Subjective Response to Alcohol Among Alcohol-Dependent Individuals: Effects of the Mu-Opioid Receptor (OPRM1) Gene and Alcoholism Severity

Alcoholism: Clinical and Experimental Research

Volumn 37, Issue SUPPL.1, 2013, Pages

  Ray, Lara A ^a   Bujarski, Spencer ^a   Mackillop, James ^b   Courtney, Kelly E ^a   Monti, Peter M ^c   Miotto, Karen ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of Georgia   (United States)

^c BROWN UNIVERSITY   (United States)

Author keywords

A118G SNP; Alcohol dependence; Endophenotype; Genetics; OPRM1; Responses to alcohol

Indexed keywords

ALCOHOL; MU 1 OPIATE RECEPTOR; MU OPIATE RECEPTOR; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ADULT; AGED; ALCOHOL CONSUMPTION; ALCOHOLISM; ALLELE; ARTICLE; BREATH ALCOHOL ANALYZER; CLINICAL ASSESSMENT; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE SEVERITY; DRINKING BEHAVIOR; DRUG INFUSION; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENOTYPE; HOMOZYGOTE; HUMAN; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; MOOD; PREDICTOR VARIABLE; PRIORITY JOURNAL; PROSPECTIVE PRICING; RANDOMIZED CONTROLLED TRIAL; SEDATION; SINGLE BLIND PROCEDURE; SINGLE NUCLEOTIDE POLYMORPHISM; TREND STUDY; WITHDRAWAL SYNDROME;

ADULT; AFFECT; ALCOHOL DRINKING; ALCOHOLISM; ETHANOL; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; RECEPTORS, OPIOID, MU; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 84872495795     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2012.01916.x     Document Type: Article

References (52)

