Oral administration of tributyrin increases concentration of butyrate in the portal vein and prevents lipopolysaccharide-induced liver injury in rats

Clinical Nutrition

Volumn 30, Issue 2, 2011, Pages 252-258

  Miyoshi, Makoto ^a,b   Sakaki, Hiroe ^a,c   Usami, Makoto ^a,d   Iizuka, Norihito ^a   Shuno, Katsuhito ^a   Aoyama, Michiko ^a   Usami, Yu ^e  

^a KOBE UNIVERSITY   (Japan)

^b KAGAWA PREFECTURAL UNIVERSITY OF HEALTH SCIENCES   (Japan)

^c TOKUSHIMA PREFECTURAL CENTRAL HOSPITAL   (Japan)

^d KOBE UNIVERSITY HOSPITAL   (Japan)

^e OSAKA UNIVERSITY DENTAL HOSPITAL   (Japan)

Author keywords

Lipopolysaccharide; Liver injury; Nuclear factor B; Plasma butyrate concentration; Tributyrin

Indexed keywords

BUTYRIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; TOLL LIKE RECEPTOR 2; TRIBUTYRIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; FATTY ACID BLOOD LEVEL; GENE EXPRESSION; HISTOPATHOLOGY; LIVER INJURY; MALE; NONHUMAN; PORTAL VEIN; RAT;

ADMINISTRATION, ORAL; ANIMALS; BLOTTING, WESTERN; BUTYRATES; DRUG-INDUCED LIVER INJURY; LIPOPOLYSACCHARIDES; LIVER; MALE; NF-KAPPA B; PORTAL VEIN; RATS; RATS, WISTAR; RNA, MESSENGER; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA; UPPER GASTROINTESTINAL TRACT;

EID: 79953036634     PISSN: 02615614     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clnu.2010.09.012     Document Type: Article

References (33)

