Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 44, 2012, Pages 18156-18161

  George, Olivier ^a   Sanders, Chelsea ^a   Freiling, John ^a   Grigoryan, Edward ^a   Vu, Shayla ^a   Allen, Camryn D ^a   Crawford, Elena ^a   Mandyam, Chitra D ^a   Koob, George F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Addiction; Alcoholism; Compulsivity; Connectivity; Stress

Indexed keywords

ALCOHOL; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR;

ALCOHOL CONSUMPTION; ALCOHOL WITHDRAWAL; ALCOHOLISM; AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANXIETY; ARTICLE; BRAIN CELL; COGNITIVE DEFECT; CONTROLLED STUDY; HIPPOCAMPUS; MALE; MEDIAL PREFRONTAL CORTEX NEURON; NONHUMAN; NUCLEUS ACCUMBENS; PREDICTION; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WORKING MEMORY;

ALCOHOL DRINKING; ANIMALS; ANXIETY; COGNITION DISORDERS; ETHANOL; MALE; PREFRONTAL CORTEX; RATS; RATS, WISTAR; SUBSTANCE WITHDRAWAL SYNDROME;

MURINAE; RATTUS;

EID: 84868103665     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1116523109     Document Type: Article

References (34)

1. Koob GF, et al. (2004) Neurobiological mechanisms in the transition from drug use to drug dependence. Neurosci Biobehav Rev 27(8):739-749.
2. Simms JA, et al. (2008) Intermittent access to 20% ethanol induces high ethanol consumption in Long-Evans and Wistar rats. Alcohol Clin Exp Res 32(10):1816-1823.
3. Wise RA (1973) Voluntary ethanol intake in rats following exposure to ethanol on various schedules. Psychopharmacology (Berl) 29(3):203-210.
4. Nielsen CK, et al. (2008) A novel delta opioid receptor antagonist, SoRI-9409, produces a selective and long-lasting decrease in ethanol consumption in heavy-drinking rats. Biol Psychiatry 64(11):974-981.
5. Simms JA, Bito-Onon JJ, Chatterjee S, Bartlett SE (2010) Long-Evans rats acquire operant self-administration of 20% ethanol without sucrose fading. Neuropsychopharmacology 35(7):1453-1463.
6. Steensland P, et al. (2010) The neurokinin 1 receptor antagonist, ezlopitant, reduces appetitive responding for sucrose and ethanol. PLoS One 5(9):e12527.
7. Barak S, Carnicella S, Yowell QV, Ron D (2011) Glial cell line-derived neurotrophic factor reverses alcohol-induced allostasis of the mesolimbic dopaminergic system: Implications for alcohol reward and seeking. J Neurosci 31(27):9885-9894.
8. Adermark L, Jonsson S, Ericson M, Söderpalm B (2011) Intermittent ethanol consumption depresses endocannabinoid-signaling in the dorsolateral striatum of rat. Neuropharmacology 61(7):1160-1165.
9. Koob GF (2008) A role for brain stress systems in addiction. Neuron 59(1):11-34.
10. Peters A, Jones EG (1984) Classification of cortical neurons. Cerebral Cortex, Volume 1, Cellular Components of the Cerebral Cortex, eds Peters A, Jones EG (Plenum, New York), Vol 1, pp 107-121.
11. Swanson LW, Sawchenko PE, Rivier J, Vale WW (1983) Organization of ovine corticotropin- releasing factor immunoreactive cells and fibers in the rat brain: An immunohistochemical study. Neuroendocrinology 36(3):165-186.
12. Ryabinin AE, Criado JR, Henriksen SJ, Bloom FE, Wilson MC (1997) Differential sensitivity of c-Fos expression in hippocampus and other brain regions to moderate and low doses of alcohol. Mol Psychiatry 2(1):32-43.
13. Hansson AC, Rimondini R, Neznanova O, Sommer WH, Heilig M (2008) Neuroplasticity in brain reward circuitry following a history of ethanol dependence. Eur J Neurosci 27 (8):1912-1922.
14. Bachtell RK, et al. (2003) The Edinger-Westphal-lateral septum urocortin pathway and its relationship to alcohol consumption. J Neurosci 23(6):2477-2487.
15. Chang SL, Patel NA, Romero AA (1995) Activation and desensitization of Fos immunoreactivity in the rat brain following ethanol administration. Brain Res 679(1):89-98.
