메뉴 건너뛰기




Volumn 18, Issue 2, 2015, Pages 180-187

Putative mechanism for apoptosis-inducing properties of crude saponin isolated from sea cucumber (Holothuria leucospilota) as an antioxidant compound

Author keywords

Antioxidant; Apoptosis; MCF7 cell line; Saponin; Sea cucumber

Indexed keywords

ASCORBIC ACID; BUTYLATED HYDROXYANISOLE; PROTEIN BAX; PROTEIN BCL 2; SAPONIN;

EID: 84923366323     PISSN: 20083866     EISSN: 20083874     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (31)

References (40)
  • 1
    • 84877946228 scopus 로고    scopus 로고
    • Antioxidant and cytotoxic properties of two sea cucumbers, Holothuria edulis Lesson and Stichopus horrens Selenka
    • Althunibat O, Ridzwan B, Taher M, Daud J, Jauhari Arief Ichwan S, Qaralleh H. Antioxidant and cytotoxic properties of two sea cucumbers, Holothuria edulis Lesson and Stichopus horrens Selenka. Acta Biol Hung 2013; 64:10-20.
    • (2013) Acta Biol Hung , vol.64 , pp. 10-20
    • Althunibat, O.1    Ridzwan, B.2    Taher, M.3    Daud, J.4    Jauhari Arief Ichwan, S.5    Qaralleh, H.6
  • 2
    • 84871942530 scopus 로고    scopus 로고
    • In vitro antioxidant activity of coumarin compounds by DPPH, Super oxide and nitric oxide free radical scavenging methods
    • Patel-Rajesh M, Patel-Natvar J. In vitro antioxidant activity of coumarin compounds by DPPH, Super oxide and nitric oxide free radical scavenging methods. JAPER. 2011;1:52-68.
    • (2011) JAPER. , vol.1 , pp. 52-68
    • Patel-Rajesh, M.1    Patel-Natvar, J.2
  • 5
    • 29844452617 scopus 로고    scopus 로고
    • Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by Antrodia camphorata
    • Yang HL, Chen CS, Chang WH, Lu FJ, Lai YC, Chen CC, et al. Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by Antrodia camphorata. Cancer Lett 2006; 231:215-227.
    • (2006) Cancer Lett , vol.231 , pp. 215-227
    • Yang, H.L.1    Chen, C.S.2    Chang, W.H.3    Lu, F.J.4    Lai, Y.C.5    Chen, C.C.6
  • 6
    • 0035144834 scopus 로고    scopus 로고
    • Expression of apoptosis-related genes and proteins in experimental chronic renal scarring
    • Yang B, Johnson TS, Thomas GL, Watson PF, Wagner B, Skill NJ, et al. Expression of apoptosis-related genes and proteins in experimental chronic renal scarring. J Am Soc Nephrol 2001; 12:275-288.
    • (2001) J am Soc Nephrol , vol.12 , pp. 275-288
    • Yang, B.1    Johnson, T.S.2    Thomas, G.L.3    Watson, P.F.4    Wagner, B.5    Skill, N.J.6
  • 8
    • 84923330831 scopus 로고    scopus 로고
    • Antioxidant and antiprolifereative capacity of dichloromethane extract of holoturia leucospilota sea cucumber
    • Soltani M, Baharara J. Antioxidant and antiprolifereative capacity of dichloromethane extract of holoturia leucospilota sea cucumber. Int J Data Min Bioinform 2014; 1-9.
    • (2014) Int J Data Min Bioinform , pp. 1-9
    • Soltani, M.1    Baharara, J.2
  • 9
    • 80054880017 scopus 로고    scopus 로고
    • High-value components and bioactives from sea cucumbers for functional f oods—a review
    • Bordbar S, Anwar F, Saari N. High-value components and bioactives from sea cucumbers for functional f oods—a review. Mar Drugs 2011; 9:1761-1805.
    • (2011) Mar Drugs , vol.9 , pp. 1761-1805
    • Bordbar, S.1    Anwar, F.2    Saari, N.3
  • 10
    • 31544458922 scopus 로고    scopus 로고
    • ESI‐QqTOF‐MS/MS and APCI‐IT‐MS/MS analysis of steroid saponins from the rhizomes of Dioscorea panthaica
    • Li R, Zhou Y, Wu Z, Ding L. ESI‐QqTOF‐MS/MS and APCI‐IT‐MS/MS analysis of steroid saponins from the rhizomes of Dioscorea panthaica. J Mass Spectrom 2006; 41:1-22.