1. Ulmer A.J., Rietschel E.T., Zahringer U., Hein H. Lipopolysaccharide: structure, bioactivity, receptors, and signal transduction. Trends Glycosci Glycotechnol 2002, 14:53-68.
2. Ruiter D.J., van der Meulen J., Brouwer A., Hummel M.J., Mauw B.J., van der Ploeg J.C., et al. Uptake by liver cells of endotoxin following its intravenous injection. Lab Invest 1981, 45:38-45.
3. Liu S., Salyapongse A.N., Geller D.A., Vodovotz Y., Billiar T.R. Hepatocyte toll-like receptor 2 expression in vivo and in vitro: role of cytokine in induction of rat TLR2 gene expression by lipopolysaccharide. Shock 2000, 14:361-365.
4. Pittner R.A., Spitzer J.A. Endotoxin and TNF alpha directly stimulate nitric oxide formation in cultured rat hepatocytes from chronically endotoxemic rats. Biochem Biophys Res Commun 1992, 185:430-435.
5. Seki E., Brenner D.A. Toll-like receptors and adaptor molecules in liver disease: update. Hepatology 2008, 48(1):322-335.
6. Matsuguchi T., Musikacharoen T., Ogawa T., Yoshikai Y. Gene expression of toll-like receptor 2, but not toll-like receptor 4, is induced by lps and inflammatory cytokine in mouse macrophages. J Immunol 2000, 165:5767-5772.
7. Matsumura T., Ito A., Takii T., Hayashi H., Onozaki K. Endotoxin and cytokine regulation of toll-like receptor (TLR) 2 and 4 gene expression in murine liver and hepatocytes. J Interferon Cytokine Res 2000, 20:915-921.
8. Ojaniemi M., Lijeroos M., Harju K., Sormunen R., Vuolteenabo R., Hallman M. TLR-2 is upregulated and mobilized to the hepatocyte plasma membrane in the space of Disse and to the Kupffer cells TLR-4 dependently during acute endotoxemia in mice. Immunol Lett 2006, 102:158-168.
9. Su G.L. Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell activation. Am J Physiol Gastrointest Liver Physiol 2002, 283(2):G256-G265.
10. Quivy V., Lint C.V. Regulation at multiple levels of NF-κB-mediated transcription by protein acetylation. Biochem Pharm 2004, 68:1221-1229.
11. Suuronen T., Huuskonen J., Pihlaja R., Kyrylenko S., Salminen A. Regulation of microglial inflammatory response by histone deacetylase inhibitors. J Neurochem 2003, 87:407-416.
12. Young G.P., Gibson R.P. Butyrate and the human cancer cell. Physiological and clinical aspects of short-chain fatty acids 1955, 319. Cambridge University Press, Cambridge. J.H. Cumming, J.L. Rombeau, T. Sakata (Eds.).
13. Usami M., Kishimoto K., Ohata A., Miyoshi M., Aoyama M., Fueda Y., et al. Short-chain fatty acids, especially butyrate, and trichostatin A attenuate nuclear factor-κB activation and TNF-α secretion and increase PGE2 secretion in peripheral blood mononuclear cells with lipopolysaccharide. Nutr Res 2008, 28:321-328.
14. Aoyama M., Kotani J., Usami M. Butyrate and propionate induced activated- or non-activated neutrophil apoptosis via HDAC inhibitor activity but without activating GPR41/GPR43 pathways. Nutrition 2010, 26:653-661.
15. Ohata A., Usami M., Miyoshi M. Short-chain fatty acids alter tight junction permeability in intestinal monolayer cells via lipoxygenase activation. Nutrition 2005, 21:838-847.
16. Miyoshi M., Usami M., Ohata A. Short-chain fatty acids and trichostatin A alter tight junction permeability in human umbilical vein endothelial cells. Nutrition 2008, 24:1189-1198.
17. Usami M., Miyoshi M., Sakaki H., Iizuka N., Aoyama M., Syuno K., et al. Regulation of intestinal integrity and inflammatory response by short-chain fatty acids. Jpn J Pediatr Surg 2008, 40:884-888. [in Japanese].
18. Zhang L.T., Yao Y.M., Lu J.Q., Yan X.J., Yu Y., Sheng Z.Y. Sodium butyrate prevents lethality of severe sepsis in rats. Shock 2007, 27:672-677.
19. Bocker U., Yezerskyy O., Feick P., Manigold T., Panja A., Kalina U., et al. Responsiveness of intestinal epithelial cell lines to lipopolysaccharide is correlated with toll-like receptor 4 but not toll-like receptor 2 or CD14 expression. Int J Colorectal Dis 2003, 18:25-32.
20. Lee S.K., Kim T.I., Kim Y.K., Choi C.H., Yang K.M., Chae B., et al. Cellular differentiation-induced attenuation of LPS response in HT-29 cells is related to the down-regulation of TLR4 expression. Biochem Biophys Res Commun 2005, 337:457-463.
21. Beale R.J., Sherry T., Lei K., Stephen L.C., McCook J., Smith J., et al. Early enteral supplementation with key pharmaconutrients improves sequential organ failure assessment score in critically ill patients with sepsis: outcome of a randomized, controlled, double-blind trial. Crit Care Med 2008, 36(1):131-144.
22. Newmark H.L., Lupton J.R., Young C.W. Butyrate as a differentiating agent: pharmacokinetics, analogues and current status. Cancer Lett 1994, 78:1-5.
23. Su Jie, He Li, Zhang Ningning, Ho Paul C. Evaluation of tributyrin lipid emulsion with affinity to low density lipoprotein: pharmacokinetics in adult male Wistar rats and cellular activity on Caco-2 and HepG2 cell lines. J Pharmacol Exp Ther 2006, 316:62-70.
24. Egorin M.J., Yuan Z.M., Sentz D.L., Plaisance K., Eiseman J.L. Plasma pharmacokinetics of butyrate after intravenous administration of sodium butyrate or oral administration of tributyrin or sodium butyrate to mice and rats. Cancer Chemother Pharmacol 1999, 43:445-453.
25. Ishak K., Baptista A., Bianchi L., Callea F., Groote J.D., Gudat F., et al. Histological grading and staging of chronic hepatitis. J Hepatol 1995, 22:696-699.
26. Gadjeva M., Tomczak M.F., Zhang M., Wang Y.Y., Dull K., Rogers A.B., et al. A role for NF-kappa B subunits p50 and p65 in the inhibition of lipopolysaccharide-induced shock. J Immunol 2004, 173(9):5786-5793.
27. Anderson J.W. Short-chain fatty acids and lipid metabolism: human studies. Physiological and clinical aspects of short-chain fatty acids 1995, 509-523. Cambridge University Press, New York. J.H. Cummings, J.L. Rombeau, T. Sakata (Eds.).
28. Bloemen J.G., Venema K., van de Poll M.C., Olde Damink S.W., Buurman W.A., Dejong C.H. Short chain fatty acids exchange across the gut and liver in humans measured at surgery. Clin Nutr 2009, 28(6):657-661.
29. Vollmar B., Bauer C., Menger M.D. n-3 polyunsaturated fatty acid-enriched diet does not protect from liver injury but attenuates mortality rate in a rat model of systemic endotoxemia. Crit Care Med 2002, 30(5):1091-1098.
30. Davie J. Inhibition of histone deacetylase activity by butyrate. J Nutr 2003, 133:2485-2493.
31. Xu F.L., You H.B., Li X.H., Chen X.F., Liu Z.J., Gong J.P. Glycine attenuates endotoxin-induced liver injury by downregulating TLR4 signaling in Kupffer cells. Am J Surg 2008, 196:139-148.
32. Park J.S., Gamboni-Robertson F., He Q., Svetkauskaite D., Kim J.Y., Strassheim D., et al. High mobility group box 1 protein interacts with multiple Toll-like receptors. Am J Physiol, Cell Physiol 2006, 290(3):917-924.
33. Wischmeyer P.E., Kahana M., Wolfson R., Ren H., Musch M.M., Chang E.B. Glutamine induces heat shock protein and protects against endotoxin shock in the rat. J Appl Physiol 2001, 90:2403-2410.