A Pharmacogenetic Determinant of Mu-Opioid Receptor Antagonist Effects on Alcohol Reward and Consumption: Evidence from Humanized Mice

Biological Psychiatry

Volumn 77, Issue 10, 2015, Pages 850-858

  Bilbao, Ainhoa ^a   Robinson, J Elliott ^b   Heilig, Markus ^c,d   Malanga, C J ^b   Spanagel, Rainer ^a   Sommer, Wolfgang H ^a   Thorsell, Annika ^d  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^d LINKÖPING UNIVERSITY   (Sweden)

Author keywords

Alcohol; Intracranial self stimulation (ICSS); Mouse; Mu opioid receptor; Pharmacogenetics; Reward

Indexed keywords

ALCOHOL; ENDORPHIN; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; NALMEFENE; NALTREXONE; NICOTINAMIDE ADENINE DINUCLEOTIDE;

ADULT; ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ALCOHOLISM; ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN DEPTH STIMULATION; CAGE; CLINICAL EFFECTIVENESS; CLINICAL EVALUATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRINKING; DRUG EFFECT; EFFECT SIZE; ELECTROSTIMULATION; GENE LOCUS; GENETIC ANALYSIS; GENETIC VARIABILITY; GENOTYPE; HUMAN; MALE; MOUSE; NONHUMAN; PARTIAL AGONISM; PERSONALIZED MEDICINE; PHARMACOGENETICS; PRIORITY JOURNAL; SELF STIMULATION; TREATMENT RESPONSE; AGONISTS; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; DRINKING BEHAVIOR; DRUG EFFECTS; DRUG SELF ADMINISTRATION; GENETICS; INSTRUMENTAL CONDITIONING; PHYSIOLOGY; REWARD; TRANSGENIC MOUSE;

ALCOHOL DRINKING; ANIMALS; CONDITIONING, OPERANT; ELECTRIC STIMULATION; ETHANOL; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NALTREXONE; RECEPTORS, OPIOID, MU; REWARD; SELF ADMINISTRATION;

EID: 84928736264     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2014.08.021     Document Type: Article

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