    • (2006) J Mass Spectrom , vol.41 , pp. 1-22
    • Li, R.1    Zhou, Y.2    Wu, Z.3    Ding, L.4
  • 12
    • 81855185501 scopus 로고    scopus 로고
    • Structure-function relationship of the saponins from the roots of Platycodon grandiflorum for hemolytic and adjuvant activity
    • Sun H, Chen L, Wang J, Wang K, Zhou J. Structure-function relationship of the saponins from the roots of Platycodon grandiflorum for hemolytic and adjuvant activity. Int Immunopharmacol 2011; 11:2047-2056.
    • (2011) Int Immunopharmacol , vol.11 , pp. 2047-2056
    • Sun, H.1    Chen, L.2    Wang, J.3    Wang, K.4    Zhou, J.5
  • 14
    • 80053451295 scopus 로고    scopus 로고
    • And phytochemical screening of Suaeda maritima (Dumort): A mangrove associate from Bhitarkanika, India
    • Patra J, Dhal N, Thatoi H. In vitro bioactivity and phytochemical screening of Suaeda maritima (Dumort): A mangrove associate from Bhitarkanika, India. Asian Pac J Trop Med 2011; 4:727-734.
    • (2011) Asian Pac J Trop Med , vol.4 , pp. 727-734
    • Patra, J.1    Dhal, N.2    Thatoi, H.3    Bioactivity, I.V.4
  • 15
    • 84891685828 scopus 로고    scopus 로고
    • In vitro screening of anti-candida activity of saponins extracted from Glycyrrhiza glabra and Quillaja saponaria
    • Moghimipour E, Sadaghi-nejad B, Handali S, Ameri A, Azemi ME. In vitro screening of anti-candida activity of saponins extracted from Glycyrrhiza glabra and Quillaja saponaria. Asian J Pharm Clin Res 2014; 7:7-9.
    • (2014) Asian J Pharm Clin Res , vol.7 , pp. 7-9
    • Moghimipour, E.1    Sadaghi-Nejad, B.2    Handali, S.3    Ameri, A.4    Azemi, M.E.5
  • 16
    • 84923368576 scopus 로고    scopus 로고
    • Angiogenesis and antioxidant activity of in vitro and in vivo tuber of ceropegia pusilla wight and arn
    • Prabakaran R, Kalimuthu K, Vani C, Brindha C. Angiogenesis and antioxidant activity of in vitro and in vivo tuber of ceropegia pusilla wight and arn. Br J Pharm Res 2014; 4: 608-616.
    • (2014) Br J Pharm Res , vol.4 , pp. 608-616
    • Prabakaran, R.1    Kalimuthu, K.2    Vani, C.3    Brindha, C.4
  • 17
    • 34548358443 scopus 로고    scopus 로고
    • Zhang X-w, Xie X, Xin X-l, Yi Y-h, et al. Philinopside E, a new sulfated saponin from sea cucumber, blocks the interaction between kinase insert domain-containing receptor (KDR) and αvβ3 integrin via binding to the extracellular domain of KDR
    • Tian F, Zhu C-h, Zhang X-w, Xie X, Xin X-l, Yi Y-h, et al. Philinopside E, a new sulfated saponin from sea cucumber, blocks the interaction between kinase insert domain-containing receptor (KDR) and αvβ3 integrin via binding to the extracellular domain of KDR. Mol Pharmacol 2007; 72:545-552.
    • (2007) Mol Pharmacol , vol.72 , pp. 545-552
    • Tian, F.1    Zhu, C.-H.2
  • 18
    • 77950389103 scopus 로고    scopus 로고
    • Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPARa and SREBP-1c signaling
    • Hu X-Q, Wang Y-M, Wang J-F, Xue Y, Li Z-J, Nagao K, et al. Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPARa and SREBP-1c signaling. Lipids Health Dis 2010; 9:25.
    • (2010) Lipids Health Dis , vol.9 , pp. 25
    • Hu, X.-Q.1    Wang, Y.-M.2    Wang, J.-F.3    Xue, Y.4    Li, Z.-J.5    Nagao, K.6
  • 19
    • 83055163371 scopus 로고    scopus 로고
    • Radical scavenging and antioxidant activity of ethanolic extract of mollugo nudicaulis by In vitro assays
    • Rajamanikandan S, Sindhu T, Durgapriya D, Sophia D, Ragavendran P, Gopalakrishnan V. Radical scavenging and antioxidant activity of ethanolic extract of mollugo nudicaulis by In vitro assays. IJPER 2011; 45:310-316.
