Differential pro-inflammatory effects of metal oxide nanoparticles and their soluble ions in vitro and in vivo; Zinc and copper nanoparticles, but not their ions, recruit eosinophils to the lungs

Nanotoxicology

Volumn 6, Issue 1, 2012, Pages 22-35

  Cho, Wan Seob ^a   Duffin, Rodger ^a   Poland, Craig A ^a   Duschl, Albert ^b   Oostingh, Gertie Janneke ^b   MacNee, William ^a   Bradley, Mark ^a   Megson, Ian L ^c   Donaldson, Ken ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF SALZBURG   (Austria)

^c UNIVERSITY OF THE HIGHLANDS AND ISLANDS   (United Kingdom)

Author keywords

A549 cells; Aqueous extract; Instillation; Lung inflammation; Metal oxide nanoparticles; Water soluble ions

Indexed keywords

COPPER NANOPARTICLE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 2; NANOPARTICLE; NICKEL NANOPARTICLE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; ZINC NANOPARTICLE;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC INFLAMMATION; CONTROLLED STUDY; CYTOTOXICITY; EOSINOPHIL; FEMALE; HUMAN; HUMAN CELL; INFLAMMATORY CELL; LUNG; LUNG ALVEOLUS EPITHELIUM; LUNG LAVAGE; NEUTROPHIL; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; RAT; SOLUBILITY;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CATTLE; CELL LINE, TUMOR; CELL SURVIVAL; CHEMOTAXIS, LEUKOCYTE; COPPER; EOSINOPHILS; HUMANS; INTERLEUKIN-8; INTUBATION, INTRATRACHEAL; IONS; LUNG; METAL NANOPARTICLES; NEUTROPHILS; NICKEL; OXIDES; PNEUMOCYTES; RATS; TRANSCRIPTION FACTOR AP-1; ZINC OXIDE;

RATTUS;

EID: 84855878885     PISSN: 17435390     EISSN: 17435404     Source Type: Journal    
DOI: 10.3109/17435390.2011.552810     Document Type: Article

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