Alterations of brain-derived neurotrophic factor serum levels in patients with alcohol dependence

Alcoholism: Clinical and Experimental Research

Volumn 35, Issue 8, 2011, Pages 1529-1533

  Zanardini, Roberta ^a   Fontana, Aldo ^b   Pagano, Raffaella ^b   Mazzaro, Emilio ^b   Bergamasco, Francesco ^b   Romagnosi, Giuliano ^b   Gennarelli, Massimo ^a,c   Bocchio Chiavetto, Luisella ^a  

^a IRCCS ISTITUTO CENTRO SAN GIOVANNI DI DIO FATEBENEFRATELLI   (Italy)

^b AFaR Ospedale S Raffaele Arcangelo Fatebenefratelli   (Italy)

^c UNIVERSITY OF BRESCIA   (Italy)

Author keywords

Alcohol dependence; Brain derived neurotrophic factor; Neurotrophin; Plasma; Serum

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR;

ADULT; ALCOHOL CONSUMPTION; ALCOHOLISM; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MALE; NERVE CELL PLASTICITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SIGNAL TRANSDUCTION; VOLUNTEER;

ADULT; AGED; ALCOHOLISM; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHRONIC DISEASE; FEMALE; HUMANS; MALE; MIDDLE AGED; NERVE GROWTH FACTORS; NEURONAL PLASTICITY; PLASMA; SERUM; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 79960629893     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2011.01489.x     Document Type: Article

References (46)

