메뉴 건너뛰기




Volumn 217, Issue 1, 2011, Pages 47-54

Effects of the enteric bacterial metabolic product propionic acid on object-directed behavior, social behavior, cognition, and neuroinflammation in adolescent rats: Relevance to autism spectrum disorder

Author keywords

Animal model; ASD; CD68; GFAP; Restricted interests; Reversal learning

Indexed keywords

PROPIONIC ACID;

EID: 78049463483     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2010.10.005     Document Type: Article
Times cited : (283)

References (67)
  • 1
    • 0043167900 scopus 로고    scopus 로고
    • Elevated levels of impulsivity and reduced place conditioning with d-amphetamine: two behavioral features of adolescence in mice
    • Adriani W., Laviola G. Elevated levels of impulsivity and reduced place conditioning with d-amphetamine: two behavioral features of adolescence in mice. Behav Neurosci 2003, 117:695-703.
    • (2003) Behav Neurosci , vol.117 , pp. 695-703
    • Adriani, W.1    Laviola, G.2
  • 2
    • 4544256595 scopus 로고    scopus 로고
    • Windows of vulnerability to psychopathology and therapeutic strategy in the adolescent rodent model
    • Adriani W., Laviola G. Windows of vulnerability to psychopathology and therapeutic strategy in the adolescent rodent model. Behav Pharmacol 2004, 15:341-352.
    • (2004) Behav Pharmacol , vol.15 , pp. 341-352
    • Adriani, W.1    Laviola, G.2
  • 3
    • 0242659184 scopus 로고    scopus 로고
    • The spontaneously-hypertensive rat as an animal model of ADHD: evidence for impulsive and non-impulsive subpopulations
    • Adriani W., Caprioli A., Granstrem O., Carli M., Laviola G. The spontaneously-hypertensive rat as an animal model of ADHD: evidence for impulsive and non-impulsive subpopulations. Neurosci Biobehav Rev 2003, 27:639-651.
    • (2003) Neurosci Biobehav Rev , vol.27 , pp. 639-651
    • Adriani, W.1    Caprioli, A.2    Granstrem, O.3    Carli, M.4    Laviola, G.5
  • 4
    • 78650179808 scopus 로고    scopus 로고
    • Biological effects of propionic acid in humans; metabolism, potential applications and underlying mechanisms
    • Al-Lahham S.H., Peppelenbosch M.P., Roelofsen H., Vonk R.J., Venema K. Biological effects of propionic acid in humans; metabolism, potential applications and underlying mechanisms. Biochim Biophys Acta 2010, 1801:1175-1183.
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 1175-1183
    • Al-Lahham, S.H.1    Peppelenbosch, M.P.2    Roelofsen, H.3    Vonk, R.J.4    Venema, K.5
  • 6
    • 0036148515 scopus 로고    scopus 로고
    • Molecular genetics and animal models in autistic disorder
    • Andres C. Molecular genetics and animal models in autistic disorder. Brain Res Bull 2002, 57:109-119.
    • (2002) Brain Res Bull , vol.57 , pp. 109-119
    • Andres, C.1
  • 8
    • 0029031842 scopus 로고
    • Reactive microglia in hippocampal sclerosis associated with human temporal lobe epilepsy
    • Beach T.G., Woodhurst W.B., MacDonald D.B., Jones M.W. Reactive microglia in hippocampal sclerosis associated with human temporal lobe epilepsy. Neurosci Lett 1995, 191:27-30.
    • (1995) Neurosci Lett , vol.191 , pp. 27-30
    • Beach, T.G.1    Woodhurst, W.B.2    MacDonald, D.B.3    Jones, M.W.4
  • 9
    • 3242773378 scopus 로고    scopus 로고
    • Contribution of sex differences in the acute stress response to sex differences in water maze performance in the rat
    • Beiko J., Lander R., Hampson E., Boon F., Cain D.P. Contribution of sex differences in the acute stress response to sex differences in water maze performance in the rat. Behav Brain Res 2004, 151:239-253.
