메뉴 건너뛰기




Volumn 32, Issue 25, 2014, Pages 2794-2803

Luminal B breast cancer: Molecular characterization, clinical management, and future perspectives

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 1; HORMONE RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SOMATOMEDIN; ESTROGEN RECEPTOR; PROGESTERONE RECEPTOR;

EID: 84906805668     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2013.54.1870     Document Type: Review
Times cited : (311)

References (126)
  • 1
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou CM, Sørlie T, Eisen MB, et al: Molecular portraits of human breast tumours. Nature 406: 747-752, 2000
    • (2000) Nature , vol.406 , pp. 747-752
    • Perou, C.M.1    Sørlie, T.2    Eisen, M.B.3
  • 2
    • 0035845511 scopus 로고    scopus 로고
    • Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    • Sørlie T, Perou CM, Tibshirani R, et al: Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A 98:10869-10874, 2001
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 10869-10874
    • Sørlie, T.1    Perou, C.M.2    Tibshirani, R.3
  • 3
    • 0037478605 scopus 로고    scopus 로고
    • Repeated observation of breast tumor subtypes in independent gene expression data sets
    • Sorlie T, Tibshirani R, Parker J, et al: Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci U S A 100:8418-8423, 2003
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 8418-8423
    • Sorlie, T.1    Tibshirani, R.2    Parker, J.3
  • 4
    • 0042838307 scopus 로고    scopus 로고
    • Breast cancer classification and prognosis based on gene expression profiles from a population-based study
    • Sotiriou C, Neo SY, McShane LM, et al: Breast cancer classification and prognosis based on gene expression profiles from a population-based study. Proc Natl Acad Sci U S A 100:10393-10398, 2003
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 10393-10398
    • Sotiriou, C.1    Neo, S.Y.2    McShane, L.M.3
  • 5
    • 28344454000 scopus 로고    scopus 로고
    • Molecular classification and molecular forecasting of breast cancer: Ready for clinical application?
    • Brenton JD, Carey LA, Ahmed AA, et al: Molecular classification and molecular forecasting of breast cancer: Ready for clinical application? J Clin Oncol 23:7350-7360, 2005
    • (2005) J Clin Oncol , vol.23 , pp. 7350-7360
    • Brenton, J.D.1    Carey, L.A.2    Ahmed, A.A.3
  • 6
    • 84872550777 scopus 로고    scopus 로고
    • Prognostic significance of progesterone receptor-positive tumor cells within immunohistochemically defined luminal A breast cancer
    • Prat A, Cheang MCU, Martín M, et al: Prognostic significance of progesterone receptor-positive tumor cells within immunohistochemically defined luminal A breast cancer. J Clin Oncol 31:203-209, 2013
    • (2013) J Clin Oncol , vol.31 , pp. 203-209
    • Prat, A.1    Cheang, M.C.U.2    Martín, M.3
  • 7
    • 13044304179 scopus 로고    scopus 로고
    • Distinctive gene expression patterns in human mammary epithelial cells and breast cancers
    • Perou CM, Jeffrey SS, van de Rijn M, et al: Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. Proc Natl Acad Sci U S A 96:9212-9217, 1999
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 9212-9217
    • Perou, C.M.1    Jeffrey, S.S.2    Van De Rijn, M.3
  • 8
    • 33646874546 scopus 로고    scopus 로고
    • The molecular portraits of breast tumors are conserved across microarray platforms
    • Hu Z, Fan C, Oh DS, et al: The molecular portraits of breast tumors are conserved across microarray platforms. BMC Genomics 7:96, 2006
    • (2006) BMC Genomics , vol.7 , pp. 96
    • Hu, Z.1    Fan, C.2    Oh, D.S.3
  • 9
    • 58149330982 scopus 로고    scopus 로고
    • Metaanalysis of gene expression profiles in breast cancer: Toward a unified understanding of breast cancer subtyping and prognosis signatures
    • Wirapati P, Sotiriou C, Kunkel S, et al: Metaanalysis of gene expression profiles in breast cancer: Toward a unified understanding of breast cancer subtyping and prognosis signatures. Breast Cancer Res 10:R65, 2008
    • (2008) Breast Cancer Res , vol.10
    • Wirapati, P.1    Sotiriou, C.2    Kunkel, S.3
  • 10
    • 77953248475 scopus 로고    scopus 로고
    • Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: A collaborative analysis of data for 10,159 cases from 12 studies
    • Blows FM, Driver KE, Schmidt MK, et al: Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: A collaborative analysis of data for 10,159 cases from 12 studies. PLoS Med 7:e1000279, 2010
    • (2010) PLoS Med , vol.7
    • Blows, F.M.1    Driver, K.E.2    Schmidt, M.K.3
  • 11
    • 66849140730 scopus 로고    scopus 로고
    • Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer
    • Cheang MC, Chia SK, Voduc D, et al: Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer. J Natl Cancer Inst 101:736-750, 2009
    • (2009) J Natl Cancer Inst , vol.101 , pp. 736-750
    • Cheang, M.C.1    Chia, S.K.2    Voduc, D.3
  • 12
    • 79960980007 scopus 로고    scopus 로고
    • Strategies for subtypes:d Dealing with the diversity of breast cancer - Highlights of the St. Gallen international expert consensus on the primary therapy of early breast cancer 2011
    • Goldhirsch A, Wood WC, Coates AS, et al: Strategies for subtypes:d Dealing with the diversity of breast cancer - Highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011. Ann Oncol 22:1736- 1747, 2011
    • (2011) Ann Oncol , vol.22 , pp. 1736-1747
    • Goldhirsch, A.1    Wood, W.C.2    Coates, A.S.3
  • 13
    • 84878518824 scopus 로고    scopus 로고
    • St. Gallen 2013 Brief preliminary summary of the consensus discussion
    • Harbeck N, Thomssen C, Gnant M: St. Gallen 2013: Brief preliminary summary of the consensus discussion. Breast Care (Basel) 8:102-109, 2013
    • (2013) Breast Care (Basel) , vol.8 , pp. 102-109
    • Harbeck, N.1    Thomssen, C.2    Gnant, M.3
  • 14
    • 84884994218 scopus 로고    scopus 로고
    • The Cancer Genome Atlas pan-cancer analysis project
    • Weinstein JN, Collisson EA, Mills GB, et al: The Cancer Genome Atlas pan-cancer analysis project. Nat Genet 45:1113-1120, 2013
    • (2013) Nat Genet , vol.45 , pp. 1113-1120
    • Weinstein, J.N.1    Collisson, E.A.2    Mills, G.B.3
  • 15
    • 33748939380 scopus 로고    scopus 로고
    • Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene-expression subtypes of breast cancer
    • Bergamaschi A, Kim YH, Wang P, et al: Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene-expression subtypes of breast cancer. Genes Chromosomes Cancer 45:1033-1040, 2006
    • (2006) Genes Chromosomes Cancer , vol.45 , pp. 1033-1040
    • Bergamaschi, A.1    Kim, Y.H.2    Wang, P.3
  • 16
    • 33845191779 scopus 로고    scopus 로고
    • Genomic and transcriptional aberrations linked to breast cancer pathophysiologies
    • Chin K, DeVries S, Fridlyand J, et al: Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Cancer Cell 10:529-541, 2006
    • (2006) Cancer Cell , vol.10 , pp. 529-541
    • Chin, K.1    Devries, S.2    Fridlyand, J.3
  • 17
    • 79952078260 scopus 로고    scopus 로고
    • ZNF703 gene amplification at 8p12 specifies luminal B breast cancer
    • Sircoulomb F, Nicolas N, Ferrari A, et al: ZNF703 gene amplification at 8p12 specifies luminal B breast cancer. EMBO Mol Med 3:153-166, 2011
    • (2011) EMBO Mol Med , vol.3 , pp. 153-166
