Deletion of STK40 protein in mice causes respiratory failure and death at birth

Journal of Biological Chemistry

Volumn 288, Issue 8, 2013, Pages 5342-5352

  Yu, Hongyao ^a,d   He, Ke ^b   Li, Lingjie ^a,e   Sun, Lei ^a,f   Tang, Fan ^b   Li, Ruizhen ^b,g   Ning, Wen ^c   Jin, Ying ^a,d  

^a SHANGHAI UNIVERSITY OF MEDICINE AND HEALTH SCIENCES   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c NANKAI UNIVERSITY   (China)

^d INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^e STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f NATIONAL CANCER INSTITUTE   (United States)

^g OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALVEOLAR EPITHELIUMS; FETAL LUNGS; LUNG DEVELOPMENT; MOLECULAR REGULATION; PHYSIOLOGICAL FUNCTIONS; RESPIRATORY FAILURE;

AMINO ACIDS; GENE EXPRESSION;

BIOLOGICAL ORGANS;

GLYCOGEN; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; STK40 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ATELECTASIS; BINDING AFFINITY; EMBRYO; EMBRYONIC STEM CELL; ENDODERM; FEMALE; FETUS LUNG MATURITY; GENE EXPRESSION; GENETIC ASSOCIATION; GLYCOGEN METABOLISM; HOMOZYGOSITY; IMMUNE RESPONSE; IN VIVO STUDY; LIPID METABOLISM; LUNG ALVEOLUS EPITHELIUM; LUNG DEVELOPMENT; LUNG FUNCTION; MICROARRAY ANALYSIS; MOUSE; NEWBORN DEATH; NEWBORN MORTALITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PURIFICATION; RESPIRATORY DISTRESS; RESPIRATORY FAILURE;

ANIMALS; EPITHELIUM; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; GENE DELETION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; GLUTATHIONE TRANSFERASE; LUNG; MICE; MICE, TRANSGENIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN-SERINE-THREONINE KINASES; PULMONARY ALVEOLI; PULMONARY SURFACTANTS; RESPIRATORY INSUFFICIENCY; TIME FACTORS;

EID: 84874302744     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.409433     Document Type: Article

References (44)