    • (2004) Behav Brain Res , vol.151 , pp. 239-253
    • Beiko, J.1    Lander, R.2    Hampson, E.3    Boon, F.4    Cain, D.P.5
  • 10
    • 0022651747 scopus 로고
    • Inhibition of oxidative metabolism by propionic acid and its reversal by carnitine in isolated rat hepatocytes
    • Brass E.P., Fennessey P.V., Miller L.V. Inhibition of oxidative metabolism by propionic acid and its reversal by carnitine in isolated rat hepatocytes. Biochem J 1986, 236:131-136.
    • (1986) Biochem J , vol.236 , pp. 131-136
    • Brass, E.P.1    Fennessey, P.V.2    Miller, L.V.3
  • 11
    • 0027457825 scopus 로고
    • Regulation of type-II calmodulin kinase: functional implications
    • Bronstein J.M., Farber D.B., Wasterlain C.G. Regulation of type-II calmodulin kinase: functional implications. Brain Res Rev 1993, 18:135-147.
    • (1993) Brain Res Rev , vol.18 , pp. 135-147
    • Bronstein, J.M.1    Farber, D.B.2    Wasterlain, C.G.3
  • 13
    • 33646514846 scopus 로고    scopus 로고
    • Thalamic and hippocampal mechanisms in spatial navigation: a dissociation between brain mechanisms for learning how versus learning where to navigate
    • Cain D.P., Boon F., Corcoran M.E. Thalamic and hippocampal mechanisms in spatial navigation: a dissociation between brain mechanisms for learning how versus learning where to navigate. Behav Brain Res 2006, 170:241-256.
    • (2006) Behav Brain Res , vol.170 , pp. 241-256
    • Cain, D.P.1    Boon, F.2    Corcoran, M.E.3
  • 14
    • 15444373746 scopus 로고    scopus 로고
    • Epilepsy, electroencephalographic abnormalities and regression in children with autism
    • Canitano R., Luchetti A., Zappella M. Epilepsy, electroencephalographic abnormalities and regression in children with autism. J Child Neurol 2005, 20:27-31.
    • (2005) J Child Neurol , vol.20 , pp. 27-31
    • Canitano, R.1    Luchetti, A.2    Zappella, M.3
  • 17
    • 78650173122 scopus 로고    scopus 로고
    • US Centers for Disease Control.
    • US Centers for Disease Control. ; 2010. http://www.cdc.gov/ncbddd/autism/index.html.
    • (2010)
  • 18
    • 33745699617 scopus 로고    scopus 로고
    • Oxidative stress in autism
    • Chauhan A., Chauhan V. Oxidative stress in autism. Pathophysiology 2006, 13:171-181.
    • (2006) Pathophysiology , vol.13 , pp. 171-181
    • Chauhan, A.1    Chauhan, V.2
  • 19
    • 0036617156 scopus 로고    scopus 로고
    • Defining the neural mechanisms of probabilistic reversal learning using event-related functional magnetic resonance imaging
    • Cools R., Clark L., Owen A.M., Robbins T.W. Defining the neural mechanisms of probabilistic reversal learning using event-related functional magnetic resonance imaging. J Neurosci 2002, 22:4563-4567.
    • (2002) J Neurosci , vol.22 , pp. 4563-4567
    • Cools, R.1    Clark, L.2    Owen, A.M.3    Robbins, T.W.4
  • 20
    • 13444250843 scopus 로고    scopus 로고
    • Designing mouse behavioral tasks relevant to autistic-like behaviors
    • Crawley J.N. Designing mouse behavioral tasks relevant to autistic-like behaviors. Ment Retard Dev Disabil Res Rev 2004, 10:248-258.
