PTEN Upregulation May Explain the Development of Insulin Resistance and Type 2 Diabetes with High Dose Statins

Cardiovascular Drugs and Therapy

Volumn 28, Issue 5, 2014, Pages 447-457

  Birnbaum, Yochai ^a,b   Nanhwan, Manjyot K ^a   Ling, Shukuan ^a,c   Perez Polo, Jose R ^a   Ye, Yumei ^a   Bajaj, Mandeep ^b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c China Astronaut Research and Training Center   (China)

Author keywords

Cilostazol; Diabetes mellitus; Insulin resistance; PTEN; Skeletal muscle; Statins

Indexed keywords

CILOSTAZOL; FLUOROBENZENE; GLUCOSE BLOOD LEVEL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHODIESTERASE III INHIBITOR; PROTEIN KINASE B; PTEN PROTEIN, MOUSE; PYRIMIDINE DERIVATIVE; ROSUVASTATIN; SULFONAMIDE; TETRAZOLE DERIVATIVE;

ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; BLOOD; CHEMICALLY INDUCED; DRUG EFFECTS; GENE SILENCING; GENETICS; GLUCOSE BLOOD LEVEL; INSULIN RESISTANCE; METABOLISM; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; SKELETAL MUSCLE; UPREGULATION; WESTERN DIET;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DIET, WESTERN; FLUOROBENZENES; GENE KNOCKDOWN TECHNIQUES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INSULIN; INSULIN RESISTANCE; MICE; MUSCLE, SKELETAL; PHOSPHODIESTERASE 3 INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; PYRIMIDINES; SULFONAMIDES; TETRAZOLES; UP-REGULATION;

EID: 84930737140     PISSN: 09203206     EISSN: 15737241     Source Type: Journal    
DOI: 10.1007/s10557-014-6546-5     Document Type: Article

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