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Volumn 303, Issue , 2016, Pages 228-237

Severe, multimodal stress exposure induces PTSD-like characteristics in a mouse model of single prolonged stress

Author keywords

Fear conditioning; Glucocorticoid; Glutamate; Mice; Posttraumatic stress disorder; Single prolonged stress

Indexed keywords

CORTICOSTERONE; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; MESSENGER RNA; PAROXETINE; GLUTAMIC ACID; SEROTONIN UPTAKE INHIBITOR;

EID: 84958280061     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2016.01.056     Document Type: Article
Times cited : (66)

References (65)
  • 2
    • 57649210180 scopus 로고    scopus 로고
    • Exposure to severe stressors causes long-lasting dysregulation of resting and stress-induced activation of the hypothalamic-pituitary-adrenal axis
    • Belda X., Rotllant D., Fuentes S., Delgado R., Nadal R., Armario A. Exposure to severe stressors causes long-lasting dysregulation of resting and stress-induced activation of the hypothalamic-pituitary-adrenal axis. Ann. N. Y. Acad. Sci. 2008, 1148:165-173.
    • (2008) Ann. N. Y. Acad. Sci. , vol.1148 , pp. 165-173
    • Belda, X.1    Rotllant, D.2    Fuentes, S.3    Delgado, R.4    Nadal, R.5    Armario, A.6
  • 3
    • 43549119009 scopus 로고    scopus 로고
    • Stress and re-stress increases conditioned taste aversion learning in rats: possible frontal cortical and hippocampal muscarinic receptor involvement
    • Brand L., Groenewald I., Stein D.J., Wegener G., Harvey B.H. Stress and re-stress increases conditioned taste aversion learning in rats: possible frontal cortical and hippocampal muscarinic receptor involvement. Eur. J. Pharmacol. 2008, 586:205-211.
    • (2008) Eur. J. Pharmacol. , vol.586 , pp. 205-211
    • Brand, L.1    Groenewald, I.2    Stein, D.J.3    Wegener, G.4    Harvey, B.H.5
  • 5
    • 79951584334 scopus 로고    scopus 로고
    • Neurochemical, hormonal, and behavioral effects of chronic unpredictable stress in the rat
    • Cox B.M., Alsawah F., McNeill P.C., Galloway M.P., Perrine S.A. Neurochemical, hormonal, and behavioral effects of chronic unpredictable stress in the rat. Behav. Brain Res. 2011, 220:106-111.
    • (2011) Behav. Brain Res. , vol.220 , pp. 106-111
    • Cox, B.M.1    Alsawah, F.2    McNeill, P.C.3    Galloway, M.P.4    Perrine, S.A.5
  • 7
    • 84884941488 scopus 로고    scopus 로고
    • Single prolonged stress impairs social and object novelty recognition in rats
    • Eagle A.L., Fitzpatrick C.J., Perrine S.A. Single prolonged stress impairs social and object novelty recognition in rats. Behav. Brain Res. 2013, 256:591-597.
    • (2013) Behav. Brain Res. , vol.256 , pp. 591-597
    • Eagle, A.L.1    Fitzpatrick, C.J.2    Perrine, S.A.3
  • 8
    • 84875381028 scopus 로고    scopus 로고
    • Single prolonged stress enhances hippocampal glucocorticoid receptor and phosphorylated protein kinase B levels
    • Eagle A.L., Knox D., Roberts M.M., Mulo K., Liberzon I., Galloway M.P., Perrine S.A. Single prolonged stress enhances hippocampal glucocorticoid receptor and phosphorylated protein kinase B levels. Neurosci. Res. 2013, 75:130-137.
    • (2013) Neurosci. Res. , vol.75 , pp. 130-137
    • Eagle, A.L.1    Knox, D.2    Roberts, M.M.3    Mulo, K.4    Liberzon, I.5    Galloway, M.P.6    Perrine, S.A.7
  • 9
    • 84878554985 scopus 로고    scopus 로고
    • Methamphetamine-induced behavioral sensitization in a rodent model of posttraumatic stress disorder
    • Eagle A.L., Perrine S.A. Methamphetamine-induced behavioral sensitization in a rodent model of posttraumatic stress disorder. Drug Alcohol Depend. 2013, 131:36-43.