    • (2011) IJPER , vol.45 , pp. 310-316
    • Rajamanikandan, S.1    Sindhu, T.2    Durgapriya, D.3    Sophia, D.4    Ragavendran, P.5    Gopalakrishnan, V.6
  • 20
    • 79957498373 scopus 로고    scopus 로고
    • Free radical-scavenging capacity, antioxidant activity and phenolic content of Pouzolzia zeylanica
    • Li P, Huo L, Su W, Lu R, Deng C, Liu L, et al. Free radical-scavenging capacity, antioxidant activity and phenolic content of Pouzolzia zeylanica. J Serb Chem Soc 2011; 76:709-717.
    • (2011) J Serb Chem Soc , vol.76 , pp. 709-717
    • Li, P.1    Huo, L.2    Su, W.3    Lu, R.4    Deng, C.5    Liu, L.6
  • 21
    • 36849027584 scopus 로고    scopus 로고
    • Antioxidant and free radical scavenging activities of Phellinus merrillii extracts
    • Chang HY, Ho YL, Sheu MJ, Lin YH, Tseng MC, Wu SH, et al. Antioxidant and free radical scavenging activities of Phellinus merrillii extracts. Bot Stud 2007; 48:407-417.
    • (2007) Bot Stud , vol.48 , pp. 407-417
    • Chang, H.Y.1    Ho, Y.L.2    Sheu, M.J.3    Lin, Y.H.4    Tseng, M.C.5    Wu, S.H.6
  • 22
    • 79952592457 scopus 로고    scopus 로고
    • In-vitro antioxidant studies of various extracts of whole plant of Borreria hispida (Linn)
    • Shajiselvin C, Muthu AK. In-vitro antioxidant studies of various extracts of whole plant of Borreria hispida (Linn). Res J Pharm Biol Chem Sci 2010; 1:14-20.
    • (2010) Res J Pharm Biol Chem Sci , vol.1 , pp. 14-20
    • Shajiselvin, C.1    Muthu, A.K.2
  • 23
    • 84901379796 scopus 로고    scopus 로고
    • Cytotoxic effect of magnetic iron oxide nanoparticles synthesized via seaweed aqueous extract
    • Namvar F, Rahman HS, Mohamad R, Baharara J, Mahdavi M, Amini E, et al. Cytotoxic effect of magnetic iron oxide nanoparticles synthesized via seaweed aqueous extract. Int J Nanomed 2014; 9: 2479–2488.
    • (2014) Int J Nanomed , vol.9 , pp. 2479-2488
    • Namvar, F.1    Rahman, H.S.2    Mohamad, R.3    Baharara, J.4    Mahdavi, M.5    Amini, E.6
  • 24
    • 85037172344 scopus 로고    scopus 로고
    • Hydroxyl radical scavenging activity of peptide from sea cucumber using enzyme complex isolated from the digestive tract of sea cucumber
    • Pan SK, Yao DR, Zhou MQ, Wu SJ. Hydroxyl radical scavenging activity of peptide from sea cucumber using enzyme complex isolated from the digestive tract of sea cucumber. Afr J Biotechnol 2014; 11:1214-1219.
    • (2014) Afr J Biotechnol , vol.11 , pp. 1214-1219
    • Pan, S.K.1    Yao, D.R.2    Zhou, M.Q.3    Wu, S.J.4
  • 25
    • 79960203921 scopus 로고    scopus 로고
    • Free radical scavenging and reducing power of Lawsonia inermis L. Seeds
    • Philip JP, Madhumitha G, Mary SA. Free radical scavenging and reducing power of Lawsonia inermis L. seeds. Asian Pac J Trop Med 2011; 4:457-461.
    • (2011) Asian Pac J Trop Med , vol.4 , pp. 457-461
    • Philip, J.P.1    Madhumitha, G.2    Mary, S.A.3
  • 26
    • 79959922413 scopus 로고    scopus 로고
    • In vitro antioxidant and antiproliferative activities of three Malaysian sea cucumber species
    • Althunibat OY, Hashim RB, Taher M, Daud JM, Ikeda M-A, Zali B. In vitro antioxidant and antiproliferative activities of three Malaysian sea cucumber species. Eur J Sci Res 2009; 37:376-387.