    • Sircoulomb, F.1    Nicolas, N.2    Ferrari, A.3
  • 18
    • 79952093026 scopus 로고    scopus 로고
    • ZNF703 is a common luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium
    • Holland DG, Burleigh A, Git A, et al: ZNF703 is a common luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium. EMBO Mol Med 3:167-180, 2011
    • (2011) EMBO Mol Med , vol.3 , pp. 167-180
    • Holland, D.G.1    Burleigh, A.2    Git, A.3
  • 19
    • 84863441826 scopus 로고    scopus 로고
    • Expression of Six1 in luminal breast cancers predicts poor prognosis and promotes increases in tumor initiating cells by activation of extracellular signalregulated kinase and transforming growth factorbeta signaling pathways
    • Iwanaga R, Wang CA, Micalizzi DS, et al: Expression of Six1 in luminal breast cancers predicts poor prognosis and promotes increases in tumor initiating cells by activation of extracellular signalregulated kinase and transforming growth factorbeta signaling pathways. Breast Cancer Res 14: R100, 2012
    • (2012) Breast Cancer Res , vol.14
    • Iwanaga, R.1    Wang, C.A.2    Micalizzi, D.S.3
  • 20
    • 84861527388 scopus 로고    scopus 로고
    • The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
    • Curtis C, Shah SP, Chin SF, et al: The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups. Nature 486:346-352, 2012
    • (2012) Nature , vol.486 , pp. 346-352
    • Curtis, C.1    Shah, S.P.2    Chin, S.F.3
  • 21
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • Cancer Genome Atlas Network
    • Cancer Genome Atlas Network: Comprehensive molecular portraits of human breast tumours. Nature 490:61-70, 2012
    • (2012) Nature , vol.490 , pp. 61-70
  • 22
    • 84862584058 scopus 로고    scopus 로고
    • Wholegenome analysis informs breast cancer response to aromatase inhibition
    • Ellis MJ, Ding L, Shen D, et al: Wholegenome analysis informs breast cancer response to aromatase inhibition. Nature 486:353-360, 2012
    • (2012) Nature , vol.486 , pp. 353-360
    • Ellis, M.J.1    Ding, L.2    Shen, D.3
  • 23
    • 84862523863 scopus 로고    scopus 로고
    • Sequence analysis of mutations and translocations across breast cancer subtypes
    • Banerji S, Cibulskis K, Rangel-Escareno C, et al: Sequence analysis of mutations and translocations across breast cancer subtypes. Nature 486: 405-409, 2012
    • (2012) Nature , vol.486 , pp. 405-409
    • Banerji, S.1    Cibulskis, K.2    Rangel-Escareno, C.3
  • 24
    • 77955629953 scopus 로고    scopus 로고
    • Genomewide analysis of estrogen receptor alpha DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation
    • Stender JD, Kim K, Charn TH, et al: Genomewide analysis of estrogen receptor alpha DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation. Mol Cell Biol 30:3943-3955, 2010
    • (2010) Mol Cell Biol , vol.30 , pp. 3943-3955
    • Stender, J.D.1    Kim, K.2    Charn, T.H.3
  • 25
    • 77950114803 scopus 로고    scopus 로고
    • Delineating genetic alterations for tumor progression in the MCF10A series of breast cancer cell lines
    • Kadota M, Yang HH, Gomez B, et al: Delineating genetic alterations for tumor progression in the MCF10A series of breast cancer cell lines. PLoS ONE 5:e9201, 2010
    • (2010) PLoS One , vol.5
    • Kadota, M.1    Yang, H.H.2    Gomez, B.3
  • 26
    • 33746547467 scopus 로고    scopus 로고
    • Classification and risk stratification of invasive breast carcinomas using a real-time quantitative RT-PCR assay
    • Perreard L, Fan C, Quackenbush JF, et al: Classification and risk stratification of invasive breast carcinomas using a real-time quantitative RT-PCR assay. Breast Cancer Res 8:R23, 2006
    • (2006) Breast Cancer Res , vol.8
    • Perreard, L.1    Fan, C.2    Quackenbush, J.F.3
  • 27
    • 77950308839 scopus 로고    scopus 로고
    • Breast cancer molecular profiling with single sample predictors: A retrospective analysis
    • Weigelt B, Mackay A, A'Hern R, et al: Breast cancer molecular profiling with single sample predictors: A retrospective analysis. Lancet Oncol 11: 339-349, 2010
    • (2010) Lancet Oncol , vol.11 , pp. 339-349
    • Weigelt, B.1    MacKay, A.2    A'hern, R.3
  • 28
    • 84906811328 scopus 로고    scopus 로고
    • Predicting risk for late metastasis: The PAM50risk of recurrence (ROR) score after 5 years of endocrine therapy in postmenopausal women with HR+ early breast cancer - A study on 1,478 patients from the ABCSG-8 trial
    • Presented at the, Brussels, Belgium, May 2-4
    • Gnant M, Filipits M, Dubsky P: Predicting risk for late metastasis: The PAM50risk of recurrence (ROR) score after 5 years of endocrine therapy in postmenopausal women with HR+ early breast cancer - A study on 1,478 patients from the ABCSG-8 trial. Presented at the IMPAKT Breast Cancer Conference, Brussels, Belgium, May 2-4, 2013
    • (2013) IMPAKT Breast Cancer Conference
    • Gnant, M.1    Filipits, M.2    Dubsky, P.3
  • 29
    • 84884762173 scopus 로고    scopus 로고
    • Comparison of PAM50 risk of recurrence score with Oncotype DX and IHC4 for predicting risk of distant recurrence after endocrine therapy
    • Dowsett M, Sestak I, Lopez-Knowles E, et al: Comparison of PAM50 risk of recurrence score with Oncotype DX and IHC4 for predicting risk of distant recurrence after endocrine therapy. J Clin Oncol 31:2783-2790, 2013
    • (2013) J Clin Oncol , vol.31 , pp. 2783-2790
    • Dowsett, M.1    Sestak, I.2    Lopez-Knowles, E.3
  • 30
    • 60849097255 scopus 로고    scopus 로고
    • Gene-expression signatures in breast cancer
    • Sotiriou C, Pusztai L: Gene-expression signatures in breast cancer. N Engl J Med 360:790-800, 2009
    • (2009) N Engl J Med , vol.360 , pp. 790-800
    • Sotiriou, C.1    Pusztai, L.2
  • 31
    • 11244272987 scopus 로고    scopus 로고
    • Bimodal frequency distribution of estrogen receptor immunohistochemical staining results in breast cancer: An analysis of 825 cases
    • Collins LC, Botero ML, Schnitt SJ: Bimodal frequency distribution of estrogen receptor immunohistochemical staining results in breast cancer: An analysis of 825 cases. Am J Clin Pathol 123:16-20, 2005
    • (2005) Am J Clin Pathol , vol.123 , pp. 16-20
    • Collins, L.C.1    Botero, M.L.2    Schnitt, S.J.3
  • 32
    • 19944422061 scopus 로고    scopus 로고
    • A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
    • Paik S, Shak S, Tang G, et al: A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med 351: 2817-2826, 2004
    • (2004) N Engl J Med , vol.351 , pp. 2817-2826
    • Paik, S.1    Shak, S.2    Tang, G.3
  • 33
    • 0021212003 scopus 로고
    • Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67
    • Gerdes J, Lemke H, Baisch H, et al: Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 133:1710-1715, 1984
    • (1984) J Immunol , vol.133 , pp. 1710-1715
    • Gerdes, J.1    Lemke, H.2    Baisch, H.3
  • 34
    • 81555208345 scopus 로고    scopus 로고
    • Assessment of Ki67 in breast cancer: Recommendations from the International Ki67 in Breast Cancer working group
    • Dowsett M, Nielsen TO, A'Hern R, et al: Assessment of Ki67 in breast cancer: Recommendations from the International Ki67 in Breast Cancer working group. J Natl Cancer Inst 103:1656-1664, 2011
    • (2011) J Natl Cancer Inst , vol.103 , pp. 1656-1664
    • Dowsett, M.1    Nielsen, T.O.2    A'hern, R.3