    • (2004) Ment Retard Dev Disabil Res Rev , vol.10 , pp. 248-258
    • Crawley, J.N.1
  • 21
    • 0033965596 scopus 로고    scopus 로고
    • Methylmalonic and propionic acids increase the in vitro incorporation of 32P into cytoskeletal proteins from cerebral cortex of young rats through NMDA glutamate receptors
    • DeMattos-Dutra A., Meirelles R., Bevilaqua D.R., Kommers T., Wofchuk S.T., Wajner M., et al. Methylmalonic and propionic acids increase the in vitro incorporation of 32P into cytoskeletal proteins from cerebral cortex of young rats through NMDA glutamate receptors. Brain Res 2000, 856:111-118.
    • (2000) Brain Res , vol.856 , pp. 111-118
    • DeMattos-Dutra, A.1    Meirelles, R.2    Bevilaqua, D.R.3    Kommers, T.4    Wofchuk, S.T.5    Wajner, M.6
  • 23
    • 72649088982 scopus 로고    scopus 로고
    • Motivational systems in adolescence: possible implications for age differences in substance abuse and other risk-taking behaviors
    • Doremus-Fitzwater T.L., Varlinskaya E.I., Spear L.P. Motivational systems in adolescence: possible implications for age differences in substance abuse and other risk-taking behaviors. Brain Cogn 2010, 72:114-123.
    • (2010) Brain Cogn , vol.72 , pp. 114-123
    • Doremus-Fitzwater, T.L.1    Varlinskaya, E.I.2    Spear, L.P.3
  • 24
    • 24144473653 scopus 로고    scopus 로고
    • Oxidative and antioxidative potential of brain microglial cells
    • Dringen R. Oxidative and antioxidative potential of brain microglial cells. Antioxid Redox Signal 2005, 7:1223-1233.
    • (2005) Antioxid Redox Signal , vol.7 , pp. 1223-1233
    • Dringen, R.1
  • 27
    • 67650360880 scopus 로고    scopus 로고
    • Valproic acid induces up- or down-regulation of gene expression responsible for the neuronal excitation and inhibition in rat cortical neurons through its epigenetic actions
    • Fukuchi M., Nii T., Ishimaru N., Minamino A., Hara D., Takasaki I., et al. Valproic acid induces up- or down-regulation of gene expression responsible for the neuronal excitation and inhibition in rat cortical neurons through its epigenetic actions. Neurosci Res 2009, 65:35-43.
    • (2009) Neurosci Res , vol.65 , pp. 35-43
    • Fukuchi, M.1    Nii, T.2    Ishimaru, N.3    Minamino, A.4    Hara, D.5    Takasaki, I.6
  • 28
    • 77949368541 scopus 로고    scopus 로고
    • Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders
    • Herbert M.R. Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders. Curr Opin Neurol 2010, 23:103-110.
    • (2010) Curr Opin Neurol , vol.23 , pp. 103-110
    • Herbert, M.R.1
  • 30
    • 68849131751 scopus 로고    scopus 로고
    • Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism
    • James S.J., Rose S., Melnyk S., Jernigan S., Blossom S., Pavliv O., et al. Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism. FASEB J 2009, 23:2374-2383.
    • (2009) FASEB J , vol.23 , pp. 2374-2383
    • James, S.J.1    Rose, S.2    Melnyk, S.3    Jernigan, S.4    Blossom, S.5    Pavliv, O.6
  • 31
    • 60149107686 scopus 로고    scopus 로고
    • Properties of gap junction blockers and their behavioral, cognitive and electrophysiological effects: animal and human studies
    • Juszczak G.R., Swiergiel A.H. Properties of gap junction blockers and their behavioral, cognitive and electrophysiological effects: animal and human studies. Prog Neuropsychopharmacol Biol Psychiatry 2009, 33:181-198.
    • (2009) Prog Neuropsychopharmacol Biol Psychiatry , vol.33 , pp. 181-198
    • Juszczak, G.R.1    Swiergiel, A.H.2
  • 32
    • 0036970874 scopus 로고    scopus 로고
    • Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder
    • Jyonouchi H., Sun S., Itokazu N. Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder. Neuropsychobiology 2002, 46:76-84.
