Pharmacotherapy for post-traumatic stress disorder - A systematic review and meta-analysis

South African Medical Journal

Volumn 96, Issue 10, 2006, Pages 1088-1096

  Ipser, Jonathan ^a   Seedat, Soraya ^a   Stein, Dan J ^b  

^a STELLENBOSCH UNIVERSITY   (South Africa)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ALPRAZOLAM; AMITRIPTYLINE; BROFAROMINE; CITALOPRAM; DESIPRAMINE; FLUOXETINE; INOSITOL; LAMOTRIGINE; MIRTAZAPINE; NEFAZODONE; OLANZAPINE; PAROXETINE; PHENELZINE; PLACEBO; RISPERIDONE; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; VENLAFAXINE;

AVOIDANCE BEHAVIOR; CLINICAL TRIAL; COCHRANE LIBRARY; COMORBIDITY; CONFIDENCE INTERVAL; DEPRESSION; DISEASE SEVERITY; DRUG EFFICACY; DRUG TOLERABILITY; DRUG UTILIZATION; EVIDENCE BASED MEDICINE; HUMAN; INFORMATION PROCESSING; LONG TERM CARE; MEDICAL DECISION MAKING; MEDLINE; META ANALYSIS; OUTCOME ASSESSMENT; POSTTRAUMATIC STRESS DISORDER; PRACTICE GUIDELINE; PSYCINFO; QUALITY OF LIFE; RATING SCALE; REVIEW; SENSITIVITY ANALYSIS; STATISTICAL ANALYSIS; SYMPTOM; SYSTEMATIC REVIEW; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT;

CLINICAL TRIALS; HUMANS; PSYCHOTROPIC DRUGS; STRESS DISORDERS, POST-TRAUMATIC; TREATMENT OUTCOME;

EID: 33750484321     PISSN: 02569574     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (46)