  • 35
    • 34248595234 scopus 로고    scopus 로고
    • Ki-67 as prognostic marker in early breast cancer: A meta-analysis of published studies involving 12,155 patients
    • de Azambuja E, Cardoso F, de Castro G Jr, et al: Ki-67 as prognostic marker in early breast cancer: A meta-analysis of published studies involving 12,155 patients. Br J Cancer 96:1504-1513, 2007
    • (2007) Br J Cancer , vol.96 , pp. 1504-1513
    • De Azambuja, E.1    Cardoso, F.2    De Castro Jr., G.3
  • 36
    • 0038688478 scopus 로고    scopus 로고
    • Progesterone receptor status significantly improves outcome prediction over estrogen receptor status alone for adjuvant endocrine therapy in two large breast cancer databases
    • Bardou VJ, Arpino G, Elledge RM, et al: Progesterone receptor status significantly improves outcome prediction over estrogen receptor status alone for adjuvant endocrine therapy in two large breast cancer databases. J Clin Oncol 21:1973- 1979, 2003
    • (2003) J Clin Oncol , vol.21 , pp. 1973-1979
    • Bardou, V.J.1    Arpino, G.2    Elledge, R.M.3
  • 37
    • 36048980544 scopus 로고    scopus 로고
    • Biologic and clinical characteristics of breast cancer with single hormone receptor positive phenotype
    • Rakha EA, El-Sayed ME, Green AR, et al: Biologic and clinical characteristics of breast cancer with single hormone receptor positive phenotype. J Clin Oncol 25:4772-4778, 2007
    • (2007) J Clin Oncol , vol.25 , pp. 4772-4778
    • Rakha, E.A.1    El-Sayed, M.E.2    Green, A.R.3
  • 38
    • 84874565337 scopus 로고    scopus 로고
    • Progesterone receptor loss identifies luminal B breast cancer subgroups at higher risk of relapse
    • Cancello G, Maisonneuve P, Rotmensz N, et al: Progesterone receptor loss identifies luminal B breast cancer subgroups at higher risk of relapse. Ann Oncol 24:661-668, 2013
    • (2013) Ann Oncol , vol.24 , pp. 661-668
    • Cancello, G.1    Maisonneuve, P.2    Rotmensz, N.3
  • 39
    • 78049453780 scopus 로고    scopus 로고
    • A comparison of PAM50 intrinsic subtyping with immunohistochemistry and clinical prognostic factors in tamoxifen-treated estrogen receptor-positive breast cancer
    • Nielsen TO, Parker JS, Leung S, et al: A comparison of PAM50 intrinsic subtyping with immunohistochemistry and clinical prognostic factors in tamoxifen-treated estrogen receptor-positive breast cancer. Clin Cancer Res 16:5222-5232, 2010
    • (2010) Clin Cancer Res , vol.16 , pp. 5222-5232
    • Nielsen, T.O.1    Parker, J.S.2    Leung, S.3
  • 40
    • 33746910265 scopus 로고    scopus 로고
    • Concordance among gene-expression-based predictors for breast cancer
    • Fan C, Oh DS, Wessels L, et al: Concordance among gene-expression-based predictors for breast cancer. N Engl J Med 355:560-569, 2006
    • (2006) N Engl J Med , vol.355 , pp. 560-569
    • Fan, C.1    Oh, D.S.2    Wessels, L.3
  • 41
    • 33144462268 scopus 로고    scopus 로고
    • Gene expression profiling in breast cancer: Understanding the molecular basis of histologic grade to improve prognosis
    • Sotiriou C, Wirapati P, Loi S, et al: Gene expression profiling in breast cancer: Understanding the molecular basis of histologic grade to improve prognosis. J Natl Cancer Inst 98:262-272, 2006
    • (2006) J Natl Cancer Inst , vol.98 , pp. 262-272
    • Sotiriou, C.1    Wirapati, P.2    Loi, S.3
  • 42
    • 34247145491 scopus 로고    scopus 로고
    • Definition of clinically distinct molecular subtypes in estrogen receptor-positive breast carcinomas through genomic grade
    • Loi S, Haibe-Kains B, Desmedt C, et al: Definition of clinically distinct molecular subtypes in estrogen receptor-positive breast carcinomas through genomic grade. J Clin Oncol 25:1239-1246, 2007
    • (2007) J Clin Oncol , vol.25 , pp. 1239-1246
    • Loi, S.1    Haibe-Kains, B.2    Desmedt, C.3
  • 43
    • 78650958088 scopus 로고    scopus 로고
    • Building prognostic models for breast cancer patients using clinical variables and hundreds of gene expression signatures
    • Fan C, Prat A, Parker JS, et al: Building prognostic models for breast cancer patients using clinical variables and hundreds of gene expression signatures. BMC Med Genomics 4:3, 2011
    • (2011) BMC Med Genomics , vol.4 , pp. 3
    • Fan, C.1    Prat, A.2    Parker, J.S.3
  • 44
    • 80055090025 scopus 로고    scopus 로고
    • Most random gene expression signatures are significantly associated with breast cancer outcome
    • Venet D, Dumont JE, Detours V: Most random gene expression signatures are significantly associated with breast cancer outcome. PLoS Comput Biol 7:e1002240, 2011
    • (2011) PLoS Comput Biol , vol.7
    • Venet, D.1    Dumont, J.E.2    Detours, V.3
  • 45
    • 84855277725 scopus 로고    scopus 로고
    • A meta-analysis of gene expression profiling studies identifies clinically relevant oncogenic pathways in basal-like breast cancer
    • suppl 24; abstr 106
    • Ignatiadis M, Bedard P, Haibe-Kains B, et al: A meta-analysis of gene expression profiling studies identifies clinically relevant oncogenic pathways in basal-like breast cancer. Cancer Res 69, 2009 (suppl 24; abstr 106)
    • (2009) Cancer Res , vol.69
    • Ignatiadis, M.1    Bedard, P.2    Haibe-Kains, B.3
  • 46
    • 84855291245 scopus 로고    scopus 로고
    • Luminal-B breast cancer and novel therapeutic targets
    • Tran B, Bedard PL: Luminal-B breast cancer and novel therapeutic targets. Breast Cancer Res 13:221, 2011
    • (2011) Breast Cancer Res , vol.13 , pp. 221
    • Tran, B.1    Bedard, P.L.2
  • 47
    • 44849114353 scopus 로고    scopus 로고
    • Subtypes of breast cancer show preferential site of relapse
    • Smid M, Wang Y, Zhang Y, et al: Subtypes of breast cancer show preferential site of relapse. Cancer Res 68:3108-3114, 2008
    • (2008) Cancer Res , vol.68 , pp. 3108-3114
    • Smid, M.1    Wang, Y.2    Zhang, Y.3
  • 48
    • 33744814477 scopus 로고    scopus 로고
    • Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer
    • Paik S, Tang G, Shak S, et al: Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer. J Clin Oncol 24:3726-3734, 2006
    • (2006) J Clin Oncol , vol.24 , pp. 3726-3734
    • Paik, S.1    Tang, G.2    Shak, S.3
  • 49
    • 73249140371 scopus 로고    scopus 로고
    • Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: A retrospective analysis of a randomised trial
    • Albain KS, Barlow WE, Shak S, et al: Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: A retrospective analysis of a randomised trial. Lancet Oncol 11:55-65, 2010
    • (2010) Lancet Oncol , vol.11 , pp. 55-65
    • Albain, K.S.1    Barlow, W.E.2    Shak, S.3
  • 50
    • 28044472321 scopus 로고    scopus 로고
    • Gene expression profiles in paraffin-embedded core biopsy tissue predict response to chemotherapy in women with locally advanced breast cancer
    • Gianni L, Zambetti M, Clark K, et al: Gene expression profiles in paraffin-embedded core biopsy tissue predict response to chemotherapy in women with locally advanced breast cancer. J Clin Oncol 23:7265-7277, 2005
    • (2005) J Clin Oncol , vol.23 , pp. 7265-7277
    • Gianni, L.1    Zambetti, M.2    Clark, K.3
  • 51
    • 23844549918 scopus 로고    scopus 로고
    • Breast cancer molecular subtypes respond differently to preoperative chemotherapy
