A novel rodent model of autism: Intraventricular infusions of propionic acid increase locomotor activity and induce neuroinflammation and oxidative stress in discrete regions of adult rat brain

American Journal of Biochemistry and Biotechnology

Volumn 4, Issue 2, 2008, Pages 146-166

  MacFabe, Derrick F ^a   Rodríguez Capote, Karina ^a   Hoffman, Jennifer E ^a   Franklin, Andrew E ^a   Mohammad Asef, Yalda ^a   Taylor, A Roy ^a   Boon, Francis ^a   Cain, Donald P ^a   Kavaliers, Martin ^a   Possmayer, Fred ^a   Ossenkopp, Klaus Peter ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Animal model; Clostridia; Glutathione; Metabolic disorder; Movement disorder; Organic acidemia; Oxidative stress; Short chain fatty acids

Indexed keywords

ACIDS; BEHAVIORAL RESEARCH; BRAIN; ENZYME ACTIVITY; OXIDATIVE STRESS; PHYSIOLOGICAL MODELS;

ANIMAL MODEL; CLOSTRIDIA; GLUTATHIONE; METABOLIC DISORDER; ORGANIC ACIDEMIA; PROPIONIC ACID (PPA);

RATS;

CASPASE 3; CATALASE; CD68 ANTIGEN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; PHOSPHATE BUFFERED SALINE; PROPIONIC ACID; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTOSIS; AUTISM; BRAIN HOMOGENATE; BRAIN REGION; CELL LOSS; COMPARATIVE STUDY; CONTROLLED STUDY; CORPUS STRIATUM; ENCEPHALITIS; ENZYME ACTIVITY; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; LIPID OXIDATION; LIPID PEROXIDATION; LOCOMOTION; MALE; MICROGLIA; NEOCORTEX; NONHUMAN; OPEN FIELD BEHAVIOR; OXIDATIVE STRESS; PATHOPHYSIOLOGY; RAT; THALAMUS; WHITE MATTER;

ANIMALIA; BACTERIA (MICROORGANISMS); CLOSTRIDIA; RATTUS; RODENTIA;

EID: 41949122332     PISSN: 15533468     EISSN: None     Source Type: Journal    
DOI: 10.3844/ajbbsp.2008.146.166     Document Type: Article

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