    • (2002) Neuropsychobiology , vol.46 , pp. 76-84
    • Jyonouchi, H.1    Sun, S.2    Itokazu, N.3
  • 33
    • 0027368474 scopus 로고
    • Selective cellular acidification and toxicity of weak organic acids in an acidic microenvironment
    • Karuri A.R., Dobrowsky E., Tannock I.F. Selective cellular acidification and toxicity of weak organic acids in an acidic microenvironment. Br J Cancer 1993, 68:1080-1087.
    • (1993) Br J Cancer , vol.68 , pp. 1080-1087
    • Karuri, A.R.1    Dobrowsky, E.2    Tannock, I.F.3
  • 34
    • 0038491435 scopus 로고    scopus 로고
    • Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation
    • Le Poul E., Loison E.C., Struyf S., Springael J.Y., Lannoy V., Decobecq M.E., et al. Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J Biol Chem 2003, 278:25481-25489.
    • (2003) J Biol Chem , vol.278 , pp. 25481-25489
    • Le Poul, E.1    Loison, E.C.2    Struyf, S.3    Springael, J.Y.4    Lannoy, V.5    Decobecq, M.E.6
  • 35
    • 33845391588 scopus 로고    scopus 로고
    • Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders
    • MacFabe D.F., Cain D.P., Rodriguez-Capote K., Franklin A.E., Hoffman J.E., Kavaliers M., et al. Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders. Behav Brain Res 2007, 176:149-169.
    • (2007) Behav Brain Res , vol.176 , pp. 149-169
    • MacFabe, D.F.1    Cain, D.P.2    Rodriguez-Capote, K.3    Franklin, A.E.4    Hoffman, J.E.5    Kavaliers, M.6
  • 36
    • 41949122332 scopus 로고    scopus 로고
    • A novel rodent model of autism: intraventricular infusions of propionic acid increase locomotor activity and induce neuroinflammation and oxidative stress in discrete regions of adult rat brain
    • MacFabe D.F., Rodriguez-Capote K., Hoffman J.E., Franklin A.E., Mohammad-Asef Y., Taylor R., et al. A novel rodent model of autism: intraventricular infusions of propionic acid increase locomotor activity and induce neuroinflammation and oxidative stress in discrete regions of adult rat brain. Am J Biochem Biotechnol 2008, 4:146-166.
    • (2008) Am J Biochem Biotechnol , vol.4 , pp. 146-166
    • MacFabe, D.F.1    Rodriguez-Capote, K.2    Hoffman, J.E.3    Franklin, A.E.4    Mohammad-Asef, Y.5    Taylor, R.6
  • 37
    • 0036900189 scopus 로고    scopus 로고
    • A role for electrotonic coupling in the striatum in the expression of dopamine receptor-mediated stereotypes
    • Moore H., Grace A.A. A role for electrotonic coupling in the striatum in the expression of dopamine receptor-mediated stereotypes. Neuropsychopharmacology 2002, 27:980-982.
    • (2002) Neuropsychopharmacology , vol.27 , pp. 980-982
    • Moore, H.1    Grace, A.A.2
  • 38
    • 0021173996 scopus 로고
    • Developments of a water-maze procedure for studying spatial learning in the rat
    • Morris R.G.M. Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 1984, 11:47-60.
    • (1984) J Neurosci Methods , vol.11 , pp. 47-60
    • Morris, R.G.M.1
  • 39
    • 34247402503 scopus 로고    scopus 로고
    • Propionate increases neuronal histone acetylation, but is metabolized oxidatively by glia. Relevance for propionic acidemia
    • Nguyen N.H., Morland C., Gonzalez S.V., Rise F., Storm-Mathisen J., Gundersen V., et al. Propionate increases neuronal histone acetylation, but is metabolized oxidatively by glia. Relevance for propionic acidemia. J Neurochem 2007, 101:806-814.
