F, Rozier L, Lachages AM, Bieth A, Simili M, Debatisse M. (2007). Sustained mitotic block elicits DNA breaks: one-step alteration of ploidy and chromosome integrity in mammalian cells. Oncogene 26: 165-172. (Pubitemid 46095728)
-
(2007)
Oncogene
, vol.26
, Issue.2
, pp. 165-172
-
-
Quignon, F.1
Rozier, L.2
Lachages, A.-M.3
Bieth, A.4
Simili, M.5
Debatisse, M.6
-
43
-
-
1542377277
-
Inactivation of hCDC4 can cause chromosomal instability
-
DOI 10.1038/nature02313
-
Rajagopalan H, Jallepalli PV, Rago C, Velculescu VE, Kinzler KW, Vogelstein B et al. (2004). Inactivation of hCDC4 can cause chromosomal instability. Nature 428: 77-81. (Pubitemid 38332360)
-
(2004)
Nature
, vol.428
, Issue.6978
, pp. 77-81
-
-
Rajagopalan, H.1
Jallepalli, P.V.2
Rago, C.3
Velculescu, V.E.4
Kinzler, K.W.5
Vogelstein, B.6
Lengauer, C.7
-
44
-
-
7744233719
-
Stuck in division or passing through: What happens when cells cannot satisfy the spindle assembly checkpoint
-
DOI 10.1016/j.devcel.2004.09.002, PII S1534580704003016
-
Rieder CL, Maiato H. (2004). Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpoint. Dev Cell 7: 637-651. (Pubitemid 39462685)
-
(2004)
Developmental Cell
, vol.7
, Issue.5
, pp. 637-651
-
-
Rieder, C.L.1
Maiato, H.2
-
45
-
-
0032861343
-
Megabase chromatin domains involved in DNA double-strand breaks in vivo
-
DOI 10.1083/jcb.146.5.905
-
Rogakou EP, Boon C, Redon C, Bonner WM. (1999). Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol 146: 905-916. (Pubitemid 29430435)
-
(1999)
Journal of Cell Biology
, vol.146
, Issue.5
, pp. 905-915
-
-
Rogakou, E.P.1
Boon, C.2
Redon, C.3
Bonner, W.M.4
-
46
-
-
0032489520
-
DNA double-stranded breaks induce histone H2AX phosphoryla-tion on serine 139
-
Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. (1998). DNA double-stranded breaks induce histone H2AX phosphoryla-tion on serine 139. J Biol Chem 273: 5858-5868.
-
(1998)
J Biol Chem
, vol.273
, pp. 5858-5868
-
-
Rogakou, E.P.1
Pilch, D.R.2
Orr, A.H.3
Ivanova, V.S.4
Bonner, W.M.5
-
47
-
-
0017252257
-
Classification and relationships of induced chromosomal structual changes
-
Savage JR. (1976). Classification and relationships of induced chromosomal structual changes. J Med Genet 13: 103-122.
-
(1976)
J Med Genet
, vol.13
, pp. 103-122
-
-
Savage, J.R.1
-
48
-
-
44849127993
-
Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5
-
Shi J, Orth JD, Mitchison T. (2008). Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5. Cancer Res 68: 3269-3276.
-
(2008)
Cancer Res
, vol.68
, pp. 3269-3276
-
-
Shi, J.1
Orth, J.D.2
Mitchison, T.3
-
49
-
-
34247329362
-
P53 gain-of-function cancer mutants induce genetic instability by inactivating ATM
-
DOI 10.1038/ncb1571, PII NCB1571
-
Song H, Hollstein M, Xu Y. (2007). p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM. Nat Cell Biol 9: 573-580. (Pubitemid 46696539)
-
(2007)
Nature Cell Biology
, vol.9
, Issue.5
, pp. 573-580
-
-
Song, H.1
Hollstein, M.2
Xu, Y.3
-
50
-
-
33845986330
-
Mad2 overexpression promotes aneuploidy and tumorigenesis in mice
-
DOI 10.1016/j.ccr.2006.10.019, PII S1535610806003710
-
Sotillo R, Hernando E, Diaz-Rodriguez E, Teruya-Feldstein J, Cordon-Cardo C, Lowe SW et al. (2007). Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Cancer Cell 11: 9-23. (Pubitemid 46054519)