    • (2013) Drug Alcohol Depend. , vol.131 , pp. 36-43
    • Eagle, A.L.1    Perrine, S.A.2
  • 10
    • 0036020027 scopus 로고    scopus 로고
    • Are the neural substrates of memory the final common pathway in posttraumatic stress disorder (PTSD)
    • Elzinga B.M., Bremner J.D. Are the neural substrates of memory the final common pathway in posttraumatic stress disorder (PTSD). J. Affect. Disord. 2002, 70:1-17.
    • (2002) J. Affect. Disord. , vol.70 , pp. 1-17
    • Elzinga, B.M.1    Bremner, J.D.2
  • 13
    • 84925582565 scopus 로고    scopus 로고
    • The effect of chronic phenytoin administration on single prolonged stress induced extinction retention deficits and glucocorticoid upregulation in the rat medial prefrontal cortex
    • George S.A., Rodriguez-Santiago M., Riley J., Rodriguez E., Liberzon I. The effect of chronic phenytoin administration on single prolonged stress induced extinction retention deficits and glucocorticoid upregulation in the rat medial prefrontal cortex. Psychopharmacology (Berl) 2014.
    • (2014) Psychopharmacology (Berl)
    • George, S.A.1    Rodriguez-Santiago, M.2    Riley, J.3    Rodriguez, E.4    Liberzon, I.5
  • 14
    • 84925532848 scopus 로고    scopus 로고
    • Early handling attenuates enhancement of glucocorticoid receptors in the prefrontal cortex in an animal model of post-traumatic stress disorder
    • George S.A., Stout S.A., Tan M., Knox D., Liberzon I. Early handling attenuates enhancement of glucocorticoid receptors in the prefrontal cortex in an animal model of post-traumatic stress disorder. Biol. Mood Anxiety Disord. 2013, 3:22.
    • (2013) Biol. Mood Anxiety Disord. , vol.3 , pp. 22
    • George, S.A.1    Stout, S.A.2    Tan, M.3    Knox, D.4    Liberzon, I.5
  • 15
    • 84880425478 scopus 로고    scopus 로고
    • Single-prolonged stress induces endoplasmic reticulum-dependent apoptosis in the hippocampus in a rat model of post-traumatic stress disorder
    • Han F., Yan S., Shi Y. Single-prolonged stress induces endoplasmic reticulum-dependent apoptosis in the hippocampus in a rat model of post-traumatic stress disorder. PLoS One 2013, 8:e69340.
    • (2013) PLoS One , vol.8 , pp. e69340
    • Han, F.1    Yan, S.2    Shi, Y.3
  • 16
    • 84867063828 scopus 로고    scopus 로고
    • Emotion and cognition interactions in PTSD: a review of neurocognitive and neuroimaging studies
    • Hayes J.P., Vanelzakker M.B., Shin L.M. Emotion and cognition interactions in PTSD: a review of neurocognitive and neuroimaging studies. Front. Integr. Neurosci. 2012, 6:89.
    • (2012) Front. Integr. Neurosci. , vol.6 , pp. 89
    • Hayes, J.P.1    Vanelzakker, M.B.2    Shin, L.M.3
  • 17
    • 0344683235 scopus 로고    scopus 로고
    • National Academy Press, Washington, D.C
    • Institute of Laboratory Animal Resources (U.S.) Guide for the Care and Use of Laboratory Animals 2011, National Academy Press, Washington, D.C.
    • (2011) Guide for the Care and Use of Laboratory Animals
  • 18
    • 33750484321 scopus 로고    scopus 로고
    • Pharmacotherapy for post-traumatic stress disorder - a systematic review and meta-analysis
    • Ipser J., Seedat S., Stein D.J. Pharmacotherapy for post-traumatic stress disorder - a systematic review and meta-analysis. S. Afr. Med. J. 2006, 96:1088-1096.
