Enhanced hippocampal BDNF/TrkB signaling in response to fear conditioning in an animal model of posttraumatic stress disorder

Journal of Psychiatric Research

Volumn 45, Issue 4, 2011, Pages 460-468

  Takei, Shiro ^a   Morinobu, Shigeru ^a   Yamamoto, Shigeto ^a   Fuchikami, Manabu ^a   Matsumoto, Tomoya ^a   Yamawaki, Shigeto ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

BDNF; Fear consolidation; Histone acetylation; Posttraumatic stress disorder; Single prolonged stress; TrkB

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; HISTONE H3; HISTONE H4; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONDITIONING; EXON; FEAR; HIPPOCAMPUS; HISTONE ACETYLATION; MALE; NONHUMAN; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; RAT;

ACETYLATION; ANALYSIS OF VARIANCE; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHROMATIN IMMUNOPRECIPITATION; CONDITIONING (PSYCHOLOGY); DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEAR; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HISTONES; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, TRKB; RNA, MESSENGER; SIGNAL TRANSDUCTION; STRESS DISORDERS, POST-TRAUMATIC;

EID: 79952624303     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2010.08.009     Document Type: Article

References (45)

1. Aid T., Kazantseva A., Piirsoo M., Palm K., Timmusk T. Mouse and rat BDNF gene structure and expression revisited. Journal of Neuroscience Research 2007, 85:525-535.
2. Berchtold N.C., Oliff H.S., Isackson P., Cotman C.W. Hippocampal BDNF mRNA shows a diurnal regulation, primarily in the exon III transcript. Brain Research. Molecular Brain Research 1999, 71:11-22.
3. Bredy T.W., Wu H., Crego C., Zellhoefer J., Sun Y.E., Barad M. Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear. Learning and Memory 2007, 14:268-276.
4. Cheung P., Tanner K.G., Cheung W.L., Sassone-Corsi P., Denu J.M., Allis C.D. Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation. Molecular Cell 2000, 5:905-915.
5. Dell'Osso L., Carmassi C., Debbio A.D., Dell'Osso M.C., Bianchi C., Pozzo E., et al. Brain-derived neurotrophic factor plasma levels in patients suffering from post-traumatic stress disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2009, 33:899-902.
6. Duman R.S. Synaptic plasticity and mood disorders. Molecular Psychiatry 2002, 7:29-34.
7. Fuchikami M., Morinobu S., Kurata A., Yamamoto S., Yamawaki S. Single immobilization stress differentially alters the expression profile of transcripts of the brain-derived neurotrophic factor (BDNF) gene and histone acetylation at its promoters in the rat hippocampus. The International Journal of Neuropsychopharmacology 2009, 12:73-82.
8. Hauk S., Kapczinski F., Roesler R., Moura Silveira E., Magalhães P.V., Kruel L.R.P., et al. Serum brain-derived neurotrophic factor in patients with trauma psychopathology. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2010, 34:459-462.
9. Huang Y., Doherty J.J., Dingledine R. Altered histone acetylation at glutamate receptor 2 and brain-derived neurotrophic factor genes is an early event triggered by status epilepticus. The Journal of Neuroscience 2002, 22:8422-8428.
10. Imanaka A., Morinobu S., Toki S., Yamawaki S. Importance of early environment in the development of post-traumatic stress disorder-like behaviors. Behavioural Brain Research 2006, 173:129-137.
11. Iwamoto Y., Morinobu S., Takahashi T., Yamawaki S. Single prolonged stress increases contextual freezing and the expression of glycine transporter 1 and vesicle-associated membrane protein 2 mRNA in the hippocampus of rats. Progress in Neuro-psychopharmacology and Biological Psychiatry 2007, 31:642-651.
12. Khan S., Liberzon I. Topiramate attenuates exaggerated acoustic startle in an animal model of PTSD. Psychopharmacology (Berl) 2004, 172:225-229.
13. Klein R., Conway D., Parada L., Barbacid M. The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lack the catalytic kinase domain. Cell 1990, 61:647-656.
14. Kokaia Z., Metsis M., Kokaia M., Bengzon J., Elmer E., Smith M.L., et al. Brain insults in rats induce increased expression of the BDNF gene through differential use of multiple promoters. The European Journal of Neuroscience 1994, 6:587-596.
15. Korzus E., Rosenfeld M.G., Mayford M. CBP histone acetyltransferase activity is a critical component of memory consolidation. Neuron 2004, 42:961-972.
16. Kozlovsky N., Matar M.A., Kaplan Z., Kotler M., Zohar J., Cohen H. Long-term down-regulation of BDNF mRNA in rat hippocampal CA1 subregion correlates with PTSD-like behavioural stress response. The International Journal of Neuropsychopharmacology 2007, 10:741-758.
17. Levenson J.M., O'Riordan K.J., Brown K.D., Trinh M.A., Molfese D.L., Sweatt J.D. Regulation of histone acetylation during memory formation in the hippocampus. The Journal of Biological Chemistry 2004, 279:40545-40559.
18. Levenson J.M., Sweatt J.D. Epigenetic mechanisms in memory formation. Nature Reviews. Neuroscience 2005, 6:108-118.