    • (2009) Eur J Sci Res , vol.37 , pp. 376-387
    • Althunibat, O.Y.1    Hashim, R.B.2    Taher, M.3    Daud, J.M.4    Ikeda, M.-A.5    Zali, B.6
  • 27
    • 34249861186 scopus 로고    scopus 로고
    • Compositional characteristics and antioxidant properties of fresh and processed sea cucumber (Cucumaria frondosa)
    • Zhong Y, Khan MA, Shahidi F. Compositional characteristics and antioxidant properties of fresh and processed sea cucumber (Cucumaria frondosa). J Agric Food Chem 2007; 55:1188-1192.
    • (2007) J Agric Food Chem , vol.55 , pp. 1188-1192
    • Zhong, Y.1    Khan, M.A.2    Shahidi, F.3
  • 28
    • 80054877966 scopus 로고    scopus 로고
    • Study on the separation and antioxidant activity of enzymatic hydrolysates from sea cucumber
    • Chenghui L, Beiwei Z, Xiuping D, Liguo C. Study on the separation and antioxidant activity of enzymatic hydrolysates from sea cucumber. Food Ferment Ind 2007; 33:50–53.
    • (2007) Food Ferment Ind , vol.33 , pp. 50-53
    • Chenghui, L.1    Beiwei, Z.2    Xiuping, D.3    Liguo, C.4
  • 29
    • 84897954210 scopus 로고    scopus 로고
    • Antioxidant activities of saponins extracted from Radix Trichosanthis: An in vivo and in vitro evaluation
    • Chen Y, Miao Y, Huang L, Li J, Sun H, Zhao Y, Yang J. Antioxidant activities of saponins extracted from Radix Trichosanthis: an in vivo and in vitro evaluation. BMC Complement Altern Med 2014; 14:1-8.
    • (2014) Bmccomplement Altern Med , vol.14 , pp. 1-8
    • Chen, Y.1    Miao, Y.2    Huang, L.3    Li, J.4    Sun, H.5    Zhao, Y.6    Yang, J.7
  • 30
    • 84886714328 scopus 로고    scopus 로고
    • Assessment of antioxidant and cytotoxicity activities of saponin and crude extracts of chlorophytum borivilianum
    • Ashraf MF, Abd Aziz M, Stanslas J, Ismail I, Abdul Kadir M. Assessment of antioxidant and cytotoxicity activities of saponin and crude extracts of chlorophytum borivilianum. Scientific WorldJournal 2013; 2013: 216894.
    • (2013) Scientific Worldjournal , vol.2013
    • Ashraf, M.F.1    Abd Aziz, M.2    Stanslas, J.3    Ismail, I.4    Abdul Kadir, M.5
  • 31
    • 84923358496 scopus 로고    scopus 로고
    • Saponin rich fractions (SRPs) from soapwort show antioxidant and hemolytic activity
    • Arslan I, Çelik A. Saponin rich fractions (SRPs) from soapwort show antioxidant and hemolytic activity. APCBEE Procedia 2013; 7:103-108.
    • (2013) APCBEE Procedia , vol.7 , pp. 103-108
    • Arslan, I.1    Çelik, A.2
  • 32
    • 84864015594 scopus 로고    scopus 로고
    • Extraction of saponin from Camellia oleifera cake and evaluation of its antioxidant activity
    • Hu JL, Nie SP, Huang DF, Li C, Xie MY. Extraction of saponin from Camellia oleifera cake and evaluation of its antioxidant activity. Int J Food Sci Technol 2012; 47:1676-1687.
    • (2012) Int J Food Sci Technol , vol.47 , pp. 1676-1687
    • Hu, J.L.1    Nie, S.P.2    Huang, D.F.3    Li, C.4    Xie, M.Y.5
  • 33
    • 80052457593 scopus 로고    scopus 로고
    • Induction of apoptosis by Rhizoma Paridis saponins in MCF-7 human breast cancer cells
    • Lu C, Li C, Wu D, Lu J, Tu F, Wang L. Induction of apoptosis by Rhizoma Paridis saponins in MCF-7 human breast cancer cells. Afr J Pharm Pharmaco 2011; 5:1086-1091.
    • (2011) Afr J Pharm Pharmaco , vol.5 , pp. 1086-1091
    • Lu, C.1    Li, C.2    Wu, D.3    Lu, J.4    Tu, F.5    Wang, L.6
  • 34
    • 84879686480 scopus 로고    scopus 로고
    • Cytotoxic activity of Pulsatilla chinensis saponins and their structure–activity relationship
    • Xu K, Shu Z, Xu Q-M, Liu Y-L, Li X-R, Wang Y-L, Yang SL. Cytotoxic activity of Pulsatilla chinensis saponins and their structure–activity relationship. J Asian Nat Prod Res 2013; 15:680-686.