1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 3rd ed. Washington, DC: APA, 1980.
2. Kessler RC, Sonnega A, Bromet E, Hughes M, Nelson CB. Posttraumatic stress disorder in the National Comorbidity Survey. Arch Gen Psychiatry 1995; 52: 1048-1060.
3. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: APA, 1994.
4. Rose S, Bisson J, Wessely S. Psychological debriefing for preventing post traumatic stress disorder (PTSD). The Cochrane Database of Systematic Reviews. Issue 2. New York: John Willey & Sons, 2002.
5. Bisson JI, Andrew M. Psychological treatment of post-traumatic stress disorder (PTSD). The Cochrane Database of Systematic Reviews, Issue 3. New York: John Wiley & Sons, 2005.
6. National Institute of Clinical Exellence (NICE). Post-traumatic Stress Disorder: The Management of PTSD in Adults and Children in Primary and Secondary Care. 26. London: Gaskell and the British Psychological Society, 2005.
7. Foa EB, Davidson JRT, Frances A. The expert consensus guideline series: treatment of posttraumatic stress disorder: The Expert Consensus Panel for PTSD. J Clin Psychiatry 1999; 60: 1-75.
8. Stein DJ, Ipser J, Seedat S. Pharmacotherapy for posttraumatic stress disorder (PTSD). The Cochrane Database of Systematic Reviews, Issue 1. New York: John Wiley & Sons, 2006.
9. Blake DD, Weathers FW, Nagy LM, et al. A clinician rating scale for assessing current and lifetime PTSD: The CAPS-1. Behavior Therapy 1990; 21:187-188.
10. Guy W. ECDEU Assessment Manual for Psychopharmacology. Washington, DC: US National Institute of Health, 1976.
11. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry 1961; 4: 561-571.
12. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960; 23: 56-62.
13. Review Manager (RevMan). Version 4.2 for Windows. Oxford, England: The Cochrane Collaboration, 2003.
14. Gury C, Cousin F. Pharmacokinetics of SSRI antidepressants: half-life and clinical applicability. Encephale 1999; 25: 470-476.
15. Deeks JJ, Altman DG, Bradburn MJ. Statistical methods for examining heterogeneity and combining results from several studies in meta-analysis. In: Egger M, Smith GD, Altman D, eds. Systematic Reviews in Health Care: Meta-Analysis in Context. London: BMJ Publication Group, 2001.
16. McRae AL, Brady KT, Mellman TA, et al. Comparison of nefazodone and sertraline for the treatment of posttraumatic stress disorder. Depress Anxiety 2004; 19: 190-196.
17. Chung MY, Min KH, Jun YJ, Kim SS, Kim WC, Jun EM. Efficacy and tolerability of mirtazapine and sertraline in Korean veterans with posttraumatic stress disorder: A randomized open label trial. Hum Psychopharmacol 2004; 19: 489-494.
18. Smajkic A, Weine S, Djuric-Bijedic Z, Boskailo E, Lewis J, Pavkovic I. Sertraline, paroxetine, and venlafaxine in refugee posttraumatic stress disorder with depression symptoms. J Trauma Stress 2001; 14: 445-452.
19. Saygin MZ, Sungur MZ, Sabol EU, Cetinkaya P. Nefazodone versus sertraline in treatment of posttraumatic stress disorder. Bull Clin Psychopharmacol 2002; 12: 1-5.
20. Braun P, Greenberg D, Dasberg H, Lerer B. Core symptoms of posttraumatic stress disorder unimproved by alprazolam treatment. J Clin Psychiatry 1990; 51: 236-238.
21. Kaplan Z, Amir M, Swartz M, Levine J. Inositol treatment of post-traumatic stress disorder. Anxiety 1996; 2(1): 51-52.
22. Reist C, Kauffmann CD, Haier RJ, et al. A controlled trial of desipramine in 18 men with posttraumatic stress disorder. Am J Psychiatry 1989; 146: 513-516.
23. Shestatzky M, Greenberg D, Lerer B. A controlled trial of phenelzine in posttraumatic stress disorder. Psychiatric Research 1988; 24: 149-155.
24. Kosten TR, Frank JB, Dan E, McDougle CJ, Giller ELJ. Pharmacotherapy for posttraumatic stress disorder using phenelzine or imipramine. J Nerv Ment Dis 1991; 179: 366-370.
25. Tucker P, Potter-Kimball R, Wyatt DB, et al. Can physiologic assessment and side effects tease out differences in PTSD trials? A double-blind comparison of citalopram, sertraline, and placebo. Gen Psychopharmacol 2003; 37: 135-149.
26. Brady K, Sonne S, Anton RF, Randall CL, Back-SE, Simpson K. Sertraline in the treatment of co-occurring alcohol dependence and posttraumatic stress disorder. Alcohol Clin Exp Res 2005; 29: 395-401.
27. Marshall RD, Lewis-Fernandez R, Blanco C, et al. A controlled trial of paroxetine for chronic PTSD, dissociation and interpersonal problems in mostly minority adults (in press).
28. Martenyi F, Brown EB, Zhang H, Prakash A, Koke SC. Fluoxetine versus placebo in posttraumatic stress disorder. J Clin Psychiatry 2002; 63: 199-206.
29. Davidson J, Rothbaum BO, van der Kolk BA, Sikes CR, Farfel GM. Multicenter, double-blind comparison of sertraline and placebo in the treatment of posttraumatic stress disorder. Arch Gen Psychiatry 2001; 58: 485-492.
30. Dow B, Kline N. Antidepressant treatment of posttraumatic stress disorder and major depression in veterans. Ann Clin Psychiatry 1997; 9(1): 1-5.
31. Ballenger JC, Davidson JRT, Lecrubier Y, et al. Consensus statement update on posttraumatic stress disorder from the international consensus group on depression and anxiety. J Clin Psychiatry 2004; 65: Suppl 1, 55-62.
32. Baker DG, Diamond BI, Gillette G, et al. A double-blind randomized placebo-controlled multi-centre study of brofaromine in the treatment of post-traumatic stress disorder. Psychopharmacology (Berl) 1995; 122: 386-389.
33. Katz RJ, Lott MH, Arbus P, et al. Pharmacotherapy of post-traumatic stress disorder with a novel psychotropic. Anxiety 1995; 1(4): 169-174.
34. Brady K, Pearlstein T, Asnis GM, et al. Efficacy and safety of sertraline treatment of posttraumatic stress disorder. Arch Gen Psychiatry 2000; 283: 1837-1844.
35. Connor KM, Sutherland SM, Tupler LA, Malik ML, Davidson JRT. Fluoxetine in post-traumatic stress disorder. Randomized, double-blind study. Br J Psychiatry 1999; 175: 17-22.
36. Hertzberg MA, Feldman ME, Beckham JC, Kudler HS, Davidson JRT. Lack of efficacy for fluoxetine in PTSD: A placebo controlled trial in combat veterans. Ann Clin Psychiatry 2000; 12: 101-105.
37. Marshall RD, Beebe KL, Oldham M, Zaninelli R, Efficacy and safety of paroxetine treatment for chronic PTSD: A fixed-dose, placebo-controlled study. Am J Psychiatry 2001; 158: 1982-1988.
38. Tucker P, Zaninelli R, Yehuda R, Ruggiero L, Dillingham K, Pitts CD. Paroxetine in the treatment of chronic posttraumatic stress disorder: Results of a placebo-controlled, flexible-dosage trial. J Clin Psychiatry 2001; 62: 860-868.
39. van der Kolk BA, Dreyfuss D, Michaels M, et al. Fluoxetine in posttraumatic stress disorder. J Clin Psychiatry 1994; 55: 517-522.
40. Zohar J, Amital D, Miodownik C, Kotler M, Bleich A, Lane RM. Double-blind placebo-controlled pilot study of sertraline in military veterans with posttraumatic stress disorder. J Clin Psychopharmacol 2002; 22: 190-195.
41. Davidson J, Kudler H, Smith R, et al. Treatment of posttraumatic stress disorder with amitriptyline and placebo. Arch Gen Psychiatry 1990; 47: 259-266.
42. Butterfield MI, Becker ME, Connor KM, Sutherland S, Churchill LE, Davidson JRT. Olanzapine in the treatment of post-traumatic stress disorder: A pilot study. Int Clin Psychopharmacol 2001; 16: 197-203.
43. Davidson J, Weisler RH, Butterfield MI, et al. Mirtazapine vs. placebo in posttraumatic stress disorder: A pilot trial. Biol Psychiatry 2003; 53: 188-191.
44. Davis LL, Jewell ME, Ambrose S, et al. A placebo-controlled study of nefazadone for the treatment of chronic posttraumatic stress disorder. J Clin Psychopharmacol 2004; 24: 291-297.
45. Hertzberg MA, Butterfield MI, Feldman ME, et al. A preliminary study of lamotrigine for the treatment of posttraumatic stress disorder. Biol Psychiatry 1999; 45: 1226-1229,
46. Reich DB, Winternitz S, Hennen J, Watts T, Stanculescu C. A preliminary study of risperidone in the treatment of posttraumatic stress disorder related to childhood abuse in women. J Clin Psychiatry 2004; 65: 1601-1605.