    • Rouzier R, Perou CM, Symmans WF, et al: Breast cancer molecular subtypes respond differently to preoperative chemotherapy. Clin Cancer Res 11:5678-5685, 2005
    • (2005) Clin Cancer Res , vol.11 , pp. 5678-5685
    • Rouzier, R.1    Perou, C.M.2    Symmans, W.F.3
  • 52
    • 33847063053 scopus 로고    scopus 로고
    • The triple negative paradox: Primary tumor chemosensitivity of breast cancer subtypes
    • Carey LA, Dees EC, Sawyer L, et al: The triple negative paradox: Primary tumor chemosensitivity of breast cancer subtypes. Clin Cancer Res 13:2329-2334, 2007
    • (2007) Clin Cancer Res , vol.13 , pp. 2329-2334
    • Carey, L.A.1    Dees, E.C.2    Sawyer, L.3
  • 53
    • 72449204608 scopus 로고    scopus 로고
    • Concordance of clinical and molecular breast cancer subtyping in the context of preoperative chemotherapy response
    • de Ronde JJ, Hannemann J, Halfwerk H, et al: Concordance of clinical and molecular breast cancer subtyping in the context of preoperative chemotherapy response. Breast Cancer Res Treat 119:119-126, 2010
    • (2010) Breast Cancer Res Treat , vol.119 , pp. 119-126
    • De Ronde, J.J.1    Hannemann, J.2    Halfwerk, H.3
  • 54
    • 70450221384 scopus 로고    scopus 로고
    • Breast cancer molecular profiles and tumor response of neoadjuvant doxorubicin and paclitaxel: The I-SPY trial (CALGB 150007/150012, ACRIN 6657)
    • suppl; abstr LBA515
    • Esserman LJ, Perou C, Cheang M, et al: Breast cancer molecular profiles and tumor response of neoadjuvant doxorubicin and paclitaxel: The I-SPY trial (CALGB 150007/150012, ACRIN 6657). J Clin Oncol 27:10s, 2009 (suppl; abstr LBA515)
    • (2009) J Clin Oncol , vol.27 , Issue.10 S
    • Esserman, L.J.1    Perou, C.2    Cheang, M.3
  • 55
    • 77949357106 scopus 로고    scopus 로고
    • Immunohistochemical surrogate markers of breast cancer molecular classes predicts response to neoadjuvant chemotherapy: A single institutional experience with 359 cases
    • Bhargava R, Beriwal S, Dabbs DJ, et al: Immunohistochemical surrogate markers of breast cancer molecular classes predicts response to neoadjuvant chemotherapy: A single institutional experience with 359 cases. Cancer 116:1431-1439, 2010
    • (2010) Cancer , vol.116 , pp. 1431-1439
    • Bhargava, R.1    Beriwal, S.2    Dabbs, D.J.3
  • 56
    • 84866333922 scopus 로고    scopus 로고
    • Predictive role of molecularsubtypesinresponsetoneoadjuvantchemotherapy in breast cancer patients in Northeast China
    • Lv M, Li B, Li Y, et al: Predictive role of molecularsubtypesinresponsetoneoadjuvantchemotherapy in breast cancer patients in Northeast China. Asian Pac J Cancer Prev 12:2411-2417, 2011
    • (2011) Asian Pac J Cancer Prev , vol.12 , pp. 2411-2417
    • Lv, M.1    Li, B.2    Li, Y.3
  • 57
    • 74849111553 scopus 로고    scopus 로고
    • The 70-gene signature as a response predictor for neoadjuvant chemotherapy in breast cancer
    • Straver ME, Glas AM, Hannemann J, et al: The 70-gene signature as a response predictor for neoadjuvant chemotherapy in breast cancer. Breast Cancer Res Treat 119:551-558, 2010
    • (2010) Breast Cancer Res Treat , vol.119 , pp. 551-558
    • Straver, M.E.1    Glas, A.M.2    Hannemann, J.3
  • 58
    • 84856217284 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy in ER+ HER2+ breast cancer: Response prediction based on immunohistochemical and molecular characteristics
    • Lips EH, Mulder L, de Ronde JJ, et al: Neoadjuvant chemotherapy in ER+ HER2+ breast cancer: Response prediction based on immunohistochemical and molecular characteristics. Breast Cancer Res Treat 131:827-836, 2012
    • (2012) Breast Cancer Res Treat , vol.131 , pp. 827-836
    • Lips, E.H.1    Mulder, L.2    De Ronde, J.J.3
  • 59
    • 84863936531 scopus 로고    scopus 로고
    • Gene modules and response to neoadjuvant chemotherapy in breast cancer subtypes: A pooled analysis
    • Ignatiadis M, Singhal SK, Desmedt C, et al: Gene modules and response to neoadjuvant chemotherapy in breast cancer subtypes: A pooled analysis. J Clin Oncol 30:1996-2004, 2012
    • (2012) J Clin Oncol , vol.30 , pp. 1996-2004
    • Ignatiadis, M.1    Singhal, S.K.2    Desmedt, C.3
  • 60
    • 84856636292 scopus 로고    scopus 로고
    • Comparisons between different polychemotherapy regimens for early breast cancer: Meta-analyses of long-term outcome among 100,000 women in 123 randomised trials
    • Peto R, Davies C, Godwin J, et al: Comparisons between different polychemotherapy regimens for early breast cancer: Meta-analyses of long-term outcome among 100,000 women in 123 randomised trials. Lancet 379:432-444, 2012
    • (2012) Lancet , vol.379 , pp. 432-444
    • Peto, R.1    Davies, C.2    Godwin, J.3
  • 61
    • 36549060490 scopus 로고    scopus 로고
    • The MINDACT trial: The first prospective clinical validation of a genomic tool
    • Cardoso F, Piccart-Gebhart M, Van't Veer L, et al: The MINDACT trial: The first prospective clinical validation of a genomic tool. Mol Oncol 1:246-251, 2007
    • (2007) Mol Oncol , vol.1 , pp. 246-251
    • Cardoso, F.1    Piccart-Gebhart, M.2    Van't Veer, L.3
  • 62
    • 33750895236 scopus 로고    scopus 로고
    • TAILORx: Trial assigning individualized options for treatment (Rx)
    • Sparano JA: TAILORx: Trial assigning individualized options for treatment (Rx). Clin Breast Cancer 7:347-350, 2006
    • (2006) Clin Breast Cancer , vol.7 , pp. 347-350
    • Sparano, J.A.1
  • 63
    • 84871719398 scopus 로고    scopus 로고
    • SWOG S1007: A phase III, randomized clinical trial of standard adjuvant endocrine therapy with or without chemotherapy in patients with one to three positive nodes, hormone receptor (HR)-positive, and HER2-negative breast cancer with recurrence score (RS) of 25 or less
    • suppl; abstr TPS104
    • Gonzalez-Angulo AM, Barlow WE, Gralow J, et al: SWOG S1007: A phase III, randomized clinical trial of standard adjuvant endocrine therapy with or without chemotherapy in patients with one to three positive nodes, hormone receptor (HR)-positive, and HER2-negative breast cancer with recurrence score (RS) of 25 or less. J Clin Oncol 29:8s, 2011 (suppl; abstr TPS104)
    • (2011) J Clin Oncol , vol.29
    • Gonzalez-Angulo, A.M.1    Barlow, W.E.2    Gralow, J.3
  • 64
    • 0032537396 scopus 로고    scopus 로고
    • Tamoxifen for early breast cancer: An overview of the randomised trials - Early Breast Cancer Trialists' Collaborative Group
    • Tamoxifen for early breast cancer: An overview of the randomised trials - Early Breast Cancer Trialists' Collaborative Group. Lancet 351:1451-1467, 1998
    • (1998) Lancet , vol.351 , pp. 1451-1467
  • 65
    • 34548536058 scopus 로고    scopus 로고
    • Prognostic and predictive value of centrally reviewed expression of estrogen and progesterone receptors in a randomized trial comparing letrozole and tamoxifen adjuvant therapy for postmenopausal early breast cancer: BIG 1-98
    • Viale G, Regan MM, Maiorano E, et al: Prognostic and predictive value of centrally reviewed expression of estrogen and progesterone receptors in a randomized trial comparing letrozole and tamoxifen adjuvant therapy for postmenopausal early breast cancer: BIG 1-98. J Clin Oncol 25:3846-3852, 2007
    • (2007) J Clin Oncol , vol.25 , pp. 3846-3852
    • Viale, G.1    Regan, M.M.2    Maiorano, E.3
  • 66
    • 29444435534 scopus 로고    scopus 로고