-
(2007)
Cancer Cell
, vol.11
, Issue.1
, pp. 9-23
-
-
Sotillo, R.1
Hernando, E.2
Diaz-Rodriguez, E.3
Teruya-Feldstein, J.4
Cordon-Cardo, C.5
Lowe, S.W.6
Benezra, R.7
-
51
-
-
34548037643
-
Mitotic cell death by chromosome fragmentation
-
DOI 10.1158/0008-5472.CAN-07-0472
-
Stevens JB, Liu G, Bremer SW, Ye KJ, Xu W, Xu J et al. (2007). Mitotic cell death by chromosome fragmentation. Cancer Res 67: 7686-7694. (Pubitemid 47281361)
-
(2007)
Cancer Research
, vol.67
, Issue.16
, pp. 7686-7694
-
-
Stevens, J.B.1
Liu, G.2
Bremer, S.W.3
Ye, K.J.4
Xu, W.5
Xu, J.6
Sun, Y.7
Gen, S.W.8
Savasan, S.9
Krawetz, S.A.10
Ye, C.J.11
Heng, H.H.Q.12
-
52
-
-
17244367777
-
Structural and numerical chromosome changes in colon cancer develop through telomere-mediated anaphase bridges, not through mitotic multipolarity
-
DOI 10.1073/pnas.0408454102
-
Stewenius Y, Gorunova L, Jonson T, Larsson N, Hoglund M, Mandahl N et al. (2005). Structural and numerical chromosome changes in colon cancer develop through telomere-mediated anaphase bridges, not through mitotic multipolarity. Proc Natl Acad Sci USA 102: 5541-5546. (Pubitemid 40530294)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.15
, pp. 5541-5546
-
-
Stewenius, Y.1
Gorunova, L.2
Jonson, T.3
Larsson, N.4
Hoglund, M.5
Mandahl, N.6
Mertens, F.7
Mitelman, F.8
Gisselsson, D.9
-
53
-
-
2942642800
-
Triggering p53 after cytokinesis failure
-
Stukenberg PT. (2004). Triggering p53 after cytokinesis failure. J Cell Biol 165: 607-608.
-
(2004)
J Cell Biol
, vol.165
, pp. 607-608
-
-
Stukenberg, P.T.1
-
54
-
-
66649137945
-
Chromosomal instability determines taxane response
-
Swanton C, Nicke B, Schuett M, Eklund AC, Ng C, Li Q et al. (2009). Chromosomal instability determines taxane response. Proc Natl Acad Sci USA 106: 8671-8676.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 8671-8676
-
-
Swanton, C.1
Nicke, B.2
Schuett, M.3
Eklund, A.C.4
Ng, C.5
Li, Q.6
-
55
-
-
33846172672
-
An inhibitor of the kinesin spindle protein activates the intrinsic apoptotic pathway independently of p53 and de novo protein synthesis
-
DOI 10.1128/MCB.01505-06
-
Tao W, South VJ, Diehl RE, Davide JP, Sepp-Lorenzino L, Fraley ME et al. (2007). An inhibitor of the kinesin spindle protein activates the intrinsic apoptotic pathway independently of p53 and de novo protein synthesis. Mol Cell Biol 27: 689-698. (Pubitemid 46080134)
-
(2007)
Molecular and Cellular Biology
, vol.27
, Issue.2
, pp. 689-698
-
-
Tao, W.1
South, V.J.2
Diehl, R.E.3
Davide, J.P.4
Sepp-Lorenzino, L.5
Fraley, M.E.6
Arrington, K.L.7
Lobell, R.B.8
-
56
-
-
0025883614
-
Monoclonal antibody CC-3 recognizes phosphoproteins in interphase and mitotic cells
-
Thibodeau A, Vincent M. (1991). Monoclonal antibody CC-3 recognizes phosphoproteins in interphase and mitotic cells. Exp Cell Res 195: 145-153. (Pubitemid 121006305)
-
(1991)
Experimental Cell Research
, vol.195
, Issue.1
, pp. 145-153
-
-
Thibodeau, A.1
Vincent, M.2
-
57
-
-
40849096242
-
Examining the link between chromosomal instability and aneuploidy in human cells
-
Thompson SL, Compton DA. (2008). Examining the link between chromosomal instability and aneuploidy in human cells. J Cell Biol 180: 665-672.