    • (2006) S. Afr. Med. J. , vol.96 , pp. 1088-1096
    • Ipser, J.1    Seedat, S.2    Stein, D.J.3
  • 19
    • 33947584042 scopus 로고    scopus 로고
    • Single prolonged stress increases contextual freezing and the expression of glycine transporter 1 and vesicle-associated membrane protein 2 mRNA in the hippocampus of rats
    • Iwamoto Y., Morinobu S., Takahashi T., Yamawaki S. Single prolonged stress increases contextual freezing and the expression of glycine transporter 1 and vesicle-associated membrane protein 2 mRNA in the hippocampus of rats. Prog. Neuropsychopharmacol. Biol. Psychiatry 2007, 31:642-651.
    • (2007) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.31 , pp. 642-651
    • Iwamoto, Y.1    Morinobu, S.2    Takahashi, T.3    Yamawaki, S.4
  • 23
    • 1642358151 scopus 로고    scopus 로고
    • Topiramate attenuates exaggerated acoustic startle in an animal model of PTSD
    • Khan S., Liberzon I. Topiramate attenuates exaggerated acoustic startle in an animal model of PTSD. Psychopharmacology (Berl) 2004, 172:225-229.
    • (2004) Psychopharmacology (Berl) , vol.172 , pp. 225-229
    • Khan, S.1    Liberzon, I.2
  • 25
    • 84865559044 scopus 로고    scopus 로고
    • Glucocorticoid receptors and extinction retention deficits in the single prolonged stress model
    • Knox D., Nault T., Henderson C., Liberzon I. Glucocorticoid receptors and extinction retention deficits in the single prolonged stress model. Neuroscience 2012, 223:163-173.
    • (2012) Neuroscience , vol.223 , pp. 163-173
    • Knox, D.1    Nault, T.2    Henderson, C.3    Liberzon, I.4
  • 26
    • 77954383813 scopus 로고    scopus 로고
    • Single prolonged stress decreases glutamate, glutamine, and creatine concentrations in the rat medial prefrontal cortex
    • Knox D., Perrine S.A., George S.A., Galloway M.P., Liberzon I. Single prolonged stress decreases glutamate, glutamine, and creatine concentrations in the rat medial prefrontal cortex. Neurosci. Lett. 2010, 480:16-20.
    • (2010) Neurosci. Lett. , vol.480 , pp. 16-20
    • Knox, D.1    Perrine, S.A.2    George, S.A.3    Galloway, M.P.4    Liberzon, I.5
  • 27
    • 34547697687 scopus 로고    scopus 로고
    • Glucocorticoid receptor activation is involved in producing abnormal phenotypes of single-prolonged stress rats: a putative post-traumatic stress disorder model
    • Kohda K., Harada K., Kato K., Hoshino A., Motohashi J., Yamaji T., Morinobu S., Matsuoka N., Kato N. Glucocorticoid receptor activation is involved in producing abnormal phenotypes of single-prolonged stress rats: a putative post-traumatic stress disorder model. Neuroscience 2007, 148:22-33.
    • (2007) Neuroscience , vol.148 , pp. 22-33
    • Kohda, K.1    Harada, K.2    Kato, K.3    Hoshino, A.4    Motohashi, J.5    Yamaji, T.6    Morinobu, S.7    Matsuoka, N.8    Kato, N.9
  • 29
    • 0344359767 scopus 로고    scopus 로고
    • Differential regulation of hippocampal glucocorticoid receptors mRNA and fast feedback: relevance to post-traumatic stress disorder
    • Liberzon I., Lopez J.F., Flagel S.B., Vazquez D.M., Young E.A. Differential regulation of hippocampal glucocorticoid receptors mRNA and fast feedback: relevance to post-traumatic stress disorder. J. Neuroendocrinol. 1999, 11:11-17.