    • (2007) J Neurochem , vol.101 , pp. 806-814
    • Nguyen, N.H.1    Morland, C.2    Gonzalez, S.V.3    Rise, F.4    Storm-Mathisen, J.5    Gundersen, V.6
  • 40
    • 0032888457 scopus 로고    scopus 로고
    • Neurological nonmetabolic presentation of propionic acidemia
    • Nyhan W.L., Bay C., Beyer E.W., Mazi M. Neurological nonmetabolic presentation of propionic acidemia. Arch Neurol 1999, 56:1143-1147.
    • (1999) Arch Neurol , vol.56 , pp. 1143-1147
    • Nyhan, W.L.1    Bay, C.2    Beyer, E.W.3    Mazi, M.4
  • 41
    • 33846222019 scopus 로고    scopus 로고
    • La Gamma E.F. Differential regulation of the tyrosine hydroxylase and enkephalin neuropeptide transmitter genes in rat PC12 cells by short chain fatty acids: concentration-dependant effects on transcription and RNA stability
    • Parab S., Nankova B.B., La Gamma E.F. Differential regulation of the tyrosine hydroxylase and enkephalin neuropeptide transmitter genes in rat PC12 cells by short chain fatty acids: concentration-dependant effects on transcription and RNA stability. Brain Res 2007, 1132:42-50.
    • (2007) Brain Res , vol.1132 , pp. 42-50
    • Parab, S.1    Nankova, B.B.2
  • 43
    • 77954657070 scopus 로고    scopus 로고
    • Functional impact of global rare copy number variation in autism spectrum disorders
    • Pinto D., Pagnamenta A.T., Klei L., Anney R., Merico D., Regan R. Functional impact of global rare copy number variation in autism spectrum disorders. Nature 2010, 466:368-372.
    • (2010) Nature , vol.466 , pp. 368-372
    • Pinto, D.1    Pagnamenta, A.T.2    Klei, L.3    Anney, R.4    Merico, D.5    Regan, R.6
  • 44
    • 0021238320 scopus 로고
    • L-Carnitine enhances excretion of propionyl coenzyme A as propionylcarnitine in propionic acidemia
    • Roe C.R., Millington D.S., Maltby D.A., Bohan T.P., Hoppel C.L. l-Carnitine enhances excretion of propionyl coenzyme A as propionylcarnitine in propionic acidemia. J Clin Invest 1984, 73:1785-1788.
    • (1984) J Clin Invest , vol.73 , pp. 1785-1788
    • Roe, C.R.1    Millington, D.S.2    Maltby, D.A.3    Bohan, T.P.4    Hoppel, C.L.5
  • 45
    • 65549139332 scopus 로고    scopus 로고
    • Children with autism demonstrate circumscribed attention during passive viewing of complex social and nonsocial picture arrays
    • Sasson N.J., Turner-Brown L.M., Holtzclaw T.N., Lam K.S., Bodfish J.W. Children with autism demonstrate circumscribed attention during passive viewing of complex social and nonsocial picture arrays. Autism Res 2008, 1:31-42.
    • (2008) Autism Res , vol.1 , pp. 31-42
    • Sasson, N.J.1    Turner-Brown, L.M.2    Holtzclaw, T.N.3    Lam, K.S.4    Bodfish, J.W.5
  • 48
    • 0034717594 scopus 로고    scopus 로고
    • Creatine reduces 3-nitropropionic-acid induced cognitive and motor abnormalities in rats
    • Shear D.A., Haik K.L., Dunbar G.L. Creatine reduces 3-nitropropionic-acid induced cognitive and motor abnormalities in rats. NeuroReport 2000, 11:1833-1837.
    • (2000) NeuroReport , vol.11 , pp. 1833-1837
    • Shear, D.A.1    Haik, K.L.2    Dunbar, G.L.3
  • 49
    • 0030778215 scopus 로고    scopus 로고
    • Glial-neuronal interactions in Alzheimer disease: progressive association of IL-1alpha+ microglia and S100beta+ astrocytes with neurofibrillary tangle stages
    • Sheng J.G., Mrak R.E., Griffin W.S. Glial-neuronal interactions in Alzheimer disease: progressive association of IL-1alpha+ microglia and S100beta+ astrocytes with neurofibrillary tangle stages. J Neuropathol Exp Neurol 1997, 56:285-290.