-
(2008)
J Cell Biol
, vol.180
, pp. 665-672
-
-
Thompson, S.L.1
Compton, D.A.2
-
58
-
-
13444261036
-
Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability
-
DOI 10.1242/jcs.01556
-
Tighe A, Johnson VL, Taylor SS. (2004). Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability. J Cell Sci 117: 6339-6353. (Pubitemid 40214561)
-
(2004)
Journal of Cell Science
, vol.117
, Issue.26
, pp. 6339-6353
-
-
Tighe, A.1
Johnson, V.L.2
Taylor, S.S.3
-
59
-
-
33845270990
-
Regulating the p53 pathway: In vitro hypotheses, in vivo veritas
-
DOI 10.1038/nrc2012, PII NRC2012
-
Toledo F, Wahl GM. (2006). Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat Rev Cancer 6: 909-923. (Pubitemid 44862676)
-
(2006)
Nature Reviews Cancer
, vol.6
, Issue.12
, pp. 909-923
-
-
Toledo, F.1
Wahl, G.M.2
-
60
-
-
2942679807
-
Cell cycle progression after cleavage failure: Mammalian somatic cells do not possess a tetraploidy checkpoint
-
DOI 10.1083/jcb.200403014
-
Uetake Y, Sluder G. (2004). Cell cycle progression after cleavage failure: mammalian somatic cells do not possess a 'tetraploidy checkpoint'. J Cell Biol 165: 609-615. (Pubitemid 38765762)
-
(2004)
Journal of Cell Biology
, vol.165
, Issue.5
, pp. 609-615
-
-
Uetake, Y.1
Sluder, G.2
-
61
-
-
36549024010
-
Cell-Cycle Progression without an Intact Microtubule Cytoskeleton
-
DOI 10.1016/j.cub.2007.10.065, PII S0960982207021975
-
Uetake Y, Sluder G. (2007). Cell-cycle progression without an intact microtuble cytoskeleton. Curr Biol 17: 2081-2086. (Pubitemid 350180474)
-
(2007)
Current Biology
, vol.17
, Issue.23
, pp. 2081-2086
-
-
Uetake, Y.1
Sluder, G.2
-
62
-
-
0035289717
-
Chromosomal stability and the DNA double-stranded break connection
-
DOI 10.1038/35056049
-
van Gent DC, Hoeijmakers JH, Kanaar R. (2001). Chromosomal stability and the DNA double-stranded break connection. Nat Rev Genet 2: 196-206. (Pubitemid 33674018)
-
(2001)
Nature Reviews Genetics
, vol.2
, Issue.3
, pp. 196-206
-
-
Van Gent, D.C.1
Hoeijmakers, J.H.J.2
Kanaar, R.3
-
63
-
-
4644281946
-
Crosstalk of the mitotic spindle assembly checkpoint with p53 to prevent polyploidy
-
DOI 10.1038/sj.onc.1207860
-
Vogel C, Kienitz A, Hofmann I, Muller R, Bastians H. (2004). Crosstalk of the mitotic spindle assembly checkpoint with p53 to prevent polyploidy. Oncogene 23: 6845-6853. (Pubitemid 39279985)
-
(2004)
Oncogene
, vol.23
, Issue.41
, pp. 6845-6853
-
-
Vogel, C.1
Kienitz, A.2
Hofmann, I.3
Muller, R.4
Bastians, H.5
-
65
-
-
0036674617
-
Live or let die: The cell's response to p53
-
DOI 10.1038/nrc864
-
Vousden KH, Lu X. (2002). Live or let die: the cell's response to p53. Nat Rev Cancer 2: 594-604. (Pubitemid 37328926)
-
(2002)
Nature Reviews Cancer
, vol.2
, Issue.8
, pp. 594-604
-
-
Vousden, K.H.1
Lu, X.2
-
66
-
-
0030026934
-
Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis
-
DOI 10.1038/nm0196-72
-
Wahl AF, Donaldson KL, Fairchild C, Lee FY, Foster SA, Demers GW et al. (1996). Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis. Nat Med 2: 72-79. (Pubitemid 26029571)
-
(1996)
Nature Medicine
, vol.2
, Issue.1
, pp. 72-79
-
-
Wahl, A.F.1
Donaldson, K.L.2
Fairchild, C.3
Lee, F.Y.F.4
Foster, S.A.5
William Demers, G.6
Galloway, D.A.7
-
67
-
-
27644593844
-
53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice
-
DOI 10.1128/MCB.25.22.10079-10086.2005
-
Ward IM, Difilippantonio S, Minn K, Mueller MD, Molina JR, Yu X et al. (2005). 53BP1 cooperates with p53 and functions as a haplo-insufficient tumor suppressor in mice. Mol Cell Biol 25: 10079-10086. (Pubitemid 41572753)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.22
, pp. 10079-10086
-
-
Ward, I.M.1
Difilippantonio, S.2
Minn, K.3
Mueller, M.D.4
Molina, J.R.5
Yu, X.6
Frisk, C.S.7
Ried, T.8
Nussenzweig, A.9
Chen, J.10
-
68
-
-
33846065784
-
Aneuploidy Acts Both Oncogenically and as a Tumor Suppressor
-
DOI 10.1016/j.ccr.2006.12.003, PII S1535610806003680
-
Weaver BA, Silk AD, Montagna C, Verdier-Pinard P, Cleveland DW. (2007). Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell 11: 25-36. (Pubitemid 46070223)
-
(2007)
Cancer Cell
, vol.11
, Issue.1
, pp. 25-36
-
-
Weaver, B.A.A.1
Silk, A.D.2
Montagna, C.3
Verdier-Pinard, P.4
Cleveland, D.W.5
-
69
-
-
20244376754
-
A substantial proportion of microsatellite-unstable colon tumors carry TP53 mutations while not showing chromosomal instability
-
DOI 10.1002/gcc.20148
-
Westra JL, Boven LG, van der Vlies P, Faber H, Sikkema B, Schaapveld M et al. (2005). A substantial proportion of micro-satellite-unstable colon tumors carry TP53 mutations while not showing chromosomal instability. Genes Chromosomes Cancer 43: 194-201. (Pubitemid 40570739)
-
(2005)
Genes Chromosomes and Cancer
, vol.43
, Issue.2
, pp. 194-201
-
-
Westra, J.L.1
Boven, L.G.2
Van Der Vlies, P.3
Faber, H.4
Sikkema, B.5
Schaapveld, M.6
Dijkhuizen, T.7
Hollema, H.8
Buys, C.H.C.M.9
Plukker, J.T.M.10
Kok, K.11
Hofstra, R.M.W.12
-
70
-
-
25444533618
-
Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure
-
DOI 10.1186/1471-2121-6-6
-
Wong C, Stearns T. (2005). Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure. BMC Cell Biol 6: 6. (Pubitemid 41357630)
-
(2005)
BMC Cell Biology
, vol.6
, pp. 6
-
-
Wong, C.1
Stearns, T.2
-
71
-
-
0029328641
-
Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway
-
Woods CM, Zhu J, McQueney PA, Bollag D, Lazarides E. (1995). Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway. Mol Med 1: 506-526.
