Synonymous deoptimization of foot-and-Mouth disease virus causes attenuation in vivo while inducing a strong neutralizing antibody response

Journal of Virology

Volumn 90, Issue 3, 2016, Pages 1298-1310

  Segundo, Fayna Diaz San ^a,b   Medina, Gisselle N ^a   Ramirez Medina, Elizabeth ^c   Velazquez Salinas, Lauro ^c   Koster, Marla ^a   Grubman, Marvin J ^a   de los Santos, Teresa ^a  

^a PLUM ISLAND ANIMAL DISEASE CENTER   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

^c OAK RIDGE INSTITUTE FOR SCIENCE AND EDUCATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUTRALIZING ANTIBODY; LIVE VACCINE; VIRUS ANTIBODY; VIRUS VACCINE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; CELL CULTURE; CODON USAGE; CONTROLLED STUDY; FEMALE; FOOT AND MOUTH DISEASE; FOOT AND MOUTH DISEASE VIRUS; IN VIVO STUDY; INOCULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROGENY; VIRUS ATTENUATION; VIRUS PATHOGENESIS; VIRUS STRAIN; VIRUS VIRULENCE; ANIMAL; BLOOD; C57BL MOUSE; GENETICS; GROWTH, DEVELOPMENT AND AGING; IMMUNOLOGY; ISOLATION AND PURIFICATION; PIG; SILENT MUTATION; SURVIVAL ANALYSIS; VIRULENCE;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; FEMALE; FOOT-AND-MOUTH DISEASE VIRUS; MICE, INBRED C57BL; SILENT MUTATION; SURVIVAL ANALYSIS; SWINE; VACCINES, ATTENUATED; VIRAL VACCINES; VIRULENCE;

EID: 84958092731     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02167-15     Document Type: Article

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