    • (1999) J. Neuroendocrinol. , vol.11 , pp. 11-17
    • Liberzon, I.1    Lopez, J.F.2    Flagel, S.B.3    Vazquez, D.M.4    Young, E.A.5
  • 30
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2-δδCT method
    • Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2-δδCT method. Methods 2001, 25:402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 32
    • 84881609833 scopus 로고    scopus 로고
    • Vorinostat ameliorates impaired fear extinction possibly via the hippocampal NMDA-CaMKII pathway in an animal model of posttraumatic stress disorder
    • Matsumoto Y., Morinobu S., Yamamoto S., Matsumoto T., Takei S., Fujita Y., Yamawaki S. Vorinostat ameliorates impaired fear extinction possibly via the hippocampal NMDA-CaMKII pathway in an animal model of posttraumatic stress disorder. Psychopharmacology (Berl) 2013, 229:51-62.
    • (2013) Psychopharmacology (Berl) , vol.229 , pp. 51-62
    • Matsumoto, Y.1    Morinobu, S.2    Yamamoto, S.3    Matsumoto, T.4    Takei, S.5    Fujita, Y.6    Yamawaki, S.7
  • 33
    • 40849118026 scopus 로고    scopus 로고
    • Presence and acquired origin of reduced recall for fear extinction in PTSD: results of a twin study
    • Milad M.R., Orr S.P., Lasko N.B., Chang Y., Rauch S.L., Pitman R.K. Presence and acquired origin of reduced recall for fear extinction in PTSD: results of a twin study. J. Psychiatr. Res. 2008, 42:515-520.
    • (2008) J. Psychiatr. Res. , vol.42 , pp. 515-520
    • Milad, M.R.1    Orr, S.P.2    Lasko, N.B.3    Chang, Y.4    Rauch, S.L.5    Pitman, R.K.6
  • 35
    • 77952511600 scopus 로고    scopus 로고
    • The vomeronasal organ mediates interspecies defensive behaviors through detection of protein pheromone homologs
    • Papes F., Logan D.W., Stowers L. The vomeronasal organ mediates interspecies defensive behaviors through detection of protein pheromone homologs. Cell 2010, 141:692-703.
    • (2010) Cell , vol.141 , pp. 692-703
    • Papes, F.1    Logan, D.W.2    Stowers, L.3
  • 36
    • 77955055634 scopus 로고    scopus 로고
    • Hyperbaric oxygen preconditioning ameliorates anxiety-like behavior and cognitive impairments via upregulation of thioredoxin reductases in stressed rats
    • Peng Y., Feng S.F., Wang Q., Wang H.N., Hou W.G., Xiong L., Luo Z.J., Tan Q.R. Hyperbaric oxygen preconditioning ameliorates anxiety-like behavior and cognitive impairments via upregulation of thioredoxin reductases in stressed rats. Prog. Neuropsychopharmacol. Biol. Psychiatry 2010, 34:1018-1025.
    • (2010) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.34 , pp. 1018-1025
    • Peng, Y.1    Feng, S.F.2    Wang, Q.3    Wang, H.N.4    Hou, W.G.5    Xiong, L.6    Luo, Z.J.7    Tan, Q.R.8
  • 37
    • 0343851737 scopus 로고    scopus 로고
    • Psychophysiologic assessment of aversive conditioning in posttraumatic stress disorder
    • Peri T., Ben-Shakhar G., Orr S.P., Shalev A.Y. Psychophysiologic assessment of aversive conditioning in posttraumatic stress disorder. Biol. Psychiatry 2000, 47:512-519.
    • (2000) Biol. Psychiatry , vol.47 , pp. 512-519
    • Peri, T.1    Ben-Shakhar, G.2    Orr, S.P.3    Shalev, A.Y.4
  • 39
    • 53149086276 scopus 로고    scopus 로고
    • Cocaine regulates protein kinase B and glycogen synthase kinase-3 activity in selective regions of rat brain
    • Perrine S.A., Miller J.S., Unterwald E.M. Cocaine regulates protein kinase B and glycogen synthase kinase-3 activity in selective regions of rat brain. J. Neurochem. 2008, 107:570-577.
