Conditioned fear stress combined with single-prolonged stress: A new PTSD mouse model

Neuroscience Research

Volumn 73, Issue 2, 2012, Pages 142-152

  Wang, Haifeng ^a   Zuo, Daiying ^a   He, Bin ^a   Qiao, Foxiao ^a   Zhao, Mingqi ^a   Wu, Yingliang ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Conditioned fear stress; Double stresses; Mouse model; Paroxetine; Post traumatic stress disorder; Single prolonged stress

Indexed keywords

PROTEIN BAX; PROTEIN BCL 2; PROTEIN C FOS; SYNAPSIN; SYNAPTOTAGMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONDITIONING; FEAR; FLOW CYTOMETRY; HIPPOCAMPUS; LOCOMOTION; MALE; MOUSE; NONHUMAN; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; SYNAPSE; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; CONDITIONING (PSYCHOLOGY); DISEASE MODELS, ANIMAL; FEAR; MALE; MICE; PAROXETINE; RANDOM ALLOCATION; STRESS DISORDERS, POST-TRAUMATIC; STRESS, PSYCHOLOGICAL;

EID: 84860343504     PISSN: 01680102     EISSN: 18728111     Source Type: Journal    
DOI: 10.1016/j.neures.2012.03.003     Document Type: Article

References (27)