1. Anton RF, Oroszi G, O'Malley S, Couper D, Swift R, Pettinati H, Goldman D (2008) An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the combined pharmacotherapies and behavioral interventions for alcohol dependence (COMBINE) study. Arch Gen Psychiatry 65:135-144.
2. Arias A, Feinn R, Kranzler HR (2006) Association of an Asn40Asp (A118G) polymorphism in the mu-opioid receptor gene with substance dependence: a meta-analysis. Drug Alcohol Depend 83:262-268.
3. Barr CS, Chen SA, Schwandt ML, Lindell SG, Sun H, Suomi SJ, Heilig M (2011) Suppression of alcohol preference by naltrexone in the rhesus macaque: a critical role of genetic variation at the micro-opioid receptor gene locus. Biol Psychiatry 67:78-80.
4. Barr CS, Schwandt M, Lindell SG, Chen SA, Goldman D, Suomi SJ, Higley JD, Heilig M (2007) Association of a functional polymorphism in the mu-opioid receptor gene with alcohol response and consumption in male rhesus macaques. Arch Gen Psychiatry 64:369-376.
5. Bohn MJ, Krahn DD, Staehler BA (1995) Development and initial validation of a measure of drinking urges in abstinent alcoholics. Alcohol Clin Exp Res 19:600-606.
6. Bond C, LaForge KS, Tian M, Melia D, Zhang S, Borg L, Gong J, Schluger J, Strong JA, Leal SM, Tischfield JA, Kreek MJ, Yu L (1998) Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction. Proc Natl Acad Sci USA 95:9608-9613.
7. Ducci F, Goldman D (2008) Genetic approaches to addiction: genes and alcohol. Addiction 103:1414-1428.
8. Erblich J, Earleywine M (1995) Distraction does not impair memory during intoxication: support for the attention-allocation model. J Stud Alcohol 56:444-448.
9. Filbey FM, Ray L, Smolen A, Claus ED, Audette A, Hutchison KE (2008) Differential neural response to alcohol priming and alcohol taste cues is associated with DRD4 VNTR and OPRM1 genotypes. Alcohol Clin Exp Res 32:1113-1123.
10. First MB, Spitzer RL, Gibbon M, Williams JBW (1995) Structured Clinical Interview for DSM-IV Axis I Disorders-Patient Edition (SCID-I/P, Version 2.0). Biometrics Research Department, New York State Psychiatric Institute, New York.
11. Flannery BA, Volpicelli JR, Pettinati HM (1999) Psychometric properties of the Penn Alcohol Craving Scale. Alcohol Clin Exp Res 23:1289-1295.
12. Gelernter J, Gueorguieva R, Kranzler HR, Zhang H, Cramer J, Rosenheck R, Krystal JH (2007) Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study. Alcohol Clin Exp Res 31:555-563.
13. Gianoulakis C (2009) Endogenous opioids and addiction to alcohol and other drugs of abuse. Curr Top Med Chem 9:999-1015.
14. Gottesman I, Gould TD (2003) The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160:636-645.
15. Heilig M, Goldman D, Berrettini W, O'Brien CP (2011) Pharmacogenetic approaches to the treatment of alcohol addiction. Nat Rev Neurosci 12:670-684.
16. Heilig M, Thorsell A, Sommer WH, Hansson AC, Ramchandani VA, George DT, Hommer D, Barr CS (2010) Translating the neuroscience of alcoholism into clinical treatments: from blocking the buzz to curing the blues. Neurosci Biobehav Rev 35:334-344.
17. Hines LM, Ray L, Hutchison K, Tabakoff B (2005) Alcoholism: the dissection for endophenotypes. Dialogues Clin Neurosci 7:153-163.
18. Kendler KS, Prescott CA, Neale MC, Pedersen NL (1997) Temperance board registration for alcohol abuse in a national sample of Swedish male twins, born 1902 to 1949. Arch Gen Psychiatry 54:178-184.
19. King AC, Roche DJ, Rueger SY (2011b) Subjective responses to alcohol: a paradigm shift may be brewing. Alcohol Clin Exp Res 35:1726-1728.
20. King AC, de Wit H, McNamara PJ, Cao D (2011a) Rewarding, stimulant, and sedative alcohol responses and relationship to future binge drinking. Arch Gen Psychiatry 68:389-399.
21. Koob GF (2003) Alcoholism: allostasis and beyond. Alcohol Clin Exp Res 27:232-243.
22. Koob GF (2009) Neurobiological substrates for the dark side of compulsivity in addiction. Neuropharmacology 56:18-31.
23. Koob GF, Kreek MJ (2007) Stress, dysregulation of drug reward pathways, and the transition to drug dependence. Am J Psychiatry 164:1149-1159.
24. Koob GF, Le Moal M (2005) Plasticity of reward neurocircuitry and the 'dark side' of drug addiction. Nat Neurosci 8:1442-1444.
25. Koob GF, Le Moal M (2008) Review. Neurobiological mechanisms for opponent motivational processes in addiction. Philos Trans R Soc Lond B BiolSci 363:3113-3123.
26. Li TK, Yin SJ, Crabb DW, O'Connor S, Ramchandani VA (2001) Genetic and environmental influences on alcohol metabolism in humans. Alcohol Clin Exp Res 25:136-144.
27. MacKillop J (2006) Factor structure of the alcohol urge questionnaire under neutral conditions and during a cue-elicited urge state. Alcohol Clin Exp Res 30:1315-1321.
28. Martin CS, Earleywine M, Musty RE, Perrine MW, Swift RM (1993) Development and validation of the Biphasic Alcohol Effects Scale. Alcohol Clin Exp Res 17:140-146.