    • (1997) J Neuropathol Exp Neurol , vol.56 , pp. 285-290
    • Sheng, J.G.1    Mrak, R.E.2    Griffin, W.S.3
  • 51
    • 41949122947 scopus 로고    scopus 로고
    • Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: implications for an animal model of autism
    • Shultz S.R., MacFabe D., Ossenkopp K.-P., Scratch S., Whelan J., Taylor R., et al. Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: implications for an animal model of autism. Neuropharmacology 2008, 54:901-911.
    • (2008) Neuropharmacology , vol.54 , pp. 901-911
    • Shultz, S.R.1    MacFabe, D.2    Ossenkopp, K.-P.3    Scratch, S.4    Whelan, J.5    Taylor, R.6
  • 52
    • 62649112890 scopus 로고    scopus 로고
    • Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the Long-Evans rat: further development of a rodent model of autism
    • Shultz S.R., MacFabe D., Martin S., Jackson J., Taylor R., Boon F., et al. Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the Long-Evans rat: further development of a rodent model of autism. Behav Brain Res 2009, 200:33-41.
    • (2009) Behav Brain Res , vol.200 , pp. 33-41
    • Shultz, S.R.1    MacFabe, D.2    Martin, S.3    Jackson, J.4    Taylor, R.5    Boon, F.6
  • 53
    • 77953800799 scopus 로고    scopus 로고
    • Behavioural phenotyping assays for mouse models of autism
    • Silverman J.L., Yang M., Lord C., Crawley J.N. Behavioural phenotyping assays for mouse models of autism. Nat Rev Neurosci 2010, 11:490-502.
    • (2010) Nat Rev Neurosci , vol.11 , pp. 490-502
    • Silverman, J.L.1    Yang, M.2    Lord, C.3    Crawley, J.N.4
  • 54
    • 8744264007 scopus 로고    scopus 로고
    • Real-time PCR quantification of clostridia in feces of autistic children
    • Song Y., Liu C., Finegold S.M. Real-time PCR quantification of clostridia in feces of autistic children. Appl Environ Microbiol 2004, 70:6459-6465.
    • (2004) Appl Environ Microbiol , vol.70 , pp. 6459-6465
    • Song, Y.1    Liu, C.2    Finegold, S.M.3
  • 55
    • 0034056125 scopus 로고    scopus 로고
    • The adolescent brain and age-related behavioral manifestations
    • Spear L.P. The adolescent brain and age-related behavioral manifestations. Neurosci Biobehav Rev 2000, 24:417-463.
    • (2000) Neurosci Biobehav Rev , vol.24 , pp. 417-463
    • Spear, L.P.1
  • 56
    • 29144536209 scopus 로고    scopus 로고
    • Long-term changes in blood-brain barrier permeability and white matter following prolonged systemic inflammation in early development in the rat
    • Stolp H.B., Dziegielewska K.M., Ek C.J., Potter A.M., Saunders N.R. Long-term changes in blood-brain barrier permeability and white matter following prolonged systemic inflammation in early development in the rat. Eur J Neurosci 2005, 22:2805-2816.
    • (2005) Eur J Neurosci , vol.22 , pp. 2805-2816
    • Stolp, H.B.1    Dziegielewska, K.M.2    Ek, C.J.3    Potter, A.M.4    Saunders, N.R.5
  • 57
    • 77949667960 scopus 로고    scopus 로고
    • Altered phospholipid and acylcarnitine profiles in propionic acid-infused rodents: further development of a potential model of autism spectrum disorders
    • Thomas R.H., Foley K.A., Mepham J.R., Tichenoff L.J., Possmayer F., MacFabe D.F. Altered phospholipid and acylcarnitine profiles in propionic acid-infused rodents: further development of a potential model of autism spectrum disorders. J Neurochem 2010, 113:515-529.