    • (2008) J. Neurochem. , vol.107 , pp. 570-577
    • Perrine, S.A.1    Miller, J.S.2    Unterwald, E.M.3
  • 40
    • 79955526587 scopus 로고    scopus 로고
    • Binge toluene exposure alters glutamate, glutamine and GABA in the adolescent rat brain as measured by proton magnetic resonance spectroscopy
    • Perrine S.A., O'Leary-Moore S.K., Galloway M.P., Hannigan J.H., Bowen S.E. Binge toluene exposure alters glutamate, glutamine and GABA in the adolescent rat brain as measured by proton magnetic resonance spectroscopy. Drug Alcohol Depend. 2011, 115:101-106.
    • (2011) Drug Alcohol Depend. , vol.115 , pp. 101-106
    • Perrine, S.A.1    O'Leary-Moore, S.K.2    Galloway, M.P.3    Hannigan, J.H.4    Bowen, S.E.5
  • 42
    • 0027375098 scopus 로고
    • Estimation of metabolite concentrations from localized in vivo proton NMR spectra
    • Provencher S.W. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn. Reson. Med. 1993, 30:672-679.
    • (1993) Magn. Reson. Med. , vol.30 , pp. 672-679
    • Provencher, S.W.1
  • 43
    • 33746501292 scopus 로고    scopus 로고
    • Prefrontal mechanisms in extinction of conditioned fear
    • Quirk G.J., Garcia R., Gonzalez-Lima F. Prefrontal mechanisms in extinction of conditioned fear. Biol. Psychiatry 2006, 60:337-343.
    • (2006) Biol. Psychiatry , vol.60 , pp. 337-343
    • Quirk, G.J.1    Garcia, R.2    Gonzalez-Lima, F.3
  • 44
  • 45
    • 1342347749 scopus 로고    scopus 로고
    • Applying learning principles to the treatment of post-trauma reactions
    • Rothbaum B.O., Davis M. Applying learning principles to the treatment of post-trauma reactions. Ann. N. Y. Acad. Sci. 2003, 1008:112-121.
    • (2003) Ann. N. Y. Acad. Sci. , vol.1008 , pp. 112-121
    • Rothbaum, B.O.1    Davis, M.2
  • 46
    • 0033800486 scopus 로고    scopus 로고
    • Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders
    • Sapolsky R.M. Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Arch. Gen. Psychiatry 2000, 57:925-935.
    • (2000) Arch. Gen. Psychiatry , vol.57 , pp. 925-935
    • Sapolsky, R.M.1
  • 47
    • 74549217807 scopus 로고    scopus 로고
    • Is posttraumatic stress disorder a stress-induced fear circuitry disorder?
    • Shin L.M., Handwerger K. Is posttraumatic stress disorder a stress-induced fear circuitry disorder?. J. Trauma. Stress 2009.
    • (2009) J. Trauma. Stress
    • Shin, L.M.1    Handwerger, K.2
  • 48
    • 33746423882 scopus 로고    scopus 로고
    • Amygdala, medial prefrontal cortex, and hippocampal function in PTSD
    • Shin L.M., Rauch S.L., Pitman R.K. Amygdala, medial prefrontal cortex, and hippocampal function in PTSD. Ann. N. Y. Acad. Sci. 2006, 1071:67-79.
    • (2006) Ann. N. Y. Acad. Sci. , vol.1071 , pp. 67-79
    • Shin, L.M.1    Rauch, S.L.2    Pitman, R.K.3
  • 49
    • 33750609342 scopus 로고    scopus 로고
    • Effect of paroxetine on enhanced contextual fear induced by single prolonged stress in rats
    • Takahashi T., Morinobu S., Iwamoto Y., Yamawaki S. Effect of paroxetine on enhanced contextual fear induced by single prolonged stress in rats. Psychopharmacology (Berl) 2006, 189:165-173.
    • (2006) Psychopharmacology (Berl) , vol.189 , pp. 165-173
    • Takahashi, T.1    Morinobu, S.2    Iwamoto, Y.3    Yamawaki, S.4
  • 50
    • 79952624303 scopus 로고    scopus 로고
    • Enhanced hippocampal BDNF/TrkB signaling in response to fear conditioning in an animal model of posttraumatic stress disorder
    • Takei S., Morinobu S., Yamamoto S., Fuchikami M., Matsumoto T., Yamawaki S. Enhanced hippocampal BDNF/TrkB signaling in response to fear conditioning in an animal model of posttraumatic stress disorder. J. Psychiatry Res. 2011, 45:460-468.
