Different mechanisms are involved in oxidative DNA damage and genotoxicity induction by ZnO and TiO2 nanoparticles in human colon carcinoma cells

Toxicology in Vitro

Volumn 29, Issue 7, 2015, Pages 1503-1512

  Zijno, Andrea ^a   De Angelis, Isabella ^a   De Berardis, Barbara ^a   Andreoli, Cristina ^a   Russo, Maria Teresa ^a   Pietraforte, Donatella ^a   Scorza, Giuseppe ^a   Degan, Paolo ^b   Ponti, Jessica ^c   Rossi, Francois ^c   Barone, Flavia ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c EUROPEAN COMMISSION   (Belgium)

Author keywords

Caco 2 cells; Genotoxicity; Nanoparticles; Oxidative DNA damage; Oxidative stress

Indexed keywords

8 HYDROXYGUANINE; DNA GLYCOSYLTRANSFERASE; FREE RADICAL; OGG1 DNA GLYCOSYLASE; REACTIVE OXYGEN METABOLITE; TITANIUM DIOXIDE NANOPARTICLE; UNCLASSIFIED DRUG; ZINC OXIDE NANOPARTICLE; 8-OXO-7-HYDRODEOXYGUANOSINE; DEOXYGUANOSINE; MUTAGENIC AGENT; NANOPARTICLE; OXOGUANINE GLYCOSYLASE 1, HUMAN; TITANIUM; TITANIUM DIOXIDE; ZINC OXIDE;

ARTICLE; CACO 2 CELL LINE; CELL FREE SYSTEM; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; ELECTRON SPIN RESONANCE; GENOTOXICITY; HUMAN; HUMAN CELL; MICRONUCLEUS; OXIDATION KINETICS; OXIDATIVE STRESS; PHYSICAL CHEMISTRY; PROTEIN EXPRESSION; STEADY STATE; ANALOGS AND DERIVATIVES; COLON TUMOR; METABOLISM; MICRONUCLEUS TEST;

CACO-2 CELLS; COLONIC NEOPLASMS; COMET ASSAY; DEOXYGUANOSINE; DNA DAMAGE; DNA GLYCOSYLASES; HUMANS; MICRONUCLEUS TESTS; MUTAGENS; NANOPARTICLES; REACTIVE OXYGEN SPECIES; TITANIUM; ZINC OXIDE;

EID: 84935030090     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2015.06.009     Document Type: Article

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