Involvement of the PTEN-AKT-FOXO3a pathway in neuronal apoptosis in developing rat brain after hypoxia-ischemia

Journal of Cerebral Blood Flow and Metabolism

Volumn 29, Issue 12, 2009, Pages 1903-1913

  Li, Deyuan ^a   Qu, Yi ^a   Mao, Meng ^a   Zhang, Xiaolan ^a   Li, Jinhui ^a   Ferriero, Donna ^b   Mu, Dezhi ^a,b  

^a SICHUAN UNIVERSITY   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Akt; Bim; FOXO3a; Hypoxia ischemia; Neuronal apoptosis; PTEN

Indexed keywords

BIM PROTEIN; BISPEROXOVANADIUM; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN INHIBITOR; PROTEIN KINASE B; TRANSCRIPTION FACTOR FKHRL1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN DAMAGE; BRAIN DEVELOPMENT; BRAIN HYPOXIA; BRAIN ISCHEMIA; CONTROLLED STUDY; DOWN REGULATION; FEMALE; IMMUNOHISTOCHEMISTRY; MALE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; RAT; UPREGULATION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL NUCLEUS; CYTOPLASM; ENZYME INHIBITORS; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION; HYPOXIA-ISCHEMIA, BRAIN; MEMBRANE PROTEINS; NEURONS; PHOSPHORYLATION; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RATS; RATS, SPRAGUE-DAWLEY; VANADIUM COMPOUNDS;

EID: 72049105843     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2009.102     Document Type: Article

References (30)

1. Arden KC (2006) Multiple roles of FOXO transcription factors in mammalian cells point to multiple roles in cancer. Exp Gerontol 41:709-717
2. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96:857-868
3. Downes CP, Bennett D, McConnachie G, Leslie NR, Pass I, MacPhee C, Patel L, Gray A (2001) Antagonism of PI 3-kinase-dependent signalling pathways by the tumour suppressor protein, PTEN. Biochem Soc Trans 29:846-851
4. Downward J (2004) PI 3-kinase, Akt and cell survival. Semin Cell Dev Biol 15:177-182
5. Ferriero DM (2004) Neonatal brain injury. N Engl J Med 351:1985-1995
6. Franke TF, Hornik CP, Segev L, Shostak GA, Sugimoto C (2003) PI3K/Akt and apoptosis: size matters. Oncogene 22:8983-8998
7. Fresno Vara JA, Casado E, de Castro J, Cejas P, Belda-Iniesta C, González-Barón M (2004) PI3K/Akt signalling pathway and cancer. Cancer Treat Rev 30:193-204
8. Gilley J, Coffer PJ, Ham J (2003) FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. J Cell Biol 162:613-622
9. Griffin RJ, Moloney A, Kelliher M, Johnston JA, Ravid R, Dockery P, O'Connor R, O'Neill C (2005) Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology. J Neurochem 93:105-117
10. Hill MM, Andjelkovic M, Brazil DP, Ferrari S, Fabbro D, Hemmings BA (2001) Insulin-stimulated protein kinase B phosphorylation on Ser-473 is independent of its activity and occurs through a staurosporine-insensitive kinase. J Biol Chem 276:25643-25646
11. Hoekman MF, Jacobs FM, Smidt MP, Burbach JP (2006) Spatial and temporal expression of FoxO transcription factors in the developing and adult murine brain. Gene Expr Patterns 6:134-140
12. Huang H, Tindall DJ (2007) Dynamic FoxO transcription factors. J Cell Sci 120:2479-2487
13. Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, Tycko B, Hibshoosh H, Wigler MH, Parsons R (1997) PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275:1943-1947
14. Li L, Liu F, Salmonsen RA, Turner TK, Litofsky NS, Di Cristofano A, Pandolfi PP, Jones SN, Recht LD, Ross AH (2002) PTEN in neural precursor cells: regulation of migration, apoptosis, and proliferation. Mol Cell Neurosci 20:21-29
15. Li L, Qu Y, Li J, Xiong Y, Mao M, Mu D (2007) Relationship between HIF-1alpha expression and neuronal apoptosis in neonatal rats with hypoxia-ischemia brain injury. Brain Res 1180:133-139
16. Li L, Qu Y, Mao M, Xiong Y, Mu D (2008) The involvement of phosphoinositid 3-kinase/Akt pathway in the activation of hypoxia-inducible factor-1alpha in the developing rat brain after hypoxia-ischemia. Brain Res 1197:152-158
17. Mao M, Hua Y, Jiang X, Li L, Zhang L, Mu D (2006) Expression of tumor necrosis factor alpha and neuronal apoptosis in the developing rat brain after neonatal stroke. Neurosci Lett 403:227-232
18. Meller R, Cameron JA, Torrey DJ, Clayton CE, Ordonez AN, Henshall DC, Minami M, Schindler CK, Saugstad JA, Simon RP (2006) Rapid degradation of Bim by the ubiquitin-proteasome pathway mediates short-term ischemic tolerance in cultured neurons. J Biol Chem 281:7429-7436
19. Nakamura N, Ramaswamy S, Vazquez F, Signoretti S, Loda M, Sellers WR (2000) Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN. Mol Cell Biol 20:8969-8982
20. Obexer P, Geiger K, Ambros PF, Meister B, Ausserlechner MJ (2007) FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells. Cell Death Differ 14:534-547
21. Omori N, Jin G, Li F, Zhang WR, Wang SJ, Hamakawa Y, Nagano I, Manabe Y, Shoji M, Abe K (2002) Enhanced phosphorylation of PTEN in rat brain after transient middle cerebral artery occlusion. Brain Res 954:317-322
22. Schmid AC, Byrne RD, Vilar R, Woscholski R (2004) Bisperoxovanadium compounds are potent PTEN inhibitors. FEBS Lett 566:35-38
23. Stahl JM, Cheung M, Sharma A, Trivedi NR, Shanmugam S, Robertson GP (2003) Loss of PTEN promotes tumor development in malignant melanoma. Cancer Res 63:2881-2890
24. Torres J, Pulido R (2001) The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation. J Biol Chem 276:993-998
25. Van Der Heide LP, Hoekman MF, Smidt MP (2004) The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation. Biochem J 380:297-309
26. Vazquez F, Ramaswamy S, Nakamura N, Sellers WR (2000) Phosphorylation of the PTEN tail regulates protein stability and function. Mol Cell Biol 20:5010-5018
27. Vazquez F, Grossman SR, Takahashi Y, Rokas MV, Nakamura N, Sellers WR (2001) Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex. J Biol Chem 276:48627-48630
28. Zhang QG, Wu DN, Han D, Zhang GY (2007) Critical role of PTEN in the coupling between PI3K/Akt and JNK1/2 signaling in ischemic brain injury. FEBS Lett 581:495-505
29. Zhao H, Shimohata T, Wang JQ, Sun G, Schaal DW, Sapolsky RM, Steinberg GK (2005) Akt contributes to neuroprotection by hypothermia against cerebral ischemia in rats. J Neurosci 25:9794-9806
30. Zhu Y, Hoell P, Ahlemeyer B, Sure U, Bertalanffy H, Krieglstein J (2007) Implication of PTEN in production of reactive oxygen species and neuronal death in in vitro models of stroke and Parkinson's disease. Neurochem Int 50:507-516