1. Angelucci F, Ricci V, Pomponi M, Conte G, Mathe AA, Attilio Tonali P, Bria P (2007) Chronic heroin and cocaine abuse is associated with decreased serum concentrations of the nerve growth factor and brain-derived neurotrophic factor. J Psychopharmacol 21:820-825.
2. Begliuomini S, Casarosa E, Pluchino N, Lenzi E, Centofanti M, Freschi L, Pieri M, Genazzani AD, Luisi S, Genazzani AR (2007) Influence of endogenous and exogenous sex hormones on plasma brain-derived neurotrophic factor. Hum Reprod 22:995-1002.
3. Bocchio-Chiavetto L, Bagnardi V, Zanardini R, Molteni R, Gabriela Nielsen M, Placentino A, Giovannini C, Rillosi L, Ventriglia M, Riva MA, Gennarelli M (2010) Serum and plasma BDNF levels in major depression: a replication study and meta-analyses. World J Biol Psychiatry 11:763-773.
4. Ceccanti M, Mancinelli R, Tirassa P, Laviola G, Rossi S, Romeo M, Fiore M (2010) Early exposure to ethanol or red wine and long-lasting effects in aged mice. A study on nerve growth factor, brain-derived neurotrophic factor, hepatocyte growth factor, and vascular endothelial growth factor. Neurobiol Aging in press.
5. Chao MV (2000) Trophic factors: an evolutionary cul-de-sac or door into higher neuronal function? J Neurosci Res 59:353-355.
6. Chao MV (2003) Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat Rev Neurosci 4:299-309.
7. Chul BL, Choi IG, Kim YK, Ham BJ, Yang BH, Roh S, Choi J, Lee JS, Oh DY, Chai YG (2009) Relation between plasma brain-derived neurotrophic factor and nerve growth factor in the male patients with alcohol dependence. Alcohol 43:265-269.
8. Davis MI (2008) Ethanol-BDNF interactions: still more questions than answers. Pharmacol Ther 118:36-57.
9. D'Souza DC, Pittman B, Perry E, Simen A (2009) Preliminary evidence of cannabinoid effects on brain-derived neurotrophic factor (BDNF) levels in humans. Psychopharmacology (Berl) 202:569-578.
10. Duman RS, Monteggia LM (2006) A neurotrophic model for stress-related mood disorders. Biol Psychiatry 59:1116-1127.
11. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, Zaitsev E, Gold B, Goldman D, Dean M, Lu B, Weinberger DR (2003) The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112:257-269.
12. Eker C, Kitis O, Taneli F, Eker OD, Ozan E, Yucel K, Coburn K, Gonul AS (2010) Correlation of serum BDNF levels with hippocampal volumes in first episode, medication-free depressed patients. Eur Arch Psychiatry Clin Neurosci 260:527-533.
13. Erickson KI, Prakash RS, Voss MW, Chaddock L, Heo S, McLaren M, Pence BD, Martin SA, Vieira VJ, Woods JA, McAuley E, Kramer AF (2010) Brain-derived neurotrophic factor is associated with age-related decline in hippocampal volume. J Neurosci 30:5368-5375.
14. Fitzgerald LW, Nestler EJ (1995) Molecular and cellular adaptations in signal transduction pathways following ethanol exposure. Clin Neurosci 3:165-173.
15. Fujimura H, Altar CA, Chen R, Nakamura T, Nakahashi T, Kambayashi J, Sun B, Tandon NN (2002) Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation. Thromb Haemost 87:728-734.
16. Heberlein A, Muschler M, Wilhelm J, Frieling H, Lenz B, Groschl M, Kornhuber J, Bleich S, Hillemacher T (2010) Bdnf and gdnf serum levels in alcohol-dependent patients during withdrawal. Prog Neuropsychopharmacol Biol Psychiatry 34:1060-1064.
17. Hellmann J, Rommelspacher H, Wernicke C (2009) Long-term ethanol exposure impairs neuronal differentiation of human neuroblastoma cells involving neurotrophin-mediated intracellular signaling and in particular protein kinase C. Alcohol Clin Exp Res 33:538-550.
18. Huang MC, Chen CH, Chen CH, Liu SC, Ho CJ, Shen WW, Leu SJ (2008) Alterations of serum brain-derived neurotrophic factor levels in early alcohol withdrawal. Alcohol Alcohol 43:241-245.
19. Joe KH, Kim YK, Kim TS, Roh SW, Choi SW, Kim YB, Lee HJ, Kim DJ (2007) Decreased plasma brain-derived neurotrophic factor levels in patients with alcohol dependence. Alcohol Clin Exp Res 31:1833-1838.
20. Jung ME, Metzger DB (2010) Alcohol withdrawal and brain injuries: beyond classical mechanisms. Molecules 15:4984-5011.
21. Karege F, Perret G, Bondolfi G, Schwald M, Bertschy G, Aubry JM (2002a) Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Res 109:143-148.
22. Karege F, Schwald M, Cisse M (2002b) Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets. Neurosci Lett 328:261-264.
23. Keyvani K, Schallert T (2002) Plasticity-associated molecular and structural events in the injured brain. J Neuropathol Exp Neurol 61:831-840.