    • Expression of the 21 genes in the recurrence score assay and tamoxifen clinical benefit in the NSABP study B-14 of node negative, estrogen receptor positive breast cancer
    • suppl; abstr 510
    • Paik S, Shak S, Tang G, et al: Expression of the 21 genes in the recurrence score assay and tamoxifen clinical benefit in the NSABP study B-14 of node negative, estrogen receptor positive breast cancer. J Clin Oncol 23, 2005 (suppl; abstr 510)
    • (2005) J Clin Oncol , vol.23
    • Paik, S.1    Shak, S.2    Tang, G.3
  • 67
    • 33846545851 scopus 로고    scopus 로고
    • Survival and safety of exemestane versus tamoxifen after 2-3 years' tamoxifen treatment (Intergroup Exemestane Study): A randomised controlled trial
    • Coombes RC, Kilburn LS, Snowdon CF, et al: Survival and safety of exemestane versus tamoxifen after 2-3 years' tamoxifen treatment (Intergroup Exemestane Study): A randomised controlled trial. Lancet 369:559-570, 2007
    • (2007) Lancet , vol.369 , pp. 559-570
    • Coombes, R.C.1    Kilburn, L.S.2    Snowdon, C.F.3
  • 68
    • 77951637777 scopus 로고    scopus 로고
    • Prediction of risk of distant recurrence using the 21-gene recurrence score in node-negative and node-positive postmenopausal patients with breast cancer treated with anastrozole or tamoxifen: A TransATAC study
    • Dowsett M, Cuzick J, Wale C, et al: Prediction of risk of distant recurrence using the 21-gene recurrence score in node-negative and node-positive postmenopausal patients with breast cancer treated with anastrozole or tamoxifen: A TransATAC study. J Clin Oncol 28:1829-1834, 2010
    • (2010) J Clin Oncol , vol.28 , pp. 1829-1834
    • Dowsett, M.1    Cuzick, J.2    Wale, C.3
  • 69
    • 20044377912 scopus 로고    scopus 로고
    • Molecular classification of tamoxifen-resistant breast carcinomas by gene expression profiling
    • Jansen MP, Foekens JA, van Staveren IL, et al: Molecular classification of tamoxifen-resistant breast carcinomas by gene expression profiling. J Clin Oncol 23:732-740, 2005
    • (2005) J Clin Oncol , vol.23 , pp. 732-740
    • Jansen, M.P.1    Foekens, J.A.2    Van Staveren, I.L.3
  • 70
    • 58149267913 scopus 로고    scopus 로고
    • Comparison of gene expression profiles predicting progression in breast cancer patients treated with tamoxifen
    • Kok M, Linn SC, Van Laar RK, et al: Comparison of gene expression profiles predicting progression in breast cancer patients treated with tamoxifen. Breast Cancer Res Treat 113:275-283, 2009
    • (2009) Breast Cancer Res Treat , vol.113 , pp. 275-283
    • Kok, M.1    Linn, S.C.2    Van Laar, R.K.3
  • 71
    • 62549091454 scopus 로고    scopus 로고
    • Breast cancer subtypes and response to docetaxel in node-positive breast cancer: Use of an immunohistochemical definition in the BCIRG 001 trial
    • Hugh J, Hanson J, Cheang MCU, et al: Breast cancer subtypes and response to docetaxel in node-positive breast cancer: Use of an immunohistochemical definition in the BCIRG 001 trial. J Clin Oncol 27:1168-1176, 2009
    • (2009) J Clin Oncol , vol.27 , pp. 1168-1176
    • Hugh, J.1    Hanson, J.2    Cheang, M.C.U.3
  • 72
    • 33846965616 scopus 로고    scopus 로고
    • Prognostic value of Ki67 expression after short-term presurgical endocrine therapy for primary breast cancer
    • Dowsett M, Smith IE, Ebbs SR, et al: Prognostic value of Ki67 expression after short-term presurgical endocrine therapy for primary breast cancer. J Natl Cancer Inst 99:167-170, 2007
    • (2007) J Natl Cancer Inst , vol.99 , pp. 167-170
    • Dowsett, M.1    Smith, I.E.2    Ebbs, S.R.3
  • 73
    • 53249154813 scopus 로고    scopus 로고
    • Outcome prediction for estrogen receptor-positive breast cancer based on postneoadjuvant endocrine therapy tumor characteristics
    • Ellis MJ, Tao Y, Luo J, et al: Outcome prediction for estrogen receptor-positive breast cancer based on postneoadjuvant endocrine therapy tumor characteristics. J Natl Cancer Inst 100:1380-1388, 2008
    • (2008) J Natl Cancer Inst , vol.100 , pp. 1380-1388
    • Ellis, M.J.1    Tao, Y.2    Luo, J.3
  • 74
    • 79958766471 scopus 로고    scopus 로고
    • Association between breast cancer subtypes and response to neoadjuvant anastrozole
    • Dunbier AK, Anderson H, Ghazoui Z, et al: Association between breast cancer subtypes and response to neoadjuvant anastrozole. Steroids 76: 736-740, 2011
    • (2011) Steroids , vol.76 , pp. 736-740
    • Dunbier, A.K.1    Anderson, H.2    Ghazoui, Z.3
  • 75
    • 81755162797 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase and antiestrogen resistance in breast cancer
    • Miller TW, Balko JM, Arteaga CL: Phosphatidylinositol 3-kinase and antiestrogen resistance in breast cancer. J Clin Oncol 29:4452-4461, 2011
    • (2011) J Clin Oncol , vol.29 , pp. 4452-4461
    • Miller, T.W.1    Balko, J.M.2    Arteaga, C.L.3
  • 76
    • 79959268722 scopus 로고    scopus 로고
    • Randomized phase II neoadjuvant comparison between letrozole, anastrozole, and exemestane for postmenopausal women with estrogen receptor-rich stage 2 to 3 breast cancer: Clinical and biomarker outcomes and predictive value of the baseline PAM50-based intrinsic subtype - ACOSOG Z1031
    • Ellis MJ, Suman VJ, Hoog J, et al: Randomized phase II neoadjuvant comparison between letrozole, anastrozole, and exemestane for postmenopausal women with estrogen receptor-rich stage 2 to 3 breast cancer: Clinical and biomarker outcomes and predictive value of the baseline PAM50-based intrinsic subtype - ACOSOG Z1031. J Clin Oncol 29:2342-2349, 2011
    • (2011) J Clin Oncol , vol.29 , pp. 2342-2349
    • Ellis, M.J.1    Suman, V.J.2    Hoog, J.3
  • 77
    • 32944457272 scopus 로고    scopus 로고
    • Retrospective analysis of time to recurrence in the ATAC trial according to hormone receptor status: A hypothesis-generating study
    • Dowsett M, Cuzick J, Wale C, et al: Retrospective analysis of time to recurrence in the ATAC trial according to hormone receptor status: A hypothesis-generating study. J Clin Oncol 23:7512-7517, 2005
    • (2005) J Clin Oncol , vol.23 , pp. 7512-7517
    • Dowsett, M.1    Cuzick, J.2    Wale, C.3
  • 78
    • 79959884829 scopus 로고    scopus 로고
    • Which patients benefit most from adjuvant aromatase inhibitors? Results using a composite measure of prognostic risk in the BIG 1-98 randomized trial
    • Viale G, Regan MM, Dell'Orto P, et al: Which patients benefit most from adjuvant aromatase inhibitors? Results using a composite measure of prognostic risk in the BIG 1-98 randomized trial. Ann Oncol 22:2201-2207, 2011
    • (2011) Ann Oncol , vol.22 , pp. 2201-2207
    • Viale, G.1    Regan, M.M.2    Dell'orto, P.3
  • 79
    • 0035884620 scopus 로고    scopus 로고
    • Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and/or ErbB-2-positive, estrogen receptor-positive primary breast cancer: Evidence from a phase III randomized trial
    • Ellis MJ, Coop A, Singh B, et al: Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and/or ErbB-2-positive, estrogen receptor-positive primary breast cancer: Evidence from a phase III randomized trial. J Clin Oncol 19:3808-3816, 2001
    • (2001) J Clin Oncol , vol.19 , pp. 3808-3816
    • Ellis, M.J.1    Coop, A.2    Singh, B.3
  • 80
    • 24644490871 scopus 로고    scopus 로고
