A combined proteomic and targeted analysis unravels new toxic mechanisms for zinc oxide nanoparticles in macrophages

Journal of Proteomics

Volumn 134, Issue , 2016, Pages 174-185

  Aude Garcia, Catherine ^a,b,c   Dalzon, Bastien ^a,b,c   Ravanat, Jean Luc ^a,b   Collin Faure, Véronique ^a,b,c   Diemer, Hélène ^c,d   Strub, Jean Marc ^c,d   Cianferani, Sarah ^c,d   Van Dorsselaer, Alain ^c,d   Carrière, Marie ^a,b   Rabilloud, Thierry ^a,b,c  

^a CEA GRENOBLE   (France)

^b UNIV GRENOBLE ALPES   (France)

^c CNRS   (France)

^d UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

DNA damage; Glutathione biosynthesis; Heme oxygenase; Macrophages; Methyglyoxal; Mitochondria; Nanoparticles; Phagocytosis; Proteomics; Zinc oxide; Zirconium dioxide

Indexed keywords

ALDEHYDE REDUCTASE; DEOXYRIBONUCLEOTIDE; DEOXYRIBONUCLEOTIDE HYDROLASE; DNA BASE; GLYOXALASE; GLYOXALASE 2 ALDOSE REDUCTASE; HYDROLASE; MITOCHONDRIAL PROTEIN; MYELOID DIFFERENTIATION FACTOR 88; UNCLASSIFIED DRUG; ZINC OXIDE NANOPARTICLE; NANOPARTICLE; PROTEOME; ZINC OXIDE;

ANIMAL CELL; ARTICLE; CELL TRANSPORT; CONTROLLED STUDY; CYTOSKELETON; CYTOTOXICITY; DNA DAMAGE; GENOTOXICITY; MACROPHAGE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NANOTOXICOLOGY; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEOMICS; SIGNAL TRANSDUCTION; TOXICITY TESTING; ANIMAL; CELL LINE; CHEMISTRY; METABOLISM; PATHOLOGY;

ANIMALS; CELL LINE; MACROPHAGES; MICE; NANOPARTICLES; PROTEOME; PROTEOMICS; ZINC OXIDE;

EID: 84958181930     PISSN: 18743919     EISSN: 18767737     Source Type: Journal    
DOI: 10.1016/j.jprot.2015.12.013     Document Type: Article

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