24. Kim DJ, Roh S, Kim Y, Yoon SJ, Lee HK, Han CS, Kim YK (2005) High concentrations of plasma brain-derived neurotrophic factor in methamphetamine users. Neurosci Lett 388:112-115.
25. Klein AB, Williamson R, Santini MA, Clemmensen C, Ettrup A, Rios M, Knudsen GM, Aznar S (2011) Blood BDNF concentrations reflect brain-tissue BDNF levels across species. Int J Neuropsychopharmacol 14:347-353.
26. Koob GF, Roberts AJ, Schulteis G, Parsons LH, Heyser CJ, Hyytia P, Merlo-Pich E, Weiss F (1998) Neurocircuitry targets in ethanol reward and dependence. Alcohol Clin Exp Res 22:3-9.
27. Lang UE, Hellweg R, Seifert F, Schubert F, Gallinat J (2007) Correlation between serum brain-derived neurotrophic factor level and an in vivo marker of cortical integrity. Biol Psychiatry 62:530-535.
28. Lee BH, Kim YK (2009) Reduced platelet BDNF level in patients with major depression. Prog Neuropsychopharmacol Biol Psychiatry 33:849-853.
29. Logrip ML, Janak PH, Ron D (2009) Escalating ethanol intake is associated with altered corticostriatal BDNF expression. J Neurochem 109:1459-1468.
30. Matsushita S, Kimura M, Miyakawa T, Yoshino A, Murayama M, Masaki T, Higuchi S (2004) Association study of brain-derived neurotrophic factor gene polymorphism and alcoholism. Alcohol Clin Exp Res 28:1609-1612.
31. McGough NN, He DY, Logrip ML, Jeanblanc J, Phamluong K, Luong K, Kharazia V, Janak PH, Ron D (2004) RACK1 and brain-derived neurotrophic factor: a homeostatic pathway that regulates alcohol addiction. J Neurosci 24:10542-10552.
32. Mitoma M, Yoshimura R, Sugita A, Umene W, Hori H, Nakano H, Ueda N, Nakamura J (2008) Stress at work alters serum brain-derived neurotrophic factor (BDNF) levels and plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) levels in healthy volunteers: BDNF and MHPG as possible biological markers of mental stress? Prog Neuropsychopharmacol Biol Psychiatry 32:679-685.
33. Moonat S, Starkman BG, Sakharkar A, Pandey SC (2010) Neuroscience of alcoholism: molecular and cellular mechanisms. Cell Mol Life Sci 67:73-88.
34. Nestler EJ (2001) Molecular neurobiology of addiction. Am J Addict 10:201-217.
35. Pan W, Banks WA, Fasold MB, Bluth J, Kastin AJ (1998) Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology 37:1553-1561.
36. Robbins TW, Everitt BJ (1999) Drug addiction: bad habits add up. Nature 398:567-570.
37. Saito S, Watanabe K, Hashimoto E, Saito T (2009) Low serum BDNF and food intake regulation: a possible new explanation of the pathophysiology of eating disorders. Prog Neuropsychopharmacol Biol Psychiatry 33:312-316.
38. Sakai R, Ukai W, Sohma H, Hashimoto E, Yamamoto M, Ikeda H, Saito T (2005) Attenuation of brain derived neurotrophic factor (BDNF) by ethanol and cytoprotective effect of exogenous BDNF against ethanol damage in neuronal cells. J Neural Transm 112:1005-1013.
39. Sen S, Duman R, Sanacora G (2008) Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications. Biol Psychiatry 64:527-532.
40. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC (1998) The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59(Suppl 20):22-33; quiz 34-57.
41. Shimizu E, Hashimoto K, Okamura N, Koike K, Komatsu N, Kumakiri C, Nakazato M, Watanabe H, Shinoda N, Okada S, Iyo M (2003) Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiatry 54:70-75.
42. Shin S, Stewart R, Ferri CP, Kim JM, Shin IS, Kim SW, Yang SJ, Yoon JS (2010) An investigation of associations between alcohol use disorder and polymorphisms on ALDH2, BDNF, 5-HTTLPR, and MTHFR genes in older Korean men. Int J Geriatr Psychiatry 25:441-448.
43. Umene-Nakano W, Yoshimura R, Ikenouchi-Sugita A, Hori H, Hayashi K, Ueda N, Nakamura J (2009) Serum levels of brain-derived neurotrophic factor in comorbidity of depression and alcohol dependence. Hum Psychopharmacol 24:409-413.
44. Wang ZY, Miki T, Lee KY, Yokoyama T, Kusaka T, Sumitani K, Warita K, Matsumoto Y, Yakura T, Hosomi N, Ameno K, Bedi KS, Takeuchi Y (2010) Short-term exposure to ethanol causes a differential response between nerve growth factor and brain-derived neurotrophic factor ligand/receptor systems in the mouse cerebellum. Neuroscience 165:485-491.
45. Wojnar M, Brower KJ, Strobbe S, Ilgen M, Matsumoto H, Nowosad I, Sliwerska E, Burmeister M (2009) Association between Val66Met brain-derived neurotrophic factor (BDNF) gene polymorphism and post-treatment relapse in alcohol dependence. Alcohol Clin Exp Res 33:693-702.
46. World Health Organization (2004) WHO Global Status Report on Alcohol. World Health Organization, Geneva.