Attenuation of dengue (and other RNA viruses) with codon pair recoding can be explained by increased CpG/UpA dinucleotide frequencies

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 28, 2015, Pages E3633-E3634

  Simmonds, Peter ^a   Tulloch, Fiona ^b   Evans, David J ^c   Ryan, Martin D ^b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF ST ANDREWS   (United Kingdom)

^c UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CPG DINUCLEOTIDE; DINUCLEOTIDE; UNCLASSIFIED DRUG; UPA DINUCLEOTIDE;

BHK CELL LINE; CODON; DENGUE VIRUS 2; LETTER; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; RNA VIRUS; VIRUS MUTANT; VIRUS REPLICATION; ANIMAL; ARBOVIRUS; HUMAN; INSECT VECTOR; MAMMAL; PHYSIOLOGY; VIROLOGY; VIRUS GENOME;

RNA VIRUSES;

ANIMALS; ARBOVIRUSES; GENOME, VIRAL; HUMANS; INSECT VECTORS; MAMMALS;

EID: 84937113784     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1507339112     Document Type: Letter

References (2)

1. Shen SH, et al. (2015) Large-scale recoding of an arbovirus genome to rebalance its insect versus mammalian preference. Proc Natl Acad Sci USA 112(15):4749-4754.
2. Tulloch F, Atkinson NJ, Evans DJ, Ryan MD, Simmonds P (2014) RNA virus attenuation by codon pair deoptimisation is an artefact of increases in CpG/UpA dinucleotide frequencies. eLife 3:e04531.