16. Ryabinin AE, Galvan-Rosas A, Bachtell RK, Risinger FO (2003) High alcohol/sucrose consumption during dark circadian phase in C57BL/6J mice: Involvement of hippocampus, lateral septum and urocortin-positive cells of the Edinger-Westphal nucleus. Psychopharmacology (Berl) 165(3):296-305.
17. Weitemier AZ, Woerner A, Bäckström P, Hyytiä P, Ryabinin AE (2001) Expression of c- Fos in Alko alcohol rats responding for ethanol in an operant paradigm. Alcohol Clin Exp Res 25(5):704-710.
18. Sharpe AL, Tsivkovskaia NO, Ryabinin AE (2005) Ataxia and c-Fos expression in mice drinking ethanol in a limited access session. Alcohol Clin Exp Res 29(8):1419-1426.
19. Borlikova GG, Le Merrer J, Stephens DN (2006) Previous experience of ethanol withdrawal increases withdrawal-induced c-fos expression in limbic areas, but not withdrawal-induced anxiety and prevents withdrawal-induced elevations in plasma corticosterone. Psychopharmacology (Berl) 185(2):188-200.
20. Knapp DJ, Duncan GE, Crews FT, Breese GR (1998) Induction of Fos-like proteins and ultrasonic vocalizations during ethanol withdrawal: Further evidence for withdrawalinduced anxiety. Alcohol Clin Exp Res 22(2):481-493.
21. Olive MF, et al. (2001) Reduced ethanol withdrawal severity and altered withdrawalinduced c-fos expression in various brain regions of mice lacking protein kinase Cepsilon. Neuroscience 103(1):171-179.
22. Sarter M, Bodewitz G, Stephens DN (1988) Attenuation of scopolamine-induced impairment or spontaneous alternation behaviour by antagonist but not inverse agonist and agonist beta-carbolines. Psychopharmacology (Berl) 94(4):491-495.
23. Gué M, et al. (2004) Sex differences in learning deficits induced by prenatal stress in juvenile rats. Behav Brain Res 150(1-2):149-157.
24. Chudasama Y, Robbins TW (2006) Functions of frontostriatal systems in cognition: Comparative neuropsychopharmacological studies in rats, monkeys and humans. Biol Psychol 73(1):19-38.
25. Moselhy HF, Georgiou G, Kahn A (2001) Frontal lobe changes in alcoholism: A review of the literature. Alcohol Alcohol 36(5):357-368.
26. Stephens DN, Duka T (2008) Review. Cognitive and emotional consequences of binge drinking: Role of amygdala and prefrontal cortex. Philos Trans R Soc Lond B Biol Sci 363(1507):3169-3179.
27. Fanous S, et al. (2012) Role of orbitofrontal cortex neuronal ensembles in the expression of incubation of heroin craving. J Neurosci 32(34):11600-11609.
28. Seamans JK, Gorelova N, Durstewitz D, Yang CR (2001) Bidirectional dopamine modulation of GABAergic inhibition in prefrontal cortical pyramidal neurons. J Neurosci 21(10):3628-3638.
29. Sawaguchi T, Iba M (2001) Prefrontal cortical representation of visuospatial working memory in monkeys examined by local inactivation with muscimol. J Neurophysiol 86 (4):2041-2053.
30. Mishkin M (1964) Perseveration of central sets after frontal lesions in man. The Frontal Granular Cortex and Behavior, eds Warren JM, Akert K (McGraw-Hill, New York), pp 219-294.
31. Pribram KH (1961) A further experimental analysis of the behavioral deficit that follows injury to the primate frontal cortex. Exp Neurol 3:432-466.
32. George O, Mandyam CD, Wee S, Koob GF (2008) Extended access to cocaine selfadministration produces long-lasting prefrontal cortex-dependent working memory impairments. Neuropsychopharmacology 33(10):2474-2482.
33. Roberto M, et al. (2010) Corticotropin releasing factor-induced amygdala gammaaminobutyric Acid release plays a key role in alcohol dependence. Biol Psychiatry 67 (9):831-839.
34. Kash TL, Winder DG (2006) Neuropeptide Y and corticotropin-releasing factor bi-directionally modulate inhibitory synaptic transmission in the bed nucleus of the stria terminalis. Neuropharmacology 51(5):1013-1022.