BDNF Val66Met genotype is associated with drug-seeking phenotypes in heroin-dependent individuals: A pilot study

Addiction Biology

Volumn 18, Issue 5, 2013, Pages 836-845

  Greenwald, Mark K ^a   Steinmiller, Caren L ^a,c   Śliwerska, Elzbieta ^b   Lundahl, Leslie ^a   Burmeister, Margit ^b  

^a Dept Psychiat and Behav Neurosci   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

BDNF; cigarette; drug seeking; genotype; heroin; opioid.

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR;

AFRICAN AMERICAN; ARTICLE; DRUG SEEKING BEHAVIOR; EUROPEAN AMERICAN; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HEROIN DEPENDENCE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; INTERVIEW; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PILOT STUDY; PRIORITY JOURNAL; SMOKING;

BDNF; CIGARETTE; DRUG-SEEKING; GENOTYPE; HEROIN; OPIOID.;

ADOLESCENT; ADULT; AFRICAN AMERICANS; AMINO ACID SUBSTITUTION; ANALYSIS OF VARIANCE; BEHAVIOR, ADDICTIVE; BRAIN-DERIVED NEUROTROPHIC FACTOR; DRUG-SEEKING BEHAVIOR; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENOTYPE; HEROIN DEPENDENCE; HUMANS; INTERVIEW, PSYCHOLOGICAL; MALE; METHIONINE; MIDDLE AGED; PHENOTYPE; PILOT PROJECTS; POLYMORPHISM, SINGLE NUCLEOTIDE; REGRESSION ANALYSIS; SMOKING; VALINE; YOUNG ADULT;

EID: 84882633248     PISSN: 13556215     EISSN: 13691600     Source Type: Journal    
DOI: 10.1111/j.1369-1600.2011.00431.x     Document Type: Article

References (51)