    • Neoadjuvant treatment of postmenopausal breast cancer with anastrozole, tamoxifen, or both in combination: The Immediate Preoperative Anastrozole, Tamoxifen, or Combined with Tamoxifen (IMPACT) multicenter double-blind randomized trial
    • Smith IE, Dowsett M, Ebbs SR, et al: Neoadjuvant treatment of postmenopausal breast cancer with anastrozole, tamoxifen, or both in combination: The Immediate Preoperative Anastrozole, Tamoxifen, or Combined with Tamoxifen (IMPACT) multicenter double-blind randomized trial. J Clin Oncol 23:5108-5116, 2005
    • (2005) J Clin Oncol , vol.23 , pp. 5108-5116
    • Smith, I.E.1    Dowsett, M.2    Ebbs, S.R.3
  • 81
    • 27644597480 scopus 로고    scopus 로고
    • A meta-analysis on the interaction between HER-2 expression and response to endocrine treatment in advanced breast cancer
    • De Laurentiis M, Arpino G, Massarelli E, et al: A meta-analysis on the interaction between HER-2 expression and response to endocrine treatment in advanced breast cancer. Clin Cancer Res 11:4741-4748, 2005
    • (2005) Clin Cancer Res , vol.11 , pp. 4741-4748
    • De Laurentiis, M.1    Arpino, G.2    Massarelli, E.3
  • 82
    • 84873918443 scopus 로고    scopus 로고
    • Activating HER2 mutations in HER2 gene amplification negative breast cancer
    • Bose R, Kavuri SM, Searleman AC, et al: Activating HER2 mutations in HER2 gene amplification negative breast cancer. Cancer Discov 3:224-237, 2013
    • (2013) Cancer Discov , vol.3 , pp. 224-237
    • Bose, R.1    Kavuri, S.M.2    Searleman, A.C.3
  • 83
    • 84880502601 scopus 로고    scopus 로고
    • Designing transformative clinical trials in the cancer genome era
    • Sleijfer S, Bogaerts J, Siu LL: Designing transformative clinical trials in the cancer genome era. J Clin Oncol 31:1834-1841, 2013
    • (2013) J Clin Oncol , vol.31 , pp. 1834-1841
    • Sleijfer, S.1    Bogaerts, J.2    Siu, L.L.3
  • 84
    • 77954974573 scopus 로고    scopus 로고
    • Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor-positive human breast cancer
    • Miller TW, Hennessy BT, González-Angulo AM, et al: Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor-positive human breast cancer. J Clin Invest 120:2406-2413, 2010
    • (2010) J Clin Invest , vol.120 , pp. 2406-2413
    • Miller, T.W.1    Hennessy, B.T.2    González-Angulo, A.M.3
  • 85
    • 66249119060 scopus 로고    scopus 로고
    • Loss of phosphatase and tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer
    • Miller TW, Pérez-Torres M, Narasanna A, et al: Loss of phosphatase and tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer. Cancer Res 69:4192-4201, 2009
    • (2009) Cancer Res , vol.69 , pp. 4192-4201
    • Miller, T.W.1    Pérez-Torres, M.2    Narasanna, A.3
  • 86
    • 38849091433 scopus 로고    scopus 로고
    • Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic function
    • Massarweh S, Osborne CK, Creighton CJ, et al: Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic function. Cancer Res 68:826-833, 2008
    • (2008) Cancer Res , vol.68 , pp. 826-833
    • Massarweh, S.1    Osborne, C.K.2    Creighton, C.J.3
  • 87
    • 33748080758 scopus 로고    scopus 로고
    • Insulin-like growth factor binding protein 2 is a marker for antiestrogen resistant human breast cancer cell lines but is not a major growth regulator
    • Juncker-Jensen A, Lykkesfeldt AE, Worm J, et al: Insulin-like growth factor binding protein 2 is a marker for antiestrogen resistant human breast cancer cell lines but is not a major growth regulator. Growth Horm IGF Res 16:224-239, 2006
    • (2006) Growth Horm IGF Res , vol.16 , pp. 224-239
    • Juncker-Jensen, A.1    Lykkesfeldt, A.E.2    Worm, J.3
  • 88
    • 84868212708 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway inhibition: A breakthrough in the management of luminal (ER+/HER2+) breast cancers?
    • Zardavas D, Fumagalli D, Loi S: Phosphatidylinositol 3-kinase/AKT/ mammalian target of rapamycin pathway inhibition: A breakthrough in the management of luminal (ER+/HER2+) breast cancers? Curr Opin Oncol 24:623-634, 2012
    • (2012) Curr Opin Oncol , vol.24 , pp. 623-634
    • Zardavas, D.1    Fumagalli, D.2    Loi, S.3
  • 89
    • 77953422867 scopus 로고    scopus 로고
    • PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer
    • Loi S, Haibe-Kains B, Majjaj S, et al: PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer. Proc Natl Acad Sci U S A 107:10208-10213, 2010
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 10208-10213
    • Loi, S.1    Haibe-Kains, B.2    Majjaj, S.3
  • 90
    • 37149020235 scopus 로고    scopus 로고
    • The oral mTOR inhibitor RAD001 (everolimus) in combination with letrozole in patients with advanced breast cancer: Results of a phase i study with pharmacokinetics
    • Awada A, Cardoso F, Fontaine C, et al: The oral mTOR inhibitor RAD001 (everolimus) in combination with letrozole in patients with advanced breast cancer: Results of a phase I study with pharmacokinetics. Eur J Cancer 44:84-91, 2008
    • (2008) Eur J Cancer , vol.44 , pp. 84-91
    • Awada, A.1    Cardoso, F.2    Fontaine, C.3
  • 91
    • 66849136781 scopus 로고    scopus 로고
    • Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer
    • Baselga J, Semiglazov V, van Dam P, et al: Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer. J Clin Oncol 27:2630-2637, 2009
    • (2009) J Clin Oncol , vol.27 , pp. 2630-2637
    • Baselga, J.1    Semiglazov, V.2    Van Dam, P.3
  • 92
    • 84864558874 scopus 로고    scopus 로고
    • Randomized phase II trial of everolimus in combination with tamoxifen in patients with hormone receptor- positive, human epidermal growth factor receptor 2-negative metastatic breast cancer with prior exposure to aromatase inhibitors: A GINECO study
    • Bachelot T, Bourgier C, Cropet C, et al: Randomized phase II trial of everolimus in combination with tamoxifen in patients with hormone receptor- positive, human epidermal growth factor receptor 2-negative metastatic breast cancer with prior exposure to aromatase inhibitors: A GINECO study. J Clin Oncol 30:2718-2724, 2012
    • (2012) J Clin Oncol , vol.30 , pp. 2718-2724
    • Bachelot, T.1    Bourgier, C.2    Cropet, C.3
  • 93
    • 84863078767 scopus 로고    scopus 로고
    • Everolimus in postmenopausal hormone-receptorpositive advanced breast cancer
    • Baselga J, Campone M, Piccart M, et al: Everolimus in postmenopausal hormone-receptorpositive advanced breast cancer. N Engl J Med 366:520-529, 2012
    • (2012) N Engl J Med , vol.366 , pp. 520-529
    • Baselga, J.1    Campone, M.2    Piccart, M.3
  • 94
    • 84885435345 scopus 로고    scopus 로고
    • Correlation of molecular alterations with efficacy of everolimus in hormone receptor-positive, HER2- negative advanced breast cancer: Results from BOLERO-2
    • suppl 15s; abstr LBA509
    • Hortobagyi GN, Piccart MJ, Rugo HS, et al: Correlation of molecular alterations with efficacy of everolimus in hormone receptor-positive, HER2- negative advanced breast cancer: Results from BOLERO-2. J Clin Oncol 31, 2013 (suppl 15s; abstr LBA509)
    • (2013) J Clin Oncol , vol.31
    • Hortobagyi, G.N.1    Piccart, M.J.2    Rugo, H.S.3
  • 95
    • 84871820669 scopus 로고    scopus 로고
    • PIK3CA genotype and a PIK3CA mutation-related gene signature and response to everolimus and letrozole in estrogen receptor positive breast cancer
