Determination of protodioscin in rat plasma by liquid chromatography-tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 848, Issue 2, 2007, Pages 363-368

  Wang, Tiejie ^a,b   Liu, Zhongbo ^a   Li, Jun ^b   Zhong, Min ^b   Li, Junpeng ^b   Chen, Xiaohui ^a   Bi, Kaishun ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b Shenzhen Institute for Drug Control   (China)

Author keywords

Liquid chromatography; Mass spectrometry; Pharmacokinetics; Protodioscin

Indexed keywords

MOBILE PHASES; PLASMA PROTEIN PRECIPITATION; PROTODIOSCIN; PROTODIOSCINS;

CONCENTRATION (PROCESS); LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS; PLASMAS; PRECIPITATION (CHEMICAL); RATS;

PROTEINS;

ACETONITRILE; FORMIC ACID; PHOTODIOSCIN; SAPONIN; UNCLASSIFIED DRUG; WATER;

ACCURACY; ANALYTICAL ERROR; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; ELECTROSPRAY MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; PROCESS MONITORING; QUANTITATIVE ANALYSIS; QUANTITATIVE ASSAY; RAT; REACTION ANALYSIS; SUPERNATANT; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIOSGENIN; DRUGS, CHINESE HERBAL; MALE; MOLECULAR STRUCTURE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SAPONINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 33947419632     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2006.10.050     Document Type: Article

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