1. Berhow MT, Russell DS, Terwilliger RZ, Beitner-Johnson D, Self DW, Lindsay RM, Nestler EJ, (1995) Influence of neurotrophic factors on morphine- and cocaine-induced biochemical changes in the mesolimbic dopamine system. Neuroscience 68: 969-979.
2. Beuten J, Ma JZ, Payne TJ, Dupont RT, Quezada P, Huang W, Crews KM, Li MD, (2005) Significant association of BDNF haplotypes in European-American male smokers but not in European-American female or African-American smokers. Am J Med Genet B Neuropsychiatr Genet 139: 73-80. (Pubitemid 41552302)
3. Bolanos CA, Nestler EJ, (2004) Neurotrophic mechanisms in drug addiction. Neuromolecular Med 5: 69-83. (Pubitemid 38391958)
4. Bueller JA, Aftab M, Sen S, Gomez-Hassan D, Burmeister M, Zubieta J-K, (2006) BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects. Biol Psychiatry 59: 812-815.
5. Carvalho AL, Caldeira MV, Santos SD, Duarte CB, (2008) Role of the brain-derived neurotrophic factor at glutamatergic synapses. Br J Pharmacol 153 (Suppl 1): S310-S324. (Pubitemid 351340985)
6. Chen ZY, Jing D, Bath KG, Ieraci A, Khan T, Siao CJ, Herrera DG, Toth M, Yang C, McEwen BS, Hempstead BL, Lee FS, (2006) Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science 314: 140-143. (Pubitemid 44547760)
7. Chen ZY, Patel PD, Sant G, Meng CX, Teng KK, Hempstead BL, Lee FS, (2004) Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. J Neurosci 24: 4401-4411. (Pubitemid 38608151)
8. Cheng C-Y, Hong C-J, Yu YW-Y, Chen T-J, Wu H-C, Tsai S-J, (2005) Brain-derived neurotrophic factor (Val66Met) genetic polymorphism is associated with substance abuse in males. Brain Res Mol Brain Res 140: 86-90. (Pubitemid 41446150)
9. Di Lorenzo C, Di Lorenzo G, Sances G, Ghiotto N, Guaschino E, Grieco GS, Santorelli FM, Casali C, Troisi A, Siracusano A, Pierelli F, (2008) Drug consumption in medication overuse headache is influenced by brain-derived neurotrophic factor Val66Met polymorphism. J Headache Pain 10: 349-355.
10. Ducci F, Goldman D, (2008) Genetic approaches to addiction: genes and alcohol. Addiction 103: 1414-1428.
11. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, Zaitsev E, Gold B, Goldman D, Dean M, Lu B, Weinberger DR, (2003) The BDNF Val66Met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112: 257-269. (Pubitemid 36144114)
12. Enoch MA, Hodgkinson CA, Yuan Q, Albaugh B, Virkkunen M, Goldman D, (2009) GABRA1 and GABRA2 as independent predictors for alcoholism in two populations. Neuropsychopharmacology 34: 1245-1254.
13. Everitt BJ, Robbins TW, (2000) Second-order schedules of drug reinforcement in rats and monkeys: measurement of reinforcing efficacy and drug-seeking behaviour. Psychopharmacology (Berl) 153: 17-30. (Pubitemid 32127901)
14. Frodl T, Schüle C, Schmitt G, Born C, Baghai T, Zill P, Bottlender R, Rupprecht R, Bondy B, Reiser M, Möller HJ, Meisenzahl EM, (2007) Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression. Arch Gen Psychiatry 64: 410-416. (Pubitemid 46556460)
15. Gerdeman GL, Partridge JG, Lupica CR, Lovinger DM, (2003) It could be habit forming: drugs of abuse and striatal synaptic plasticity. Trends Neurosci 26: 184-192. (Pubitemid 36412000)
16. Goggi J, Pullar IA, Carney SL, Bradford HF, (2002) Modulation of neurotransmitter release induced by brain-derived neurotrophic factor in rat brain striatal slices in vitro. Brain Res 941: 34-42. (Pubitemid 34603281)
17. Gottesman II, Gould TD, (2003) The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160: 636-645. (Pubitemid 41079594)
18. Greenwald MK, (2010) Effects of experimental unemployment, employment and punishment analogs on opioid seeking and consumption in heroin-dependent volunteers. Drug Alcohol Depend 111: 64-73.
19. Greenwald MK, Hursh SR, (2006) Behavioral economic analysis of opioid consumption in heroin-dependent individuals: effects of unit price and pre-session drug supply. Drug Alcohol Depend 85: 35-48. (Pubitemid 44310833)
20. Greenwald MK, Steinmiller CL, (2009) Behavioral economic analysis of opioid consumption in heroin-dependent individuals: Effects of alternative reinforcer magnitude and post-session drug supply. Drug Alcohol Depend 104: 84-93.
21. Hariri A, Goldberg TE, Mattay VS, Kolachana BS, Callicott JH, Egan MF, Weinberger DR, (2003) Brain-derived neurotrophic factor Val66Met polymorphism affects human memory-related hippocampal activity and predicts memory performance. J Neurosci 23: 6690-6694. (Pubitemid 36951196)
22. Hatami H, Oryan S, Semnanian S, Kazemi B, Bandepour M, Admadiani A, (2007) Alterations of BDNF and NT-3 genes expression in the nucleus paragigantocellularis during morphine dependency and withdrawal. Neuropeptides 41: 321-328. (Pubitemid 47247863)
23. Hodgkinson CA, Yuan Q, Xu K, Shen P-H, Heinz E, Lobos EA, Binder EB, Cubells J, Ehlers CL, Gelernter J, Mann J, Riley B, Roy A, Tabakoff B, Todd RD, Zhou Z, Goldman D, (2008) Addictions biology: haplotype-based analysis for 130 candidate genes on a single array. Alcohol Alcohol 43: 505-515.
24. Khokhar JY, Ferguson CS, Zhu AZX, Tyndale RF, (2010) Pharmacogenetics of drug dependence: role of gene variations in susceptibility and treatment. Annu Rev Pharmacol Toxicol 50: 39-61.
25. Koob GF, Le Moal M, (2001) Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology 24: 97-129.
26. Lang UE, Sander T, Lohoff FW, Hellweg R, Bajbouj M, Winterer G, Gallinat J, (2007) Association of the met66 allele of brain-derived neurotrophic factor (BDNF) with smoking. Psychopharmacology (Berl) 190: 433-439. (Pubitemid 46204460)
