Vorinostat ameliorates impaired fear extinction possibly via the hippocampal NMDA-CaMKII pathway in an animal model of posttraumatic stress disorder

Psychopharmacology

Volumn 229, Issue 1, 2013, Pages 51-62

  Matsumoto, Yasutaka ^a   Morinobu, Shigeru ^a   Yamamoto, Shigeto ^a   Matsumoto, Tomoya ^a   Takei, Shiro ^a   Fujita, Yosuke ^a   Yamawaki, Shigeto ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Fear extinction; HDAC inhibitor; Hippocampus; NMDA receptor; PTSD; Single prolonged stress; Vorinostat

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II ALPHA; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II BETA; HISTONE H3; HISTONE H4; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; UNCLASSIFIED DRUG; VORINOSTAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONDITIONING; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FEAR; HISTONE ACETYLATION; INTRACELLULAR SIGNALING; MALE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1 GENE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B GENE; NONHUMAN; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION; REINFORCEMENT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; DISEASE MODELS, ANIMAL; EXTINCTION, PSYCHOLOGICAL; FEAR; HIPPOCAMPUS; HISTONE DEACETYLASE INHIBITORS; HYDROXAMIC ACIDS; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; STRESS DISORDERS, POST-TRAUMATIC;

EID: 84881609833     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-013-3078-9     Document Type: Article

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