19. Liberzon I., Krstov M., Young E.A. Stress-restress: effects on ACTH and fast feedback. Psychoneuroendocrinology 1997, 22:443-453.
20. Liberzon I., Lopez J.F., Flagel S.B., Vazquez D.M., Young E.A. Differential regulation of hippocampal glucocorticoid receptors mRNA and fast feedback: relevance to post-traumatic stress disorder. Journal of Neuroendocrinology 1999, 11:11-17.
21. Liu Q.R., Lu L., Zhu X.G., Gong J.P., Shaham Y., Uhl G.R. Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine. Brain Research 2006, 1067:1-12.
22. Lubin F.D., Roth T.L., Sweatt J.D. Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory. The Journal of Neuroscience 2008, 28:10576-10586.
23. Lynch M.A. Long-term potentiation and memory. Physiological Reviews 2004, 84:87-136.
24. Milad M.R., Rauch S.L., Pitman R.K., Quirk G.J. Fear extinction in rats: implications for human brain imaging and anxiety disorders. Biological Psychology 2006, 73:61-71.
25. Miller C.A., Campbell S.L., Sweatt J.D. DNA methylation and histone acetylation work in concert to regulate memory formation and synaptic plasticity. Neurobiology of Learning and Memory 2008, 89:599-603.
26. Minichiello L., Calella A.M., Medina D.L., Bonhoeffer T., Klein R., Korte M. Mechanism of TrkB-mediated hippocampal long-term potentiation. Neuron 2002, 36:121-137.
27. Minichiello L., Korte M., Wolfer D., Kuhn R., Unsicker K., Cestari V., et al. Essential role for TrkB receptors in hippocampus-mediated learning. Neuron 1999, 24:401-414.
28. Neves G., Cooke S.F., Bliss T.V. Synaptic plasticity, memory and the hippocampus: a neural network approach to causality. Nature Reviews. Neuroscience 2008, 9:65-75.
29. Oliff H.S., Berchtold N.C., Isackson P., Cotman C.W. Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus. Brain Research. Molecular Brain Research 1998, 61:147-153.
30. Ou L.C., Gean P.W. Transcriptional regulation of brain-derived neurotrophic factor in the amygdala during consolidation of fear memory. Molecular Pharmacology 2007, 72:350-358.
31. Quirk G.J., Garcia R., Gonzalez-Lima F. Prefrontal mechanisms in extinction of conditioned fear. Biological Psychiatry 2006, 60:337-343.
32. Rasmusson A.M., Shi L., Duman R. Downregulation of BDNF mRNA in the hippocampal dentate gyrus after re-exposure to cues previously associated with footshock. Neuropsychopharmacology 2002, 27(2):133-142.
33. Rattiner L.M., Davis M., French C.T., Ressler K.J. Brain-derived neurotrophic factor and tyrosine kinase receptor B involvement in amygdala-dependent fear conditioning. The Journal of Neuroscience 2004, 24:4796-4806.
34. Rattiner L.M., Davis M., Ressler K.J. Differential regulation of brain-derived neurotrophic factor transcripts during the consolidation of fear learning. Learning and Memory 2004, 11:727-731.
35. Rauch S.L., Shin L.M., Phelps E.A. Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research-past, present, and future. Biological Psychiatry 2006, 60:376-382.
36. Rothbaum B.O., Davis M. Applying learning principles to the treatment of post-trauma reactions. Annals of the New York Academy of Sciences 2003, 1008:112-121.
37. Saarelainen T., Pussinen R., Koponen E., Alhonen L., Wong G., Sirvio J., et al. Transgenic mice overexpressing truncated trkB neurotrophin receptors in neurons have impaired long-term spatial memory but normal hippocampal LTP. Synapse 2000, 38:102-104.
38. Saland L.C., Cunningham L.A., Su C., Morales M., Gaddy J. Glial cell line-derived neurotrophic factor in the rat pituitary gland. Brain Research Bulletin 2000, 52:109-113.
39. Schaaf M.J., de Jong J., de Kloet E.R., Vreugdenhil E. Downregulation of BDNF mRNA and protein in the rat hippocampus by corticosterone. Brain Research 1998, 813:112-120.
40. Suenaga T., Morinobu S., Kawano K., Sawada T., Yamawaki S. Influence of immobilization stress on the levels of CaMKII and phospho-CaMKII in the rat hippocampus. The International Journal of Neuropsychopharmacology 2004, 7:299-309.
41. Takahashi T., Morinobu S., Iwamoto Y., Yamawaki S. Effect of paroxetine on enhanced contextual fear induced by single prolonged stress in rats. Psychopharmacology (Berl) 2006, 189:165-173.
42. Timmusk T., Palm K., Metsis M., Reintam T., Paalme V., Saarma M., et al. Multiple promoters direct tissue-specific expression of the rat BDNF gene. Neuron 1993, 10:475-489.
43. Tsankova N.M., Kumar A., Nestler E.J. Histone modifications at gene promoter regions in rat hippocampus after acute and chronic electroconvulsive seizures. The Journal of Neuroscience 2004, 24:5603-5610.
44. Wood M.A., Hawk J.D., Abel T. Combinatorial chromatin modifications and memory storage: a code for memory?. Learning and Memory 2006, 13:241-244.
45. Yamamoto S., Morinobu S., Takei S., Fuchikami M., Matsuki A., Yamawaki S., et al. Single prolonged stress: toward an animal model of posttraumatic stress disorder. Depression and Anxiety 2009, 26:1110-1117.