Metabolism in cancer metastasis

International Journal of Cancer

Volumn 138, Issue 9, 2016, Pages 2061-2066

  Weber, Georg F ^a  

^a UNIVERSITY OF CINCINNATI ACADEMIC HEALTH CENTER   (United States)

Author keywords

deadhesion; energy; metabolism; metastasis; peroxide; signal transduction; Warburg effect

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUTAMINE; OSTEOPONTIN; PEROXIDE; REACTIVE OXYGEN METABOLITE;

ADHERENT CELL; APOPTOSIS; CANCER STAGING; CARCINOGENESIS; GENE EXPRESSION; GLUCOSE TRANSPORT; GLYCOLYSIS; HUMAN; METABOLISM; METASTASIS; MITOCHONDRION; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; TUMOR CELL; ANIMAL; NEOPLASM; PATHOLOGY;

ANIMALS; HUMANS; NEOPLASM METASTASIS; NEOPLASMS;

EID: 84958849651     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.29839     Document Type: Review

References (56)

1. Warburg O., Über den Stoffwechsel der Tumoren. London: Constable, 1930.
2. Weinberg RA., Racing to the beginning of the road. The search for the origin of cancer, 2nd edn. New York: W.H. Freeman and Company, 1998.
3. Folkman J, Merler E, Abernathy C, et al., Isolation of a tumor factor responsible for angiogenesis. J Exp Med 1971; 133: 275-88.
4. Vaupel V, Thews G, Wendling P., Kritische Sauerstoff- und Glucoseversorgung maligner Tumoren. Deutsche Medizinische Wochenschrift 1976; 101: 1810-6.
5. Racker E., A view of misconduct in science. Nature 1989; 339: 91-3.
6. Ramanathan A, Wang C, Schreiber SL., Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements. Proc Natl Acad Sci USA 2005; 102: 5992-7.
7. Pan JG, Mak TW., Metabolic targeting as an anticancer strategy: dawn of a new era? Sci STKE 2007; 381: pe14.
8. McKnight SL., On getting there from here. Science 2010; 330: 1338-9.
9. + channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 2007; 11: 37-51.
10. DeBerardinis RJ, Mancuso A, Daikhin E, et al., Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci USA 2007; 104: 19345-50.
11. Deberardinis RJ, Sayed N, Ditsworth D, et al., Brick by brick: metabolism and tumor cell growth. Curr Opin Genet Dev 2008; 18: 54-61.
12. Vander Heiden MG, Cantley LC, Thompson CB., Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009; 324: 1029-33.
13. Christofk HR, Vander Heiden MG, Harris MH, et al., The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 2008; 452: 230-3.
14. Weber GF., Molecular mechanisms of metastasis. Cancer Lett 2008; 270: 181-90.
15. Schafer ZT, Grassian AR, Song L, et al., Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature 2009; 461: 109-13.
16. Shi Z, Mirza M, Wang B, et al., Osteopontin-a alters glucose homeostasis in anchorage independent breast cancer cells. Cancer Lett 2014; 344: 47-53.
17. Shi Z, Wang B, Chihanga T, et al., Energy metabolism during anchorage independence. Induction by osteopontin-c. Plos One 2014;: e105675.
18. LeBleu VS, O'Connell JT, Gonzalez Herrera KN, et al., PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis. Nat Cell Biol 2014; 16: 992-1003.
19. 2-generating peroxisomal fatty acyl-CoA oxidase. Proc Natl Acad Sci USA 1995; 92: 7080-4.
20. 2 is directly related to increased proliferation and transformation of tracheal epithelial cells. Cancer Res 1995; 55: 2723-6.
21. Okamoto M, Kawai K, Reznikoff CA, et al., Transformation in vitro of a nontumorigenic rat urothelial cell line by hydrogen peroxide. Cancer Res 1996; 56: 4649-53.
22. Ishikawa K, Takenaga K, Akimoto M, et al., ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis. Science 2008; 320: 661-4.
23. Kamarajugadda S, Stemboroski L, Cai Q, et al., Glucose oxidation modulates anoikis and tumor metastasis. Mol Cell Biol 2012; 32: 1893-907.
24. Liu W, Beck BH, Vaidya KS, et al., Metastasis suppressor KISS1 seems to reverse the Warburg effect by enhancing mitochondrial biogenesis. Cancer Res 2014; 74: 954-63.
25. Glinsky GV, Glinsky VV., Apoptosis metastasis a superior resistance of metastatic cancer cells to programmed cell death. Cancer Lett 1996; 101: 43-51.
26. Takaoka A, Adachi M, Okuda H, et al., Anti-cell death activity promotes pulmonary metastasis of melanoma cells. Oncogene 1997; 14: 2971-2977.
27. Wong CW, Lee A, Shientag L, et al., Apoptosis: an early event in metastatic inefficiency. Cancer Res 2001; 61: 333-8.
28. He B, Mirza M, Weber GF., An osteopontin splice variant induces anchorage independence in human breast cancer cells. Oncogene 2006; 25: 2192-202.
29. Caneba CA, Bellance N, Yang L, et al., Pyruvate uptake is increased in highly invasive ovarian cancer cells under anoikis conditions for anaplerosis, mitochondrial function, and migration. Am J Physiol Endocrinol Metab 2012; 303: E1036-52.