    • (2013) J Asian Nat Prod Res , vol.15 , pp. 680-686
    • Xu, K.1    Shu, Z.2    Xu, Q.-M.3    Liu, Y.-L.4    Li, X.-R.5    Wang, Y.-L.6    Yang, S.L.7
  • 35
    • 79960011947 scopus 로고    scopus 로고
    • Saponin from sea cucumber Stichopus badionotus sluiter as potential cytotoxic agent on CEM-SS T-lymphoblastic cell
    • Kaswandi M, Hing H, Sahalan A, Farah F, Ridzwan B, Samsudin M, et al. Saponin from sea cucumber Stichopus badionotus sluiter as potential cytotoxic agent on CEM-SS T-lymphoblastic cell. J Microsc Soc Thailand 2004; 18:79-84.
    • (2004) J Microsc Soc Thailand , vol.18 , pp. 79-84
    • Kaswandi, M.1    Hing, H.2    Sahalan, A.3    Farah, F.4    Ridzwan, B.5    Samsudin, M.6
  • 36
    • 0038813761 scopus 로고    scopus 로고
    • Sweeney‐Gotsch B, McConkey D, et al. Inhibition of proliferation of PC3 cells by the branched‐chain fatty acid, 12‐methyltetradecanoic acid, is associated with inhibition of 5‐lipoxygenase
    • Yang P, Collin P, Madden T, Chan D, Sweeney‐Gotsch B, McConkey D, et al. Inhibition of proliferation of PC3 cells by the branched‐chain fatty acid, 12‐ methyltetradecanoic acid, is associated with inhibition of 5‐lipoxygenase. Prostate 2003; 55:281-291.
    • (2003) Prostate , vol.55 , pp. 281-291
    • Yang, P.1    Collin, P.2    Madden, T.3    Chan, D.4
  • 37
    • 79958813865 scopus 로고    scopus 로고
    • Cytotoxicity of a plant steroidal saponin on human lung cancer cells
    • Huang W, Zou K. Cytotoxicity of a plant steroidal saponin on human lung cancer cells. Asian Pac J Cancer Prev 2011; 12:513-517.
    • (2011) Asian Pac J Cancer Prev , vol.12 , pp. 513-517
    • Huang, W.1    Zou, K.2
  • 38
    • 84875923202 scopus 로고    scopus 로고
    • Anticancer activity and mediation of apoptosis in human HL-60 leukaemia cells by edible sea cucumber (Holothuria edulis) extract
    • Wijesinghe W, Jeon YJ, Ramasamy P, Wahid MEA, Vairappan CS. Anticancer activity and mediation of apoptosis in human HL-60 leukaemia cells by edible sea cucumber (Holothuria edulis) extract. Food Chem 2013; 139:326-331.
    • (2013) Food Chem , vol.139 , pp. 326-331
    • Wijesinghe, W.1    Jeon, Y.J.2    Ramasamy, P.3    Wahid, M.4    Vairappan, C.S.5
  • 39
    • 0033638986 scopus 로고    scopus 로고
    • Effect of saikosaponin, a triterpene saponin, on apoptosis in lymphocytes: Association with c‐myc, p53, and bcl‐2 mRNA
    • Hsu MJ, Cheng JS, Huang HC. Effect of saikosaponin, a triterpene saponin, on apoptosis in lymphocytes: association with c‐myc, p53, and bcl‐2 mRNA. Br J Pharmacol 2000; 131:1285-1293.
    • (2000) Br J Pharmacol , vol.131 , pp. 1285-1293
    • Hsu, M.J.1    Cheng, J.S.2    Huang, H.C.3
  • 40
    • 84861625416 scopus 로고    scopus 로고
    • The anti-tumor activities of cerebrosides derived from sea cucumber Acaudina molpadioides and starfish Asterias amurensis in vitro and in vivo
    • Du L, Li Z-J, Xu J, Wang J-F, Xue Y, Xue C-H, et al. The anti-tumor activities of cerebrosides derived from sea cucumber Acaudina molpadioides and starfish Asterias amurensis in vitro and in vivo. J Oleo Sci 2012; 61:321-330.
    • (2012) J Oleo Sci , vol.61 , pp. 321-330
    • Du, L.1    Li, Z.-J.2    Xu, J.3    Wang, J.-F.4    Xue, Y.5    Xue, C.-H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.