    • (2010) J Neurochem , vol.113 , pp. 515-529
    • Thomas, R.H.1    Foley, K.A.2    Mepham, J.R.3    Tichenoff, L.J.4    Possmayer, F.5    MacFabe, D.F.6
  • 59
    • 11144230769 scopus 로고    scopus 로고
    • Neuroglial activation and neuroinflammation in the brain of patients with autism
    • Vargas D.L., Nascimbene C., Krishnan C., Zimmerman A.W., Pardo C.A. Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann Neurol 2004, 57:67-81.
    • (2004) Ann Neurol , vol.57 , pp. 67-81
    • Vargas, D.L.1    Nascimbene, C.2    Krishnan, C.3    Zimmerman, A.W.4    Pardo, C.A.5
  • 60
    • 0036798561 scopus 로고    scopus 로고
    • Acute effects of ethanol on social behavior of adolescent and adult rats: role of familiarity of the test situation
    • Varlinskaya E.I., Spear L.P. Acute effects of ethanol on social behavior of adolescent and adult rats: role of familiarity of the test situation. Alcohol Clin Exp Res 2002, 26:1502-1511.
    • (2002) Alcohol Clin Exp Res , vol.26 , pp. 1502-1511
    • Varlinskaya, E.I.1    Spear, L.P.2
  • 61
    • 39149110252 scopus 로고    scopus 로고
    • Social interactions in adolescent adult Sprague-Dawley rats: impact of social deprivation and test context familiarity
    • Varlinskaya E.I., Spear L.P. Social interactions in adolescent adult Sprague-Dawley rats: impact of social deprivation and test context familiarity. Behav Brain Res 2008, 188:398-405.
    • (2008) Behav Brain Res , vol.188 , pp. 398-405
    • Varlinskaya, E.I.1    Spear, L.P.2
  • 62
    • 4344630828 scopus 로고    scopus 로고
    • The role of oxidative damage in the neuropathology of organic acidurias: insights from animal studies
    • Wajner M., Latini A., Wyse A.T., Dutra-Filho C.S. The role of oxidative damage in the neuropathology of organic acidurias: insights from animal studies. J Inherit Metab Dis 2004, 27:427-448.
    • (2004) J Inherit Metab Dis , vol.27 , pp. 427-448
    • Wajner, M.1    Latini, A.2    Wyse, A.T.3    Dutra-Filho, C.S.4
  • 63
    • 34247366072 scopus 로고    scopus 로고
    • Inflammation as a causative factor in the aetiology of Parkinson's disease
    • Whitton P.S. Inflammation as a causative factor in the aetiology of Parkinson's disease. Br J Pharmacol 2007, 150:963-976.
    • (2007) Br J Pharmacol , vol.150 , pp. 963-976
    • Whitton, P.S.1
  • 66
    • 33747202981 scopus 로고    scopus 로고
    • Altered vascular phenotype in autism: correlation with oxidative stress
    • Yao Y., Walsh W.J., McGinnis W.R., Pratico D. Altered vascular phenotype in autism: correlation with oxidative stress. Arch Neurol 2006, 63:1161-1164.
    • (2006) Arch Neurol , vol.63 , pp. 1161-1164
    • Yao, Y.1    Walsh, W.J.2    McGinnis, W.R.3    Pratico, D.4
  • 67
    • 4043104160 scopus 로고    scopus 로고
    • Assessing survival of dairy propionibacteria in gastrointestinal conditions and adherence to intestinal epithelia
    • Zarate G., Gonzalez S., Chaia A.P. Assessing survival of dairy propionibacteria in gastrointestinal conditions and adherence to intestinal epithelia. Methods Mol Biol 2004, 268:423-432.
    • (2004) Methods Mol Biol , vol.268 , pp. 423-432
    • Zarate, G.1    Gonzalez, S.2    Chaia, A.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.