1. Ten Have-Opbroek, A. A. (1991) Lung development in the mouse embryo. Exp. Lung Res. 17, 111-130
2. Cardoso, W. V. (2001) Molecular regulation of lung development. Annu. Rev. Physiol. 63, 471-494
3. Burri, P. H. (1984) Fetal and postnatal development of the lung. Annu. Rev. Physiol. 46, 617-628
4. Avery, M. E., and Mead, J. (1959) Surface properties in relation to atelectasis and hyaline membrane disease. AMA J. Dis. Child 97, 517-523
5. Minoo, P., Su, G., Drum, H., Bringas, P., and Kimura, S. (1999) Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(α/β) mouse embryos. Dev. Biol. 209, 60-71
6. Kimura, S., Ward, J. M., and Minoo, P. (1999) Thyroid-specific enhancerbinding protein/thyroid transcription factor 1 is not required for the initial specification of the thyroid and lung primordia. Biochimie 81, 321-327
7. Lazzaro, D., Price, M., de Felice, M., and Di Lauro, R. (1991) The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain. Development 113, 1093-1104
8. Wongtrakool, C., Malpel, S., Gorenstein, J., Sedita, J., Ramirez, M. I., Underhill, T. M., and Cardoso, W. V. (2003) Down-regulation of retinoic acid receptor α signaling is required for sacculation and type I cell formation in the developing lung. J. Biol. Chem. 278, 46911-46918
9. Tichelaar, J. W., Wert, S. E., Costa, R. H., Kimura, S., and Whitsett, J. A. (1999) HNF-3/forkhead homologue-4 (HFH-4) is expressed in ciliated epithelial cells in the developing mouse lung. J. Histochem. Cytochem. 47, 823-832
10. Bohinski, R. J., Di Lauro, R., and Whitsett, J. A. (1994) The lung-specific surfactant protein B gene promoter is a target for thyroid transcription factor 1 and hepatocyte nuclear factor 3, indicating common factors for organ-specific gene expression along the foregut axis. Mol. Cell Biol. 14, 5671-5681
11. Martis, P. C., Whitsett, J. A., Xu, Y., Perl, A. K., Wan, H., and Ikegami, M. (2006) C/EBPα is required for lung maturation at birth. Development 133, 1155-1164
12. Bachurski, C. J., Yang, G. H., Currier, T. A., Gronostajski, R. M., and Hong, D. (2003) Nuclear factor I/thyroid transcription factor 1 interactions modulate surfactant protein C transcription. Mol. Cell Biol. 23, 9014-9024
13. Samakovlis, C., Hacohen, N., Manning, G., Sutherland, D. C., Guillemin, K., and Krasnow, M. A. (1996) Development of the Drosophila tracheal system occurs by a series of morphologically distinct but genetically coupled branching events. Development 122, 1395-1407
14. Min, H., Danilenko, D. M., Scully, S. A., Bolon, B., Ring, B. D., Tarpley, J. E., DeRose, M., and Simonet, W. S. (1998) Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless. Genes Dev. 12, 3156-3161
15. Bellusci, S., Grindley, J., Emoto, H., Itoh, N., and Hogan, B. L. (1997) Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung. Development 124, 4867-4878
16. Warburton, D., Schwarz, M., Tefft, D., Flores-Delgado, G., Anderson, K. D., and Cardoso, W. V. (2000) The molecular basis of lung morphogenesis. Mech. Dev. 92, 55-81
17. Villavicencio, E. H., Walterhouse, D. O., and Iannaccone, P. M. (2000) The sonic hedgehog-patched-gli pathway in human development and disease. Am. J. Hum. Genet. 67, 1047-1054
18. Usui, H., Shibayama, M., Ohbayashi, N., Konishi, M., Takada, S., and Itoh, N. (2004) Fgf18 is required for embryonic lung alveolar development. Biochem. Biophys. Res. Commun. 322, 887-892
19. Kaplan, F. (2000) Molecular determinants of fetal lung organogenesis. Mol. Genet. Metab. 71, 321-341
20. Li, L., Sun, L., Gao, F., Jiang, J., Yang, Y., Li, C., Gu, J., Wei, Z., Yang, A., Lu, R., Ma, Y., Tang, F., Kwon, S. W., Zhao, Y., Li, J., and Jin, Y. (2010) Stk40 links the pluripotency factor Oct4 to the ERK/MAPK pathway and controls extraembryonic endoderm differentiation. Proc. Natl. Acad. Sci. U.S.A. 107, 1402-1407
21. Geng, Y., Dong, Y., Yu, M., Zhang, L., Yan, X., Sun, J., Qiao, L., Geng, H., Nakajima, M., Furuichi, T., Ikegawa, S., Gao, X., Chen, Y. G., Jiang, D., and Ning, W. (2011) Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development. Proc. Natl. Acad. Sci. U.S.A. 108, 7058-7063
22. Morita, S., Kojima, T., and Kitamura, T. (2000) Plat-E. An efficient and stable system for transient packaging of retroviruses. Gene Ther. 7, 1063-1066
23. Rice, W. R., Conkright, J. J., Na, C. L., Ikegami, M., Shannon, J. M., and Weaver, T. E. (2002) Maintenance of the mouse type II cell phenotype in vitro. Am. J. Physiol. Lung Cell. Mol. Physiol. 283, L256-L264
24. Huang da, W., Sherman, B. T., and Lempicki, R. A. (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc. 4, 44-57
25. Ridsdale, R., and Post, M. (2004) Surfactant lipid synthesis and lamellar body formation in glycogen-laden type II cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 287, L743-L751