1. Bachmann A.W., Sedgley T.L., Jackson R.V., Gibson J.N., Young R.M., Torpy D.J. Glucocorticoid receptor polymorphisms and post-traumatic stress disorder. Psychoneuroendocrinology 2005, 30:297-306.
2. Davidson J.R., Rothbaum B.O., van der Kolk B.A., Sikes C.R., Farfel G.M. Multicenter, double-blind comparison of sertraline and placebo in the treatment of posttraumatic stress disorder. Arch. Gen. Psychiatry 2001, 58:485-492.
3. Ding J., Han F., Shi Y. Single-prolonged stress induces apoptosis in the amygdala in a rat model of post-traumatic stress disorder. J. Psychiatr. Res. 2010, 44:48-55.
4. Herrera D.G., Robertson H.A. Activation of c-fos in the brain. Prog. Neurobiol. 1996, 50:83-107.
5. Iwamoto Y., Morinobu S., Takahashi T., Yamawaki S. Single prolonged stress increases contextual freezing and the expression of glycine transporter 1 and vesicle-associated membrane protein 2 mRNA in the hippocampus of rats. Prog. Neuropsychopharmacol. Biol. Psychiatry 2007, 31:642-651.
6. Khan S., Liberzon I. Topiramate attenuates exaggerated acoustic startle in an animal model of PTSD. Psychopharmacology (Berl) 2004, 172:225-229.
7. Kohda K., Harada K., Kato K., Hoshino A., Motohashi J., Yamaji T., Morinobu S., Matsuoka N., Kato N. Glucocorticoid receptor activation is involved in producing abnormal phenotypes of single-prolonged stress rats: a putative post-traumatic stress disorder model. Neuroscience 2007, 148:22-33.
8. Kung J.-C., Chen T.-C., Shyu B.-C., Hsiao S., Huang A.C.W. Anxiety- and depressive-like responses and c-fos activity in preproenkephalin knockout mice: oversensitivity hypothesis of enkephalin deficit-induced posttraumatic stress disorder. J. Biomed. Sci. 2010, 17:29.
9. Li X., Han F., Liu D., Shi Y. Changes of Bax, Bcl-2 and apoptosis in hippocampus in the rat model of post-traumatic stress disorder. Neurol. Res. 2010, 32:579-586.
10. Liberzon I., Krstov M., Young E.A. Stress-restress: effects on ACTH and fast feedback. Psychoneuroendocrinology 1997, 22:443-453.
11. Liberzon I., Lopez J.F., Flagel S.B., Vazquez D.M., Young E.A. Differential regulation of hippocampal glucocorticoid receptors mRNA and fast feedback: relevance to post-traumatic stress disorder. J. Neuroendocrinol. 1999, 11:11-17.
12. Marshall R.D., Beebe K.L., Oldham M., Zaninelli R. Efficacy and safety of paroxetine treatment for chronic PTSD: a fixed-dose, placebo-controlled study. Am. J. Psychiatry 2001, 158:1982-1988.
13. Oltvai Z.N., Milliman C.L., Korsmeyer S.J. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993, 74:609-619.
14. Pynoos R.S., Ritzmann R.F., Steinberg A.M., Goenjian A., Prisecaru I. A behavioral animal model of posttraumatic stress disorder featuring repeated exposure to situational reminders. Biol. Psychiatry 1996, 39:129-134.
15. Reed J.C. Mini-review: cellular mechanisms of disease series. Cell 1994, 124:1-6.
16. Sawamura T., Shimizu K., Nibuya M., Wakizono T., Suzuki G., Tsunoda T., Takahashi Y., Nomura S. Effect of paroxetine on a model of posttraumatic stress disorder in rats. Neurosci. Lett. 2004, 357:37-40.
17. Shimizu K., Sawamura T., Nibuya M., Nakai K., Takahashi Y., Nomura S. An animal model of posttraumatic stress disorder and its validity: effect of paroxetine on a PTSD model in rats. Nihon Shinkei Seishin Yakurigaku Zasshi 2004, 24:283-290.
18. Sze C.-I., Bi H., Kleinschmidt-DeMasters B.K., Filley C.M., Martin L.J. Selective regional loss of exocytotic presynaptic vesicle proteins in Alzheimer's disease brains. J. Neurol. Sci. 2000, 175:81-90.
19. Takei S., Morinobu S., Yamamoto S., Fuchikami M., Matsumoto T., Yamawaki S. Enhanced hippocampal BDNF/TrkB signaling in response to fear conditioning in an animal model of posttraumatic stress disorder. J. Psychiatr. Res. 2011, 45:460-468.
20. Thomaes K., Dorrepaal E., Draijer N.P.J., de Ruiter M.B., Elzinga B.M., van Balkom A.J., Smoor P.L.M., Smit J., Veltman D.J. Increased activation of the left hippocampus region in complex PTSD during encoding and recognition of emotional words: a pilot study. Psychiatry Res. 2009, 171:44-53.
21. Wang W., Liu Y., Zheng H., Wang H.N., Jin X., Chen Y.C., Zheng L.N., Luo X.X., Tan Q.R. A modified single-prolonged stress model for post-traumatic stress disorder. Neurosci. Lett. 2008, 441:237-241.
22. Yamamoto S., Morinobu S., Takei S., Fuchikami M., Matsuki A., Yamawaki S., Liberzon I. Single prolonged stress: toward an animal model of posttraumatic stress disorder. Depress. Anxiety 2009, 26:1110-1117.
23. Yehuda R., Golier J.A., Bierer L.M., Mikhno A., Pratchett L.C., Burton C.L., Makotkine I., Devanand D.P., Pradhaban G., Harvey P.D., Mann J.J. Hydrocortisone responsiveness in Gulf War veterans with PTSD: effects on ACTH, declarative memory hippocampal [(18)F]FDG uptake on PET. Psychiatry Res. 2010, 184:117-127.
24. Yoshii T., Sakamoto H., Kawasaki M., Ozawa H., Ueta Y., Onaka T., Fukui K., Kawata M. The single-prolonged stress paradigm alters both the morphology and stress response of magnocellular vasopressin neurons. Neuroscience 2008, 156:466-474.
25. Zhang L., Zhou R., Li X., Ursano R.J., Li H. Stress-induced change of mitochondria membrane potential regulated by genomic and non-genomic GR signaling: a possible mechanism for hippocampus atrophy in PTSD. Med. Hypotheses 2006, 66:1205-1208.
26. Zhao H., Li Q., Zhang Z., Pei X., Wang J., Li Y. Long-term ginsenoside consumption prevents memory loss in aged SAMP8 mice by decreasing oxidative stress and up-regulating the plasticity-related proteins in hippocampus. Brain Res. 2009, 1256:111-122.
27. Zhou J., Li L., Tang S., Cao X., Li Z., Li W., Li C., Zhang X. Effects of serotonin depletion on the hippocampal GR/MR and BDNF expression during the stress adaptation. Behav. Brain Res. 2008, 195:129-138.