30. Sotgia F, Martinez-Outschoorn UE, Lisanti MP., The reverse Warburg effect in osteosarcoma. Oncotarget 2014; 5: 7982-3.
31. Schütze S, Potthoff K, Machleidt T, et al., TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown. Cell 1992; 71: 765-76.
32. Obeid LM, Linardic CM, Karolak LA, et al., Programmed cell death induced by ceramide. Science 1993; 259: 1769-71.
33. Weber GF, Abromson-Leeman S, Cantor HA., Signalling pathway coupled to T cell receptor ligation by MMTV superantigen leading to transient activation and programmed cell death. Immunity 1995; 2: 363-72.
34. Harman D., Aging: a theory based on free radical and radiation chemistry. J Gerontol 1956; 11: 298-300.
35. Harman D., The free radical theory of aging. In:, Warner HR, Butler RN, Sprott RL, Schneider EL, eds. Modern biological theories of aging. New York: Raven Press, 1987. 81-7.
36. Sitte N, Saretzki G, von Zglinicki T., Accelerated telomere shortening in fibroblasts after extended periods of confluency. Free Rad Biol Med 1998; 24: 885-93.
37. von Zglinicki T, Saretzki G, Docke W, et al., Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence? Exp Cell Res 1995; 220: 186-93.
38. Chen Q, Fisher A, Reagan JD, et al., Oxidative DNA damage and senescence of human diploid fibroblast cells. Proc Natl Acad Sci USA 1995; 92: 4337-41.
39. Nelson KK, Ranganathan AC, Mansouri J, et al., Elevated sod2 activity augments matrix metalloproteinase expression: evidence for the involvement of endogenous hydrogen peroxide in regulating metastasis. Clin Cancer Res 2003; 9: 424-432.
40. Connor KM, Hempel N, Nelson KK, et al., Manganese superoxide dismutase enhances the invasive and migratory activity of tumor cells. Cancer Res 2007; 67: 10260-7.
41. Dadras SS, Thorgeirsson SS, Rao MS, et al., Implication of hydrogen peroxide generation and apoptosis in the neoplastic transformation of mouse fibroblasts overexpressing peroxisomal fatty acyl-CoA oxidase. Int J Oncol 1998; 12: 37-44.
42. Yeldandi AV, Rao MS, Reddy JK., Hydrogen peroxide generation in peroxisome proliferator-induced oncogenesis. Mutat Res 2000; 448: 159-77.
43. Weinberg F, Hamanaka R, Wheaton WW, et al., Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity. Proc Natl Acad Sci USA 2010; 107: 8788-93.
44. Giannoni E, Buricchi F, Grimaldi G, et al., Redox regulation of anoikis: reactive oxygen species as essential mediators of cell survival. Cell Death Differ 2008; 15: 867-78.
45. Porporato PE, Payen VL, Pérez-Escuredo J, et al., A mitochondrial switch promotes tumor metastasis. Cell Rep 2014; 8: 754-66.
46. Davison CA, Durbin SM, Thau MR, et al., Antioxidant enzymes mediate survival of breast cancer cells deprived of extracellular matrix. Cancer Res 2013; 73: 3704-15.
47. Weber GF, Lett S, Haubein N., Osteopontin is a marker for cancer aggressiveness and patient survival. Br J Cancer 2010; 103: 861-9.
48. Young MF, Kerr JM, Termine JD, et al., cDNA cloning, mRNA distribution and heterogeneity, chromosomal location, and RFLP analysis of human osteopontin (OPN). Genomics 1990; 7: 491-502.
49. Mirza M, Shaughnessy E, Hurley JK, et al., Osteopontin-c is a highly selective marker for breast cancer. Int J Cancer 2008; 122: 889-97.
50. Behera R, Kumar V, Lohite K, et al., Activation of JAK2/STAT3 signaling by osteopontin promotes tumor growth in human breast cancer cells. Carcinogenesis 2010; 31: 192-200.
51. Zheng Y, Wang Z, Deng L, et al., Osteopontin promotes inflammation in patients with acute coronary syndrome through its activity on IL-17 producing cells. Eur J Immunol 2012; 42: 2803-14.
52. Weber GF, Adler B, Ashkar S., Osteopontin in oxidative stress responses. In:, Ruffolo RR, Jr, Feuerstein GZ, Hunter AJ, Poste G, Metcalf BW, eds). Inflammatory cells and mediators in CNS diseases. Amsterdam: Harwood Academic Publishers, 1999. 97-112.
53. Possemato R, Marks KM, Shaul YD, et al., Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature 2011; 476: 346-50.
54. Jain M, Nilsson R, Sharma S, et al., Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science 2012; 336: 1040-4.
55. Schreiber SN, Emter R, Hock MB, et al., The estrogen-related receptor α (ERRα) functions in PPARγ coactivator 1α (PGC-1α)-induced mitochondrial biogenesis. Proc Natl Acad Sci USA 2004; 101: 6472-7.
56. Rowe GC, Raghuram S, Jang C, et al., PGC-. 1α induces SPP1 to activate macrophages and orchestrate functional angiogenesis in skeletal muscle. Circ Res 2014; 115: 504-17.