29. McNair DM, Lorr M, Droppleman LF (1971) Manual for the Profile of Mood States. Educational & Industrial Testing Service, San Diego, CA.
30. Miller WR, Tonigan JS, Longabaugh R (1995) The Drinker Inventory of Consequences (DrInC): An Instrument for Assessing Adverse Consequences of Alcohol Abuse. National Institute on Alcohol Abuse and Alcoholism, Rockville, MD.
31. Miranda R, Ray L, Justus A, Meyerson LA, Knopik VS, McGeary J, Monti PM (2010) Initial evidence of an association between OPRM1 and adolescent alcohol misuse. Alcohol Clin Exp Res 34:112-122.
32. O'Connor S, Morzorati S, Christian J, Li TK (1998) Clamping breath alcohol concentration reduces experimental variance: application to the study of acute tolerance to alcohol and alcohol elimination rate. Alcohol Clin Exp Res 22:202-210.
33. Oslin DW, Berrettini W, Kranzler HR, Pettinati H, Gelernter J, Volpicelli JR, O'Brien CP (2003) A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients. Neuropsychopharmacology 28:1546-1552.
34. Prescott CA, Kendler KS (1999) Genetic and environmental contributions to alcohol abuse and dependence in a population-based sample of male twins. Am J Psychiatry 156:34-40.
35. Quinn PD, Fromme K (2011) Subjective response to alcohol challenge: a quantitative review. Alcohol Clin Exp Res 35:1759-1770.
36. Ramchandani VA, Bolane J, Li TK, O'Connor S (1999) A physiologically-based pharmacokinetic (PBPK) model for alcohol facilitates rapid BrAC clamping. Alcohol Clin Exp Res 23:617-623.
37. Ramchandani VA, Umhau J, Pavon FJ, Ruiz-Velasco V, Margas W, Sun H, Damadzic R, Eskay R, Schoor M, Thorsell A, Schwandt ML, Sommer WH, George DT, Parsons LH, Herscovitch P, Hommer D, Heilig M (2011) A genetic determinant of the striatal dopamine response to alcohol in men. Mol Psychiatry 16:809-817.
38. Ray LA, Barr CS, Blendy JA, Oslin D, Goldman D, Anton RF (2012) The role of the Asn40Asp polymorphism of the mu opioid receptor gene (OPRM1) on alcoholism etiology and treatment: a critical review. Alcohol Clin Exp Res 36:385-394.
39. Ray LA, Hutchison KE (2004) A polymorphism of the mu-opioid receptor gene (OPRM1) and sensitivity to the effects of alcohol in humans. Alcohol Clin Exp Res 28:1789-1795.
40. Ray LA, Hutchison KE (2007) Effects of naltrexone on alcohol sensitivity and genetic moderators of medication response: a double-blind placebo-controlled study. Arch Gen Psychiatry 64:1069-1077.
41. Ray LA, Hutchison KE, Tartter M (2010a) Application of human laboratory models to pharmacotherapy development for alcohol dependence. Curr Pharm Des 16:2149-2158.
42. Ray LA, MacKillop J, Leventhal A, Hutchison KE (2009) Catching the alcohol buzz: an examination of the latent factor structure of subjective intoxication. Alcohol Clin Exp Res 33:2154-2161.
43. Ray LA, Mackillop J, Monti PM (2010b) Subjective responses to alcohol consumption as endophenotypes: advancing behavioral genetics in etiological and treatment models of alcoholism. Subst Use Misuse 45:1742-1765.
44. Ray LA, Meskew-Stacer S, Hutchison KE (2007) The relationship between prospective self-rating of alcohol sensitivity and craving and experimental results from two alcohol challenge studies. J Stud Alcohol Drugs 68: 379-384.
45. Ray LA, Miranda R Jr, Tidey JW, McGeary JE, MacKillop J, Gwaltney CJ, Rohsenow DJ, Swift RM, Monti PM (2010c) Polymorphisms of the mu-opioid receptor and dopamine D4 receptor genes and subjective responses to alcohol in the natural environment. J Abnorm Psychol 119:115-125.
46. Robinson TE, Berridge KC (2001) Incentive-sensitization and addiction. Addiction 96:103-114.
47. Setiawan E, Pihl RO, Cox SM, Gianoulakis C, Palmour RM, Benkelfat C, Leyton M (2011) The effect of naltrexone on alcohol's stimulant properties and self-administration behavior in social drinkers: influence of gender and genotype. Alcohol Clin Exp Res 35:1134-1141.
48. Singer JD (1998) Using SAS PROC MIXED to fit multilevel models, hierarchical models, and individual growth models. J Educ Behav Stat 24:323-355.
49. Skinner HA, Allen BA (1982) Alcohol dependence syndrome: measurement and validation. J Abnorm Psychol 91:199-209.
50. Sobell LC, Sobell MB (1980) Convergent validity: An approach to increasing confidence in treatment oucome conclusions with alcohol and drug abusers, in Evaluating Alcohol and Drug Abuse Treatment Effectiveness: Recent Advances (Sobell LC, Sobell MB, Ward E eds), pp 177-209. Pergamon Press, Elmsford, NY.
51. Sullivan J, Sykora K, Schneiderman J, Naranjo C, Sellers E (1989) Assessment of alcohol withdrawal: the revised Clinical Institute Withdrawal Assessment for Alcohol scale (CIWA-AR). Br J Addict 84:1353-1357.
52. Zhang Y, Wang D, Johnson AD, Papp AC, Sadee W (2005) Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G. J Biol Chem 280:32618-32624.