26. Nogee, L. M., Garnier, G., Dietz, H. C., Singer, L., Murphy, A. M., deMello, D. E., and Colten, H. R. (1994) A mutation in the surfactant protein B gene responsible for fatal neonatal respiratory disease in multiple kindreds. J. Clin. Invest. 93, 1860-1863
27. Nogee, L. M., Dunbar, A. E., 3rd, Wert, S. E., Askin, F., Hamvas, A., and Whitsett, J. A. (2001) A mutation in the surfactant protein C gene associated with familial interstitial lung disease. N. Engl. J. Med. 344, 573-579
28. Clark, J. C., Wert, S. E., Bachurski, C. J., Stahlman, M. T., Stripp, B. R., Weaver, T. E., and Whitsett, J. A. (1995) Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice. Proc. Natl. Acad. Sci. U.S.A. 92, 7794-7798
29. Shulenin, S., Nogee, L. M., Annilo, T., Wert, S. E., Whitsett, J. A., and Dean, M. (2004) ABCA3 gene mutations in newborns with fatal surfactant deficiency. N. Engl. J. Med. 350, 1296-1303
30. Ramirez, M. I., Millien, G., Hinds, A., Cao, Y., Seldin, D. C., and Williams, M. C. (2003) T1α, a lung type I cell differentiation gene, is required for normal lung cell proliferation and alveolus formation at birth. Dev. Biol. 256, 61-72
31. Basseres, D. S., Levantini, E., Ji, H., Monti, S., Elf, S., Dayaram, T., Fenyus, M., Kocher, O., Golub, T., Wong, K. K., Halmos, B., and Tenen, D. G. (2006) Respiratory failure due to differentiation arrest and expansion of alveolar cells following lung-specific loss of the transcription factor C/EBPα in mice. Mol. Cell Biol. 26, 1109-1123
32. Pepicelli, C. V., Lewis, P. M., and McMahon, A. P. (1998) Sonic hedgehog regulates branching morphogenesis in the mammalian lung. Curr. Biol. 8, 1083-1086
33. Goss, A. M., Tian, Y., Tsukiyama, T., Cohen, E. D., Zhou, D., Lu, M. M., Yamaguchi, T. P., and Morrisey, E. E. (2009) Wnt2/2b and α-Catenin signaling are necessary and sufficient to specify lung progenitors in the foregut. Dev. Cell 17, 290-298
34. Imai, T., Matsuda, K., Shimojima, T., Hashimoto, T., Masuhiro, Y., Kitamoto, T., Sugita, A., Suzuki, K., Matsumoto, H., Masushige, S., Nogi, Y., Muramatsu, M., Handa, H., and Kato, S. (1997) ERC-55, a binding protein for the papilloma virus E6 oncoprotein, specifically interacts with vitamin D receptor among nuclear receptors. Biochem. Biophys. Res. Commun. 233, 765-769
35. Kling, D. E., Lorenzo, H. K., Trbovich, A. M., Kinane, T. B., Donahoe, P. K., and Schnitzer, J. J. (2002) MEK-1/2 inhibition reduces branching morphogenesis and causes mesenchymal cell apoptosis in fetal rat lungs. Am. J. Physiol. Lung Cell. Mol. Physiol. 282, L370-L378
36. Wang, J., Ito, T., Udaka, N., Okudela, K., Yazawa, T., and Kitamura, H. (2005) PI3K-AKT pathway mediates growth and survival signals during development of fetal mouse lung. Tissue Cell 37, 25-35
37. Li, F. F., Shen, J., Shen, H. J., Zhang, X., Cao, R., Zhang, Y., Qui, Q., Lin, X. X., Xie, Y. C., Zhang, L. H., Jia, Y. L., Dong, X. W., Jiang, J. X., Bao, M. J., Zhang, S., Ma, W. J., Wu, X. M., Shen, H., Xie, Q. M., and Ke, Y. (2012) Shp2 plays an important role in acute cigarette smoke-mediated lung inflammation. J. Immunol. 189, 3159-3167
38. Zhang, X., Zhang, Y., Tao, B., Teng, L., Li, Y., Cao, R., Gui, Q., Ye, M., Mou, X., Cheng, H., Hu, H., Zhou, R., Wu, X., Xie, Q., Ning, W., Lai, M., Shen, H., Feng, G. S., and Ke, Y. (2012) Loss of Shp2 in alveoli epithelia induces deregulated surfactant homeostasis, resulting in spontaneous pulmonary fibrosis. FASEB J. 26, 2338-2350
39. Whitsett, J. A., Wert, S. E., and Trapnell, B. C. (2004) Genetic disorders influencing lung formation and function at birth. Hum. Mol. Genet. 13, R207-R215
40. Wan, H., Xu, Y., Ikegami, M., Stahlman, M. T., Kaestner, K. H., Ang, S. L., and Whitsett, J. A. (2004) Foxa2 is required for transition to air breathing at birth. Proc. Natl. Acad. Sci. U.S.A. 101, 14449-14454
41. Cole, T. J., Solomon, N. M., Van Driel, R., Monk, J. A., Bird, D., Richardson, S. J., Dilley, R. J., and Hooper, S. B. (2004) Altered epithelial cell proportions in the fetal lung of glucocorticoid receptor null mice. Am. J. Respir. Cell Mol. Biol. 30, 613-619
42. Yamamoto, H., Yun, E. J., Gerber, H. P., Ferrara, N., Whitsett, J. A., and Vu, T. H. (2007) Epithelial-vascular cross-talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesis. Dev. Biol. 308, 44-53
43. Whitsett, J. A., Clark, J. C., Picard, L., Tichelaar, J. W., Wert, S. E., Itoh, N., Perl, A. K., and Stahlman, M. T. (2002) Fibroblast growth factor 18 influences proximal programming during lung morphogenesis. J. Biol. Chem. 277, 22743-22749
44. Wan, H., Luo, F., Wert, S. E., Zhang, L., Xu, Y., Ikegami, M., Maeda, Y., Bell, S. M., and Whitsett, J. A. (2008) Kruppel-like factor 5 is required for perinatal lung morphogenesis and function. Development 135, 2563-2572