-
(1995)
Mol Med
, vol.1
, pp. 506-526
-
-
Woods, C.M.1
Zhu, J.2
McQueney, P.A.3
Bollag, D.4
Lazarides, E.5
-
72
-
-
4544381708
-
Regulation of Bax activation and apoptotic response to microtubule-damaging agents by p53 transcription-dependent and -independent pathways
-
DOI 10.1074/jbc.M401530200
-
Yamaguchi H, Chen J, Bhalla K, Wang HG. (2004). Regulation of Bax activation and apoptotic response to microtubule-damaging agents by p53 transcription-dependent and-independent pathways. J Biol Chem 279: 39431-39437. (Pubitemid 39258208)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.38
, pp. 39431-39437
-
-
Yamaguchi, H.1
Chen, J.2
Bhalla, K.3
Wang, H.-G.4
-
73
-
-
44649126775
-
Extra centrosomes and/or chromosomes prolong mitosis in human cells
-
DOI 10.1038/ncb1738, PII NCB1738
-
Yang Z, Loncarek J, Khodjakov A, Rieder CL. (2008). Extra centrosomes and/or chromosomes prolong mitosis in human cells. Nat Cell Biol 10: 748-751. (Pubitemid 351772940)
-
(2008)
Nature Cell Biology
, vol.10
, Issue.6
, pp. 748-751
-
-
Yang, Z.1
Loncarek, J.2
Khodjakov, A.3
Rieder, C.L.4
-
74
-
-
21244499737
-
Kruppel-like factor 4 prevents centrosome amplification following gamma-irradiation-induced DNA damage
-
Yoon HS, Ghaleb AM, Nandan MO, Hisamuddin IM, Dalton WB, Yang VW. (2005). Kruppel-like factor 4 prevents centrosome amplification following gamma-irradiation-induced DNA damage. Oncogene 24: 4017-4025.
-
(2005)
Oncogene
, vol.24
, pp. 4017-4025
-
-
Yoon, H.S.1
Ghaleb, A.M.2
Nandan, M.O.3
Hisamuddin, I.M.4
Dalton, W.B.5
Yang, V.W.6
-
75
-
-
0037113913
-
Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells
-
DOI 10.1074/jbc.M203214200
-
Zhang H, Shi X, Zhang QJ, Hampong M, Paddon H, Wahyuningsih D et al. (2002). Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells. J Biol Chem 277: 43648-43658. (Pubitemid 36157780)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.46
, pp. 43648-43658
-
-
Zhang, H.1
Shi, X.2
Zhang, Q.-J.3
Hampong, M.4
Paddon, H.5
Wahyuningsih, D.6
Pelech, S.7
-
76
-
-
33847706508
-
Chromatid-type aberrations following irradiation in G0 lymphocytes with heavy ions
-
DOI 10.1016/j.mrfmmm.2007.01.003, PII S0027510707000218
-
Zhuanzi W, Wenjian L, Dejuan Z, Wei W, Xigang J, Qingxiang G. (2007). Chromatid-type aberrations following irradiation in G0 lymphocytes with heavy ions. Mutat Res 617: 98-103. (Pubitemid 46386088)
-
(2007)
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
, vol.617
, Issue.1-2
, pp. 98-103
-
-
Zhuanzi, W.1
Wenjian, L.2
Dejuan, Z.3
Wei, W.4
Xigang, J.5
Qingxiang, G.6
|