    • (2011) J. Psychiatry Res. , vol.45 , pp. 460-468
    • Takei, S.1    Morinobu, S.2    Yamamoto, S.3    Fuchikami, M.4    Matsumoto, T.5    Yamawaki, S.6
  • 51
    • 84904480030 scopus 로고    scopus 로고
    • Only susceptible rats exposed to a model of PTSD exhibit reactivity to trauma-related cues and other symptoms: An effect abolished by a single amphetamine injection
    • Toledano D., Gisquet-Verrier P. Only susceptible rats exposed to a model of PTSD exhibit reactivity to trauma-related cues and other symptoms: An effect abolished by a single amphetamine injection. Behav. Brain Res. 2014, 272:165-174.
    • (2014) Behav. Brain Res. , vol.272 , pp. 165-174
    • Toledano, D.1    Gisquet-Verrier, P.2
  • 52
    • 84860343504 scopus 로고    scopus 로고
    • Conditioned fear stress combined with single-prolonged stress: a new PTSD mouse model
    • Wang H., Zuo D., He B., Qiao F., Zhao M., Wu Y. Conditioned fear stress combined with single-prolonged stress: a new PTSD mouse model. Neurosci. Res. 2012, 73:142-152.
    • (2012) Neurosci. Res. , vol.73 , pp. 142-152
    • Wang, H.1    Zuo, D.2    He, B.3    Qiao, F.4    Zhao, M.5    Wu, Y.6
  • 53
    • 77953932094 scopus 로고    scopus 로고
    • Quetiapine ameliorates anxiety-like behavior and cognitive impairments in stressed rats: implications for the treatment of posttraumatic stress disorder
    • Wang H.N., Peng Y., Tan Q.R., Chen Y.C., Zhang R.G., Qiao Y.T., Wang H.H., Liu L., Kuang F., Wang B.R., Zhang Z.J. Quetiapine ameliorates anxiety-like behavior and cognitive impairments in stressed rats: implications for the treatment of posttraumatic stress disorder. Physiol. Res. 2010, 59:263-271.
    • (2010) Physiol. Res. , vol.59 , pp. 263-271
    • Wang, H.N.1    Peng, Y.2    Tan, Q.R.3    Chen, Y.C.4    Zhang, R.G.5    Qiao, Y.T.6    Wang, H.H.7    Liu, L.8    Kuang, F.9    Wang, B.R.10    Zhang, Z.J.11
  • 54
    • 70349319632 scopus 로고    scopus 로고
    • Activity of the 5-HT1A receptor is involved in the alteration of glucocorticoid receptor in hippocampus and corticotropin-releasing factor in hypothalamus in SPS rats
    • Wang H.T., Han F., Shi Y.X. Activity of the 5-HT1A receptor is involved in the alteration of glucocorticoid receptor in hippocampus and corticotropin-releasing factor in hypothalamus in SPS rats. Int. J. Mol. Med. 2009, 24:227-231.
    • (2009) Int. J. Mol. Med. , vol.24 , pp. 227-231
    • Wang, H.T.1    Han, F.2    Shi, Y.X.3
  • 55
    • 84861940047 scopus 로고    scopus 로고
    • Effect of neonatal respiratory infection on adult BALB/c hippocampal glucocorticoid and mineralocorticoid receptors
    • Wynne O., Horvat J.C., Smith R., Hansbro P.M., Clifton V.L., Hodgson D.M. Effect of neonatal respiratory infection on adult BALB/c hippocampal glucocorticoid and mineralocorticoid receptors. Dev. Psychobiol. 2012, 54:568-575.