27. Le Foll B, Diaz J, Sokoloff P, (2005) A single cocaine exposure increases BDNF and D3 receptor expression: implications for drug-conditioning. Neuroreport 16: 175-178. (Pubitemid 40250395)
28. Lerman C, Perkins KA, Gould TJ, (2009) Nicotine-dependence endophenotypes in chronic smokers. In:, Swan GE, Baker TB, Chassin L, Conti DV, Lerman C, Perkins KA, eds. National Cancer Institute. Phenotypes and Endophenotypes: Foundations for Genetic Studies of Nicotine Use and Dependence. Tobacco Control Monograph No. 20, pp. 403-484. Bethesda, MD: US Dept. of Health and Human Services, National Institutes of Health, National Cancer Institute. NIH Publication No. 09-6366.
29. Li MD, Burmeister M, (2009) New insights into the genetics of addiction. Nat Rev Genet 10: 225-231.
30. Lipsky RH, Marini AM, (2007) Brain-derived neurotrophic factor in neuronal survival and behavior-related plasticity. Ann N Y Acad Sci 1122: 130-143. (Pubitemid 350249544)
31. Lu B, (2003) Pro-region of neurotrophins: role in synaptic modulation. Neuron 39: 735-738. (Pubitemid 37088086)
32. Lu L, Dempsey J, Liu SY, Bossert JM, Shaham Y, (2004) A single infusion of brain-derived neurotrophic factor into the ventral tegmental area induces long-lasting potentiation of cocaine seeking after withdrawal. J Neurosci 24: 1604-1611. (Pubitemid 38240955)
33. Maisonpierre PC, Le Beau MM, Espinosa R III, Ip NY, Belluscio L, de la Monte SM, Squinto S, Furth ME, Yancopoulos GD, (1991) Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations. Genomics 10: 558-568.
34. Matsushita S, Kimura M, Miyakawa T, Yoshino A, Murayama M, Masaki T, Higuchi S, (2004) Association study of brain-derived neurotrophic factor gene polymorphism and alcoholism. Alcohol Clin Exp Res 28: 1609-1612. (Pubitemid 39551819)
35. Novak G, LeBlanc M, Zai C, Shaikh S, Renou J, DeLuca V, Bulgin N, Kennedy JL, Le Foll B, (2010) Association of polymorphisms in the BDNF, DRD1 and DRD3 genes with tobacco smoking in schizophrenia. Ann Hum Genet 74: 291-298.
36. Numan S, Lane-Ladd SB, Zhang L, Lundgren KH, Russell DS, Seroogy KB, Nestler EJ, (1998) Differential regulation of neurotrophin and trk receptor mRNAs in catecholaminergic nuclei during chronic opiate treatment and withdrawal. J Neurosci 18: 10700-10708. (Pubitemid 29016587)
37. Petryshen TL, Sabeti PC, Aldinger KA, Fry B, Fan JB, Schaffner SF, Waggoner SG, Tahl AR, Sklar P, (2010) Population genetic study of the brain-derived neurotrophic factor (BDNF) gene. Mol Psychiatry 15: 810-815.
38. Pezawas L, Verchinski BA, Mattay VS, Callicott JH, Kolachana BS, Straub RE, Egan MF, Meyer-Lindenberg A, Weinberger DR, (2004) The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology. J Neurosci 24: 10099-10102. (Pubitemid 39492034)
39. Roddy JK, Greenwald MK, (2009) An economic analysis of income and expenditures in heroin-using research volunteers. Subst Use Misuse 44: 1503-1518.
40. Roddy JK, Steinmiller CL, Greenwald MK, (2011) Heroin purchasing is income- and price-sensitive. Psychol Addict Behav 25: 358-364.
41. Russo SJ, Mazei-Robison MS, Ables JL, Nestler EJ, (2009) Neurotrophic factors and structural plasticity in addiction. Neuropharmacology 56: 73-82.
42. Saccone NL, Saccone SF, Hinrichs AL, Stitzel JA, Duan W, Pergadia ML, Agrawal A, Breslau N, Grucza RA, Hatsukami D, Johnson EO, Madden PA, Swan GE, Wang JC, Goate AM, Rice JP, Bierut LJ, (2009) Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. Am J Med Genet B Neuropsychiatr Genet 150B: 453-466.
43. Sklair-Tavron L, Shi W-X, Lane SB, Harris HW, Bunney BS, Nestler EJ, (1996) Chronic morphine induces visible changes in the morphology of mesolimbic dopamine neurons. Proc Natl Acad Sci U S A 93: 11202-11207. (Pubitemid 26333142)
44. Sokoloff P, Diaz J, Le Foll B, Guillin O, Leriche L, Bezard E, Gross C, (2006) The dopamine D3 receptor: A therapeutic target for the treatment of neuropsychiatric disorders. CNS Neurol Disord Drug Targets 5: 25-43. (Pubitemid 43796626)
45. Szeszko PR, Lipsky R, Mentschel C, Robinson D, Gunduz-Bruce H, Sevy S, Ashtari M, Napolitano B, Bilder RM, Kane JM, Goldman D, Malhotra AK, (2005) Brain-derived neurotrophic factor val66met polymorphism and volume of the hippocampal formation. Mol Psychiatry 10: 631-636. (Pubitemid 40961733)
46. The Tobacco and Genetics Consortium (2010) Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nat Genet 42: 441-447.
47. Vanderschuren LJMJ, Kalivas PW, (2000) Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: A critical review of preclinical studies. Psychopharmacology (Berl) 151: 99-120. (Pubitemid 30646415)
48. Vargas-Perez H, Kee RT-A, Walton CH, Hansen DM, Razavi R, Clarke L, Bufalino MR, Allison DW, Steffensen SC, van der Kooy D, (2009) Ventral tegmental area BDNF induces an opiate-dependent-like reward state in naïve rats. Science 324: 1732-1734.
49. Wojnar M, Brower KJ, Strobbe S, Ilgen M, Matsumoto H, Nowosad I, Sliwerska E, Burmeister M, (2009) Association between Val66Met brain-derived neurotrophic factor (BDNF) gene polymorphism and post-treatment relapse in alcohol dependence. Alcohol Clin Exp Res 33: 1-10.
50. Wong CCY, Schumann G, (2008) Genetics of addictions: strategies for addressing heterogeneity and polygenicity of substance use disorders. Philos Trans R Soc Lond B Biol Sci 363: 3213-3222.
51. Yuferov V, Levran O, Proudnikov D, Nielsen DA, Kreek MJ, (2010) Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment. Ann N Y Acad Sci 1187: 184-207.