Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem/progenitor cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 8, 2016, Pages 2258-2263

  Schwer, Bjoern ^a,b   Wei, Pei Chi ^a,b   Chang, Amelia N ^a,b   Kao, Jennifer ^a,b   Du, Zhou ^a,b   Meyers, Robin M ^a,b   Alt, Frederick W ^a,b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Alternative end joining; Neural stem cells; Nonhomologous end joining; Transcription; Translocation

Indexed keywords

DOUBLE STRANDED DNA; ATM PROTEIN; ATM PROTEIN, MOUSE; DNA BINDING PROTEIN; MYC PROTEIN; MYC PROTEIN, MOUSE; PROTEIN P53; XRCC4 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELLS BY BODY ANATOMY; COMPARATIVE STUDY; CONTROLLED STUDY; DNA END JOINING REPAIR; DNA SEQUENCE; DNA TRANSCRIPTION; DOUBLE STRANDED DNA BREAK; GENE EXPRESSION; GENE TRANSLOCATION; HIGH THROUGHPUT GENOME WIDE TRANSLOCATION SEQUENCING; MOUSE; NEURAL STEM CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TRANSCRIPTION INITIATION SITE; ANIMAL; CELL CULTURE; DEFICIENCY; GENETIC TRANSCRIPTION; GENETICS; KNOCKOUT MOUSE; METABOLISM; ONCOGENE MYC; TUMOR SUPPRESSOR GENE;

ANIMALS; ATAXIA TELANGIECTASIA MUTATED PROTEINS; B-LYMPHOCYTES; CELLS, CULTURED; DNA BREAKS, DOUBLE-STRANDED; DNA END-JOINING REPAIR; DNA-BINDING PROTEINS; GENES, MYC; GENES, P53; MICE; MICE, KNOCKOUT; NEURAL STEM CELLS; PROTO-ONCOGENE PROTEINS C-MYC; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION, GENETIC; TRANSLOCATION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84958205734     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1525564113     Document Type: Article

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