    • Loi S, Michiels S, Baselga J, et al: PIK3CA genotype and a PIK3CA mutation-related gene signature and response to everolimus and letrozole in estrogen receptor positive breast cancer. PLoS ONE 8:e53292, 2013
    • (2013) PLoS One , vol.8
    • Loi, S.1    Michiels, S.2    Baselga, J.3
  • 96
    • 84906811329 scopus 로고    scopus 로고
    • Translational studies within the TAMRAD randomized Gineco trial: Evidence for TORC1 activation marker as a predictive factor for everolimus efficacy in metastatic breast cancer (MBC)
    • Presented at the, Brussels, Belgium, May 3-5
    • Bachelot T, Ferrero J, Cropet C, et al: Translational studies within the TAMRAD randomized Gineco trial: Evidence for TORC1 activation marker as a predictive factor for everolimus efficacy in metastatic breast cancer (MBC). Presented at the IMPAKT Breast Cancer Conference, Brussels, Belgium, May 3-5, 2012
    • (2012) IMPAKT Breast Cancer Conference
    • Bachelot, T.1    Ferrero, J.2    Cropet, C.3
  • 97
    • 61449235398 scopus 로고    scopus 로고
    • Not all substrates are treated equally: Implications for mTOR, rapamycinresistance and cancer therapy
    • Choo AY, Blenis J: Not all substrates are treated equally: Implications for mTOR, rapamycinresistance and cancer therapy. Cell Cycle 8:567-572, 2009
    • (2009) Cell Cycle , vol.8 , pp. 567-572
    • Choo, A.Y.1    Blenis, J.2
  • 98
    • 3342958797 scopus 로고    scopus 로고
    • The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
    • Harrington LS, Findlay GM, Gray A, et al: The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J Cell Biol 166:213-223, 2004
    • (2004) J Cell Biol , vol.166 , pp. 213-223
    • Harrington, L.S.1    Findlay, G.M.2    Gray, A.3
  • 99
    • 84875752240 scopus 로고    scopus 로고
    • Emerging targeted agents in metastatic breast cancer
    • Zardavas D, Baselga J, Piccart M: Emerging targeted agents in metastatic breast cancer. Nat Rev Clin Oncol 10:191-210, 2013
    • (2013) Nat Rev Clin Oncol , vol.10 , pp. 191-210
    • Zardavas, D.1    Baselga, J.2    Piccart, M.3
  • 100
    • 75149170979 scopus 로고    scopus 로고
    • Fibroblast growth factor signalling: From development to cancer
    • Turner N, Grose R: Fibroblast growth factor signalling: From development to cancer. Nat Rev Cancer 10:116-129, 2010
    • (2010) Nat Rev Cancer , vol.10 , pp. 116-129
    • Turner, N.1    Grose, R.2
  • 101
    • 77950278598 scopus 로고    scopus 로고
    • FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer
    • Turner N, Pearson A, Sharpe R, et al: FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer. Cancer Res 70:2085-2094, 2010
    • (2010) Cancer Res , vol.70 , pp. 2085-2094
    • Turner, N.1    Pearson, A.2    Sharpe, R.3
  • 102
    • 34447325266 scopus 로고    scopus 로고
    • FGFR1 amplification in breast carcinomas: A chromogenic in situ hybridisation analysis
    • Elbauomy Elsheikh S, Green AR, Lambros MB, et al: FGFR1 amplification in breast carcinomas: A chromogenic in situ hybridisation analysis. Breast Cancer Res 9:R23, 2007
    • (2007) Breast Cancer Res , vol.9
    • Elbauomy Elsheikh, S.1    Green, A.R.2    Lambros, M.B.3
  • 103
    • 84874088896 scopus 로고    scopus 로고
    • 319O: Significant antitumor activity of E-3810, a novel FGFR and VEGFR inhibitor, in patients with FGFR1 amplified breast cancer
    • Presented at the, Vienna, Austria, September 28-October 2
    • Dienstmann R, Andre F, Soria J, et al: 319O: Significant antitumor activity of E-3810, a novel FGFR and VEGFR inhibitor, in patients with FGFR1 amplified breast cancer. Presented at the European Society for Medical Oncology Congress, Vienna, Austria, September 28-October 2, 2012
    • (2012) European Society for Medical Oncology Congress
    • Dienstmann, R.1    Andre, F.2    Soria, J.3
  • 104
    • 84875693922 scopus 로고    scopus 로고
    • A multicenter, open-label phase II trial of dovitinib, a fibroblast growth factor receptor 1 (FGFR1) inhibitor, inFGFR1-amplified and nonamplified metastatic breast cancer (BC)
    • suppl; abstr 289
    • Andre F, Bachelot T, Campone M, et al: A multicenter, open-label phase II trial of dovitinib, a fibroblast growth factor receptor 1 (FGFR1) inhibitor, inFGFR1-amplified and nonamplified metastatic breast cancer (BC). J Clin Oncol 29, 2011 (suppl; abstr 289)
    • (2011) J Clin Oncol , vol.29
    • Andre, F.1    Bachelot, T.2    Campone, M.3
  • 105
    • 84857640868 scopus 로고    scopus 로고
    • The insulin and insulin-like growth factor receptor family in neoplasia: An update
    • Pollak M: The insulin and insulin-like growth factor receptor family in neoplasia: An update. Nat Rev Cancer 12:159-169, 2012
    • (2012) Nat Rev Cancer , vol.12 , pp. 159-169
    • Pollak, M.1
  • 106
    • 0031014164 scopus 로고    scopus 로고
    • Type i insulin-like growth factor receptor gene expression in normal human breast tissue treated with oestrogen and progesterone
    • Clarke RB, Howell A, Anderson E: Type I insulin-like growth factor receptor gene expression in normal human breast tissue treated with oestrogen and progesterone. Br J Cancer 75:251-257, 1997
    • (1997) Br J Cancer , vol.75 , pp. 251-257
    • Clarke, R.B.1    Howell, A.2    Anderson, E.3
  • 107
    • 0036346061 scopus 로고    scopus 로고
    • Synergistic proliferative action of insulinlike growth factor i and 17 beta-estradiol in MCF-7S breast tumor cells
    • Hamelers IH, van Schaik RF, van Teeffelen HA, et al: Synergistic proliferative action of insulinlike growth factor I and 17 beta-estradiol in MCF-7S breast tumor cells. Exp Cell Res 273:107-117, 2002
    • (2002) Exp Cell Res , vol.273 , pp. 107-117
    • Hamelers, I.H.1    Van Schaik, R.F.2    Van Teeffelen, H.A.3
  • 108
    • 0027762610 scopus 로고
    • Type i IGF receptor and acquired tamoxifen resistance in oestrogen-responsive human breast cancer cells
    • Wiseman LR, Johnson MD, Wakeling AE, et al: Type I IGF receptor and acquired tamoxifen resistance in oestrogen-responsive human breast cancer cells. Eur J Cancer 29A:2256-2264, 1993
    • (1993) Eur J Cancer , vol.29 A , pp. 2256-2264
    • Wiseman, L.R.1    Johnson, M.D.2    Wakeling, A.E.3
  • 109
    • 0033001742 scopus 로고    scopus 로고
    • Altered expression of the IGF-1 receptor in a tamoxifenresistant human breast cancer cell line
    • Parisot JP, Hu XF, DeLuise M, et al: Altered expression of the IGF-1 receptor in a tamoxifenresistant human breast cancer cell line. Br J Cancer 79:693-700, 1999
    • (1999) Br J Cancer , vol.79 , pp. 693-700
    • Parisot, J.P.1    Hu, X.F.2    Deluise, M.3
  • 110
    • 56749118600 scopus 로고    scopus 로고
    • The aromatase inhibitor letrozole and inhibitors of insulin-like growth factor i receptor synergistically induce apoptosis in in vitro models of estrogendependent breast cancer
    • Lisztwan J, Pornon A, Chen B, et al: The aromatase inhibitor letrozole and inhibitors of insulin-like growth factor I receptor synergistically induce apoptosis in in vitro models of estrogendependent breast cancer. Breast Cancer Res 10: R56, 2008
    • (2008) Breast Cancer Res , vol.10
    • Lisztwan, J.1    Pornon, A.2    Chen, B.3
  • 111
    • 84255192030 scopus 로고    scopus 로고
    • Dual IGF- 1R/InsR inhibitor BMS-754807 synergizes with hormonal agents in treatment of estrogen-dependent breast cancer