    • (2012) Dev. Psychobiol. , vol.54 , pp. 568-575
    • Wynne, O.1    Horvat, J.C.2    Smith, R.3    Hansbro, P.M.4    Clifton, V.L.5    Hodgson, D.M.6
  • 56
    • 47249103361 scopus 로고    scopus 로고
    • Effects of single prolonged stress and d-cycloserine on contextual fear extinction and hippocampal NMDA receptor expression in a rat model of PTSD
    • Yamamoto S., Morinobu S., Fuchikami M., Kurata A., Kozuru T., Yamawaki S. Effects of single prolonged stress and d-cycloserine on contextual fear extinction and hippocampal NMDA receptor expression in a rat model of PTSD. Neuropsychopharmacology 2008, 33:2108-2116.
    • (2008) Neuropsychopharmacology , vol.33 , pp. 2108-2116
    • Yamamoto, S.1    Morinobu, S.2    Fuchikami, M.3    Kurata, A.4    Kozuru, T.5    Yamawaki, S.6
  • 58
    • 33744977703 scopus 로고    scopus 로고
    • Neuroendocrine aspects of PTSD
    • Yehuda R. Neuroendocrine aspects of PTSD. Handb. Exp. Pharmacol. 2005, 371-403.
    • (2005) Handb. Exp. Pharmacol. , pp. 371-403
    • Yehuda, R.1
  • 59
    • 0027253001 scopus 로고
    • Criteria for rationally evaluating animal models of posttraumatic stress disorder
    • Yehuda R., Antelman S.M. Criteria for rationally evaluating animal models of posttraumatic stress disorder. Biol. Psychiatry 1993, 33:479-486.
    • (1993) Biol. Psychiatry , vol.33 , pp. 479-486
    • Yehuda, R.1    Antelman, S.M.2
  • 62
    • 0027476739 scopus 로고
    • Enhanced suppression of cortisol following dexamethasone administration in posttraumatic stress disorder
    • Yehuda R., Southwick S.M., Krystal J.H., Bremner D., Charney D.S., Mason J.W. Enhanced suppression of cortisol following dexamethasone administration in posttraumatic stress disorder. Am. J. Psychiatry 1993, 150:83-86.
    • (1993) Am. J. Psychiatry , vol.150 , pp. 83-86
    • Yehuda, R.1    Southwick, S.M.2    Krystal, J.H.3    Bremner, D.4    Charney, D.S.5    Mason, J.W.6
  • 63
    • 84874302744 scopus 로고    scopus 로고
    • Deletion of STK40 protein in mice causes respiratory failure and death at birth
    • Yu H., He K., Li L., Sun L., Tang F., Li R., Ning W., Jin Y. Deletion of STK40 protein in mice causes respiratory failure and death at birth. J. Biol. Chem. 2013, 288:5342-5352.
    • (2013) J. Biol. Chem. , vol.288 , pp. 5342-5352
    • Yu, H.1    He, K.2    Li, L.3    Sun, L.4    Tang, F.5    Li, R.6    Ning, W.7    Jin, Y.8
  • 64
    • 33645216575 scopus 로고    scopus 로고
    • Stress-induced change of mitochondria membrane potential regulated by genomic and non-genomic GR signaling: a possible mechanism for hippocampus atrophy in PTSD
    • Zhang L., Zhou R., Li X., Ursano R.J., Li H. Stress-induced change of mitochondria membrane potential regulated by genomic and non-genomic GR signaling: a possible mechanism for hippocampus atrophy in PTSD. Med. Hypotheses 2006, 66:1205-1208.
    • (2006) Med. Hypotheses , vol.66 , pp. 1205-1208
    • Zhang, L.1    Zhou, R.2    Li, X.3    Ursano, R.J.4    Li, H.5
  • 65
    • 84856024507 scopus 로고    scopus 로고
    • Cannabinoids prevent the development of behavioral and endocrine alterations in a rat model of intense stress
    • Ganon-Elazar E., Akirav I. Cannabinoids prevent the development of behavioral and endocrine alterations in a rat model of intense stress. Neuropsychopharmacology 2012, 37:456-466.
    • (2012) Neuropsychopharmacology , vol.37 , pp. 456-466
    • Ganon-Elazar, E.1    Akirav, I.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.