    • Hou X, Huang F, Macedo LF, et al: Dual IGF- 1R/InsR inhibitor BMS-754807 synergizes with hormonal agents in treatment of estrogen-dependent breast cancer. Cancer Res 71:7597-7607, 2011
    • (2011) Cancer Res , vol.71 , pp. 7597-7607
    • Hou, X.1    Huang, F.2    MacEdo, L.F.3
  • 112
    • 80052157331 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, phase 2 study of AMG 479 with exemestane (E) or fulvestrant (F) in postmenopausal women with hormonereceptor positive (HR+) metastatic (M) or locally advanced (LA) breast cancer (BC)
    • abstr S1-4
    • Kaufman P, Ferrero J, Bourgeois H, et al: A randomized, double-blind, placebo-controlled, phase 2 study of AMG 479 with exemestane (E) or fulvestrant (F) in postmenopausal women with hormonereceptor positive (HR+) metastatic (M) or locally advanced (LA) breast cancer (BC). Cancer Res 70, 2011 (abstr S1-4)
    • (2011) Cancer Res , vol.70
    • Kaufman, P.1    Ferrero, J.2    Bourgeois, H.3
  • 113
    • 77956579297 scopus 로고    scopus 로고
    • A phase i study of the oral mTOR inhibitor ridaforolimus (RIDA) in combination with the IGF-1R antibody dalotozumab (DALO) in patients (pts) with advanced solid tumors
    • suppl; abstr 3008
    • Di Cosimo S, Bendell JC, Cervantes-Ruiperez A, et al: A phase I study of the oral mTOR inhibitor ridaforolimus (RIDA) in combination with the IGF-1R antibody dalotozumab (DALO) in patients (pts) with advanced solid tumors. J Clin Oncol 28:235s, 2010 (suppl; abstr 3008)
    • (2010) J Clin Oncol , vol.28
    • Di Cosimo, S.1    Bendell, J.C.2    Cervantes-Ruiperez, A.3
  • 114
    • 32944457518 scopus 로고    scopus 로고
    • MTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
    • O'Reilly KE, Rojo F, She QB, et al: MTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res 66:1500-1508, 2006
    • (2006) Cancer Res , vol.66 , pp. 1500-1508
    • O'reilly, K.E.1    Rojo, F.2    She, Q.B.3
  • 116
    • 2942533005 scopus 로고    scopus 로고
    • Cyclin D1 overexpression is a negative predictive factor for tamoxifen response in postmenopausal breast cancer patients
    • Stendahl M, Kronblad A, Rydén L, et al: Cyclin D1 overexpression is a negative predictive factor for tamoxifen response in postmenopausal breast cancer patients. Br J Cancer 90:1942-1948, 2004
    • (2004) Br J Cancer , vol.90 , pp. 1942-1948
    • Stendahl, M.1    Kronblad, A.2    Rydén, L.3
  • 117
    • 41549097895 scopus 로고    scopus 로고
    • Cyclin D1 expression in breast cancer patients receiving adjuvant tamoxifen-based therapy
    • Rudas M, Lehnert M, Huynh A, et al: Cyclin D1 expression in breast cancer patients receiving adjuvant tamoxifen-based therapy. Clin Cancer Res 14:1767-1774, 2008
    • (2008) Clin Cancer Res , vol.14 , pp. 1767-1774
    • Rudas, M.1    Lehnert, M.2    Huynh, A.3
  • 118
    • 0042567223 scopus 로고    scopus 로고
    • Cyclin-E is a strong predictor of endocrine therapy failure in human breast cancer
    • Span PN, Tjan-Heijnen VC, Manders P, et al: Cyclin-E is a strong predictor of endocrine therapy failure in human breast cancer. Oncogene 22:4898-4904, 2003
    • (2003) Oncogene , vol.22 , pp. 4898-4904
    • Span, P.N.1    Tjan-Heijnen, V.C.2    Manders, P.3
  • 119
    • 84863803266 scopus 로고    scopus 로고
    • Cyclin E2 overexpression is associated with endocrine resistance but not insensitivity to CDK2 inhibition in human breast cancer cells
    • Caldon CE, Sergio CM, Kang J, et al: Cyclin E2 overexpression is associated with endocrine resistance but not insensitivity to CDK2 inhibition in human breast cancer cells. Mol Cancer Ther 11: 1488-1499, 2012
    • (2012) Mol Cancer Ther , vol.11 , pp. 1488-1499
    • Caldon, C.E.1    Sergio, C.M.2    Kang, J.3
  • 120
    • 84875697676 scopus 로고    scopus 로고
    • Results of a randomized phase 2 study of PD 0332991, a cyclindependent kinase (CDK) 4/6 inhibitor, in combination with letrozole vs letrozole alone for first-line treatment of ER+, HER2+ advanced breast cancer (TRIO-18)
    • Presented at the, Brussels, Belgium, May 3-5
    • Finn R, Crown J, Boer K, et al: Results of a randomized phase 2 study of PD 0332991, a cyclindependent kinase (CDK) 4/6 inhibitor, in combination with letrozole vs letrozole alone for first-line treatment of ER+, HER2+ advanced breast cancer (TRIO-18). Presented at the IMPAKT Breast Cancer Conference, Brussels, Belgium, May 3-5, 2012
    • (2012) IMPAKT Breast Cancer Conference
    • Finn, R.1    Crown, J.2    Boer, K.3
  • 121
    • 53049108040 scopus 로고    scopus 로고
    • Targeting the MDM2- p53 interaction for cancer therapy
    • Shangary S, Wang S: Targeting the MDM2- p53 interaction for cancer therapy. Clin Cancer Res 14:5318-5324, 2008
    • (2008) Clin Cancer Res , vol.14 , pp. 5318-5324
    • Shangary, S.1    Wang, S.2
  • 122
    • 84879614664 scopus 로고    scopus 로고
    • Altered expression of MLL methyltransferase family genes in breast cancer
    • Rabello Ddo A, de Moura CA, de Andrade RV, et al: Altered expression of MLL methyltransferase family genes in breast cancer. Int J Oncol 43:653-660, 2013
    • (2013) Int J Oncol , vol.43 , pp. 653-660
    • Rabello Ddo, A.1    De Moura, C.A.2    De Andrade, R.V.3
  • 123
    • 79952384705 scopus 로고    scopus 로고
    • Cancer epigenetics reaches mainstream oncology
    • Rodríguez-Paredes M, Esteller M: Cancer epigenetics reaches mainstream oncology. Nat Med 17:330-339, 2011
    • (2011) Nat Med , vol.17 , pp. 330-339
    • Rodríguez-Paredes, M.1    Esteller, M.2
  • 124
    • 33847111684 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor LBH589 reactivates silenced estrogen receptor alpha (ER) gene expression without loss of DNA hypermethylation
    • Zhou Q, Atadja P, Davidson NE: Histone deacetylase inhibitor LBH589 reactivates silenced estrogen receptor alpha (ER) gene expression without loss of DNA hypermethylation. Cancer Biol Ther 6:64-69, 2007
    • (2007) Cancer Biol Ther , vol.6 , pp. 64-69
    • Zhou, Q.1    Atadja, P.2    Davidson, N.E.3
  • 125
    • 59349106138 scopus 로고    scopus 로고
    • Timing is everything: Order of administration of 5-aza 2+ deoxycytidine, trichostatin A and tamoxifen changes estrogen receptor mRNA expression and cell sensitivity
    • Hostetter CL, Licata LA, Keen JC: Timing is everything: Order of administration of 5-aza 2+ deoxycytidine, trichostatin A and tamoxifen changes estrogen receptor mRNA expression and cell sensitivity. Cancer Lett 275:178-184, 2009
    • (2009) Cancer Lett , vol.275 , pp. 178-184
    • Hostetter, C.L.1    Licata, L.A.2    Keen, J.C.3
  • 126
    • 84879834815 scopus 로고    scopus 로고
    • Randomized phase II, double-blind, placebocontrolled study of exemestane with or without entinostat in postmenopausal women with locally recurrent or metastatic estrogen receptor-positive breast cancer progressing on treatment with a nonsteroidal aromatase inhibitor
    • Yardley DA, Ismail-Khan RR, Melichar B, et al: Randomized phase II, double-blind, placebocontrolled study of exemestane with or without entinostat in postmenopausal women with locally recurrent or metastatic estrogen receptor-positive breast cancer progressing on treatment with a nonsteroidal aromatase inhibitor. J Clin Oncol 31:2128-2135, 2013
    • (2013) J Clin Oncol , vol.31 , pp. 2128-2135
    • Yardley, D.A.1    Ismail-Khan, R.R.2    Melichar, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.